Asthma Study for Subjects Using Oral Steroids

What we are studying

The purpose of this study is to see if benralizumab, given as injections under the skin for once every 4 weeks or once every 8 weeks, for a total of 24 weeks, can reduce the dose of your oral corticosteroids and help control your asthma better if it is added to currently available asthma medications (eg anti-inflammatory inhaled steroid also referred to as inhaled corticosteroids (ICS) and a long lasting airway opener also referred to as long acting ß-agonists (LABA)). This study will explore whether benralizumab helps to reduce oral corticosteroids dependence, how often benralizumab needs to be given, who responds best to benralizumab, and how well benralizumab is tolerated. This study will measure levels of benralizumab in the blood and see how the body accepts the study drug.

Who we are studying

  • Men and Women
  • Races:
    • White
    • African American
    • Asian
    • American Indian or Alaska Native
    • Native Hawaiian or Pacific Islander
    • Other
  • All Ethnicities
  • Ages 18 - 80

Eligibility Criteria

  • Diagnosed with asthma
  • Non smoker (less than 100 cigarettes in your life)
  • Currently using daily oral steroids for at least 6 months
  • Using additional inhaled asthma medications

What is involved

  • Informed consent
  • Medical and asthma history
  • Complete physical examination
  • Vital Signs
  • ECG
  • Local laboratory eosinophil test
  • Serum chemistry
  • Hematology
  • Urinalysis
  • Serology (hepatitis B;C; HIV-1; HIV-2)
  • Serum pregnancy test
  • Fshb
  • Asthma Daily Diary adherence check
  • ACQ-6 adherence check
  • AQLQ(S)+12 adherence check
  • Assessment of asthma exacerbations
  • Urine pregnancy test (dipstick)
  • OCS dose titration
  • Pre-BD Spirometry
  • Post-BD spirometry for Sputum collection
  • Body plethysmography (3 times)


You will be paid $800.00 if you complete all the scheduled study visits. If you withdraw for any reason from the study before completion you will be paid $50.00 for each complete study visit.

Contact Information

Study Coordinator
Bob Hmieleski
Principal Investigator
Dr. Eugene Bleecker

Disclaimer: The information on this website is for general informational purposes only and SHOULD NOT be relied upon as a substitute for sound professional medical advice, evaluation or care from your physician or other qualified health care provider.