Moderate Alcohol and Cardiovascular Health Study (MACH15)

What we are studying

There is a lot of debate on the health effects of moderate (no more than 1-2 alcoholic beverages each day) alcohol use. Many studies found that adults who reported drinking alcohol in moderation tended to develop heart disease and diabetes less often than adults who drank no alcohol. However, other studies found opposite results or showed no relationship between drinking alcohol and these diseases. This study examines the relationship between moderate drinking of alcohol and risk of heart disease and diabetes. Participants in this study will be asked to either drink one serving of alcohol each day or to abstain from drinking alcohol for about 6 years.

Who is Eligible

  • Genders:
    • Men
    • Women
  • Races:
    • White
    • African American
    • Asian
    • American Indian or Alaska Native
    • Native Hawaiian or Pacific Islander
    • Other
  • All Ethnicities
  • Ages 50+

Eligibility Criteria

  • Ability to provide consent
  • Postmenopausal
  • Consumed at least one drink of alcohol in the past 5 years
  • At risk for heart disease or have had one or more of the following; high blood pressure; high cholesterol; pre-diabetes; diabetes; heart attack; stroke or stent
  • Must be willing to provide an emergency contact

What is involved

  • Approximately 10 clinic visits as well as telephone checks over 6 years
  • Questionnaires related to health; mood; and lifestyle; Collection of blood; Urine; Hair; Vital signs- including blood pressure and pulse; Weight; Height


Participants will receive $30 for each completed visit after randomization and will receive compensation for staying in their assigned group.

Contact Information

Study Coordinator
Beth Lovette
Principal Investigator
William Applegate, MD

Disclaimer: The information on this website is for general informational purposes only and SHOULD NOT be relied upon as a substitute for sound professional medical advice, evaluation or care from your physician or other qualified health care provider.