Martha A. Alexander-Miller, Ph.D.Wake Forest School of Medicine

Martha A. Alexander-Miller, Ph.D.


Contact Information

Academic: 336-716-5936 | Department: 336-716-2011


Education & Training

  • B.S., Butler University, 1988
  • Ph.D., Washington University, 1993
  • Fellowship, National Institutes Hlth, 1997


  • Am Assn Of Immunologists
  • Am Soc of Microbiology
Martha A. Alexander-Miller, Ph.D.

Martha A. Alexander-Miller, Ph.D.

Chair, Microbiology & Immunology
Professor, Microbiology & Immunology
Comprehensive Cancer Center
Center for Comparative Medicine Research
Translational Science Institute

Research Interests

education/training (all f, t,, immunology/allergy/inflammatio, infectious diseases, vaccines

Contact Information

Academic: 336-716-5936 | Department: 336-716-2011


Recent Publications

Holbrook BC, Hayward SL, Blevins LK, Kock N, Aycock T, Parks GD, Alexander-Miller MA. Nonhuman primate infants have an impaired respiratory but not systemic IgG antibody response following influenza virus infection. Virology. 2015;476():124-133.

Kim JR, Holbrook BC, Hayward SL, Blevins LK, Jorgensen MJ, Kock ND, De Paris K, D'Agostino R Jr, Aycock ST, Mizel SB, Parks GD, Alexander-Miller MA. Inclusion of flagellin during vaccination against influenza enhances recall responses in nonhuman primate neonates. J Virol. 2015;():.

Wren JT, Blevins LK, Pang B, King LB, Perez AC, Murrah KA, Reimche JL, Alexander-Miller MA, Swords WE. Influenza a virus alters pneumococcal nasal colonization and middle ear infection independently of phase variation. Infect Immun. 2014;82(11):4802-4812.

Blevins LK, Wren JT, Holbrook BC, Hayward SL, Swords WE, Parks GD, Alexander-Miller MA. Coinfection with Streptococcus pneumoniae negatively modulates the size and composition of the ongoing influenza-specific CD8+ T cell response. J Immunol. 2014;193(10):5076-5087.

Parks GD, Alexander-Miller MA. Paramyxovirus activation and inhibition of innate immune responses. J Mol Biol. 2013;425(24):4872-4892.

Holbrook BC, Yammani RD, Blevins LK, Alexander-Miller MA. In vivo modulation of avidity in highly sensitive CD8(+) effector T cells following viral infection. Viral Immunol. 2013;26(5):302-313.

Amoah S, Yammani RD, Grayson JM, Alexander-Miller MA. Changes in functional but not structural avidity during differentiation of CD8+ effector cells in vivo after virus infection. J Immunol. 2012;189(2):638-645.

Brown AL, Zhu X, Rong S, Shewale S, Seo J, Boudyguina E, Gebre AK, Alexander-Miller MA, Parks JS. Omega-3 fatty acids ameliorate atherosclerosis by favorably altering monocyte subsets and limiting monocyte recruitment to aortic lesions. Arterioscler Thromb Vasc Biol. 2012;32(9):2122-2130.

Johnson JB, Douglas LS [sic] [Lyles DS], Martha AMA [sic] [Alexander-Miller MA], Griffith DG [sic] [Parks GD]. Virion-associated complement regulator CD55 is more potent than CD46 in mediating resistance of mumps virus and VSV to neutralization [abstract]. Immunobiology. 2012;217(11):1215-1216.

Busick RY, Yammani RD, Alexander-Miller MA. Differentiation-dependent differences in murine T cell susceptibility to negative regulation by the lung. Am J Respir Cell Mol Biol. 2011;44(5):597-605.

Arimilli S, Sharma SK, Yammani R, Reid SD, Parks GD, Alexander-Miller MA. Pivotal advance: nonfunctional lung effectors exhibit decreased calcium mobilization associated with reduced expression of ORAI1. J Leukoc Biol. 2010;87(6):977-988.

Beauchamp NM, Busick RY, Alexander-Miller MA. Functional divergence among CD103+ dendritic cell subpopulations following pulmonary poxvirus infection. J Virol. 2010;84(19):10191-9.

Palmer EM, Holbrook BC, Arimilli S, Parks GD, Alexander-Miller MA. IFNgamma-producing, virus-specific CD8+ effector cells acquire the ability to produce IL-10 as a result of entry into the infected lung environment. Virology. 2010;404(2):225-230.

Brown AL, Zhu X, Wilson MD, Alexander-Miller M, Parks JS. Echium oil promotes phenotypic shifting in the macrophage lineage [abstract]. Arterioscler Thromb Vasc Biol. 2009;29(7):e24.

Kroger CJ, Amoah S, Alexander-Miller MA. Cutting edge: dendritic cells prime a high avidity CTL response independent of the level of presented antigen. J Immunol. 2008;180(9):5784-5788.

Arimilli S, Palmer EM, Alexander-Miller MA. Loss of function in virus-specific lung effector T cells is independent of infection. J Leukoc Biol. 2008;83(3):564-574.

Yammani RD, Pejawar-Gaddy S, Gurley TC, Weimer ET, Hiltbold EM, Alexander-Miller MA. Regulation of maturation and activating potential in CD8+ versus CD8- dendritic cells following in vivo infection with vaccinia virus. Virology. 2008;378(1):142-150.

Yates NL, Yammani RD, Alexander-Miller MA. Dose-dependent lymphocyte apoptosis following respiratory infection with Vaccinia virus. Virus Res. 2008;137(2):198-205.

Arimilli S, Johnson JB, Clark KM, Graff AH, Alexander-Miller MA, Mizel SB, Parks GD. Engineered expression of the TLR5 ligand flagellin enhances paramyxovirus activation of human dendritic cell function. J Virol. 2008;82(22):10975-85.

Pejawar-Gaddy S, Gitiban-Vaghefi N, Parks GD, Alexander-Miller MA. Distinct pathways for signaling maturation in macrophages and dendritic cells after infection with paramyxovirus simian virus 5. Viral Immunol. 2007;20(1):76-87.

Kroger CJ, Alexander-Miller MA. Cutting edge: CD8+ T cell clones possess the potential to differentiate into both high- and low-avidity effector cells. J Immunol. 2007;179(2):748-751.

Kroger CJ, Alexander-Miller MA. Dose-dependent modulation of CD8 and functional avidity as a result of peptide encounter. Immunology. 2007;122(2):167-178.

Pejawar-Gaddy S, Alexander-Miller MA. Ligation of CD80 is critical for high-level CD25 expression on CD8+ T lymphocytes. J Immunol. 2006;177(7):4495-4502.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

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