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Edward Abraham, M.D.Wake Forest School of Medicine

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Edward Abraham, M.D.

Dean,
Professor,

Contact Information

Department: 336-716-4424

Email: eabraham@wakehealth.edu

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Education & Training

  • B.A., Stanford University, 1974
  • M.D., Stanford University School of Medicine, 1978
  • Internship, UCLA Hosp, 1979
  • Residency, UCLA Hosp, 1981
  • Fellowship, Emergency Medicine, University of California-Los A, 1982
  • Fellowship, Critical Care Medicine, LA County Harbor-UCLA Med Ctr, 1983

Board Certifications

  • American Board of Internal Medicine, Critical Care Medicine
  • American Board of Internal Medicine, Internal Medicine

Memberships

  • Am Assn Of Immunologists
  • Shock Society
  • Soc Of Critical Care Medicine
  • Southern Society Of Clinical I
  • Am Coll Of Critical Care Medic
  • Am Coll Of Physicians
  • Am Soc Of Clinical Investigati
  • American Thoracic Society
  • Assn Of American Physicians
  • Assn of Professors of Medicine

NPI Number

  • 1962456715
Edward Abraham, M.D.

Doctor Rating

No Rating Available
Why No Ratings?

Edward Abraham, M.D.

Dean, Dean's Office
Professor, Pulmonary, Critical Care, Allergy, and Immunologic Medicine

Research Interests

Neutrophils; Sepsis; NF-kappa B; Respiratory Distress Syndrome, Adult; Hemorrhage
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Contact Information

Department: 336-716-4424

Email: eabraham@wakehealth.edu

Recent Publications

New definitions for sepsis and septic shock: continuing evolution but with much still to be done [editorial]. Abraham E.. JAMA. 2016;315(8):757-759.

Pneumonia prevention to decrease mortality in intensive care unit: a systematic review and meta-analysis. Roquilly A, Marret E, Abraham E, Asehnoune K.. Clin Infect Dis. 2015;60(1):64-75.

Reply to Hurley [Is selective decontamination of the digestive tract safe?] [reply to letter]. Roquilly A, Marret E, Abraham E, Asehnoune K.. Clin Infect Dis. 2015;60(11):1730-1731.

Participation of proteasome-ubiquitin protein degradation in autophagy and the activation of AMP-activated protein kinase. Jiang S, Park DW, Gao Y, Ravi S, Darley-Usmar V, Abraham E, Zmijewski JW.. Cell Signal. 2015;27(6):1186-1197.

Pyruvate dehydrogenase kinase 1 participates in macrophage polarization via regulating glucose metabolism. Tan Z, Xie N, Cui H, Moellering DR, Abraham E, Thannickal VJ, Liu G.. J Immunol. 2015;194(12):6082-6089.

Reply to Kuriyama and Urushidani [Pneumonia prevention to decrease mortality in intensive care units] [reply to letter]. Roquilly A, Marret E, Abraham E, Asehnoune K.. Clin Infect Dis. 2015;61(5):855-856.

AMP-activated protein kinase and Glycogen Synthase Kinase 3beta modulate the severity of sepsis-induced lung injury. Liu Z, Bone N, Jiang S, Park DW, Tadie JM, Deshane J, Rodriguez CA, Pittet JF, Abraham E, Zmijewski JW.. Mol Med. 2015;():.

Association of interferon-stimulated gene expression with worse outcomes in the acute respiratory distress syndrome [abstract]. Nick JA, Caceres SM, Kret JE, Poch KR, Strand M, Faino A, Nichols D, Saavedra M, Taylor-Cousar JL, Coldren CD, Geraci M, Burnham EL Suratt BT, Fessler M, Abraham E, Moss M, Malcolm KC.. Am J Respir Crit Care Med. 2015;191():A2376.

Amp-activated protein kinase activation diminishes the severity of experimental lung fibrosis [abstract]. Rangarajan S, Liu Y, Park DW, Zmijewska A, Abraham E, Thannickal VJ, Zmijewski J.. Am J Respir Crit Care Med. 2015;191():A3474.

Serum estradiol levels predict survival and acute kidney injury in patients with septic shock- a prospective study. Feng JY, Liu KT, Abraham E, Chen CY, Tsai PY, Chen YC, Lee YC, Yang KY.. PLoS One. 2014;9(6):e97967.

Human resistin promotes neutrophil proinflammatory activation and neutrophil extracellular trap formation and increases severity of acute lung injury. Jiang S, Park DW, Tadie JM, Gregoire M, Deshane J, Pittet JF, Abraham E, Zmijewski JW.. J Immunol. 2014;192(10):4795-4803.

miR-27a regulates inflammatory response of macrophages by targeting IL-10. Xie N, Cui H, Banerjee S, Tan Z, Salomao R, Fu M, Abraham E, Thannickal VJ, Liu G.. J Immunol. 2014;193(1):327-334.

The human long noncoding RNA lnc-IL7R regulates the inflammatory response. Cui H, Xie N, Tan Z, Banerjee S, Thannickal VJ, Abraham E, Liu G.. Eur J Immunol. 2014;44(7):2085-2095.

GSK3beta-dependent inhibition of AMPK potentiates activation of neutrophils and macrophages and enhances severity of acute lung injury. Park DW, Jiang S, Liu Y, Siegal GP, Inoki K, Abraham E, Zmijewski JW.. Am J Physiol Lung Cell Mol Physiol. 2014;307(10):L735-L745.

Increasing clinical trials accrual at a Comprehensive Cancer Center [abstract]. Powell BL, Olson D, Morrell RM, Hales TL, High KP, Abraham E.. Blood. 2014;124(21):1266.

MicroRNAs in immune response and macrophage polarization. Liu G, Abraham E.. Arterioscler Thromb Vasc Biol. 2013;33(2):170-177.

Vitronectin inhibits efferocytosis through interactions with apoptotic cells as well as with macrophages. Bae HB, Tadie JM, Jiang S, Park DW, Bell CP, Thompson LC, Peterson CB, Thannickal VJ, Abraham E, Zmijewski JW.. J Immunol. 2013;190(5):2273-2281.

HMGB1 promotes neutrophil extracellular trap formation through interactions with Toll-like receptor 4. Tadie JM, Bae HB, Jiang S, Park DW, Bell CP, Yang H, Pittet JF, Tracey K, Thannickal VJ, Abraham E, Zmijewski JW.. Am J Physiol Lung Cell Mol Physiol. 2013;304(5):L342-349.

It's all in the genes: moving toward precision medicine in critical illness [editorial]. Abraham E.. Crit Care Med. 2013;41(5):1363-1364.

The dichotomy of inhibiting nuclear factor kappa-B in pneumonia [commentary]. Abraham E.. Crit Care. 2013;17(3):152.

MicroRNA let-7c regulates macrophage polarization. Banerjee S, Xie N, Cui H, Tan Z, Yang S, Icyuz M, Abraham E, Liu G.. J Immunol. 2013;190(12):6542-6549.

miR-145 regulates myofibroblast differentiation and lung fibrosis. Yang S, Cui H, Xie N, Icyuz M, Banerjee S, Antony VB, Abraham E, Thannickal VJ, Liu G.. FASEB J. 2013;27(6):2382-2391.

Activation of AMPK enhances neutrophil chemotaxis and bacterial killing. Park DW, Jiang S, Tadie JM, Stigler WS, Gao Y, Deshane J, Abraham E, Zmijewski JW.. Mol Med. 2013;19():387-398.

miR-125a-5p regulates differential activation of macrophages and inflammation. Banerjee S, Cui H, Xie N, Tan Z, Yang S, Icyuz M, Thannickal VJ, Abraham E, Liu G.. J Biol Chem. 2013;288(49):35428-36.

Differential activation of RAGE by HMGB1 modulates neutrophil-associated NADPH oxidase activity and bacterial killing. Tadie J-M, Bae H-B, Banerjee S, Zmijewski JW, Abraham E.. Am J Physiol Cell Physiol. 2012;302(1):C249-256.

Similarity-based multimarker association tests for continuous traits. Lin W-Y, Tiwari HK, Gao G, Zhang K, Arcaroli JJ, Abraham E.. Ann Hum Genet. 2012;76(3):246-260.

Derivation of a myeloid cell-binding adenovirus for gene therapy of inflammation. Alberti MO, Roth JC, Ismail M, Tsuruta Y, Abraham E, Pereboeva L, Gerson SL, Curiel DT.. PLoS ONE. 2012;7(5):e37812.

Identification of TLT2 as an engulfment receptor for apoptotic cells. de Freitas A, Banerjee S, Xie N, Cui H, Davis KI, Friggeri A, Fu M, Abraham E, Liu G.. J Immunol. 2012;188(12):6381-6388.

Toll-like receptor 4 engagement inhibits adenosine 5'-monophosphate-activated protein kinase activation through a high mobility group box 1 protein-dependent mechanism. Tadie JM, Bae HB, Deshane JS, Bell CP, Lazarowski ER, Chaplin DD, Thannickal VJ, Abraham E, Zmijewski JW.. Mol Med. 2012;18(1):659-668.

Vitronectin inhibits neutrophil apoptosis through activation of integrin-associated signaling pathways. Bae HB, Zmijewski JW, Deshane JS, Zhi D, Thompson LC, Peterson CB, Chaplin DD, Abraham E.. Am J Respir Cell Mol Biol. 2012;46(6):790-796.

miR-21 regulates chronic hypoxia-induced pulmonary vascular remodeling. Yang S, Banerjee S, de Freitas A, Cui H, Xie N, Abraham E, Liu G.. Am J Physiol Lung Cell Mol Physiol. 2012;302(6):L521-L529.

Poly(ADP-ribosyl)ation of high mobility group box 1 (HMGB1) protein enhances inhibition of efferocytosis. Davis K, Banerjee S, Friggeri A, Bell C, Abraham E, Zerfaoui M.. Mol Med. 2012;18(1):359-369.

Participation of miR-200 in pulmonary fibrosis. Yang S, Banerjee S, de Freitas A, Sanders YY, Ding Q, Matalon S, Thannickal VJ, Abraham E, Liu G.. Am J Pathol. 2012;180(2):484-493.

Innate immune dysfunction in trauma patients: from pathophysiology to treatment [editorial]. Asehnoune K, Roquilly A, Abraham E.. Anesthesiology. 2012;117(2):411-416.

Extracellular histones inhibit efferocytosis. Friggeri A, Banerjee S, Xie N, Cui H, de Freitas A, Zerfaoui M, Dupont H, Abraham E, Liu G.. Mol Med. 2012;18(5):825-833.

The association between a Darc gene polymorphism and clinical outcomes in African American patients with acute lung injury. Kangelaris KN, Sapru A, Calfee CS, Liu KD, Pawlikowska L, Witte JS, Vittinghoff E, Zhuo H, Auerbach AD, Ziv E, Matthay MA, Abraham E, et al.. Chest. 2012;141(5):1160-1169.

Intracellular HMGB1 negatively regulates efferocytosis. Banerjee S, de Freitas A, Friggeri A, Zmijewski JW, Liu G, Abraham E.. J Immunol. 2011;187(9):4686-4694.

AMP-activated protein kinase enhances the phagocytic ability of macrophages and neutrophils. Bae H-B, Zmijewski JW, Deshane JS, Tadie J-M, Chaplin DD, Takashima S, Abraham E.. FASEB J. 2011;25(12):4358-4368.

Free radical-producing myeloid-derived regulatory cells: potent activators and suppressors of lung inflammation and airway hyperresponsiveness. Deshane J, Zmijewski JW, Luther R, Gaggar A, Deshane R, Lai JF, Xu X, Spell M, Estell K, Weaver CT, Abraham E, Schwiebert LM, Chaplin DD.. Mucosal Immunol. 2011;4(5):503-518.

Inhibition of neutrophil apoptosis by PAI-1. Zmijewski JW, Bae H-B, Deshane JS, Peterson CB, Chaplin DD, Abraham E.. Am J Physiol Lung Cell Mol Physiol. 2011;301(2):L247-254.

The receptor for urokinase regulates TLR2 mediated inflammatory responses in neutrophils. Liu G, Yang Y, Yang S, Banerjee S, De Freitas A, Friggeri A, Davis KI, Abraham E.. PLoS ONE. 2011;6(10):e25843.

Identification of a microRNA signature in renal fibrosis: role of miR-21. Zarjou A, Yang S, Abraham E, Agarwal A, Liu G.. Am J Physiol Renal Physiol. 2011;301(4):F793-F801.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

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