A Comparison of Sputum Between People with COPD and Healthy Controls

What we are studying

The purpose of this study is to see the amount of MMP9 present in subjects with COPD (chronic obstructive pulmonary disease) and subjects that do not have COPD. The results will help to determine the approach for future studies involving the MMP9 and the drug GS-5745, an MMP9 inhibitor. This is a translational study. Translational study means that we will be collecting information from procedures and tests. Being in this study does not require you to take any experimental medication. For the Visit 1 this visit can last up to 2 days and can require you to visit the clinic 1 or 2 times. If you participate in the Optional Visit 2, you will be required to return to the clinic 4 to 14 days after your first visit. The Optional visit can last up to 2 days and can require you to visit the clinic 1 or 2 times.

Who we are studying

  • Men and Women
  • Races:
    • White
    • African American
    • Asian
    • American Indian or Alaska Native
    • Native Hawaiian or Pacific Islander
    • Other
  • All Ethnicities
  • Ages 40 - 80

Eligibility Criteria

  • Healthy controls; Must be breathing above 80% predicted and be a non-smoker with no past smoking history or
  • People with emphysema; Be diagnosed with COPD for 6 months or longer
  • Can be a current or ex-smoker; on a stable dose of COPD medication for at least 30 days; and have 2 episodes when you experienced a worsening of your symptoms

What is involved

  • Written Informed Consent
  • Medical History
  • Complete Physical Examination
  • Body Mass Index (BMI)
  • Vital Signs
  • Weight & Height
  • Hematology & Chemistry
  • Symptom-Driven PE
  • Urine Pregnancy Test
  • Lung Function Tests
  • Sputum Sample Collection
  • Blood Biomarker Sample
  • Optional Genomic Blood Sample
  • Adverse Events & Concomitant Medication

Compensation

You will be paid $100.00 if you complete all the scheduled study visits.

Contact Information

Study Coordinator
Bob Hmieleski
Email
bhmieles@wakehealth.edu
Phone
336-713-8550
Principal Investigator
Eugene Bleecker, MD

Disclaimer: The information on this website is for general informational purposes only and SHOULD NOT be relied upon as a substitute for sound professional medical advice, evaluation or care from your physician or other qualified health care provider.