Walter T. Ambrosius, Ph.D.Wake Forest School of Medicine

Walter T. Ambrosius, Ph.D.

Director, Design and Analysis Unit

Contact Information

Academic: 336-716-6281 | Department: 336-716-2011


Education & Training

  • A.B., Washington University, 1991
  • A.M., Washington University, 1991
  • Ph.D., University of Chicago, 1995


  • Am Statistical Assoc
  • Assn of GCRC Statisticians
  • Biometric Society
  • Institute Of Mathematical Stat
Walter T. Ambrosius, Ph.D.

Walter T. Ambrosius, Ph.D.

Professor, Biostatistical Sciences
Director, Design and Analysis Unit
Professor, Biostatistical Sciences
Translational Science Institute

Research Interests

aging, arthritis, cardiac function, cognition/learning, diabetes, fitness/physical, hormones/cytokines/signalling, hypertension, immunology/allergy/inflammatio, obesity, statistics/mathematics

Contact Information

Academic: 336-716-6281 | Department: 336-716-2011


Recent Publications

Fitzgerald JD, Johnson L, Hire DG, Ambrosius WT, Anton SD, Dodson JA, Marsh AP, McDermott MM, Nocera JR, Tudor-Locke C, White DK, Yank V, Pahor M, Manini TM, Buford TW. Association of objectively measured physical activity with cardiovascular risk in mobility-limited older adults. J Am Heart Assoc. 2015;4(2):e001288.

Espeland MA, Probstfield J, Hire D, Redmon JB, Evans GW, Coday M, Lewis CE, Johnson KC, Wilmoth S, Bahnson J, Dulin MF, Green JB, Knowler WC, Kitabchi A, Murillo AL, Osei K, Rehman SU, Cushman WC, Ambrosius WT, Greven CM, Lovato JF, Perdue LH, et al. Systolic blood pressure control among individuals with type 2 diabetes: a comparative effectiveness analysis of three interventions. Am J Hypertens. 2015;28(8):995-1009.

Botoseneanu A, Ambrosius WT, Beavers DP, de Rekeneire N, Anton S, Church T, Folta SC, Goodpaster BH, King AC, Nicklas BJ, Spring B, Wang X, Gill TM. Prevalence of metabolic syndrome and its association with physical capacity, disability, and self-rated health in Lifestyle Interventions and Independence for Elders Study participants. J Am Geriatr Soc. 2015;63(2):222-232.

Marsh AP, Janssen JA, Ip EH, Barnard RT, Ambrosius WT, Brubaker PR, Burdette JH, Sheedy JL, Rejeski WJ. Assessing walking activity in older adults: development and validation of a novel computer-animated assessment tool. J Gerontol A Biol Sci Med Sci. 2015;70(12):1555-1561.

Schwartz AV, Chen H, Ambrosius WT, Sood A, Josse RG, Bonds DE, Schnall AM, Vittinghoff E, Bauer DC, Banerji MA, Cohen RM, Hamilton BP, Isakova T, Sellmeyer DE, Simmons DL, Shibli-Rahhal A, Williamson JD, Margolis KL. Effects of TZD use and discontinuation on fracture rates in ACCORD bone study. J Clin Endocrinol Metab. 2015;100(11):4059-4066.

Siraj ES, Rubin DJ, Riddle MC, Miller ME, Hsu FC, Ismail-Beigi F, Chen SH, Ambrosius WT, Thomas A, Bestermann W, Buse JB, Genuth S, Joyce C, Kovacs CS, O'Connor PJ, Sigal RJ, Solomon S. Insulin dose and cardiovascular mortality in the ACCORD trial. Diabetes Care. 2015;38(11):2000-2008.

Wright JT Jr, Williamson JD, Whelton PK, Snyder JK, Sink KM, Rocco MV, Reboussin DM, Rahman M, Oparil S, Lewis CE, Kimmel PL, Johnson KC, Goff DC Jr, Fine LJ, Cutler JA, Cushman WC, Cheung AK, Ambrosius WT, Kitzman DW, et al. A randomized trial of intensive versus standard blood-pressure control. N Engl J Med. 2015;373(22):2103-2116.

Gundermann DM, Hire DG, Ambrosius WT, Kritchevsky SB, Pahor M, Axtell RS, Newman AB, Manini TM. Fish oil supplementation is associated with improved physical function and reduced mobility disability [abstract]. Gerontologist. 2015;55(Suppl 2):698.

Miller ME, Williamson JD, Gerstein HC, Byington RP, Cushman WC, Ginsberg HN, Ambrosius WT, Lovato L, Applegate WB. Effects of randomization to intensive glucose control on adverse events, cardiovascular disease, and mortality in older versus younger adults in the ACCORD trial. Diabetes Care. 2014;37(3):634-643.

Simons-Morton DG, Chan JC, Kimel AR, Linz PE, Stowe CL, Summerson J, Ambrosius WT. Characteristics associated with informed consent for genetic studies in the ACCORD trial. Contemp Clin Trials. 2014;37(1):155-164.

Ambrosius WT, Sink KM, Foy CG, Berlowitz DR, Cheung AK, Cushman WC, Fine LJ, Goff DC Jr, Johnson KC, Killeen AA, Lewis CE, Oparil S, Reboussin DM, Rocco MV, Williamson JD, Wright JT Jr, Whelton PK. The design and rationale of a multicenter clinical trial comparing two strategies for control of systolic blood pressure: the Systolic Blood Pressure Intervention Trial (SPRINT). Clin Trials. 2014;11(5):532-546.

Pahor M, Guralnik JM, Ambrosius WT, Blair S, Bonds DE, Church TS, Espeland MA, Fielding RA, Gill TM, Groessl EJ, King AC, Kritchevsky SB, Manini TM, McDermott MM, Miller ME, Newman AB, Rejeski WJ, Sink KM, Williamson JD. Effect of structured physical activity on prevention of major mobility disability in older adults: the LIFE study randomized clinical trial. JAMA. 2014;311(23):2387-2396.

Casanova R, Saldana S, Chew EY, Danis RP, Greven CM, Ambrosius WT. Application of random forests methods to diabetic retinopathy classification analyses. PLoS One. 2014;9(6):e98587.

Hugenschmidt CE, Lovato JF, Ambrosius WT, Bryan RN, Gerstein HC, Horowitz KR, Launer LJ, Lazar RM, Murray AM, Chew EY, Danis RP, Williamson JD, Miller ME, Ding J. The cross-sectional and longitudinal associations of diabetic retinopathy with cognitive function and brain MRI findings: the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial. Diabetes Care. 2014;37(12):3244-3252.

Mottl AK, Pajewski N, Fonseca V, Ismail-Beigi F, Chew E, Ambrosius WT, Greven C, Schubart U, Buse J. The degree of retinopathy is equally predictive for renal and macrovascular outcomes in the ACCORD trial. J Diabetes Complications. 2014;28(6):874-879.

Schwartz AV, Vittinghoff E, Margolis KL, Scibora LM, Palermo L, Ambrosius WT, Hue TF, Ensrud KE. Intensive glycemic control and thiazolidinedione use: effects on cortical and trabecular bone at the radius and tibia. Calcif Tissue Int. 2013;92(5):477-486.

Beavers KM, Ambrosius WT, Nicklas BJ, Rejeski WJ. Independent and combined effects of physical activity and weight loss on inflammatory biomarkers in overweight and obese older adults. J Am Geriatr Soc. 2013;61(7):1089-1094.

Gerstein HC, Ambrosius WT, Danis R, Ismail-Beigi F, Cushman W, Calles J, Banerji M, Schubart U, Chew EY. Diabetic retinopathy, its progression, and incident cardiovascular events in the ACCORD trial. Diabetes Care. 2013;36(5):1266-1271.

Gangaputra S, Lovato JF, Hubbard L, Davis MD, Esser BA, Ambrosius WT, Chew EY, Greven C, Perdue LH, Wong WT, Condren A, Wilkinson CP, Agron E, Adler S, Danis RP. Comparison of standardized clinical classification with fundus photograph grading for the assessment of diabetic retinopathy and diabetic macular edema severity. Retina. 2013;33(7):1393-1399.

Marsh AP, Janssen JA, Ambrosius WT, Burdette JH, Gaukstern JE, Morgan AR, Nesbit BA, Paolini JB, Sheedy JL, Rejeski WJ. The Cooperative Lifestyle Intervention Program-II (CLIP-II): design and methods. Contemp Clin Trials. 2013;36(2):382-393.

Samaropoulos XF, Light L, Ambrosius WT, Marcovina SM, Probstfield J, Goff DC Jr. The effect of intensive risk factor management in type 2 diabetes on inflammatory biomarkers. Diabetes Res Clin Pract. 2012;95(3):389-398.

Ambrosius WT, Polonsky TS, Greenland P, Goff DC Jr, Perdue LH, Fortmann SP, Margolis KL, Pajewski NM. Design of the value of imaging in enhancing the wellness of your heart (VIEW) trial and the impact of uncertainty on power. Clin Trials. 2012;9(2):232-246.

Ding J, Lovato J, Hugenschmidt CE, Ambrosius W, Horowitz K, Bryan RN, Greven C, Gerstein HC, Lazer R, Murray A, Thomas A, Launer L, Williamson J. Retinopathy in relation to cerebral ischemic lesion and cognitive decline in older patients with type 2 diabetes [abstract]. Diabetes. 2012;61(Suppl 1A):LB2.

Schwartz AV, Margolis KL, Sellmeyer DE, Vittinghoff E, Ambrosius WT, Bonds DE, Josse RG, Schnall AM, Simmons DL, Hue TF, Palermo L, Hamilton BP, Green JB, Atkinson HH, O'Connor PJ, Force RW, Bauer DC. Intensive glycemic control is not associated with fractures or falls in the ACCORD randomized trial. Diabetes Care. 2012;35(7):1525-1531.

Beavers KM, Ambrosius WT, Nicklas BJ, Rejeski WJ. The effects of a long-term physical activity and weight loss intervention on inflammatory biomarkers in older adults [abstract]. J Aging Phys Act. 2012;20(Suppl):S317.

Brawley L, Rejeski WJ, Gaukstern JE, Ambrosius WT. Social cognitive changes following weight loss and physical activity interventions in obese, older adults in poor cardiovascular health. Ann Behav Med. 2012;44(3):353-364.

Botoseneanu A, Ambrosius WT, de Rekeneire N, Goodpaster B, Nicklas B, Church T, Gill TM. Prevalence of metabolic syndrome and its association with physical performance, disability and subjective well-being among Lifestyle Interventions and Independence for Elders (LIFE) Study participants [abstract]. Gerontologist. 2012;52(Suppl 1):206.

Chew EY, Ambrosius WT. Update of the ACCORD Eye study [letter]. N Engl J Med. 2011;364(2):188-189.

Rejeski WJ, Brubaker PH, Goff DC Jr, Bearon LB, McClelland JW, Perri MG, Ambrosius WT. Translating weight loss and physical activity programs into the community to preserve mobility in older, obese adults in poor cardiovascular health. Arch Intern Med. 2011;171(10):880-886.

Ambrosius WT, Danis RP, Goff DC Jr, Greven CM, Gerstein HC, Cohen RM, Riddle MC, Miller ME, Buse JB, Perdue LH, et al. Lack of association between thiazolidinediones and macular edema in type 2 diabetes: the ACCORD eye substudy. Arch Ophthalmol. 2010;128(3):312-318.

Riddle MC, Ambrosius WT, Brillon DJ, Buse JB, Byington RP, Cohen RM, Goff DC Jr, Malozowski S, Margolis KL, Probstfield JL, et al. Epidemiologic relationships between A1C and all-cause mortality during a median 3.4-year follow-up of glycemic treatment in the ACCORD trial. Diabetes Care. 2010;33(5):983-990.

Ambrosius WT, Mahnken JD. Power for studies with random group sizes. Stat Med. 2010;29(10):1137-1144.

Rejeski WJ, Mihalko SL, Ambrosius WT, Bearon LB, Gaukstern JE, McClelland JW, Perri MG. Weight loss and self-regulatory eating efficacy in older adults: the Cooperative Lifestyle Intervention Program [abstract]. Ann Behav Med. 2010;39(Suppl 1):199.

Chew EY, Ambrosius WT, Davis MD, Danis RP, Gangaputra S, Greven CM, Hubbard L, Lovato JF, Perdue LH, Goff DC Jr, et al. Effects of medical therapies on retinopathy progression in type 2 diabetes. N Engl J Med. 2010;363(3):233-244.

Ambrosius WT, Danis RP, Riddle MC, Goff DC Jr, Gerstein HC, Greven CM, Chew EY. Macular edema and thiazolidinediones [reply to letter]. Arch Ophthalmol. 2010;128(12):1631-1632.

Chew EY, Ambrosius WT, Danis RP. Retinopathy progression in type 2 diabetes [reply to letter]. N Engl J Med. 2010;363(22):2173-2174.

Wideman L, Baker CF, Brown PK, Consitt LA, Ambrosius WT, Schechter MS. Substrate utilization during and after exercise in mild cystic fibrosis. Med Sci Sports Exerc. 2009;41(2):270-278.

Irwin RW, Watson T, Minick RP, Ambrosius WT. Age, body mass index, and gender differences in sacroiliac joint pathology. Am J Phys Med Rehabil. 2007;86(1):37-44.

Miller DP, Furberg CD, Small RH, Millman FM, Ambrosius WT, Harshbarger JS, Ohl CA. Controlling prescription drug expenditures: a report of success. Am J Manag Care. 2007;13(8):473-480.

Case LD, Ambrosius WT. Power and sample size. Methods Mol Biol. 2007;404():377-408.

Miller DP, Furberg CD, Small RH, Millman FM, Ambrosius WT, Harshbarger JS, Ohl CA. Controlling prescription drug expenditures: a case report of success [abstract]. J Gen Intern Med. 2007;22(Suppl 1):64.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Walter T. Ambrosius, Ph.D.

Walter T. Ambrosius, Ph.D.

Professor, Biostatistical Sciences
Director, Design and Analysis Unit
Professor, Biostatistical Sciences
Translational Science Institute

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