Profile

Sarfaraz Ahmad, Ph.D.Wake Forest School of Medicine

Sarfaraz Ahmad, Ph.D.

Assistant Professor, General Surgery

Contact Information

Academic: 336-716-9049 | Department: 336-716-9049

Email: sahmad@wakehealth.edu

Additional Languages

Hindi

Education & Training

  • M.S., Aligarh Muslim University J.N. Med-India, 1991
  • Ph.D., Aligarh Muslim University J.N. Med-India, 1996
  • Fellowship, Mercer University-Southern Sch, 2005
  • Fellowship, WFU School of Medicine, 2008
  • Fellowship, WFU School of Medicine, 2011
  • Fellowship, WFU School of Medicine, 2011

Memberships

  • Toxicology Letters
  • Oxygen Society
  • Society of Toxicology
  • Am Physiological Society
  • American Physiology
  • Aha - High Blood Pressure Res.
Sarfaraz Ahmad, Ph.D.

Sarfaraz Ahmad, Ph.D.

Assistant Professor, General Surgery

Research Interests

Chymases; Angiotensin II; Angiotensins; Peptide Fragments; Hypertension
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Contact Information

Academic: 336-716-9049 | Department: 336-716-9049

Email: sahmad@wakehealth.edu

Recent Publications

Increased fibroblast chymase production mediates procollagen autophagic digestion in volume overload. Fu L, Wei CC, Powell PC, Bradley WE, Ahmad S, Ferrario CM, Collawn JF, Dell'Italia LJ.. J Mol Cell Cardiol. 2016;92():1-9.

Cardiac angiotensin-(1-12) expression and systemic hypertension in rats expressing the human angiotensinogen gene. Ferrario CM, VonCannon JL, Jiao Y, Ahmad S, Bader M, Dell'Italia LJ, Groban L, Varagic J.. Am J Physiol Heart Circ Physiol. 2016;310(8):H995-H1002.

Mast cell inhibition attenuates cardiac remodeling and diastolic dysfunction in middle-aged, ovariectomized Fischer 344 x Brown Norway rats. Wang H, da Silva J, Alencar A, Zapata-Sudo G, Lin MS, Sun X, Ahmad S, Ferrario CM, Groban L.. J Cardiovasc Pharmacol. 2016;68(1):49-57.

Intracrine angiotensin II functions originate from noncanonical pathways in the human heart. Ferrario CM, Ahmad S, Varagic J, Cheng CP, Groban L, Wang H, Collawn JF, Dell'Italia LJ.. Am J Physiol Heart Circ Physiol. 2016;311(2):H404-H414.

Primacy of cardiac chymase over angiotensin converting enzyme as an angiotensin-(1-12) metabolizing enzyme. Ahmad S, Varagic J, VonCannon JL, Groban L, Collawn JF, Dell'Italia LJ, Ferrario CM.. Biochem Biophys Res Commun. 2016;478(2):559-564.

Differential expression of the angiotensin-(1-12)/chymase axis in human atrial tissue. Nagata S, Varagic J, Kon ND, Wang H, Groban L, Simington SW, Ahmad S, Dell'Italia LJ, VonCannon JL, Deal D, Ferrario CM.. Ther Adv Cardiovasc Dis. 2015;9(4):168-180.

Functional significance of the chymase/ang-(1-12) pathway on cardiomyocytes [abstract]. Zhang X, Li T, Ahmad S, Varagic J, Groban L, Dell'Italia LJ, Cheng C-P, Ferrario CM.. Hypertension. 2015;66(Suppl 1):A078.

ACE2: angiotensin II/angiotensin-(1-7) balance in cardiac and renal injury. Varagic J, Ahmad S, Nagata S, Ferrario CM.. Curr Hypertens Rep. 2014;16(3):420.

Angiotensin-(1-12): a chymase-mediated cellular angiotensin II substrate. Ahmad S, Varagic J, Groban L, Dell'italia LJ, Nagata S, Kon ND, Ferrario CM.. Curr Hypertens Rep. 2014;16(5):429.

An evolving story of angiotensin-II-forming pathways in rodents and humans. Ferrario CM, Ahmad S, Nagata S, Simington SW, Varagic J, Kon N, Dell'italia LJ.. Clin Sci. 2014;126(7-8):461-469.

Human Ang-(1-12) and hemodynamic and cardiac biometrics in rats overexpressing human angiotensinogen [abstract]. Varagic J, VonCannon JL, Nagata S, Ahmad S, Ferrario CM.. Hypertension. 2014;64(Suppl 1):A477.

Chymase-mediated angiotensin II formation in the heart of rats overexpressing the human angiotensinogen gene [abstract]. Ahmad S, VonCannon JL, Bader M, Delbruck M, Varagic J, Ferrario CM.. Hypertension. 2014;64(Suppl 1):A621.

Angiotensin-(1-12) is a better substrate compared to angiotensin I to generate angiotensin Ii by rat chymase [abstract]. Ahmad S, Varagic J, VonCannon JL, Dell'Italia LJ, Groban L, Ferrario CM.. Hypertension. 2014;64(Suppl 1):A622.

Hemodynamic and hormonal changes to dual Renin-Angiotensin system inhibition in experimental hypertension. Moniwa N, Varagic J, Ahmad S, Voncannon JL, Simington SW, Wang H, Groban L, Brosnihan KB, Nagata S, Kato J, Kitamura K, Gomez RA, Lopez ML, Ferrario CM.. Hypertension. 2013;61(2):417-424.

Predominance of AT(1) blockade over mas-mediated angiotensin-(1-7) mechanisms in the regulation of blood pressure and renin-angiotensin system in mRen2.Lewis rats. Varagic J, Ahmad S, VonCannon JL, Moniwa N, Brosnihan KB, Wysocki J, Batlle D, Ferrario CM.. Am J Hypertens. 2013;26(5):583-590.

Chymase mediates angiotensin-(1-12) metabolism in normal human hearts. Ahmad S, Wei CC, Tallaj J, Dell'Italia LJ, Moniwa N, Varagic J, Ferrario CM.. J Am Soc Hypertens. 2013;7(2):128-136.

Characterization of the cardiac renin angiotensin system in oophorectomized and estrogen-replete mRen2.Lewis rats. Wang H, Jessup JA, Zhao Z, Da Silva J, Lin M, Macnamara LM, Ahmad S, Chappell MC, Ferrario CM, Groban L.. PLoS One. 2013;8(10):e76992.

Estrogen replacement downregulates cardiac angiotensin II in an ACE-independent manner in oophorectomized mRen2.Lewis rats [abstract]. Wang H, Zhao Z, Jessup J, Lin M, MacNamara L, Ahmad S, Ferrario C, Groban L.. Circ Res. 2013;113(4 Suppl):A086.

Primacy of angiotensin converting enzyme in angiotensin-(1-12) metabolism. Moniwa N, Varagic J, Simington SW, Ahmad S, Nagata S, Voncannon JL, Ferrario CM.. Am J Physiol Heart Circ Physiol. 2013;305(5):H644-H650.

Renin independent Ang-(1-12) production in both the systemic and coronary circulation [abstract]. Moniwa N, Varagic J, Nagata S, Ahmad S, Simington SW, VonCannon JL, Shimamura Y, Hasegawa K, Takizawa H, Ura N, Tanaka S, Furuhashi M, Yoshida H, Miura T, Ferrario CM.. Hypertension. 2013;62(3 Suppl):604.

Differential expression of angiotensin-(1-12)/chymase in human atrial tissue [abstract]. Nagata S, Varagic J, Simington SW, Ahmad S, VonCannon JL, Wang H, Groban L, Kon ND, Dell'Italia LJ, Ferrario CM.. Hypertension. 2013;62(3 Suppl):629.

Does cardiac ang-(1-12) have a role in sex-specific heart disease? [abstract]. Nagata S, Varagic J, Simington SW, Ahmad S, VonCannon JL, Wang H, Kon ND, Dell'Italia LJ, Ferrario CM, Groban L.. Hypertension. 2013;62(3 Suppl):632.

Restoration of the blood pressure circadian rhythm by direct renin inhibition and blockade of angiotensin II receptors in mRen2.Lewis hypertensive rats. Moniwa N, Varagic J, Ahmad S, VonCannon JL, Ferrario CM.. Ther Adv Cardiovasc Dis. 2012;6(1):15-29.

Effects of combination therapy with valsartan and aliskiren on arterial pressure, cardiac hypertrophy and urinary protein excretion in hypertensive rats [abstract]. Moniwa N, Varagic J, Ahmad S, Ferrario CM.. FASEB J. 2012;26(Meeting Abstracts):1105.4.

Chymase-mediated angiotensin II generation from angiotensin-(1-12) in left ventricular tissue of normal and diseased human subjects [abstract]. Moniwa N, Wei C-C, Dell'Italia LJ, Ferrario CM, Ahmad S, Varagic J.. J Clin Hypertens (Greenwich). 2012;14(Suppl 1):149.

Nebivolol reduces cardiac angiotensin II, associated oxidative stress and fibrosis but not arterial pressure in salt-loaded spontaneously hypertensive rats. Varagic J, Ahmad S, Voncannon JL, Moniwa N, Simington SW Jr, Brosnihan BK, Gallagher PE, Habibi J, Sowers JR, Ferrario CM.. J Hypertens. 2012;30(9):1766-1774.

Cardiac kallikrein-kinin system is upregulated in chronic volume overload and mediates an inflammatory induced collagen loss. Wei C-C, Chen Y, Powell LC, Zheng J, Shi K, Bradley WE, Powell PC, Ahmad S, Ferrario CM, Dell'Italia LJ.. PLoS One. 2012;7(6):e40110.

Differential effects of ACE and chymase in the metabolism of exogenous angiotensin-(1-12) in Wistar-Kyoto rats [abstract]. Moniwa N, Varagic J, Ahmad S, Ferrario CM.. FASEB J. 2012;26(Meeting Abstracts Suppl):1105.3.

Role of angiotensin converting enzyme on the production of angiotensins from angiotensin-(1-12) in normotensive Winstar-kyoto rats and spontaneously hypertensive rats [abstract]. Moniwa N, Ahmad S, VonCannon JL, Simington SW, Varagic J, Ferrario CM.. Hypertension. 2012;60(3 Suppl):235.

Predominance of angiotensin II type 1 receptor blockade over antiotensin-(1-7) mechanisms in the regulation of blood pressure and renin angiotensin system in mRen.Lewis rats [abstract]. Varagic J, Ahmad S, Moniwa N, Brosnihan KB, Wysocki J, Batlle D, Ferrario CM.. Hypertension. 2012;60(Suppl 3):283.

Renin does not participate in the production of plasma ang-(1-12) from angiotensinogen [abstract]. Simington SW, Moniwa N, Ahmad S, VonCannon JL, Dell'Italia LJ, Varagic J, Ferrario CM.. Hypertension. 2012;60(3 Suppl):628.

Uptake and metabolism of the novel peptide angiotensin-(1-12) by neonatal cardiac myocytes. Ahmad S, Varagic J, Westwood BM, Chappell MC, Ferrario CM.. PLoS ONE. 2011;6(1):e15759.

Differential regulation of NOS in kidney and heart of SHR fed high salt diet [abstract]. Varagic J, Ahmad S, Habibi J, Sowers JR, Ferrario CM.. FASEB J. 2011;25(Meeting Abstracts):643.7.

Olmesartan reduces angiotensin II without affecting ACE activity in kidneys of mRen2.Lewis rats [abstract]. Varagic J, Ahmad S, Moniwa N, Brosnihan KB, Ferrario CM.. FASEB J. 2011;25(Meeting Abstracts):1b358.

Localization and metabolism of angiotensin-(1-12) in human atrial tissue [abstract]. Ahmad S, Simmons T, Varagic J, Moniwa N, Chappell MC, Lively M, Ferrario CM.. Hypertension. 2011;58(5):e50.

RAS blockade restores circadian rhythm of arterial pressure in a renin-dependent model of experimental hypertension [abstract]. Moniwa N, Varagic J, Ahmad S, Ferrario CM.. Hypertension. 2011;58(5):e151.

Nebivolol reduces cardiac angiotensin II, associated oxidative stress and fibrosis but not arterial pressure in salt-loaded SHR [abstract]. Varagic J, Ahmad S, Gallagher PE, Habibi J, Sowers J, Ferrario CM.. Hypertension. 2011;58(5):e80.

Chymase-dependent generation of angiotensin II from angiotensin-(1-12) in human atrial tissue. Ahmad S, Simmons T, Varagic J, Moniwa N, Chappell MC, Ferrario CM.. PLoS ONE. 2011;6(12):e28501.

Decreased cardiac Ang-(1-7) is associated with salt-induced cardiac remodeling and dysfunction. Varagic J, Ahmad S, Brosnihan KB, Groban L, Chappell MC, Tallant EA, Gallagher PE, Ferrario CM.. Ther Adv Cardiovasc Dis. 2010;4(1):17-25.

Chymase-dependent generation of angiotensin II from angiotensin-(1-12) in human atrial tissue [abstract]. Ahmad S, Varagic J, Westwood B, Chappell MC, Strawn WB, Simmons T, Ferrario CM.. FASEB J. 2010;24(1 Meeting Abstracts):605.4.

Advances in the renin angiotensin system focus on angiotensin-converting enzyme 2 and angiotensin-(1-7). Ferrario CM, Ahmad S, Joyner J, Varagic J.. Adv Pharmacol. 2010;59():197-233.

The effects of nebivolol on salt-induced renal injury [abstract]. Varagic J, Ahmad S, Brosnihan KB, Habibi J, Sowers JR, Ferrario CM.. Hypertension. 2010;56(5):e155.

Salt-induced renal injury in spontaneously hypertensive rats: effects of nebivolol. Varagic J, Ahmad S, Brosnihan KB, Habibi J, Tilmon RD, Sowers JR, Ferrario CM.. Am J Nephrol. 2010;32(6):557-566.

Uptake of novel peptide angiotensin-(1-12) by cardiac myocytes [abstract]. Ahmad S, Varagic J, Westwood B, Chappell MC, Ferrario CM.. Hypertension. 2009;54(4):e111.

Spironolactone and angiotensin-(1-7) in salt-induced cardiac injury [abstract]. Varagic J, Ahmad S, Brosnihan KB, Ferrario CM.. Hypertension. 2009;54(4):e26.

Cytotoxicity and mutagenicity of 5-methylchrysene and its 1,2-dihydrodiol in V79MZ cells modified to express human CYP1A1 or CYP1B1, in the presence or absence of human GSTP1 coexpression. Ahmad S, Kabler SL, Rudd L, Amin S, Doehmer J, Morrow CS, Townsend AJ.. Toxicol Lett. 2008;183(1-3):99-104.

Protective efficacy of hGSTM1-1 against B[a]P and (+)- or (-)-B[a]P-7,8-dihydrodiol cytotoxicity, mutagenicity, and macromolecular adducts in V79 cells coexpressing hCYP1A1. Kushman ME, Kabler SL, Ahmad S, Doehmer J, Morrow CS, Townsend AJ.. Toxicol Sci. 2007;99(1):51-57.

Cytotoxicity and mutagenicity of dibenzo[a,1]pyrene and (+/-)-dibenzo [a,1]pyrene-11, 12-dihydrodiol in V79MZ cells co-expressing either hCYP1A1 or hCYP1B1 together with human glutathione-S-transferase A1. Kushman ME, Kabler SL, Ahmad S, Doehmer J, Morrow CS, Townsend AJ.. Mutat Res. 2007;624(1-2):80-87.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Assistant Professor, General Surgery

Sarfaraz Ahmad, Ph.D.

Sarfaraz Ahmad, Ph.D.

Assistant Professor, General Surgery

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