Comparison of Axillary Lymph Node Dissection With Axillary Radiation for Patients With Node-Positive Breast Cancer Treated With Chemotherapy

What we are studying

Patients with your type of breast cancer usually have neoadjuvant (which means “given before surgery) chemotherapy followed by breast and arm pit surgery to remove any remaining breast cancer. The lymph nodes in the arm pit are examined during surgery and if there is still cancer in the lymph nodes, then the majority of lymph nodes in the arm pit are removed. The purpose of this study is to examine whether removing some of the lymph nodes from the arm pit, but not removing them all followed with radiation therapy (experimental) will be as good as having the majority of the lymph nodes from the arm pit removed during breast surgery followed with radiation (standard of care).

Who we are studying

  • Men and Women
  • Races:
    • White
    • African American
    • Asian
    • American Indian or Alaska Native
    • Native Hawaiian or Pacific Islander
    • Other
  • All Ethnicities
  • Ages 18+

Eligibility Criteria

  • Breast cancer spread to lymph nodes in arm pit
  • Completed > 6 cycles of chemotherapy before surgery
  • No endocrine or radiation therapy before surgery

What is involved

  • Medical history
  • Mammogram
  • Breast ultrasound
  • Blood and urine tests
  • Surgery to example a few lymph nodes at the same time of your breast cancer surgery
  • Randomized to Group A - more lymph nodes removed from arm pit then radiation therapy or Group B - radiation therapy only
  • Physical exams every 6 months for 2 years then every year for 3-5 years.

Contact Information

Study Coordinator
Michele Harmon, RN
Email
mharmon@wakehealth.edu
Phone
336-713-6925

Disclaimer: The information on this website is for general informational purposes only and SHOULD NOT be relied upon as a substitute for sound professional medical advice, evaluation or care from your physician or other qualified health care provider.