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Steven A.  Akman, M.D.

Steven A. Akman, M.D.

Center of Excellence Director, Comprehensive Cancer Center
Contact Information
Appointment:
336-713-5440
Office:
336-716-4464
Fax:
336-716-5687
Clinical Specialties
Breast Cancer
Education & Training
  ABCornell University1971
  MDAlbert Einstein College of Medicine1975
ResidencyMedicineBeth Israel Deaconess Med Ctr1977
InternshipMedicineBeth Israel Deaconess Med Ctr1976
Memberships
American Association of Blood Banks
American Association of Cancer Research
American Society of Clinical Oncology
Association of Academic Chairmen of Plastic Sur
NPI Number
1396729414
Steven A.  Akman, M.D.

Steven A. Akman, M.D.

Center of Excellence Director, Comprehensive Cancer Center
Contact Information
Appointment:
336-713-5440
Office:
336-716-4464
Fax:
336-716-5687
Research Interests
cell growth, differentiation,d , molecular biology/molecular me
Recent Publications
Huang W, Smaldino PJ, Zhang Q, Miller LD, Cao P, Stadelman K, Wan M, Giri B, Lei M, Nagamine Y, Vaughn JP, Akman SA, Sui G. Yin Yang 1 contains G-quadruplex structures in its promoter and 5'-UTR and its expression is modulated by G4 resolvase 1. Nucleic Acids Res. 2012; 40(3):1033-1049.

Wan M, Huang W, Kute TE, Miller LD, Zhang Q, Hatcher H, Wang J, Stovall DB, Russell GB, Cao PD, Deng Z, Wang W, Zhang Q, Lei M, Torti SV, Akman SA, Sui G. Yin Yang 1 plays an essential role in breast cancer and negatively regulates p27. Am J Pathol. 2012; 180(5):2120-2133.

Cortes DF, Sha W, Hower V, Blekherman G, Laubenbacher R, Akman S, Torti SV, Shulaev V. Differential gene expression in normal and transformed human mammary epithelial cells in response to oxidative stress. Free Radic Biol Med. 2011; 50(11):1565-1574.

Blekherman G, Laubenbacher R, Cortes DF, Mendes P, Torti FM, Akman S, Torti SV, Shulaev V. Bioinformatics tools for cancer metabolomics. Metabolomics. 2011; 7(3):329-343.

Giri B, Smaldino PJ, Thys RG, Creacy SD, Routh ED, Hantgan RR, Lattmann S, Nagamine Y, Akman SA, Vaughn JP. G4 Resolvase 1 tightly binds and unwinds unimolecular G4-DNA. Nucleic Acids Res. 2011; 39(16):7161-7178.

Ding X, Singh R, Burke A, Hatcher H, Olson J, Kraft RA, Schmid M, Carroll D, Bourland JD, Akman S, Torti FM, Torti SV. Development of iron-containing multiwalled carbon nanotubes for MR-guided laser-induced thermotherapy. Nanomedicine (Lond). 2011; 6(8):1341-1352.

Lattmann S, Stadler MB, Vaughn JP, Akman SA, Nagamine Y. The DEAH-box RNA helicase RHAU binds an intramolecular RNA G-quadruplex in TERC and associates with telomerase holoenzyme. Nucleic Acids Res. 2011; 39(21):9390-9404.

Lattmann S, Giri B, Vaughn JP, Akman SA, Nagamine Y. Role of the amino terminal RHAU-specific motif in the recognition and resolution of guanine quadruplex-RNA by the DEAH-box RNA helicase RHAU. Nucleic Acids Res. 2010; 38(18):6219-6233.

Hower V, Mendes P, Torti FM, Laubenbacher R, Akman S, Shulaev V, Torti SV. A general map of iron metabolism and tissue-specific subnetworks. Mol Biosyst. 2009; 5(5):422-443.

Laubenbacher R, Hower V, Jarrah A, Torti SV, Shulaev V, Mendes P, Torti FM, Akman S. A systems biology view of cancer. Biochim Biophys Acta. 2009; 1796(2):129-139.

Burke A, Singh R, Kraft RA, Levi-Polyachenko N, Hatcher HC, D'Agostino R Jr, Kock ND, Carroll DL, Akman S, Torti FM, Torti SV, et al. Long-term survival following a single treatment of kidney tumors with multiwalled carbon nanotubes and near-infrared radiation. Proc Natl Acad Sci U S A. 2009; 106(31):12897-902.


Smith TR, Levine EA, Freimanis RI, Akman SA, Allen GO, Hoang KN, Liu-Mares W, Hu JJ. Polygenic model of DNA repair genetic polymorphisms in human breast cancer risk. Carcinogenesis. 2008; 29(11):2132-2138.

Gajewski E, Gaur S, Akman SA, Matsumoto L, van Balgooy JNA, Doroshow JH. Oxidative DNA base damage in MCF-10A breast epithelial cells at clinically achievable concentrations of doxorubicin. Biochem Pharmacol. 2007; 73(12):1947-1956.

Torti SV, Byrne F, Whelan O, Levi N, Ucer B, Schmid M, Torti FM, Akman S, Liu J, Ajayan PM, et al. Thermal ablation therapeutics based on CN(x) multi-walled nanotubes. Int J Nanomedicine. 2007; 2(4):707-714.

Upton DC, Wang X, Blans P, Perrino FW, Fishbein JC, Akman SA. Mutagenesis by exocyclic alkylamino purine adducts in Escherichia coli. Mutat Res. 2006; 599(1-2):1-10.

Upton DC, Wang X, Blans P, Perrino FW, Fishbein JC, Akman SA. Replication of N(2)-ethyldeoxyguanosine DNA adducts in the human embryonic kidney cell line 293. Chem Res Toxicol. 2006; 19(7):960-967.
All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Last Updated 5/1/2012
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