What we are studying
The purpose of this study is to test the safety and effectiveness of an investigational drug called CPI-613 (“study drug”) when given at different dose levels in combination with Fluorouracil (5-FU) when used to treat colorectal cancer. 5-FU has been approved by the FDA for the treatment of colorectal cancer. CPI-613 is thought to kill cancer cells by turning off their mitochondria. Mitochondria are used by cancer cells to produce energy and are the building blocks needed to make more cancer cells. By shutting off these mitochondria, CPI-613 deprives the cancer cells of energy and other supplies that they need to survive and grow in your body. We want to find out what effects, good and/or bad, CPI-613 has on you and your cancer when given along with 5-FU. We also want to measure the amounts of CPI-613 in your blood after it has been given to you, as well as find the highest dose of CPI-613 that should be used in humans when given along with 5-FU .