Lowering Cholesterol in Participants at High Risk for Major Cardiovascular Events

What we are studying

You may participate in this study if you had a heart attack or stroke, or you have diabetes, kidney disease, hardening of the arteries of the legs, or you have an inherited disorder of high cholesterol. Having any of these medical problems puts you at risk of developing a heart problem (such as heart attack, stroke or hospitalization for chest pain). The purpose of this research study is to learn about the effects of an investigational drug on reducing the risk of developing a heart problem when it is added to other cholesterol treatments. Increased levels of “bad” cholesterol, called LDL cholesterol, is a known risk factor for cardiovascular disease. Statins and other cholesterol treatments lower levels of the bad cholesterol and have been shown to reduce the chance having a heart attack or a stroke. This new investigational drug lowers LDL C levels and may reduce the risk of heart problems.

Who we are studying

  • Men and Women
  • Races:
    • White
    • African American
    • Asian
    • American Indian or Alaska Native
    • Native Hawaiian or Pacific Islander
    • Other
  • All Ethnicities
  • Ages 18+

Eligibility Criteria

  • You may participate in this study if you had a heart attack or stroke or you have diabetes or kidney disease or hardening of the arteries of the legs or you have an inherited disorder of high cholesterol.

What is involved

  • The study period can last up to 4 years. The length of time depends on when you are enrolled.
  • You will come for clinic visits regularly (every 3 – 4 months).
  • You will receive the study drug or placebo
  • Blood draws at regular study visits
  • Cholesterol checks
  • Physical exams including EKGs
  • Blood pressure checks
  • Counseling on heart healthy diet and lifestyle.

Compensation

Compensation for participation is available.

Contact Information

Study Coordinator
Vickie Wayne
Email
viwilson@wakehealth.edu
Phone
336-713-8335
Principal Investigator
Dr. David Herrington

Disclaimer: The information on this website is for general informational purposes only and SHOULD NOT be relied upon as a substitute for sound professional medical advice, evaluation or care from your physician or other qualified health care provider.