Recent Publications

Presentations (AAIC, Copenhagen, Denmark, July 2014):   

  • Dr. Suzanne Craft presented initial results from the intranasal insulin trials at AAIC on July 13, 2014 as part of an oral presentation entitled,  “Therapeutic Effects of Intranasal Insulin and Insulin Analogues on Cognition and MRI Measures in Mild Cognitive Impairment and Alzheimer's Disease”. Dr. Laura Baker was a coauthor.
  • Dr. Laura Baker presented initial results from the PACE study at AAIC on July 13, 2014as part of an oral presentation entitled, “Effects of Aerobic Exercise on Cognition and Biomarkers in Adults with a Double-Hit Risk for Dementia: Mild Cognitive Impairment and Prediabetes”. Dr. Suzanne Craft was a coauthor.
  • Dr. Tim Hughes presented a poster from the ACCORD MIND study, entitled: “Plasma amylin levels are associated with brain structure among individuals with type-2 diabetes”. Drs. Suzanne Craft, Mike Miller and Jeff Williamson were coauthors.
  • Bryan Neth presented a poster from the ADNI study, entitled: “Markers of inflammation and vascular dysfunction are differentially associated with hippocampal volume by cognitive status in ADNI” as part of the AAIC on July 15, 2014 and at the Imaging Pre-Conference on July 12, 2014. Drs. Ramon Casanova, Tim Hughes and Suzanne Craft were coauthors.
  • Bryan Neth also presented a poster, entitled: “An arts-based brain fitness program for persons with dementia: a pilot study” at AAIC on July 14, 2014. Drs. Christina Hugenschmidt, Henry Colmer, Ed Shaw, Kaycee Sink and Rabeena Alli were coauthors.
  • Dr. Ramon Casanova presented two posters on machine learning, entitled: “Combining structural MRI, Proteomic and Genetic ADNI data for early detection of Alzheimer's disease via Random Forest classifiers” on Monday, July 14, 2014 and “Relative impact of sample size and dimensionality of predictors on two machine learning methods for detection of Alzheimer's disease” on Tuesday, July 15, 2014. Bryan Neth, Kaycee Sink, Steve Rapp, Jeff Williamson, Mark Espeland and Suzanne Craft were coauthors.

Other Presentations:

  • Dr. Suzanne Craft presented "Insulin Resistance and Pathological Brain Aging: New Approaches to Understanding, Treating, and Preventing Alzheimer’s Disease" at the Wake Forest School of Medicine Internal Medicine Grand Rounds on February 20, 2014.
  • Dr. Suzanne Craft presented "Promising Therapies for Alzheimer’s Disease Prevention and Treatment" at the Dementia Counseling and Care Conference in Winston Salem, NC on May 10, 2014.
  • Dr. Tim Hughes presented "Vascular Disease, Sleep and Alzheimer's Disease" at the WFSM Heart and Vascular Center for Excellence, May 29, 2014.
  • Dr. Laura Baker presented "Cognitive Decline and Dementia: What is IT? Who gets IT? What do we do about IT?" at the Piedmont Triad Regional Council:  Area Agency on Aging, May 29, 2014.
  • Dr. Ed Shaw presented "Caregivers Support for Families of Patients with Alzheimer's Disease" t the Piedmont Triad Regional Council:  Area Agency on Aging, May 29, 2014.Dr. Suzanne Craft presented "New Advances in Prevention and Treatment of Alzheimer’s Disease" at the Wake Forest Baptist Medical Center June 4, 2014, Board of Director’s Meeting.
  • Dr. Kaycee Sink presented "Is My Patient Demented or Delirious:  Telling the Difference" at the WFSM Graduate Registered Nursing Program on June 10, 2014.
  • Dr. Laura Baker presented "Caregiving; Healthy Aging; Pathological Aging; Impact of Alzheimer's Disease on African-Americans; Research Opportunities" at a Forget Me Not Project Sponsored Lunch-and-Learn on July 23, 2014.
  • Dr. Suzanne Craft presented “Alzheimer’s Disease, Aging and Cancer: Mechanistic Linkages and Therapeutic Implications” at the July 25, 2014, Comprehensive Cancer Center Membership Retreat.
  • Dr. Laura Baker presented "Link Between Type 2 Diabetes and Cognition Impairment and Decline in Adults 50 Years and Older" at the North Carolina American Indian Health Board Meeting, Cherokee, NC, August 2014.
  • Dr. Laura Baker presented "Planning of a National Trial of Aerobic Exercise to Slow Alzheimer’s Disease: Balancing Proof of Concept and Translational Value – Where to Draw the Line?" at the Wake Forest School of Medicine, Department of Social Sciences and Health Policy, Works in Progress Seminar, Winston Salem, NC, October 2014.
  • Dr. Suzanne Craft presented "Alzheimer’s Disease, Cognitive Disorders and Aging" on October 15, 2014, at the Wake Forest University Graduate School of Arts and Sciences Clinical Neuroscience Seminar.


  • Breitner J, Evans D, Saucedo HH, Kramer K, Casper AV, Martin B, Meinert J, Drye LT, Belden C, Weber M, Gavett B, Brandt J, Porsteinsson A, Craft S, Lyketsos C. Follow-up evaluation of cognitive function in the randomized alzheimer’s disease anti-inflammatory prevention trial (adapt) and its follow-up study (adapt-fs). Alzheimer's & dementia : the journal of the Alzheimer's Association. In press.
  • Hughes TM, Sink KM. Hypertension and its role in cognitive function: Current evidence and challenges for the future. Am J Hypertension. In press.
  • Sink KM, Craft S, Smith C, Maldjian JA, Bowden D, Xu J, Freedman BI, Divers J. Montreal cognitive assessment (moca) and modified mini-mental state examination (3mse) in african americans. J Aging Research. In press.
  • Bettcher BM, Yaffe K, Boudreau RM, Neuhaus J, Aizenstein H, Ding J, Kritchevsky SB, Launer LJ, Liu Y, Satterfield S, Rosano C, Health ABCs. Declines in inflammation predict greater white matter microstructure in older adults. Neurobiology of aging. 2015 Feb;36(2):948-54. PubMed PMID: 25554492. Pubmed Central PMCID: 4339188.
  • Chichester L, Wylie AT, Craft S, Kavanagh K. Muscle heat shock protein 70 predicts insulin resistance with aging. The journals of gerontology Series A, Biological sciences and medical sciences. 2015 Feb;70(2):155-62. PubMed PMID: 24532784. Pubmed Central PMCID: 4311181.
  • Claxton A, Baker LD, Hanson A, Trittschuh EH, Cholerton B, Morgan A, Callaghan M, Arbuckle M, Behl C, Craft S. Long-acting intranasal insulin detemir improves cognition for adults with mild cognitive impairment or early-stage alzheimer's disease dementia. Journal of Alzheimer's disease : JAD. 2015;44(3):897-906. PubMed PMID: 25374101.
  • Espeland MA, Beavers KM, Gibbs BB, Johnson KC, Hughes TM, Baker LD, Jakicic J, Korytkowski M, Miller M, Bray GA. Ankle-brachial index and inter-artery blood pressure differences as predictors of cognitive function in overweight and obese older adults with diabetes: Results from the action for health in diabetes movement and memory study. International journal of geriatric psychiatry. 2015 Oct;30(10):999-1007. PubMed PMID: 25546032.
  • Espeland MA, Brinton RD, Hugenschmidt C, Manson JE, Craft S, Yaffe K, Weitlauf J, Vaughan L, Johnson KC, Padula CB, Jackson RD, Resnick SM, Whims Study Group. Impact of type 2 diabetes and postmenopausal hormone therapy on incidence of cognitive impairment in older women. Diabetes care. 2015 Dec;38(12):2316-24. PubMed PMID: 26486190. Pubmed Central PMCID: 4657616.
  • Espeland MA, Brinton RD, Manson JE, Yaffe K, Hugenschmidt C, Vaughan L, Craft S, Edwards BJ, Casanova R, Masaki K, Resnick SM, Whims MRI Study Group. Postmenopausal hormone therapy, type 2 diabetes mellitus, and brain volumes. Neurology. 2015 Sep 29;85(13):1131-8. PubMed PMID: 26163429. Pubmed Central PMCID: 4603880.
  • Espeland MA, Newman AB, Sink K, Gill TM, King AC, Miller ME, Guralnik J, Katula J, Church T, Manini T, Reid KF, McDermott MM, Life Study Group. Associations between ankle-brachial index and cognitive function: Results from the lifestyle interventions and independence for elders trial. Journal of the American Medical Directors Association. 2015 Aug 1;16(8):682-9. PubMed PMID: 25869993. Pubmed Central PMCID: 4516564.
  • Freedman BI, Divers J, Whitlow CT, Bowden DW, Palmer ND, Smith SC, Xu J, Register TC, Carr JJ, Wagner BC, Williamson JD, Sink KM, Maldjian JA. Subclinical atherosclerosis is inversely associated with gray matter volume in african americans with type 2 diabetes. Diabetes care. 2015 Nov;38(11):2158-65. PubMed PMID: 26370382. Pubmed Central PMCID: 4613911.
  • Hanson AJ, Bayer JL, Baker LD, Cholerton B, VanFossen B, Trittschuh E, Rissman RA, Donohue MC, Moghadam SH, Plymate SR, Craft S. Differential effects of meal challenges on cognition, metabolism, and biomarkers for apolipoprotein e varepsilon4 carriers and adults with mild cognitive impairment. Journal of Alzheimer's disease : JAD. 2015;48(1):205-18. PubMed PMID: 26401941.
  • Hanson AJ, Craft S, Banks WA. The apoe genotype: Modification of therapeutic responses in alzheimer's disease. Current pharmaceutical design. 2015;21(1):114-20. PubMed PMID: 25330331.
  • Hughes T, Harrer JU. Treating arterial disease to prevent brain injury: Break out the bubbly or back to the bench? Neurology. 2015 Feb 3;84(5):440-1. PubMed PMID: 25552574.
  • Hughes TM, Craft S, Lopez OL. Review of 'the potential role of arterial stiffness in the pathogenesis of alzheimer's disease'. Neurodegenerative disease management. 2015;5(2):121-35. PubMed PMID: 25894876. Pubmed Central PMCID: 4423756.
  • Kaup AR, Nettiksimmons J, Harris TB, Sink KM, Satterfield S, Metti AL, Ayonayon HN, Yaffe K, Health A, Body Composition S. Cognitive resilience to apolipoprotein e epsilon4: Contributing factors in black and white older adults. JAMA neurology. 2015 Mar;72(3):340-8. PubMed PMID: 25599330. Pubmed Central PMCID: 4624320.
  • Oh ES, Marano CM, Leoutsakos JM, Lee RW, Rissman RA, Smith GS, Craft S, Lyketsos CG. Oral glucose tolerance testing to modulate plasma amyloid levels: A novel biomarker. Alzheimer's & dementia. 2015 Sep;1(3):311-5. PubMed PMID: 26413562. Pubmed Central PMCID: 4578701.
  • Sink KM, Divers J, Whitlow CT, Palmer ND, Smith SC, Xu J, Hugenschmidt CE, Wagner BC, Williamson JD, Bowden DW, Maldjian JA, Freedman BI. Cerebral structural changes in diabetic kidney disease: African american-diabetes heart study mind. Diabetes care. 2015 Feb;38(2):206-12. PubMed PMID: 25205141. Pubmed Central PMCID: 4302263.
  • Sink KM, Espeland MA, Castro CM, Church T, Cohen R, Dodson JA, Guralnik J, Hendrie HC, Jennings J, Katula J, Lopez OL, McDermott MM, Pahor M, Reid KF, Rushing J, Verghese J, Rapp S, Williamson JD, Life Study Investigators. Effect of a 24-month physical activity intervention vs health education on cognitive outcomes in sedentary older adults: The life randomized trial. Jama. 2015 Aug 25;314(8):781-90. PubMed PMID: 26305648. Pubmed Central PMCID: 4698980.
  • Skinner JS, Morgan A, Hernandez-Saucedo H, Hansen A, Corbett S, Arbuckle M, Leverenz JB, Wilkins CH, Craft S, Baker LD. Associations between markers of glucose and insulin function and cognitive function in healthy african american elders. Journal of gerontology & geriatric research. 2015 Aug;4(4). PubMed PMID: 26798567. Pubmed Central PMCID: 4718579.
  • Snyder HM, Corriveau RA, Craft S, Faber JE, Greenberg SM, Knopman D, Lamb BT, Montine TJ, Nedergaard M, Schaffer CB, Schneider JA, Wellington C, Wilcock DM, Zipfel GJ, Zlokovic B, Bain LJ, Bosetti F, Galis ZS, Koroshetz W, Carrillo MC. Vascular contributions to cognitive impairment and dementia including alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2015 Jun;11(6):710-7. PubMed PMID: 25510382. Pubmed Central PMCID: 4731036.
  • Turner RS, Thomas RG, Craft S, van Dyck CH, Mintzer J, Reynolds BA, Brewer JB, Rissman RA, Raman R, Aisen PS, Alzheimer's Disease Cooperative S. A randomized, double-blind, placebo-controlled trial of resveratrol for alzheimer disease. Neurology. 2015 Oct 20;85(16):1383-91. PubMed PMID: 26362286. Pubmed Central PMCID: 4626244.
  • Tyrrell DJ, Bharadwaj MS, Van Horn CG, Kritchevsky SB, Nicklas BJ, Molina AJ. Respirometric profiling of muscle mitochondria and blood cells are associated with differences in gait speed among community-dwelling older adults. The journals of gerontology Series A, Biological sciences and medical sciences. 2015 Nov;70(11):1394-9. PubMed PMID: 25030980.
  • Tyrrell DJ, Bharadwaj MS, Van Horn CG, Marsh AP, Nicklas BJ, Molina AJ. Blood-cell bioenergetics are associated with physical function and inflammation in overweight/obese older adults. Experimental gerontology. 2015 Oct;70:84-91. PubMed PMID: 26226578.
  • Vaughan L, Hogan PE, Rapp SR, Dugan E, Marottoli RA, Snively BM, Shumaker SA, Sink KM. Driving with mild cognitive impairment or dementia: Cognitive test performance and proxy report of daily life function in older women. Journal of the American Geriatrics Society. 2015 Sep;63(9):1774-82. PubMed PMID: 26338449.
  • Whitlow CT, Sink KM, Divers J, Smith SC, Xu J, Palmer ND, Hugenschmidt CE, Williamson JD, Bowden DW, Freedman BI, Maldjian JA. Effects of type 2 diabetes on brain structure and cognitive function: African american-diabetes heart study mind. AJNR American journal of neuroradiology. 2015 Sep;36(9):1648-53. PubMed PMID: 26206811.
  • Willette AA, Johnson SC, Birdsill AC, Sager MA, Christian B, Baker LD, Craft S, Oh J, Statz E, Hermann BP, Jonaitis EM, Koscik RL, La Rue A, Asthana S, Bendlin BB. Insulin resistance predicts brain amyloid deposition in late middle-aged adults. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2015 May;11(5):504-10 e1. PubMed PMID: 25043908. Pubmed Central PMCID: 4297592.
  • Ambrosius WT, Sink KM, Foy CG, Berlowitz DR, Cheung AK, Cushman WC, Fine LJ, Goff DC, Jr., Johnson KC, Killeen AA, Lewis CE, Oparil S, Reboussin DM, Rocco MV, Snyder JK, Williamson JD, Wright JT, Jr., Whelton PK, Sprint Study Research Group. The design and rationale of a multicenter clinical trial comparing two strategies for control of systolic blood pressure: The systolic blood pressure intervention trial (sprint). Clinical trials. 2014 Oct;11(5):532-46. PubMed PMID: 24902920. Pubmed Central PMCID: 4156910.
  • Behrendt R, Ghaznavi AM, Mahan M, Craft S, Siddiqui A. Continuous bedside pressure mapping and rates of hospital-associated pressure ulcers in a medical intensive care unit. American journal of critical care : an official publication, American Association of Critical-Care Nurses. 2014 Mar;23(2):127-33. PubMed PMID: 24585161.
  • Bharadwaj MS, Zhou Y, Molina AJ, Criswell T, Lu B. Examination of bioenergetic function in the inner mitochondrial membrane peptidase 2-like (immp2l) mutant mice. Redox biology. 2014 Aug 28;2C:1008-15. PubMed PMID: 25460737. Pubmed Central PMCID: 4215389.
  • Demons JL, Chenna S, Callahan KE, Davis BL, Kearsley L, Sink KM, Watkins FS, Williamson JD, Atkinson HH. Utilizing a meals on wheels program to teach falls risk assessment to medical students. Gerontology & geriatrics education. 2014;35(4):409-20. PubMed PMID: 24905192.
  • Dysken MW, Guarino PD, Vertrees JE, Asthana S, Sano M, Llorente M, Pallaki M, Love S, Schellenberg GD, McCarten JR, Malphurs J, Prieto S, Chen P, Loreck DJ, Carney S, Trapp G, Bakshi RS, Mintzer JE, Heidebrink JL, Vidal-Cardona A, Arroyo LM, Cruz AR, Kowall NW, Chopra MP, Craft S, Thielke S, Turvey CL, Woodman C, Monnell KA, Gordon K, Tomaska J, Vatassery G. Vitamin e and memantine in alzheimer's disease: Clinical trial methods and baseline data. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2014 Jan;10(1):36-44. PubMed PMID: 23583234. Pubmed Central PMCID: 4128187.
  • Hugenschmidt CE, Lovato JF, Ambrosius WT, Bryan RN, Gerstein HC, Horowitz KR, Launer LJ, Lazar RM, Murray AM, Chew EY, Danis RP, Williamson JD, Miller ME, Ding J. The cross-sectional and longitudinal associations of diabetic retinopathy with cognitive function and brain mri findings: The action to control cardiovascular risk in diabetes (accord) trial. Diabetes care. 2014 Dec;37(12):3244-52. PubMed PMID: 25193529. Pubmed Central PMCID: 4237980.
  • Hughes TM, Kuller LH, Barinas-Mitchell EJ, McDade EM, Klunk WE, Cohen AD, Mathis CA, Dekosky ST, Price JC, Lopez OL. Arterial stiffness and beta-amyloid progression in nondemented elderly adults. JAMA neurology. 2014 May;71(5):562-8. PubMed PMID: 24687165. Pubmed Central PMCID: 4267249.
  • Hughes TM, Lopez OL, Evans RW, Kamboh MI, Williamson JD, Klunk WE, Mathis CA, Price JC, Cohen AD, Snitz BE, Dekosky ST, Kuller LH. Markers of cholesterol transport are associated with amyloid deposition in the brain. Neurobiology of aging. 2014 Apr;35(4):802-7. PubMed PMID: 24199960. Pubmed Central PMCID: 3896052.
  • Klepin HD, Geiger AM, Bandos H, Costantino JP, Rapp SR, Sink KM, Lawrence JA, Atkinson HH, Espeland MA. Cognitive factors associated with adherence to oral antiestrogen therapy: Results from the cognition in the study of tamoxifen and raloxifene (co-star) study. Cancer prevention research. 2014 Jan;7(1):161-8. PubMed PMID: 24253314. Pubmed Central PMCID: 3924583.
  • Kurinami H, Shimamura M, Ma T, Qian L, Koizumi K, Park L, Klann E, Manfredi G, Iadecola C, Zhou P. Prohibitin viral gene transfer protects hippocampal ca1 neurons from ischemia and ameliorates postischemic hippocampal dysfunction. Stroke; a journal of cerebral circulation. 2014 Apr;45(4):1131-8. PubMed PMID: 24619393. Pubmed Central PMCID: 3971834.
  • Ma T. GSK3 in Alzheimer's disease: Mind the isoforms. Journal of Alzheimer's disease : JAD. 2014;39(4):707-10. PubMed PMID: 24254703.
  • Ma T, Chen Y, Vingtdeux V, Zhao H, Viollet B, Marambaud P, Klann E. Inhibition of amp-activated protein kinase signaling alleviates impairments in hippocampal synaptic plasticity induced by amyloid beta. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2014 Sep 3;34(36):12230-8. PubMed PMID: 25186765. Pubmed Central PMCID: 4152616.
  • McCurry SM, Shortreed SM, Von Korff M, Balderson BH, Baker LD, Rybarczyk BD, Vitiello MV. Who benefits from cbt for insomnia in primary care? Important patient selection and trial design lessons from longitudinal results of the lifestyles trial. Sleep. 2014 Feb;37(2):299-308. PubMed PMID: 24497658. Pubmed Central PMCID: 3900626.
  • Novak V, Milberg W, Hao Y, Munshi M, Novak P, Galica A, Manor B, Roberson P, Craft S, Abduljalil A. Enhancement of vasoreactivity and cognition by intranasal insulin in type 2 diabetes. Diabetes care. 2014;37(3):751-9. PubMed PMID: 24101698. Pubmed Central PMCID: 3931384.
  • Pahor M, Guralnik JM, Ambrosius WT, Blair S, Bonds DE, Church TS, Espeland MA, Fielding RA, Gill TM, Groessl EJ, King AC, Kritchevsky SB, Manini TM, McDermott MM, Miller ME, Newman AB, Rejeski WJ, Sink KM, Williamson JD, Life Study Investigators. Effect of structured physical activity on prevention of major mobility disability in older adults: The life study randomized clinical trial. Jama. 2014 Jun 18;311(23):2387-96. PubMed PMID: 24866862. Pubmed Central PMCID: 4266388.
  • Palmer ND, Sink KM, Smith SC, Xu J, Bowden DW, Hugenschmidt CE, Whitlow CT, Williamson JD, Maldjian JA, Divers J, Freedman BI. Kidney disease and cognitive function: African american-diabetes heart study mind. American journal of nephrology. 2014;40(3):200-7. PubMed PMID: 25323981. Pubmed Central PMCID: 4216628.
  • Vitiello MV, McCurry SM, Shortreed SM, Baker LD, Rybarczyk BD, Keefe FJ, Von Korff M. Short-term improvement in insomnia symptoms predicts long-term improvements in sleep, pain, and fatigue in older adults with comorbid osteoarthritis and insomnia. Pain. 2014 Aug;155(8):1547-54. PubMed PMID: 24793909. Pubmed Central PMCID: 4104256.
  • Weinstein JS, Lezon-Geyda K, Maksimova Y, Craft S, Zhang Y, Su M, Schulz VP, Craft J, Gallagher PG. Global transcriptome analysis and enhancer landscape of human primary t follicular helper and t effector lymphocytes. Blood. 2014 Dec 11;124(25):3719-29. PubMed PMID: 25331115. Pubmed Central PMCID: 4263981.
  • Williamson JD, Launer LJ, Bryan RN, Coker LH, Lazar RM, Gerstein HC, Murray AM, Sullivan MD, Horowitz KR, Ding J, Marcovina S, Lovato L, Lovato J, Margolis KL, Davatzikos C, Barzilay J, Ginsberg HN, Linz PE, Miller ME, Action to Control Cardiovascular Risk in Diabetes Memory in Diabetes I. Cognitive function and brain structure in persons with type 2 diabetes mellitus after intensive lowering of blood pressure and lipid levels: A randomized clinical trial. JAMA internal medicine. 2014 Mar;174(3):324-33. PubMed PMID: 24493100. Pubmed Central PMCID: 4423790.
  • Wilson VK, Houston DK, Kilpatrick L, Lovato J, Yaffe K, Cauley JA, Harris TB, Simonsick EM, Ayonayon HN, Kritchevsky SB, Sink KM, Health Aging, Body Composition Study. Relationship between 25-hydroxyvitamin d and cognitive function in older adults: The health, aging and body composition study. Journal of the American Geriatrics Society. 2014 Apr;62(4):636-41. PubMed PMID: 24635412. Pubmed Central PMCID: 3989387.


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