Publications Before 2009


C Chang, Zhou XB, JJ Taylor, W Huang, X Ren, F Monzon, Y Feng, PH Rao, X Lu, F Fabio, S Hilsenbeck, CJ Creighton, ES Jaffe, and C Lau, Genomic profiling of plasmablastic lymphoma using array comparative genomic hybridization (aCGH): revealing significant overlapping genomic lesions with diffuse large B-cell lymphoma, J Hematol Oncol, 12:2-47, 2009. 

Yu, D., Pham, T., and Zhou, X., Analysis and recognition of touching cell images based on morphological structures, Computers in Biology and Medicine, 39 27-39 (2009) 

Ancuta P, Liu KY, Misra V, Wacleche VS, Gosselin A, Zhou XB, and Gabuzda D, Transcriptional profiling reveals developmental relationship and distinct biological functions of CD16+ and CD16- monocyte subsets BMC Genomics, 10:403, 2009. 

Zhang P, Li HQ, Wong STC, and Zhou X, Peak Tree: a New Tool for Multiscale hierarchical Representation and Peak Detection of Mass Spectrometry Data. IEEE/ACM Transactions on Computational Biology and Bioinformatics, 99:1-14, 2009. 

Jin, GX, Zhou, XB, Cui, KM, Wong, STC, The network biomarker discovery in prostate cancer from both genomics and proteomics levels, IET System Biology, 3(6), 475-486, 2009 

Jin, GX, Cui, KM, Zhou, XB, Wong, STC, Unraveling the Signal-Transduction Networks in Cancer Metastasis, IEEE Signal Processing Magazine, 26: 129-132, 2009 

Li, F, Zhou, X, and Wong STC, "Optimal Multiple Nuclei Tracking Using Integer Programming for Quantitative Cancer Cell Cycle Analysis," IEEE Trans. on Medical Imaging, 29(1):96-105, 2009. 

Zhou, W, Li, H.Q, Zhou, X, 3D neuron dendritic spine detection and dendrite reconstruction, International J. Comp. Aided Eng. Tech. v.1(4), pp. 516 - 531, 2009. 

Zhang, S, DeGraba, T, Wong, HH, Hoehn, G, Gonzales, DA, Suffredini, AF, Ching, WK, Ng, MK, Zhou, X, and Wong STC, A Novel Peak Detection Approach with Chemical Noise Removal Using Short-Time FFT for prOTOF MS Data, Proteomics, 2009 Aug;9(15):3833-42. 

Liu, T, Peng, H, and Zhou, X, Imaging Informatics for Personalized Medicine: Applications and Challenges, International Journal of Functional Informatics and Personalized Medicine, 2(2):125-135, 2009 

Fan J, Zhou X, Dy J, Zhang Y, Spires TL, Hyman BT, and Wong STC, An Automatic Approach for Dendrite Spine Detection and Tracking in vivo 3D Confocal Microscopy Images, Neuroinformatics, 7(2):113-130, 2009. 

Yang, X. Zhou, X., Huang, W, Wu, L,Mozon, F., Chang, CC, and Wong, STC, Pattern-selection Based Power Analysis and Discrimination of Low- and High-Grade Myelodysplastic Syndromes Study Using SNP Arrays, Plos One, 4(4):e5054, 2009 

Zhou, X, Wang, HH, Wang, J, Hoehn, G, Azok, J, Brennan, ML, Hazen, SL, Li, K, Chang, SF, and Wong, STC, "Biomarker Panel Discovery for Risk Stratification of Cardiovascular Events Using Genetic Algorithm with Recursive Local Floating Search Embedding," Proteomics, 9:2286-2294, 2009 

Zhou, XB, Li, F, Yan, J, and Wong, STC. A Novel Cell Segmentation Method and Cell Phase Identification sing Markov Model. IEEE Trans on Information Technology in Biomedicine, 13(2):152-157, 2009. 

Wu LY, Zhou X, Li FH, Yang XR, Chang CC and Wong STC. Conditional Random Pattern Algorithm for LOH Inference and Segmentation. Bioinformatics, 25(1):61-67, 2009 

Pham T, Zhou X: Special issue on pattern recognition in computational life sciences. Pattern Recognition 42(4): 497, 2009 

Geng, B, Zhou, XB, and Hung, YS, Growing Enzyme Gene Networks by Integration of Gene Expression, Motif Sequence and Metabolic Information, Pattern recognition, 42(4):557-561, 2009 

Yin Z, Zhou XB, Sun Y, and Wong STC. Online Phenotype Discovery based on Minimum Classification Error Model, Pattern Recognition, 42(4):509-522, 2009 

Yu D, Pham T, Zhou X, Wong STC, Recognition and analysis of cell nuclear phases for high-content screening based on morphological features. Pattern Recognition 42(4): 498-508 (2009) 

Huang WT, Yang X, Zhou X, ..., and Chang CC. Multiple distinct clones may co-exist in different lineages in myelodysplastic syndromes. Leukemia Research, 33(6):847-853,2009 

Zhang, P, Li, HQ, Zhou, XB, and Wong, STC, Peak Detection Using Peak Tree Approach for Mass Spectrometry Data, International Journal of Hybrid Intelligent Systems, 5:197-208, 2009 

Kamali M, Day LJ, Brooks DH, Zhou XB, and O'Malley DM, Automated Identification of Neurons in 3D Confocal Datasets from Zebrafish Brainstem, Microscopy, 233, pp. 114-131, 2009 

Wang J, Zhou X, Li F, Bradley PL, Chang SF, Perrimon N, and Wong STC, An Image Score Inference System for RNAi Genome-wide Screening Based on Fuzzy Mixture Regression Modeling, Biomed Informatics, 42 (1): 32-40, 2009



Chahrour M, Jung SY, Shaw C, Zhou XB, Wong STC, Qin J, and Zoghbi HY. MeCP2, a Key Contributor to Neurological Disease, Activates and Represses Transcription. Science, 2008 May 30, Vol. 320. no. 5880, pp. 1224 - 1229

Jin, GX, Zhou, XB, Wang, HH; Zhao, H, Zhang, XS, Chen, L, Hazen, S, Li, K; Wong, STC, The knowledge-integrated network biomarkers discovery for Major Adverse Cardiac Events, Journal of Proteome Research, 7 (9): 4013-4021, 2008

Wang Y, Zhou X, Wang H, Li K, Yao L, and Wong STC, Reversible Jump MCMC Approach for Peak identification for Stroke SELDI Mass Spectrometry Using Mixture Model. Bioinformatics, 2008 24(13):i407-i413, 2008

Yin Z, Zhou XB, Bakal C, Li F, Sun Y, Perrimon Y, and Wong STC, Using Iterative Cluster Merging with Improved Gap Statistics to Perform Online Phenotype Discovery in the Context of High-throughput RNAi Screens. BMC Bioinformatics, 9:264, 2008.

Zhou X and Wong STC, Computational Systems Bioinformatics and Bioimaging for Pathway Analysis and Drug Screening, Proceedings of IEEE, 96(8): 1310-1331, 2008

Li FH, Zhou, X, Zhu, JM, Ma JW, Wong STC. High Content Cellular Image Based Calcium Signaling Analysis System for Cells with Mutant Presenilin-1 of Familial Alzheimer Disease. Neuroinformatics, 6(2): 97-108, 2008

Zhang K, Xiong HK, Zhou X, Yang L, Wang YL, and Wong STC, "An Object-Aware Representation Framework for Cell Migration Detection and Tracking," J of Microscopy, 231(3):395-407, 2008.

Zhang, Y, Zhou, X, Lu, J, Lichtman, J, Adjeroh, D, Wong, STC, "Axon Tracking Using 3D Curvilinear Structure Extraction and Dynamic Programming," Neural Computation, 20(8):1899-1927, 2008

Wang, M, Zhou, X, Li, FH, Huckins, J, King, RW, and Wong, STC, "Novel Cell Segmentation and Online SVM For Cell Phase Identification in Automated Time-Lapse Microscopy," Bioinformatics 24(1): 94-101 (2008)

Chen, C, Li, HQ, Zhou, X, Wong, STC, "Constraint Factor graph cut based active contour method for automated cellular image segmentation in RNAi screening, Journal of Microscopy, 230 (Partt 2):177-91, 2008

Wang, J, Zhou, X, Bradley, PL, Perrimon N, and Wong, STC. Phenotype recognition for high-content RNAi genome-wide screening. Journal of Molecular Screening, Vol. 13, No. 1, 29-39 (2008)

Geng B, Zhou X, Hung Y.S., and Wong STC, "Comparison of Bayesian and Regression Models in Missing Enzyme Identification," International Journal of Bioinformatics Research and Applications, 4(12):363-374, 2008

Geng, B, Zhou, X, Zhu, J, Hung, YS, and Wong, STC, "Missing enzyme identification using reversible-jump Markov-Chain-Monte-Carlo learning," Journal of Biomedical Informatics, 41(2): 272-281. 2008

Xia, Z., Huang, X., Zhou, X, Sun, Y, Ntziachristos, V., Wong, STC, "Registration of 3D CT and 2D Flat Images of Mouse via Affine Transformation, " IEEE Trans on Information Technology in Biomedicine, 12(5):569-78, 2008

Pham, T, Wang, HH, Zhou, X , Hoehn, G, Azok, J, Brennan, ML, Hazen, SL, Li, K, Chang, SF, and Wong, STC, "Linear Predictive Coding and its Decision Logic for Early Prediction of Major Adverse Cardiac Events using Mass Spectrometry Data, "IEEE Trans on Information Technology in Biomedicine, 12(5):636-43, 2008

Yan P, Zhou X, Shah M, and Wong STC, "Automatic Segmentation of RNAi Fluorescent Cellular Images with Interaction Model," IEEE Trans on Information Technology in Biomedicine, 12(1): 109-117, 2008

Jiang S, Zhou X, Kirchhausen, T, and Wong STC, "Tracking Molecular Particles in Live Cells Using Fuzzy Rule-Based System: Part II," Cytometry A, 71A(8): 576 - 584, 2008

Chen J, Zhu J, Cho HH, Cui K, Li F, Zhou X, Rogers JT, Wong STC, and Huang X. Differential cytotoxicity of metal oxide nanoparticles. J. of Experimental Nanoscience, 3(4): 321 - 328, 2008

Liu T, Li G, Nie J, Tarokh A, Zhou X, Guo L, Malicki J, Xia W, Wong STC. An Automated Cell Detection Method for Cell Detection in Zebrafish. Neuroinformatics, 6(1):5-21., 2008


Li, FH, Zhou, X, Zhu, J, Ma, J, Huang, XD, and Wong, STC, "High Content Image Analysis for H4 Human Neuroglioma Cells Exposed to CuO Nanoparticles," BMC Biotechnology, 2007; 7: 66.

Bai W, Zhou, X, Ji L., and Wong STC., "A Fully Automatic Dendritic Spine Analysis in Two-Photon, Laser Scanning Microscopy Images," Cytometry A, 71(10):818-26, 2007

Srinivasan R, Zhou X, Miller E, Lu J, Lichtman J, Wong STC. Automated Axon Tracking of 3D Confocal Laser Scanning Microscopy Images Using Guided Probabilistic Region Merging. Neuroinformatics, 5: 189-203(15), 2007

Cheng J, Zhou X, Miller E, Witt RM., Zhu J, Sabatini BL, and Wong STC, "A Novel Computational Approach for Automatic Dendrite Spines Detection in Two-Photon Laser Scan Microscopy," Neuroscience Methods, 165:122-134, 2007

Jiang S, Zhou X, Kirchhausen, T, and Wong STC, "Detection of Molecular Particles in Live Cells via Machine Learning: Part I," Cytometry A, 71A(8): 563 - 575, 2007

Zhang Y, Zhou, X., A. Degterev, M. Lipinski, D. Adjeroh, J. Yuan, S.T.C. Wong, "Dendritic Spine Detection Using Curvilinear Structure Detector and LDA Classifier," Neuroimage, 36:346-360, 2007.

Wang M, Zhou X, King, R, and Wong STC, "Context based mixture model for cell phase identification in automated fluorescence microscopy," BMC Bioinformatics, 8(32): 1-12, 2007

Pham, T, Tran, DT, Zhou, X, and Wong STC, "A Microscopic Image Classification System for High-Throughput Cell-Cycle Screening," International Journal of Intelligent Computing in Medical Sciences and Image Processing, 1(1): 67-77, 2007.

Xia, Z., Zhou, X., Sun, Y., and Wong, STC, "Automated Recognition of Cellular Phenotypes by Support Vector Machines with feature reduction," Journal of Knowledge-Based & Intelligent Engineering Systems, 11(4): 247-253, 2007

Mao Y, Xia Z., Yin Z, Zhou X, and Sun Y., "A Survey for Study of Feature Selection Algorithms," Journal Pattern Recognition and Artificial Intelligence; 20(2): 211-218, 2007.

Pham, T, Tran, DT, Zhou, X, and Wong STC, "Fuzzy Information Fusion of Classification Models for High-Throughput Image Screening of Cancer Cells in Time-Lapse Microscopy," Journal of Knowledge-Based & Intelligent Engineering Systems, 11(4): 237-246, 2007.

Li FH, Zhou, X, and Wong, STC. An automated feedback system with the hybrid model of scoring and classification for solving over-segmentation problems in RNAi high content screening. J of Microscopy, 2007. 226(2): 121-132.

Zhang Y, Zhou, X., A. Degterev, M. Lipinski, D. Adjeroh, J. Yuan, S.T.C. Wong, "Automated neurite extraction using dynamic programming for neuron assays based high-throughput screening," Neuroimage, Vol 35(4): 1502-1515, 2007

Zhang Y, Zhou, X., A. Degterev, M. Lipinski, D. Adjeroh, J. Yuan, S.T.C. Wong, "A novel tracing algorithm for high throughput imaging screening of neuron based assays," Journal of Neuroscience Methods, Vol. 160, pp149-162, 2007


Yang X, H. Li, and Zhou, X., "Nuclei segmentation using marker-controlled watershed, tracking using mean-shift and Kalman filter in time-lapse microscopy," IEEE Trans on Circuits and Systems - 1, 2006; 53(11): 2405-2414

Xiong G., Zhou X., L. Ji, Bradley, P., and Perrimon, N., "Automated segmentation of Drosophila RNAi fluorescence cellular images using deformable models," IEEE Trans on Circuits and Systems - 1, 2006; 53(11): 2415-2424

Xiong G, Zhou, X., A. Degterev, L. Ji, and S.T.C. Wong, "Automated neurite labeling and analysis in fluorescence microscopy images," Cytometry A, 2006 May 5; 69A (6):494-505

Liu KY, Zhou, X., and Wong STC, "Detailed replies to the reviewers Bayesian variable selection for gene expression modeling with regulatory motif binding sites in Neuroinflammatory events," Neuroinformatics, 2006; 4(1):95-117

Zhou, X., J. Zhu, K. L. Liu, B. Sabatini and Stephen, T.C. Wong, ``Mutual information based feature selection in studying perturbation of dendritic structure caused by TSC2 inactivation," Neuroinformatics, 2006;4(1):81-94.

Zhou, X., X. Cao, and STC. Wong, "Cell phase recognition and analysis of high content screening for drug discovery based on spindle model of mitosis," Journal of Biomedical Informatics, 2006 Apr;39(2):115-25.

Chen X, Zhou, X., and STC. Wong, "An image analysis system for segmentation, classification, and tracking of cell cycle phases in time-lapse fluorescence microscopy," IEEE Trans on Biomedical Engineering, 2006 Apr; 53(4):762-6.

Mao Y, Zhou, X., D. Pi, Y. Sun, "Constructing support vector machine ensemble for classification of cancer based on biochips data," Journal of Genomics, Proteomics & Bioinformatics. 3(4), 238-241. 2006.

Zhou, X., Chou J., and Wong STC, "Protein structure similarity from principle component correlation analysis," BMC Bioinformatics, 2006 Jan 25; 7-40.

Zhou, X., Wang X., and Dougherty E.R., "Multi-class cancer classification using multinomial probit regression with Bayesian gene selection," IEE System Biology, 153(2), pp. 70-78, 2006.

Zhou, X. and Wang X., "Optimization of Gaussian mixture model for satellite image classification," IEE Vision, Image & Signal Processing, 153(3), pp. 349-356, 2006.

Pham T.D., Tran D.T., Zhou, X.B. and Wong STC., Integrated algorithms for image analysis and classification of nuclear division for high-content cell-cycle screening. International Journal of Computational Intelligence and Applications, Vol. 6, No. 1 (2006) 21-43.

Zhou, X., and S.T.C. Wong, "High content cellular imaging for drug Development," IEEE Signal Processing Magazine, 2006 March, 23(2):170-174

Zhou, X. and S.T.C. Wong, "Informatics challenges of high-throughput microscopy," IEEE Signal Processing Magazine, 2006 May, 23(3): 63-72.


Liu K-Y, Lin J, Zhou, X., and Wong STC. "Boosting alternating decision trees (ADTrees) modeling of disease trait information." BMC Genetics, 2005, Vol.6, S 132.

Mao Y, Zhou, X., D. Pi, S. T.C. Wong, and Y. Sun, "Multi-class cancer classification by using fuzzy support vector machine and binary decision tree with gene selection," Journal of Biomedicine and Biotechnology, 2: 160-171, 2005.

Zhou, X, Wang, X, Dougherty, ER., Gene selection using logistic regressions based on AIC, BIC and MDL criteria. New Math. Nat. Comput. 1, No. 1, 129-145 (2005).

Mao Y, Zhou, X., D. Pi, Y. Sun, and STC Wong, "Parameters selection in gene selection using Gaussian Kernel support vector machines by genetic algorithm," International Journal of Zhejiang University SCIENCE, 6B (10), 961-973, 2005.



Zhou, X., X. Wang, and E.R. Dougherty, "Sequence Monte Carlo estimation for nonlinear-probit gene classification based on bootstrap Bayesian gene selection," Journal of Franklin Institute, special issue on Genomics, Signal Processing and Statistics, Vol. 341, pp.137-156, 2004.

Zhou X., K.Y. Liu, and Stephen, T.C. Wong, "Cancer classification and prediction based on logistic regression using approximate Bayesian gene selection," Journal of Biomedical Informatics, Vol. 37, pp. 249-259, 2004.

Zhou, X., X. Wang, M. Bittner, and E.R. Dougherty, "A Bayesian connective-based approach to constructing probabilistic gene regulatory networks," Bioinformatics, Vol. 20, pp. 2918-2927, 2004.

Zhou, X., X. Wang, and E.R. Dougherty, "Gene prediction and network construction using multinomial probit regression with Bayesian variable selection," Journal of Applied Signal Processing, special issue on Genomic Signal Processing, Vol. 3, No.1, pp.115-124, 2004.

Zhou, X., X. Wang, and E.R. Dougherty, "Nonlinear probit gene classification using mutual-Information and wavelet," Journal of Biological Systems, Vol. 12, No. 3, 371-386, 2004.

Zhou X., X. Wang, and E.R. Dougherty, "Gene clustering based on cluster-wide mutual information," Journal of Computational Biology, Vol. 11, No. 1, pp.151-165, 2004.

Zhou X. and X. Wang, "FIR-Median hybrid filters with polynomial fitting," Journal of Digital Signal Processing, Vol. 14, No. 1, pp.112-124, 2004.

G. Yue, Zhou X. and X. Wang, "Performance comparisons of channel estimations in multipath fading CDMA," IEEE Trans on Wireless Communications, Vol. 3, No.3, pp.716-724, 2004.


Zhou, X., X. Wang, and E.R. Dougherty, "Missing value estimation based on linear and nonlinear regression with Bayesian gene selection," Bioinformatics, Vol. 19, pp. 2302-2307, 2003.

Zhou X., X. Wang, and E.R. Dougherty, "Binarization of microarray data based on a mixture model," Journal of Molecular Cancer Therapeutics, vol. 2, no. 2, pp. 679-684, 2003.

Zhou X., X. Wang, and E.R. Dougherty, "Construction of genomic networks using mutual-information clustering and reversible-jump Markov-Chain-Monte-Carlo predictor design," Signal Processing Journal, special issue on Genomic Signal Processing, Vol. 83, No. 4, pp. 745-761, 2003.

Zhou X. and X. Wang, "Receiver techniques for Ultra-wide-band (UWB) multiuser systems over fading multipath channels," Journal of Communications and Networks, Vol. 5, no.2, pp. 1-7, 2003.

Zhou X. and X. Wang, "Channel estimation for OFDM system using radial basis function networks," IEEE Trans. on Vehicle Technology, Vol.52, No.1, pp.48-59, Jan. 2003.

Last Updated: 07-13-2015
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