What we are studying
This study has two parts, the first part is related to the initial treatment of your myeloma (also called induction) and a second part is related to continued long term control of the myeloma (also called maintenance). The purpose of the first part of the study is to compare the effects, good and/or bad, of a combination of carfilzomib, lenalidomide and dexamethasone with another combination of bortezomib, lenalidomide and dexamethasone, on study participants and their cancer to find out which is better. In this study, study participants will get either the combination that contains carfilzomib or that containing bortezomib. Study participants will not get both. Following the initial treatment for myeloma (induction), the second part of the study will examine if it is better to continue lenalidomide until the myeloma comes back or limit it for a defined period of 2 years. In this study, lenalidomide will be either stopped after 2 years or study participants will stay on it until the myeloma relapses.