What we are studying
You have been asked to take part in this study because you have a type of head and neck cancer which is called Squamous Cell Carcinoma of the Head and Neck (SCCHN). Your cancer has either returned or has spread to other parts of your body (either recurrent or metastatic). This study is being carried out to see if investigational anti-cancer drugs MEDI4736 and tremelimumab will work better than standard drugs (EXTREME regimen: made up of 3 different cancer drugs) for treating this type of cancer. It will also test if the study drugs are as safe as the EXTREME regimen. This is an investigational study and both MEDI4736 and tremelimumab are investigational drugs that have not been approved by the United States Food and Drug Administration (FDA). MEDI4736 and tremelimumab are antibodies (proteins produced by the defense system of the body [immune system]) that have been made in the laboratory. Both MEDI4736 alone or given with tremelimumab may boost the ability of your immune system to detect and fight cancer.
A stipend will be provided to assist with parking and travel related to study visits.