Comparing Higher-Dose Radiotherapy To Standard-Dose Radiotherapy To Treat Patients With Glioblastoma Brain Tumors

What we are studying

The purpose of this study is to compare a different radiation therapy schedule and higher radiation dose [higher dose group] to the standard dose of radiation therapy [standard dose group]. Both groups will receive usual chemotherapy, temozolomide. The higher radiotherapy dose could shrink your cancer, but it could also cause side effects. This study will allow the researchers to know whether this higher dose is better, the same, or worse than the usual approach. To be better, the study should increase life by six months or more compared to the usual approach. Two methods of giving radiation therapy will also be compared. They are proton beam radiation and intensity-modulated radiation.

Who we are studying

  • Men and Women
  • Races:
    • White
    • African American
    • Asian
    • American Indian or Alaska Native
    • Native Hawaiian or Pacific Islander
    • Other
  • All Ethnicities
  • Ages 18+

Eligibility Criteria

  • Diagnosis of glioblastoma

What is involved

  • Randomly assigned to receive standard treatment with chemotherapy and radiation or a higher dose of radiation plus chemotherapy



Contact Information

Study Coordinator
Jill Weber Pfefferkorn
Principal Investigator
Michael Chan, MD

Disclaimer: The information on this website is for general informational purposes only and SHOULD NOT be relied upon as a substitute for sound professional medical advice, evaluation or care from your physician or other qualified health care provider.