CCMR History

Wake Forest School of Medicine (WFSM) has a distinguished history of non-human primate research.  In the late 1950s, under the guidance of Thomas B. Clarkson, DVM, a research approach was developed using pigeons and other animals as clinical surrogates to study diseases of human relevance – the discipline that came to be known as "comparative medicine." Beginning in the early 1960s, Clarkson, as chairman of the Department of Comparative Medicine, pioneered the use of non-human primates at WFSM, establishing facilities for monkey housing and research at a 200-acre property located 10 miles from the Medical Center, now called the Friedberg Campus.

By 1975, the number of monkeys at WFSM was over 600, with most housed on the Friedberg Campus. By the mid-1980s the total monkey census exceeded 1,000 animals, a number that rose to 1,200 by 2008. This population included extensive breeding colonies established and managed as national research resources with funds provided by the National Heart, Lung, and Blood Institute (NHLBI). The largest colonies were comprised of Macaca fascicularis (Crab Eating monkeys) and M. mulatta (Rhesus monkeys). The colonies also included M. arctoides (Stumptail monkeys), Erythrocebus patas (Patas monkeys), and Chlorocebus (Cercopithecus) aethiops.

The next step toward the development of the Center  was the creation of the Comparative Medicine Clinical Research Center in 1988. It was organized around specialized research laboratories for vascular biology, endocrinology, and data services. That center was dedicated to the use of non-human primates in the study of chronic disease and functioned much like an animal version of a General Clinical Research Center, providing faculty, staff, equipment, and facilities to conduct research to better understand the mechanisms, prevention, and therapy of human diseases.

Although most research with monkeys was initially conducted by investigators from the Department of Comparative Medicine, by 2006, primate research at WFSM had come to involve the Departments of Pathology,Physiology and Pharmacology, Neurobiology and Anatomy, Neurology, Cancer Biology, the Division of Surgical Sciences, the Center for Investigative Neuroscience, Center for Alcohol Studies, the Wake Forest Institute for Regenerative Medicine and the Wake Forest Translational Science Institute. 

Quick Reference

Center for Comparative Medicine Research
Center Director

Jay Kaplan, PhD
336-716-1649

Email the CCMR at
wfupc@wakehealth.edu

Associate Director

Mark Cline, DVM, PhD, DACVP
336-716-1564

Center for Comparative Medicine Research

Wake Forest School of Medicine

Medical Center Boulevard

Winston-Salem, NC 27157

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