Study of Nasal Insulin to Fight Forgetfulness – Short-Acting Insulin Aspart – 12 weeks

What we are studying

This research study is to find out whether insulin aspart improves memory when administered as a spray into the nasal passages of adults with mild memory impairment or early Alzheimer’s disease. We will explore the effects of insulin aspart administered intra-nasally on memory and levels of certain hormones and proteins in the blood. Insulin is approved by the US Food and Drug Administration (FDA). However, using it in this way is experimental and we don’t know if it will be effective to help improve cognition.

Who we are studying

  • Men and Women
  • Races:
    • White
    • African American
    • Asian
    • American Indian or Alaska Native
    • Native Hawaiian or Pacific Islander
    • Other
  • All Ethnicities
  • Ages 50 - 89

Eligibility Criteria

  • Participants who have been or are subsequently diagnosed with early AD (MMSE ? 20) or MCI will be eligible. Subjects will include men and women in between the age of 50 and 89
  • And will be drawn from diverse racial and ethnic backgrounds. All subjects must have the ability to communicate in English.

What is involved

  • Give blood samples (8 times)
  • Physical exam (1 time)
  • Tests of memory/thinking
  • Answer questions about daily activities (4 times)
  • Lumbar puncture (LP) (2 times)
  • Positron Emission Tomography (PET) scans (up to 2 times)
  • Finger-Stick 3 days per week before first meal using a glucometer
  • Administer study drug twice a day for 12 weeks.

Contact Information

Study Coordinator
Erin Caulder
Email
ecaulder@wakehealth.edu
Phone
336-713-8847
Principal Investigator
Suzanne Craft, PhD

Disclaimer: The information on this website is for general informational purposes only and SHOULD NOT be relied upon as a substitute for sound professional medical advice, evaluation or care from your physician or other qualified health care provider.