CREST 2. Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial

What we are studying

CREST-2 is two parallel multi-center randomized, observer-blinded endpoint clinical trials. One trial will assess treatment differences between intensive medical management alone compared to CEA plus intensive medical management. The parallel trial will assess treatment differences between intensive medical management alone compared to CAS plus intensive medical management. Intensive medical management will involve control of blood pressure, LDL cholesterol, cigarette smoking, and other vascular risk factors.

Who is Eligible

  • Genders:
    • Men
    • Women
  • Races:
    • White
    • African American
    • Asian
    • American Indian or Alaska Native
    • Native Hawaiian or Pacific Islander
    • Other
  • Hispanic or Latino
  • Ages 35+

Eligibility Criteria

  • The study population is people aged >35 years old who have high-grade cervical carotid artery stenosis (target vessel) involving the carotid bifurcation and/or the adjacent internal carotid artery and who are confirmed to be asymptomatic defined as a participant with:
    • No prior carotid territory symptoms
    • Prior symptoms referable only to the hemisphere contralateral to the target vessel or to the vertebrobasilar distribution
    • Symptoms in either hemisphere >180 days prior to randomization (e.g. stroke
  • TIA
  • Or amaurosis fugax). Patients with prior symptoms (>180 days) referable to the target vessel will be identified as recently asymptomatic.

What is involved

  • Stroke questionnaire at each visit
  • NIHSS at each visit
  • Modified Rankin at each visit
  • Cognitive testing 6 times
  • 1 CT scan
  • 5 ultrasounds
  • Blood pressures and laboratory work at 5 visits.

Compensation

None

Contact Information

Study Coordinator
Nancy Buchheimer
Email
nbuchhe@wakehealth.edu
Phone
336-716-3961

Disclaimer: The information on this website is for general informational purposes only and SHOULD NOT be relied upon as a substitute for sound professional medical advice, evaluation or care from your physician or other qualified health care provider.