Study of the Effect of HIRREM on Hot Flashes

What we are studying

HIRREM is a computer-based technology that may help improve your hot flashes by using auditory tones that are played back based on readings of your brain's electrical frequencies, to support a shift towards a more balanced pattern, Women, age 40 and above, who have at least 5 hot flashes per day (one of which is moderate or severe) for at least one month may be eligible to participate.

Who is Eligible

  • Genders:
    • Women
  • Races:
    • White
    • African American
    • Asian
    • American Indian or Alaska Native
    • Native Hawaiian or Pacific Islander
    • Other
  • Hispanic or Latino
  • Ages 40+

Eligibility Criteria

  • Must be able to provide informed consent
  • Must be physically able to come to the study visits or to sit comfortably in a chair for up to two hours at a time
  • Must weigh less or equal to the chair limit (285lbs)
  • Must have intact uterus and ovaries
  • Not diagnosed with any seizure disorder
  • Not pregnant
  • No severe hearing impairment (because the subject will be using headphones during the interventions)
  • No ongoing need for treatment with opiate; benzodiazepine; anti-psychotic medications; anti-depressant medications (SSRI; SNRI; tricyclic); thyroid medications or sleep medications (zolpidem; eszopiclone)
  • No anticipated and ongoing use of recreational drugs; alcohol; or energy drinks
  • Not enrolled in another research study that includes an active intervention
  • Have not received HIRREM
  • BWO
  • Or the wearable B-2

What is involved

  • Three study visits
  • Eight to 16 sessions (90-120 minutes each) listening to sounds while relaxing in a chair
  • Complete a daily hot flash diary periodically throughout the study


You will be paid $100 compensation for time, travel, and inconvenience related to study visits, if you complete the study.

Contact Information

Study Coordinator
Krystal Schmidt

Disclaimer: The information on this website is for general informational purposes only and SHOULD NOT be relied upon as a substitute for sound professional medical advice, evaluation or care from your physician or other qualified health care provider.