The Role of Breathing and Opioidergic Systems on Pain

What we are studying

The purpose of this research study is to see if and how breathing based practices like meditation affects pain. Specifically, we are interested in assessing if breathing practices are associated with the release of naturally occurring opiates in your body. You may receive intravenous administration of saline or naloxone, a relatively safe drug (FDA approved drug) that blocks the transmission of opioid activity in the brain, and thermal stimulation that produces the feeling of pain.

Who we are studying

  • Men
  • Races:
    • White
    • African American
    • Asian
    • American Indian or Alaska Native
    • Native Hawaiian or Pacific Islander
    • Other
  • All Ethnicities
  • Ages 18 - 55

Eligibility Criteria

  • No experience with meditation
  • No history of chronic pain conditions
  • No anti-depressants or opioids
  • Not pregnant
  • Not sensitive to needles or blood

What is involved

  • Screening visit: Questionnaires and heat testing
  • Intervention Sessions: Up to 4 meditation or slow-breathing sessions
  • Experimental Sessions: Opiate drug screening; IV placement; questionnaires and heat testing
  • Your sessions may be spread over a period as long as 14 days.


$300 for completing all study visits

Contact Information

Study Coordinator
Jason Collier
Principal Investigator
Fadel Zeidan, PhD

Disclaimer: The information on this website is for general informational purposes only and SHOULD NOT be relied upon as a substitute for sound professional medical advice, evaluation or care from your physician or other qualified health care provider.