What we are studying
The purpose of this study is to test the safety and tolerability of ruxolitinib at different dose levels in combination with decitabine in patients with accelerated or blast phase Myeloproliferative Neoplasm (MPN), which is a group of diseases of the bone marrow in which excess cells are produced. You may qualify to take part in this research study because you have a MPN blood disorder called myelofibrosis (MF), essential thrombocythemia (ET), or polycythemia vera (PV) that is accelerated or blast phase. Accelerated (10–19% blasts in the blood or bone marrow) and blast phase MPN has been a difficult disease to treat. The term “blasts” refers to immature cells found in bone marrow. They are not fully developed, and therefore, do not yet carry out any particular function within the body. We want to find out what effects, good and/or bad it has on you and your disease.