Changes in Muscle and Nerve Connection in ALS

What we are studying

This study is designed to help understand how muscles become weaker in ALS. The purpose of this trial is to study muscle and nerve connection to the muscle (neuromuscular junction) at different stages of ALS. There, the ends of nerve fibers connect to special sites on the muscle's membrane. These membranes contain receptors that enable the muscle to respond to a chemical messenger released by the nerve. After a nerve stimulates a muscle at this junction, an electrical impulse flows through the muscle, causing it to contract. It is known that nerve cells called “motor neurons” die in brain and spinal cords of people with ALS. However previous studies have shown that the death of these cells occurs late in the disease process. This trial focuses on thigh muscles to better understand the underlying disease process in ALS.

Who we are studying

  • Men and Women
  • Races:
    • White
    • African American
    • Asian
    • American Indian or Alaska Native
    • Native Hawaiian or Pacific Islander
    • Other
  • All Ethnicities
  • Ages 18+

Eligibility Criteria

  • Diagnosis of "suspected" ALS
  • Diagnosis of ALS
  • Not eligible if patient has had ALS for more than 5 years from symptom onset

What is involved

  • 1 screening visit including: review of medical history and demographic information; vital signs; questionnaires; Electromyography (EMG); and muscle biopsy
  • Follow-Up visits every 3 to 6 months that correspond with routine care in the ALS clinics

Compensation

$100 to compensate for time and travel expenses

Contact Information

Study Coordinator
Mozhdeh Marandi
Email
mmarandi@wakehealth.edu
Phone
336-713-8577

Disclaimer: The information on this website is for general informational purposes only and SHOULD NOT be relied upon as a substitute for sound professional medical advice, evaluation or care from your physician or other qualified health care provider.