Neuro-Enteric Taste Signaling by a Naturally Occurring Bitter Food

What we are studying

The study consist of three different visits. We will measure your degree of bitter taste using bitter melon juice in the first visit. The second visit you will be given the bitterant orally and will have blood work, autonomic measuring, and the electrical signals from your stomach measured (both non-invasive). The third visit you will have the bitterant given through a naso-enteric tube (tube inserted through your nose and down past your stomach to the first part of your intestines) that will be placed by our radiology department. You will undergo the same testing as before in the second visit.

Who we are studying

  • Men and Women
  • Races:
    • White
    • African American
    • Asian
    • American Indian or Alaska Native
    • Native Hawaiian or Pacific Islander
    • Other
  • All Ethnicities
  • Ages 18 - 50

Eligibility Criteria

  • In good health
  • Age 18-50
  • BMI between 19 - 30 You cannot participate in this study if you have any of the following:
    • BMI <19 or > 30
  • Use of tobacco products
  • Diabetes; thyroid disease; cardiovascular; liver; or kidney disease
  • Digestive disorders; including malabsorption; chronic diarrhea; inflammatory bowel disease; or pancreatitis
  • History of gastrointestinal surgery
  • Use of medications that can alter taste; oral hypoglycemics; insulin; or prednisone; (you will be asked to supply a medications list)
  • Pregnancy or breast feeding (you may receive a pregnancy test)
  • Chronic sinusitis; dysgeusia (abnormal taste); inner ear disorders; or sicca syndrome (dry mouth)

What is involved

  • Three CRU visits at Wake Forest Baptist Medical Center


Yes, details will be given in the email.

Contact Information

Study Coordinator
David Fitch, MD
Principal Investigator
Richard Weinberg, MD

Disclaimer: The information on this website is for general informational purposes only and SHOULD NOT be relied upon as a substitute for sound professional medical advice, evaluation or care from your physician or other qualified health care provider.