Completed Projects

By creating partnerships with researchers and medical centers around the world, the Institute is able to fund studies that analyze how children can be treated differently with better outcomes no matter how or where a child is injured.

Click here for a full copy of the June 2013 Research Portfolio.

Improved Understanding of Pediatric Injury Utilizing the CIREN Database
Principal Investigator: Joel Stitzel, PhD (Appendix I)

The CIREN database has an abundance of real-world crash data, but there has not been much comparison with crash test data due to a lack of analytical techniques.  This study developed a method for comparing adult crash injury data as well as refining the evaluation of pediatric crash and injury data to recommend important areas of research for pediatric trauma injury prevention.

Development and Testing of PED‐ERTM
Principal Investigators: Andre A. Muelenaer, Jr., MD and Alfred Wicks, PhD (Appendix II)

The PED-ER system provides information on pediatric resuscitation on an LCD monitor that can be read by the entire treatment team.  This device was tested at three hospital simulation laboratories and its content and systems assessed for potential modifications for more widespread use.

Promoting Positive Outcomes for Youth who Have Experienced Trauma
Principal Investigator: Elizabeth Arnold, PhD (Appendix III)

The STRIVE program developed at the UCLA Center for Community Health could be used as a family-focused intervention following pediatric trauma.  Its applicability and feasibility were tested for use in this region in the hopes of improving familial relationships and recovery following trauma.

HITS (Head Impact Telemetry System) in Wake Forest University Football Players
Principal Investigators: Daryl Rosenbaum, MD and Joel Stitzel, PhD (Appendix IV)

The HITS system was purchased and installed in Wake Forest University football players’ helmets for the 2010 season to study the assessment of low-grade brain injury as well its relationship with findings in imaging studies.  This will improve the understanding of the biomechanical basis for brain injury as well as develop procedures for bringing the HITS program to Forsyth County high schools. 

Correlating Changes over Time on MRI Scans with Neuropsychological Findings
for Traumatic Brain Injury: A Functional Imaging Study

Principal Investigator: Alexander K. Powers, MD

The effect a traumatic brain injury (TBI) will have on patients, especially young adults (ages 12-25), is hard to predict because of the varying types of neurological responses to treatment.  This study uses MRI scanning and neuropsychological evaluation to compare subjects with TBI and healthy subjects to assess the effect of traumatic injury on the brain. 

Pediatric Pre-hospital Trauma Care Educational Initiative: Phases 1 & 2
Principal Investigator: Roy L. Alson, MD, PhD

Training in the pre-hospital care of pediatric trauma patients is often passed over for more general training for EMS personnel due to budgetary restraints.  CIPT will partner with WFBMC to support specialized training for instructors and providers across North Carolina.

Prevalence of Protein and Vitamin D Malnutrition in Pediatric Orthopaedic Trauma Patients
Principal Investigator: Bettina Gyr, MD

Previous studies have shown that a large portion of adults who undergo orthopaedic surgery following trauma had low vitamin D levels, but the prevalence of protein malnutrition in both adult and pediatric trauma patients is not as well known.  This study hopes to develop a protocol for screening and treating malnutrition as well as improving outcomes for trauma patients suffering from malnutrition.

Using Impedance Cardiography to study Hemodynamic Changes in Pediatric Trauma Patients
Principal Investigator: Alison Gardner, MD

Pediatric patients who are in shock often do not suffer from loss of large volumes of blood like their adult counterparts.  Impedance cardiography could be a way to monitor the cardiovascular function of a pediatric trauma patient and determine how to effectively treat symptoms of shock. 

Supplemental Material

Appendix I Report on Pediatric Research with the Wake Forest University – Virginia Tech CIREN center

The WFU-VT CIREN center analyzes real-world crash data to study occupant injuries and vehicle safety.  There were over 600 pediatric cases in this study, and most of the crashes studied occurred between 10 and 30 mph.  The face was the most frequently injured body region and the head was the most seriously injured region, followed by the pelvis and lower extremities.  A second part of this study found that over 200 pediatric occupants were not seated in a child safety seat at the time of the crash.  Data on Pediatric Quality of Life is being analyzed in crashes where family members were injured as well, and this data will help determine whether having a healthy support network improves the outcome for pediatric trauma patients. 

Appendix II – Final Report on Development and Testing of PED-ERTM

This project focused on the feasibility of use of the PED-ER system by testing it in 3 simulation laboratories.  They found that this system was helpful in tracking and administering time-sensitive medications, mapping decision logic during resuscitation, aiding in pain management and fluid resuscitation, and the ability to update the LCD display in real time using a hand-held touch screen device.  This system was so promising, in fact, that it was constantly updated and improved as the testing proceeded, and many requests were received for its use in a clinical setting. 

Appendix III – Promoting Positive Outcomes for Youth who Have Experienced Trauma

This study demonstrated that the intervention program was well-accepted and feasible in this region.  The best method for recruiting patients to the study was to approach them in a clinic setting with the help of clinicians in an outpatient child psychiatry clinic.  Modifications were made to the schedule of visits based on feedback from patients, and in the future there are plans to continue on with a larger randomized trial. 

Appendix IV - Final Report on HITS in Wake Forest University Football Players

The head impact acceleration data collected from the Wake Forest football team has provided us with the experience necessary to transition our study to the highschool and youth league levels. In the future, the equipment purchased partially with the CIPT funding can also be used for these studies.