Assistant Professor, Department of Diagnostic Radiology
Lead of LINCS-TMHRI U01 Center
Wake Forest School of Medicine
Medical Center Boulevard
Winston-Salem, NC 27157-1088
Dr. Su is interested in the dynamic interactions among cells and their environments at multiple spatial and temporal scales during development, carcinogenesis, wound healing, and post-implantation remodeling of regenerative devices. Dr. Su is focusing on the systems biology research of such dynamic biosystems and the applications in cancer and regenerative medicines. Meanwhile, as an experienced database engineer, Dr. Su is working on next generation data warehousing to integrate heterogeneous data sources, to address the Big Data challenges, and to support the translation of biomedical researches.
Data Warehousing for Big Data
Dr. Su is working on establishing a cellular signature oriented next generation data warehouse system, DrugSig, to facilitate the bench-side to bed-side translational research. The DrugSig data warehouse is to incorporate in vitro drug screening data (e.g. the pLINDAW system of the LINCS project), genomics and proteomics profiling of clinical samples (e.g. the TCGA project), enterprise databases of clinical records (e.g. the EPIC/WakeOne system), as well as general purpose annotation databases (GO, etc.) and knowledge bases (KEGG, etc.). This data warehouse is featured of fuzzy (non-literal) integration of heterogeneous data sources, mass parallel processing (MPP), pan-clouding (seamless incorporation of cloud storage, computation, data mining, and data warehouse services), and dynamic ETL. The DrugSig data warehouse will guide clinical drug repositioning as well as mechanism study and hypothesis generation of biomedical research.
• Dynamic Turing patterning. The dynamics of self-assembling processes of heterogeneous cell types and the structures and functions of such assembles;
• Multi-temporal models for bio-systems;
• The effects of micro-environment dynamics, especially the circadian hints of growth factors and hormones, on cell decision-making machineries;
• Incorporation of high-throughput experiment design, multi-omics data, data mining, and simulation to identify and characterize bio-network motifs;
• Applications of systems biology to cancer biology and tissue engineering;
• Single-cell level in situ real-time reporters for cell signaling events;
• Big Data challenges and fuzziness-based integration of heterogeneous data bases;
• Large-scale parallel computation, cloud-based storage-computation-simulation-data warehouse platforms for systems biology.
Systematically study the effects of cell-biomaterial interactions on stem cell proliferation and differentiation by incorporating the technologies of high-dimensional combinatorial libraries of biomaterials, 3D surface micro-patterning, high-throughput data acquisition, and data mining on very large image data warehouses.
Dr. Su is leading the regenerative medicine research in CTSB, featured by the integration of systems biology, biomaterial science and engineering, and post-implantation in vivo imaging. One of the current focuses is the monitoring, understanding, and control of the temporal dynamics of stem cell lineages in bioactive scaffolds under controlled release of growth factors. Another focus is to utilize computer-guided scaffold design and in silico simulation to improve vascularization in bio-scaffolds and the long-term functionalities of implants.
Work and Research Experience
01/2012 - now Wake Forest School of Medicine
Lead of the LINCS-WakeForest Center
7/2011 – 12/2012 Methodist Hospital Research Institute
Lead of the LINCS-TMHRI Center
9/2010 – 7/2011 Methodist Hospital Research Institute
3/2009 – 9/2010 UMASS Amherst
Postdoctoral Research Associate
1/2008 - 2/2009 Georgia Tech & Emory University
8/2001 - 12/2007 Georgia Tech & Emory Univ.
Graduate Research Assistant
1/2001 - 6/2001 Huijun High-tech Co., China
Lead Software Engineer of Database System
09/1997 - 12/2000 Tianjin University
10/1996 - 10/1997 Tianjin Qiming High-tech Co., China
Lead Software Engineer of Database System
Teaching and Mentoring Experience
2004 - 2006 Teaching Assistant, Georgia Institute of Technology
1997-1999 Mentor of undergraduate students, Tianjin University
Certificate of Nano Bio Fluidic MEMS, 2006, Georgia Institute of Technology
Publications and Presentations
1. Jean Z. Lin, Douglas H. Sieglaff equal contributor, Chaoshen Yuan, Jing Su, AnithaChristy S. Arumanayagam, Sharareh Firouzbakht, Jaime J. Cantu Pompa,Frances Denoto Reynolds, Xiabo Zhou, Aleksandra Cvoro, Paul Webb, PLoS One, 8(1):e52407, (2013)
2. Xiaoqiang Sun1, Jing Su1, Jiguang Bao, Tao Peng, Le Zhange, Yuanyuan Zhang, Yunzhi Yang, Xiaobo Zhou , Cytokine combination therapy prediction for bone remodeling in tissue engineering based on the intracellular signaling pathway, Biomaterials, 33(33):8265-76 (2012)
3. Le Zhang, Yao Xue, Beini Jiang, Costas Strouthos, Zhenfeng Duan,Yukun Wu, Jing Su and Xiaobo Zhou, Multiscale agent-based modeling of ovarian cancer progression under the stimulation of the STAT 3 pathway, International Journal of Data Mining and Bioinformatics, 13: 218 (2012)
4. Lei Tang, Jing Su, Deshuang Huang, Daniel Y. Lee, King C. P. Li, and Xiaobo Zhou, An Integrated Multiscale Mechanistic Model for Cancer Drug Therapy, International Scholarly Research Network ISRN Biomathematics (Vol 202, Article ID 818492, doi:10.5402/2012/818492) (2012)
5. Le Zhang, Beini Jiang, Yukun Wu, Costas Strouthos, Phillip ZHE Sun, Jing Su and Xiaobo Zhou, Developing a multiscale, multi-resolution agent-based brain tumor model by graphics processing units, Theoretical Biology and Medical Modelling Theoretical Biology and Medical Modelling 8:46 (2011)
6. Zhengwu Lu and Jing Su, Clinical data management: Current status, challenges, and future directions from industry perspectives, Open Access Journal of Clinical Trials, 2, pp. 93 – 105 (2010)
7. Jing Su and J C Meredith, “Local histogram analysis: Detecting cell-microstructure interactions on combinatorial biomaterial libraries”, Combinatorial Chemistry & High Throughput Screening 12(6), pp. 626 – 633 (2009).
8. Jing Su, Pedro J Zapata, Chien-Chiang Chen, and J. Carson Meredith, “Local cell metrics: a novel method for analysis of cell-cell interactions.”, BMC Bioinformatics 10, pp. 350 (2009).
9. Pedro Zapata, Jing Su, Andres J Garcia, and J. Carson Meredith, “Quantitative high-throughput screening of osteoblast attachment, spreading, and proliferation on demixed polymer blend micropatterns.”, Biomacromolecules 8(6), pp. 1907–1917 (2007).
10. Jing Su, Pedro Zapata, and Carson Meredith, “Knowledge discovery applications in high-throughput polymer characterization”, Combinatorial Methods and Informatics in Materials Science 894, pp. 147 – 152 (2006).
11. Hak-Joon Sung, Jing Su, Joseph D Berglund, Bianca V Russ, J. Carson Meredith, and Zorina S Galis, “The use of temperature-composition combinatorial libraries to study the effects of biodegradable polymer blend surfaces on vascular cells.”, Biomaterials 26(22), pp. 4557 – 4567 (2005).
12. Yiqing Chen, Duoxian Sun, Jing Su, and Jun Yang, “Theoretical calculation and experiments of diameter of calcium alginate gel microspheres”, Chemical Jounal of Chinese Universities 24(3), pp. 481 – 484 (2003).
13. Duoxian Sun, Yiqing Chen, Jing Su, Jun Yang, Cong Fu, and Jingyi Liu, “Aca microcapsules and ion replacement gels”, Chemical Jounal of Chinese Universities 2-Suppl., pp. 119 – 120 (2002).
14. Duoxian Sun, Yiqing Chen, Jun Yang, Jing Su, and Anthony M Sun, “Theoretical calculation and experimental study of membrane thickness of alginate-(poly- lysine)-alginate microcapsules”, Journal of Biomedical Engineering 19(4), pp. 645 – 656 (2002).
15. Duoxian Sun, Jing Su, and Jun Yang, “The study on permeating performance of the ACA membranes”, Journal of Biomedical Engineering 16, pp. 77 – 79 (1999).
16. Duoxian Sun, Jing Su, and Jun Yang, “Control of cell-immobilized ACA capsules’ size”, Journal of Biomedical Engineering 16, pp. 125 – 126 (1999).
17. Dongzhi Liu, Wei Zhang, Yonggang Li, and Jing Su, “Synthetic processes of 1-aminoamthraquinone”, Dyedtuff Industry 36(3), pp. 19 – 22 (1999).
Conference Oral Presentations
1. Jing Su, Gracy Wingkono, Pedro Zapata, Andres Garcia, Zorina Gallis, and Carson Meredith, “Combinatorial libraries for investigation of cell interactions with polymer surfaces”, AIChE Annual Meeting 2004, Austin TX (2004).
2. Jing Su, Pedro Zapata, Andres Garcia, and Carson Meredith, “Combinatorial libraries for investigation of cell interactions with polymer surfaces”, AIChE Annual Meeting 2005, Cincinnati OH (2005).
3. Jing Su, Pedro Zapata, Andres Garcia, and Carson Meredith, “Cell-surface informatics: a platform for quantifying effects of biomaterial surface features on cells”, American Chemistry Society Annual Meeting 2005, Washington DC (2005).
4. Jing Su and Carson Meredith, “Informatics and data mining of combinatorial datasets for cell-material interactions”, AIChE Annual Meeting 2006, San Francisco CA (2006).
Conference Poster Presentations
5. Hongwei Shao, Chenglin Liu, Dongmin Guo, Caty Chung, Tao Peng, Stephan Schürer, Jing Su, and Xiaobo Zhou, “itNETZ: the Signature-based Drug Discovery Platform”, LINCS Data Forum 2013, Boston MA (2013)
6. Dan Wu, Jing Su, Qianqian Song, Xiaobo Zhou, “SDF1/CXCR4 regulates stiffness of bone marrow stromal cell through RhoA and Rac1 GTPases pathway to support myeloma cell proliferation in multiple myeloma”, American Association for Cancer Research Annual Meeting 2013, Washington DC (2013)
7. Jing Su, Chenglin Liu, Caty Chung, Tao Peng, Hande Küçük, Christopher Mader, Amar Koleti, Stephan Schürer, and Xiaobo Zhou, “pLINDAW: A Fuzzy Query Based Data Warehouse System for Real-time Pan LINCS Data Integration and Visualization”, The NIH LINCS Fall Consortium Meeting, Washington DC (2012)
8. Chenglin Liu, Jing Su, Rengjing Zhang, and Xiaobo Zhou, “Molecule Signature Network Detection Using Constrained Non-Negative Matrix Factorization (csNMF)”, The NIH LINCS Fall Consortium Meeting, Washington DC (2012)
9. Tao Peng, Dong Soon Choi, Huiming Peng, Jing Su, Hongyan Wang, Youli Zu, Chung-Che (Jeff) Chang, and Xiaobo Zhou, “Systematically Model Cell-Cell Interactions in Regulating Multiple Myeloma Initiating Cell Fate”, The NIH LINCS Fall Consortium Meeting, Washington DC (2012)
10. Jing Su, Dong Soon Choi, Wen Zhang, Beini Jiang, Le Zhang, Chung-Che (Jeff) Chang, Youli Zu, and Xiaobo Zhou , “Modeling the Biomechanical Roles of Cancer Stem Cell Niche in Myeloma Development”, The Biophysical Society 56th Annual Meeting in San Diego, California (2012)
11. Jing Su, Tao Peng, Jianguo Wen, Chung-Che (Jeff) Chang, Youli Zu, and Xiaobo Zhou, “Integrating Imaging, Genomics, and Functional Proteomics Analysis for Cellular Signature Discovery”, The NIH LINCS Fall Consortium Meeting, Washington DC (2011)
12. Jing Su and Michael A. Henson, “Computational analysis of chronotolerance and chronoefficacy for breast cancer chemotherapy and hormone therapy”, The Gordon Research Conference on Chronobiology Salve Regina University in Newport RI United States (2009).
13. Jing Su, Pedro Zapata, Andres Garcia, and Carson Meredith, “Combinatorial libraries for investigation of cell interactions with polymer surfaces”, The Gordon Research Conference on Combinatorial & High Throughput Materials Science in Oxford UK (2005).
Other Conference Presentations
14. Jing Su and Carson Meredith, “Combinatorial discovery of optimal surface features for osteoblast proliferation”, Society for Biomaterial 30th Annual Meeting & Exposition, Memphis TN (2005).
15. Jing Su and Carson Meredith, “Cell-surface informatics (csi): A platform for quantifying effects of biomaterial surface features on cells”, ACS National Meeting 2006, San Francisco CA (2006).
16. Pedro Zapata, Hak-Joon Sung, Gracy Wingkono, Jing Su, Andres Garcia, and Carson Meredith, “Combinatorial biosurface chip technology for rapid assay of polymer-cell interactions”, AIChE Annual Meeting 2003, Savannah (2003).
17. Carson Meredith, Pedro Zapata, and Jing Su, “Knowledge discovery applications in high-throughput polymer characterization”, MRS Fall Meeting 2005, Boston MA (2005).
18. C Rincon, P Zapata, Jing Su, Andres Garcia, and Carson Meredith, “Combinatorial biosurface chips for quantitative characterization of polymer-cell interactions”, AIChE Annual Meeting 2006, San Francisco CA (2006).
19. Duoxian Sun, Jun Yang, Jing Su, Yiqing Chen and Lan Zhao, “The physical structure study of APA bio-microcapsules membrance”, Chinese Society of Biomedical Engineering Sixth Congress of Academic Conference (2004)
20. Duoxian Sun, Yiqing Chen, Jing Su, Jun Yang, Cong Fu, and Jingyi Liu, “Alginate-Chitosan-Alginate Microcapsules and Ion Replacement Gels”, The Ninth National Conference on Biomaterials (CBMS-9) (2002)