Treatment for Atrial Fibrillation

What we are studying

Atrial fibrillation (AF) (an abnormal, rapid heart rhythm coming from the upper chambers of the heart [atria]) is the most common type of heart rhythm disorder or arrhythmia (abnormal heart rhythm). Instead of the heart beating in a steady pattern, in AF the upper chambers of the heart (atria) quiver rapidly in an unsteady manner. Atrial fibrillation may be treated with drug therapy. In some Institutions, atrial fibrillation is also treated with catheters inserted into blood vessels that can be placed inside the heart to eliminate the hot spots or triggers that start atrial fibrillation or stop those conditions that keep it going (catheter ablation). It is not known whether drug therapy or catheter ablation is better. This study is being done to compare drug therapy and catheter ablation in patients with atrial fibrillation. This study will help decide which treatment approach is best or when one or the other therapy is preferred. The CABANA study will also compare the cost of care for the two treatment approaches and determine the effect these therapies have on quality of life.

Who is Eligible

  • Genders:
    • Men
    • Women
  • Races:
    • White
    • African American
    • Asian
    • American Indian or Alaska Native
    • Native Hawaiian or Pacific Islander
    • Other
  • All Ethnicities
  • Ages 18+

Eligibility Criteria

  • Diagnosed with atrial fibrillation (AF)
  • Age 65 or older
  • Less than age 65 and have one or more of the following:
    • Hypertension
  • Diabetes
  • Congestive heart failure
  • Prior stroke or TIA

What is involved

  • Assigned to and receive either drug therapy or ablation therapy
  • Follow-Up at 3; 6; and 12 months during the first year and every 6 months thereafter
  • Study participation will last between 2 and 5 years



Contact Information

Study Coordinator
Deborah Wesley

Disclaimer: The information on this website is for general informational purposes only and SHOULD NOT be relied upon as a substitute for sound professional medical advice, evaluation or care from your physician or other qualified health care provider.