Martha A. Alexander-Miller, Ph.D.Wake Forest School of Medicine

Martha A. Alexander-Miller, Ph.D.


Contact Information

Academic: 336-716-5936 | Department: 336-716-2011


Education & Training

  • B.S., Butler University, 1988
  • Ph.D., Washington University, 1993
  • Fellowship, National Institutes Hlth, 1997


  • Am Assn Of Immunologists
  • Am Soc of Microbiology
Martha A. Alexander-Miller, Ph.D.

Martha A. Alexander-Miller, Ph.D.

Chair, Microbiology & Immunology
Professor, Microbiology & Immunology
Center on Diabetes, Obesity, and Metabolism
Office of Women in Medicine and Science

Research Interests

CD8-Positive T-Lymphocytes; T-Lymphocytes, Cytotoxic; Lymphocyte Activation; Dendritic Cells; Vaccinia virus
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Contact Information

Academic: 336-716-5936 | Department: 336-716-2011


Recent Publications

In vivo activation of leukocyte GPR120/FFAR4 by PUFAs has minimal impact on atherosclerosis in LDL receptor knockout mice. Shewale SV, Brown AL, Bi X, Boudyguina E, Sawyer JK, Alexander-Miller MA, Parks JS.. J Lipid Res. 2017;58(1):236-246.

A novel R848-conjugated inactivated influenza virus vaccine is efficacious and safe in a neonate nonhuman primate model. Holbrook BC, Kim JR, Blevins LK, Jorgensen MJ, Kock ND, D'Agostino RB Jr, Aycock ST, Hadimani MB, King SB, Parks GD, Alexander-Miller MA.. J Immunol. 2016;197(2):555-564.

Adjuvanting an inactivated influenza vaccine with flagellin improves the function and quantity of the long-term antibody response in a nonhuman primate neonate model. Holbrook BC, D'Agostino RB Jr, Parks GD, Alexander-Miller MA.. Vaccine. 2016;34(39):4712-4717.

A novel R848-conjugated inactivated influenza virus vaccine is safe and efficacious in a neonate nonhuman primate model [abstract]. Holbrook B, Kim J, Blevins L, Jorgensen M, Kock N, D'Agostino R Jr, Aycock ST, Hadimani M, King SB, Parks G, Alexander-Miller M.. Eur J Immunol. 2016;46(Suppl 1):31.

Nonhuman primate infants have an impaired respiratory but not systemic IgG antibody response following influenza virus infection. Holbrook BC, Hayward SL, Blevins LK, Kock N, Aycock T, Parks GD, Alexander-Miller MA.. Virology. 2015;476():124-133.

Inclusion of flagellin during vaccination against influenza enhances recall responses in nonhuman primate neonates. Kim JR, Holbrook BC, Hayward SL, Blevins LK, Jorgensen MJ, Kock ND, De Paris K, D'Agostino R Jr, Aycock ST, Mizel SB, Parks GD, Alexander-Miller MA.. J Virol. 2015;89(14):7291-7303.

CD4+ T cell subset differentiation and avidity setpoint are dictated by the interplay of cytokine and antigen mediated signals. Shiner EK, Holbrook BC, Alexander-Miller MA.. PLoS One. 2014;9(6):e100175.

Influenza a virus alters pneumococcal nasal colonization and middle ear infection independently of phase variation. Wren JT, Blevins LK, Pang B, King LB, Perez AC, Murrah KA, Reimche JL, Alexander-Miller MA, Swords WE.. Infect Immun. 2014;82(11):4802-4812.

Coinfection with Streptococcus pneumoniae negatively modulates the size and composition of the ongoing influenza-specific CD8+ T cell response. Blevins LK, Wren JT, Holbrook BC, Hayward SL, Swords WE, Parks GD, Alexander-Miller MA.. J Immunol. 2014;193(10):5076-5087.

Vaccines against respiratory viral pathogens for use in neonates: opportunities and challenges. Alexander-Miller MA.. J Immunol. 2014;193(11):5363-5369.

High viral burden restricts short-lived effector cell number at late times postinfection through increased natural regulatory T cell expansion. Amoah S, Holbrook BC, Yammani RD, Alexander-Miller MA.. J Immunol. 2013;190(10):5020-5029.

Paramyxovirus activation and inhibition of innate immune responses. Parks GD, Alexander-Miller MA.. J Mol Biol. 2013;425(24):4872-4892.

In vivo modulation of avidity in highly sensitive CD8(+) effector T cells following viral infection. Holbrook BC, Yammani RD, Blevins LK, Alexander-Miller MA.. Viral Immunol. 2013;26(5):302-313.

Changes in functional but not structural avidity during differentiation of CD8+ effector cells in vivo after virus infection. Amoah S, Yammani RD, Grayson JM, Alexander-Miller MA.. J Immunol. 2012;189(2):638-645.

Omega-3 fatty acids ameliorate atherosclerosis by favorably altering monocyte subsets and limiting monocyte recruitment to aortic lesions. Brown AL, Zhu X, Rong S, Shewale S, Seo J, Boudyguina E, Gebre AK, Alexander-Miller MA, Parks JS.. Arterioscler Thromb Vasc Biol. 2012;32(9):2122-2130.

CD8 marks a subpopulation of lung-derived dendritic cells with differential responsiveness to viral infection and toll-like receptor stimulation. Beauchamp NM, Yammani RD, Alexander-Miller MA.. J Virol. 2012;86(19):10640-50.

Virion-associated complement regulator CD55 is more potent than CD46 in mediating resistance of mumps virus and vesicular stomatitis virus to neutralization. Johnson JB, Lyles DS, Alexander-Miller MA, Parks GD.. J Virol. 2012;86(18):9929-9940.

Virion-associated complement regulator CD55 is more potent than CD46 in mediating resistance of mumps virus and VSV to neutralization [abstract]. Johnson JB, Douglas LS [sic] [Lyles DS], Martha AMA [sic] [Alexander-Miller MA], Griffith DG [sic] [Parks GD].. Immunobiology. 2012;217(11):1215-1216.

Differentiation-dependent differences in murine T cell susceptibility to negative regulation by the lung. Busick RY, Yammani RD, Alexander-Miller MA.. Am J Respir Cell Mol Biol. 2011;44(5):597-605.

Increased sensitivity to antigen in high avidity CD8+ T cells results from augmented membrane proximal T-cell receptor signal transduction. Sharma SK, Alexander-Miller MA.. Immunology. 2011;133(3):307-317.

Pivotal advance: nonfunctional lung effectors exhibit decreased calcium mobilization associated with reduced expression of ORAI1. Arimilli S, Sharma SK, Yammani R, Reid SD, Parks GD, Alexander-Miller MA.. J Leukoc Biol. 2010;87(6):977-988.

Functional divergence among CD103+ dendritic cell subpopulations following pulmonary poxvirus infection. Beauchamp NM, Busick RY, Alexander-Miller MA.. J Virol. 2010;84(19):10191-9.

IFNgamma-producing, virus-specific CD8+ effector cells acquire the ability to produce IL-10 as a result of entry into the infected lung environment. Palmer EM, Holbrook BC, Arimilli S, Parks GD, Alexander-Miller MA.. Virology. 2010;404(2):225-230.

Echium oil promotes phenotypic shifting in the macrophage lineage [abstract]. Brown AL, Zhu X, Wilson MD, Alexander-Miller M, Parks JS.. Arterioscler Thromb Vasc Biol. 2009;29(7):e24.

Cutting edge: dendritic cells prime a high avidity CTL response independent of the level of presented antigen. Kroger CJ, Amoah S, Alexander-Miller MA.. J Immunol. 2008;180(9):5784-5788.

Loss of function in virus-specific lung effector T cells is independent of infection. Arimilli S, Palmer EM, Alexander-Miller MA.. J Leukoc Biol. 2008;83(3):564-574.

Regulation of maturation and activating potential in CD8+ versus CD8- dendritic cells following in vivo infection with vaccinia virus. Yammani RD, Pejawar-Gaddy S, Gurley TC, Weimer ET, Hiltbold EM, Alexander-Miller MA.. Virology. 2008;378(1):142-150.

Dose-dependent lymphocyte apoptosis following respiratory infection with Vaccinia virus. Yates NL, Yammani RD, Alexander-Miller MA.. Virus Res. 2008;137(2):198-205.

Engineered expression of the TLR5 ligand flagellin enhances paramyxovirus activation of human dendritic cell function. Arimilli S, Johnson JB, Clark KM, Graff AH, Alexander-Miller MA, Mizel SB, Parks GD.. J Virol. 2008;82(22):10975-85.

Vaccinia virus infection of mature dendritic cells results in activation of virus-specific naive CD8+ T cells: a potential mechanism for direct presentation. Yates NL, Alexander-Miller MA.. Virology. 2007;359(2):349-361.

Distinct pathways for signaling maturation in macrophages and dendritic cells after infection with paramyxovirus simian virus 5. Pejawar-Gaddy S, Gitiban-Vaghefi N, Parks GD, Alexander-Miller MA.. Viral Immunol. 2007;20(1):76-87.

Cutting edge: CD8+ T cell clones possess the potential to differentiate into both high- and low-avidity effector cells. Kroger CJ, Alexander-Miller MA.. J Immunol. 2007;179(2):748-751.

TLR-4 and -6 agonists reverse apoptosis and promote maturation of simian virus 5-infected human dendritic cells through NFkB-dependent pathways. Arimilli S, Johnson JB, Alexander-Miller MA, Parks GD.. Virology. 2007;365(1):144-156.

Dose-dependent modulation of CD8 and functional avidity as a result of peptide encounter. Kroger CJ, Alexander-Miller MA.. Immunology. 2007;122(2):167-178.

Ligation of CD80 is critical for high-level CD25 expression on CD8+ T lymphocytes. Pejawar-Gaddy S, Alexander-Miller MA.. J Immunol. 2006;177(7):4495-4502.

Exchange of P/V genes between two non-cytopathic simian virus 5 variants results in a recombinant virus that kills cells through death pathways that are sensitive to caspase inhibitors. Dillon PJ, Wansley EK, Young VA, Alexander-Miller MA, Parks GD.. J Gen Virol. 2006;87(Pt 12):3643-3648.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

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