Treatment for patients with Myeloproliferative Neoplasms

What we are studying

The purpose of this study is to test the safety and tolerability of ruxolitinib at different dose levels in combination with decitabine in patients with accelerated or blast phase Myeloproliferative Neoplasm (MPN), which is a group of diseases of the bone marrow in which excess cells are produced. You may qualify to take part in this research study because you have a MPN blood disorder called myelofibrosis (MF), essential thrombocythemia (ET), or polycythemia vera (PV) that is accelerated or blast phase. Accelerated (10–19% blasts in the blood or bone marrow) and blast phase MPN has been a difficult disease to treat. The term “blasts” refers to immature cells found in bone marrow. They are not fully developed, and therefore, do not yet carry out any particular function within the body. We want to find out what effects, good and/or bad it has on you and your disease.

Who we are studying

  • Men and Women
  • Races:
    • White
    • African American
    • Asian
    • American Indian or Alaska Native
    • Native Hawaiian or Pacific Islander
    • Other
  • All Ethnicities
  • Ages 18+

Eligibility Criteria

  • Accelerated phase Myeloproliferative Neoplasms
  • Have not received chemotherapy within the past 4 weeks
  • Do not have acute myelofibrosis

What is involved

  • 1 Screening visit
  • Receive treatment with study drug for at least 5 weeks
  • Follow-Up visits will be every 3 months for 2 years



Contact Information

Study Coordinator
Jennifer Thomas

Disclaimer: The information on this website is for general informational purposes only and SHOULD NOT be relied upon as a substitute for sound professional medical advice, evaluation or care from your physician or other qualified health care provider.