Profile

Graca Almeida-Porada, M.D., Ph.D.Wake Forest School of Medicine

Graca Almeida-Porada, M.D., Ph.D.

Professor,


Contact Information

Academic: 336-713-1630 | Department: 336-713-1630

Email: galmeida@wakehealth.edu

Additional Languages

Portuguese

Education & Training

  • M.D., University of Porto Faculty of Medicine-Portugal, 1985
  • Ph.D., University of Porto Faculty of Medicine-Portugal, 1994

Memberships

  • Am Assn Of Blood Banks
  • Am Federation Of Clinical Rese
  • Am Soc of Hematology
Graca Almeida-Porada, M.D., Ph.D.

Graca Almeida-Porada, M.D., Ph.D.

Professor, Institute for Regenerative Medicine
Office of Women in Medicine and Science
Biomedical Engineering

Research Interests

Hematopoietic Stem Cells; Sheep; Transplantation, Heterologous; Bone Marrow Cells; Hematopoietic Stem Cell Transplantation
More »

Contact Information

Academic: 336-713-1630 | Department: 336-713-1630

Email: galmeida@wakehealth.edu

Recent Publications

The hematopoietic system in the context of regenerative medicine. Porada CD, Atala AJ, Almeida-Porada G.. Methods. 2016;99():44-61.

In utero stem cell transplantation and gene therapy: rationale, history, and recent advances toward clinical application. Almeida-Porada G, Atala A, Porada CD.. Mol Ther Methods Clin Dev. 2016;5():16020.

Boosting hematopoietic engraftment after in utero transplantation through vascular niche manipulation. Mokhtari S, Colletti EJ, Atala A, Zanjani ED, Porada CD, Almeida-Porada G.. Stem Cell Reports. 2016;6(6):957-969.

Sheep CD34+ amniotic fluid cells have hematopoietic potential and engraft after autologous in utero transplantation. Shaw SW, Blundell MP, Pipino C, Shangaris P, Maghsoudlou P, Ramachandra DL, Georgiades F, Boyd M, Thrasher AJ, Porada CD, Almeida-Porada G, Cheng PJ, David AL, de Coppi P.. Stem Cells. 2015;33(1):122-132.

Consensus statement from the first international conference for in utero stem cell transplantation and gene therapy. MacKenzie TC, David AL, Flake AW, Almeida-Porada G.. Front Pharmacol. 2015;6():15.

The effect of low-frequency electromagnetic field on human bone marrow stem/progenitor cell differentiation. Ross CL, Siriwardane M, Almeida-Porada G, Porada CD, Brink P, Christ GJ, Harrison BS.. Stem Cell Res. 2015;15(1):96-108.

A human bone marrow-derived stromal cell population with hemogenic potential [abstract]. Mokhtari S, Colletti EJ, Sanada C, Lamar ZS, Simmons PJ, Atala A, Krause DS, Zanjani ED, Porada CD, Almeida-Porada G.. Blood. 2015;126(23):1201.

Defining engraftment patterns and interactions between hematopoietic stem cells and stromal cells after in utero transplantation [abstract]. Mokhtari S, Porada CD, Colletti EJ, Almeida-Porada G.. Blood. 2015;126(3):1869.

A new approach to expand cord blood derived hematopoietic stem cells, using bioengineered human fetal liver tissue 3D-constructs [abstract]. Mokhtari S, Baptista P, Vyas D, Freeman CJ, Moran E, Porada CD, Soker S, Almeida-Porada G.. Blood. 2015;126(23):3097.

Perivascular stromal cells as a potential reservoir of human cytomegalovirus. Soland MA, Keyes LR, Bayne R, Moon J, Porada CD, St Jeor S, Almeida-Porada G.. Am J Transplant. 2014;14(4):820-830.

Stem cell engineering towards the optimization of the ex-vivo expansion of human hematopoietic stem/progenitor cells for cellular therapies [abstract]. da Silva CL, Andrade PZ, Soure AM, Santos FD, Almeida-Porada G, Cabral JS.. Cytotherapy. 2014;16(4 Suppl):S60.

Temporal definition of haematopoietic stem cell niches in a large animal model of in utero stem cell transplantation. Jeanblanc C, Goodrich AD, Colletti E, Mokhtari S, Porada CD, Zanjani ED, Almeida-Porada G.. Br J Haematol. 2014;166(2):268-278.

Evaluation of gene delivery strategies to efficiently overexpress functional HLA-G on human bone marrow stromal cells. Boura JS, Vance M, Yin W, Madeira C, Lobato da Silva C, Porada CD, Almeida-Porada G.. Mol Ther Methods Clin Dev. 2014;1():14041.

Hemophilia A: an ideal disease to correct in utero. Porada CD, Rodman C, Ignacio G, Atala A, Almeida-Porada G.. Front Pharmacol. 2014;5():276.

Mesenchymal stem cells contribute to endogenous FVIII:c production. Sanada C, Kuo CJ, Colletti EJ, Soland M, Mokhtari S, Knovich MA, Owen J, Zanjani ED, Porada CD, Almeida-Porada G.. J Cell Physiol. 2013;228(5):1010-1016.

Mesenchymal stem cells engineered to inhibit complement-mediated damage. Soland MA, Bego M, Colletti E, Zanjani ED, St Jeor S, Porada CD, Almeida-Porada G.. PLoS One. 2013;8(3):e60461.

Mesenchymal stem cells as gene delivery vehicles. Porada C, Almeida-Porada G. In: Molina FM, ed. Gene therapy--tools and potential applications. [S.I.]: InTech;2013: 177-212.

Defining the potential of MSCs with a prenatal large animal model. Almeida-Porada G, Porada CD, Zanjani ED. In: Hematti P, Keating A, eds. Mesenchymal stromal cells. New York: Humana Press;2013: 259-275.

EphB2 isolates a human marrow stromal cell subpopulation with enhanced ability to contribute to the resident intestinal cellular pool. Colletti E, El Shabrawy D, Soland M, Yamagami T, Mokhtari S, Osborne C, Schlauch K, Zanjani ED, Porada CD, Almeida-Porada G.. FASEB J. 2013;27(6):2111-2121.

Amniotic fluid stem cells for the treatment of hemophilia A [abstract]. Kuo C-J, Mokhtari S, Soland M, Soker S, Yoo J, Owen J, Knovich MA, Atala A, Almeida-Porada G, Porada C.. Mol Ther. 2013;21(Suppl 1):S96-S97.

Regenerative medicine: prospects for the treatment of inflammatory bowel disease. Almeida-Porada G, Soland M, Boura J, Porada CD.. Regen Med. 2013;8(5):631-644.

Characterization of naturally-occurring humoral immunity to AAV in sheep. Tellez J, Van Vliet K, Tseng YS, Finn JD, Tschernia N, Almeida-Porada G, Arruda VR, Agbandje-McKenna M, Porada CD.. PLoS One. 2013;8(9):e75142.

Gene therapy: the promise of a permanent cure [invited commentary]. Porada CD, Stem C, Almeida-Porada G.. N C Med J. 2013;74(6):526-529.

Expression levels of the PiT-2 receptor explain, in part, the gestational age-dependent alterations in transduction efficiency after in utero retroviral-mediated gene transfer. Ozturk F, Park PJ, Tellez J, Colletti E, Eiden MV, Almeida-Porada G, Porada CD.. J Gene Med. 2012;14(3):169-181.

Characterization of naturally-occurring humoral immunity to AAV in sheep [abstract]. Tellez J, Van Vliet K, Tseng Y-s, Finn J, Tschernia N, Almeida-Porada G, Arruda V, Agbandje-McKenna M, Porada C.. Mol Ther. 2012;20(Suppl 1):S101.

Modulation of human mesenchymal stem cell immunogenicity through forced expression of human cytomegalovirus US proteins. Soland MA, Bego MG, Colletti E, Porada CD, Zanjani ED, St Jeor S, Almeida-Porada G.. PLoS ONE. 2012;7(5):e36163.

Distinct contribution of human cord blood-derived endothelial colony forming cells to liver and gut in a fetal sheep model. Wood JA, Colletti E, Mead LE, Ingram D, Porada CD, Zanjani ED, Yoder MC, Almeida-Porada G.. Hepatology. 2012;56(3):1086-1096.

Treatment of hemophilia A in utero and postnatally using sheep as a model for cell and gene delivery. Porada CD, Almeida-Porada G.. J Genet Syndr Gene Ther. 2012;Suppl 1():011.

Development and characterization of recombinant ovine coagulation factor VIII. Zakas PM, Gangadharan B, Almeida-Porada G, Porada CD, Spencer HT, Doering CB.. PLoS One. 2012;7(11):e49481.

Origin and characterization of CD166+ cells during human marrow ontogeny [abstract]. Mokhtari S, Colletti E, Porada CD, Almeida-Porada G.. Blood. 2012;120(21):1252.

Niche perivascular stromal cells as a potential reservoir and a source of HCMV reactivation [abstract]. Soland M, Keyes L, Porada CD, St Jeor S, Almeida-Porada G.. Blood. 2012;120(21):3464.

Initial CD34+ cell-enrichment of cord blood determines hematopoietic stem/progenitor cell yield upon ex vivo expansion. Andrade PZ, da Silva CL, dos Santos F, Almeida-Porada G, Cabral JMS.. J Cell Biochem. 2011;112(7):1822-1831.

Postnatal transplantation of FVIII-expressing MSC phenotypically corrects hemophilia A [abstract]. Porada CD, Sanada C, Kuo C-J, Colletti E, Moot R, Doering C, Spencer HT, Almeida-Porada G.. Mol Ther. 2011;19(7):1364.

Endothelial cells modulate hematopoietic cell recovery after mixed field irradiation [abstract]. Cary LH, Almeida-Porada G, Noutai D, Ngudiankama BF, Whitnall MH.. Exp Hematol. 2011;39(8 Suppl 1):S66.

Phenotypic correction of hemophilia A in sheep by postnatal intraperitoneal transplantation of FVIII-expressing MSC. Porada CD, Sanada C, Kuo C-J, Colletti E, Mandeville W, Hasenau J, Zanjani ED, Moot R, Doering C, Spencer HT, Almeida-Porada G.. Exp Hematol. 2011;39(12):1124-1135.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Quick Reference

Request an Appointment
New Patients

336-716-WAKE
888-716-WAKE

Existing patients may contact the clinic directly.
Find a Doctor Ways to Give
Magnet Hospital RecognitionConsumer Choice2015 Best DoctorsJoint Commission Report

Disclaimer: The information on this website is for general informational purposes only and SHOULD NOT be relied upon as a substitute for sound professional medical advice, evaluation or care from your physician or other qualified health care provider.