Walter T. Ambrosius, Ph.D.Wake Forest School of Medicine

Walter T. Ambrosius, Ph.D.

Director, Design and Analysis Unit

Contact Information

Academic: 336-716-6281 | Department: 336-716-2011


Education & Training

  • A.B., Washington University, 1991
  • A.M., Washington University, 1991
  • Ph.D., University of Chicago, 1995


  • Am Statistical Assoc
  • Assn of GCRC Statisticians
  • Biometric Society
  • Institute Of Mathematical Stat
Walter T. Ambrosius, Ph.D.

Walter T. Ambrosius, Ph.D.

Professor, Biostatistical Sciences
Director, Design and Analysis Unit
Professor, Biostatistical Sciences
Translational Science Institute

Research Interests

Diabetic Retinopathy; Weight Loss; Obesity; Cardiovascular Diseases; Sample Size
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Contact Information

Academic: 336-716-6281 | Department: 336-716-2011


Recent Publications

Cardiovascular events in a physical activity intervention compared with a successful aging intervention: the LIFE study randomized trial. Newman AB, Dodson JA, Church TS, Buford TW, Fielding RA, Kritchevsky S, Beavers D, Pahor M, Stafford RS, Szady AD, Ambrosius WT, McDermott MM.. JAMA Cardiol. 2016;1(5):568-574.

Association of objectively measured physical activity with cardiovascular risk in mobility-limited older adults. Fitzgerald JD, Johnson L, Hire DG, Ambrosius WT, Anton SD, Dodson JA, Marsh AP, McDermott MM, Nocera JR, Tudor-Locke C, White DK, Yank V, Pahor M, Manini TM, Buford TW.. J Am Heart Assoc. 2015;4(2):e001288.

Systolic blood pressure control among individuals with type 2 diabetes: a comparative effectiveness analysis of three interventions. Espeland MA, Probstfield J, Hire D, Redmon JB, Evans GW, Coday M, Lewis CE, Johnson KC, Wilmoth S, Bahnson J, Dulin MF, Green JB, Knowler WC, Kitabchi A, Murillo AL, Osei K, Rehman SU, Cushman WC, Ambrosius WT, Greven CM, Lovato JF, Perdue LH, et al.. Am J Hypertens. 2015;28(8):995-1009.

Prevalence of metabolic syndrome and its association with physical capacity, disability, and self-rated health in Lifestyle Interventions and Independence for Elders Study participants. Botoseneanu A, Ambrosius WT, Beavers DP, de Rekeneire N, Anton S, Church T, Folta SC, Goodpaster BH, King AC, Nicklas BJ, Spring B, Wang X, Gill TM.. J Am Geriatr Soc. 2015;63(2):222-232.

Assessing walking activity in older adults: development and validation of a novel computer-animated assessment tool. Marsh AP, Janssen JA, Ip EH, Barnard RT, Ambrosius WT, Brubaker PR, Burdette JH, Sheedy JL, Rejeski WJ.. J Gerontol A Biol Sci Med Sci. 2015;70(12):1555-1561.

Effects of TZD use and discontinuation on fracture rates in ACCORD bone study. Schwartz AV, Chen H, Ambrosius WT, Sood A, Josse RG, Bonds DE, Schnall AM, Vittinghoff E, Bauer DC, Banerji MA, Cohen RM, Hamilton BP, Isakova T, Sellmeyer DE, Simmons DL, Shibli-Rahhal A, Williamson JD, Margolis KL.. J Clin Endocrinol Metab. 2015;100(11):4059-4066.

Insulin dose and cardiovascular mortality in the ACCORD trial. Siraj ES, Rubin DJ, Riddle MC, Miller ME, Hsu FC, Ismail-Beigi F, Chen SH, Ambrosius WT, Thomas A, Bestermann W, Buse JB, Genuth S, Joyce C, Kovacs CS, O'Connor PJ, Sigal RJ, Solomon S.. Diabetes Care. 2015;38(11):2000-2008.

A randomized trial of intensive versus standard blood-pressure control. Wright JT Jr, Williamson JD, Whelton PK, Snyder JK, Sink KM, Rocco MV, Reboussin DM, Rahman M, Oparil S, Lewis CE, Kimmel PL, Johnson KC, Goff DC Jr, Fine LJ, Cutler JA, Cushman WC, Cheung AK, Ambrosius WT, Kitzman DW, et al.. N Engl J Med. 2015;373(22):2103-2116.

Fish oil supplementation is associated with improved physical function and reduced mobility disability [abstract]. Gundermann DM, Hire DG, Ambrosius WT, Kritchevsky SB, Pahor M, Axtell RS, Newman AB, Manini TM.. Gerontologist. 2015;55(Suppl 2):698.

Effects of randomization to intensive glucose control on adverse events, cardiovascular disease, and mortality in older versus younger adults in the ACCORD trial. Miller ME, Williamson JD, Gerstein HC, Byington RP, Cushman WC, Ginsberg HN, Ambrosius WT, Lovato L, Applegate WB.. Diabetes Care. 2014;37(3):634-643.

Characteristics associated with informed consent for genetic studies in the ACCORD trial. Simons-Morton DG, Chan JC, Kimel AR, Linz PE, Stowe CL, Summerson J, Ambrosius WT.. Contemp Clin Trials. 2014;37(1):155-164.

The design and rationale of a multicenter clinical trial comparing two strategies for control of systolic blood pressure: the Systolic Blood Pressure Intervention Trial (SPRINT). Ambrosius WT, Sink KM, Foy CG, Berlowitz DR, Cheung AK, Cushman WC, Fine LJ, Goff DC Jr, Johnson KC, Killeen AA, Lewis CE, Oparil S, Reboussin DM, Rocco MV, Williamson JD, Wright JT Jr, Whelton PK.. Clin Trials. 2014;11(5):532-546.

Effect of structured physical activity on prevention of major mobility disability in older adults: the LIFE study randomized clinical trial. Pahor M, Guralnik JM, Ambrosius WT, Blair S, Bonds DE, Church TS, Espeland MA, Fielding RA, Gill TM, Groessl EJ, King AC, Kritchevsky SB, Manini TM, McDermott MM, Miller ME, Newman AB, Rejeski WJ, Sink KM, Williamson JD.. JAMA. 2014;311(23):2387-2396.

Application of random forests methods to diabetic retinopathy classification analyses. Casanova R, Saldana S, Chew EY, Danis RP, Greven CM, Ambrosius WT.. PLoS One. 2014;9(6):e98587.

The cross-sectional and longitudinal associations of diabetic retinopathy with cognitive function and brain MRI findings: the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial. Hugenschmidt CE, Lovato JF, Ambrosius WT, Bryan RN, Gerstein HC, Horowitz KR, Launer LJ, Lazar RM, Murray AM, Chew EY, Danis RP, Williamson JD, Miller ME, Ding J.. Diabetes Care. 2014;37(12):3244-3252.

The degree of retinopathy is equally predictive for renal and macrovascular outcomes in the ACCORD trial. Mottl AK, Pajewski N, Fonseca V, Ismail-Beigi F, Chew E, Ambrosius WT, Greven C, Schubart U, Buse J.. J Diabetes Complications. 2014;28(6):874-879.

Intensive glycemic control and thiazolidinedione use: effects on cortical and trabecular bone at the radius and tibia. Schwartz AV, Vittinghoff E, Margolis KL, Scibora LM, Palermo L, Ambrosius WT, Hue TF, Ensrud KE.. Calcif Tissue Int. 2013;92(5):477-486.

Independent and combined effects of physical activity and weight loss on inflammatory biomarkers in overweight and obese older adults. Beavers KM, Ambrosius WT, Nicklas BJ, Rejeski WJ.. J Am Geriatr Soc. 2013;61(7):1089-1094.

Diabetic retinopathy, its progression, and incident cardiovascular events in the ACCORD trial. Gerstein HC, Ambrosius WT, Danis R, Ismail-Beigi F, Cushman W, Calles J, Banerji M, Schubart U, Chew EY.. Diabetes Care. 2013;36(5):1266-1271.

Comparison of standardized clinical classification with fundus photograph grading for the assessment of diabetic retinopathy and diabetic macular edema severity. Gangaputra S, Lovato JF, Hubbard L, Davis MD, Esser BA, Ambrosius WT, Chew EY, Greven C, Perdue LH, Wong WT, Condren A, Wilkinson CP, Agron E, Adler S, Danis RP.. Retina. 2013;33(7):1393-1399.

The Cooperative Lifestyle Intervention Program-II (CLIP-II): design and methods. Marsh AP, Janssen JA, Ambrosius WT, Burdette JH, Gaukstern JE, Morgan AR, Nesbit BA, Paolini JB, Sheedy JL, Rejeski WJ.. Contemp Clin Trials. 2013;36(2):382-393.

The effect of intensive risk factor management in type 2 diabetes on inflammatory biomarkers. Samaropoulos XF, Light L, Ambrosius WT, Marcovina SM, Probstfield J, Goff DC Jr.. Diabetes Res Clin Pract. 2012;95(3):389-398.

Design of the value of imaging in enhancing the wellness of your heart (VIEW) trial and the impact of uncertainty on power. Ambrosius WT, Polonsky TS, Greenland P, Goff DC Jr, Perdue LH, Fortmann SP, Margolis KL, Pajewski NM.. Clin Trials. 2012;9(2):232-246.

Retinopathy in relation to cerebral ischemic lesion and cognitive decline in older patients with type 2 diabetes [abstract]. Ding J, Lovato J, Hugenschmidt CE, Ambrosius W, Horowitz K, Bryan RN, Greven C, Gerstein HC, Lazer R, Murray A, Thomas A, Launer L, Williamson J.. Diabetes. 2012;61(Suppl 1A):LB2.

Intensive glycemic control is not associated with fractures or falls in the ACCORD randomized trial. Schwartz AV, Margolis KL, Sellmeyer DE, Vittinghoff E, Ambrosius WT, Bonds DE, Josse RG, Schnall AM, Simmons DL, Hue TF, Palermo L, Hamilton BP, Green JB, Atkinson HH, O'Connor PJ, Force RW, Bauer DC.. Diabetes Care. 2012;35(7):1525-1531.

The effects of a long-term physical activity and weight loss intervention on inflammatory biomarkers in older adults [abstract]. Beavers KM, Ambrosius WT, Nicklas BJ, Rejeski WJ.. J Aging Phys Act. 2012;20(Suppl):S317.

Social cognitive changes following weight loss and physical activity interventions in obese, older adults in poor cardiovascular health. Brawley L, Rejeski WJ, Gaukstern JE, Ambrosius WT.. Ann Behav Med. 2012;44(3):353-364.

Prevalence of metabolic syndrome and its association with physical performance, disability and subjective well-being among Lifestyle Interventions and Independence for Elders (LIFE) Study participants [abstract]. Botoseneanu A, Ambrosius WT, de Rekeneire N, Goodpaster B, Nicklas B, Church T, Gill TM.. Gerontologist. 2012;52(Suppl 1):206.

Update of the ACCORD Eye study [letter]. Chew EY, Ambrosius WT.. N Engl J Med. 2011;364(2):188-189.

Translating weight loss and physical activity programs into the community to preserve mobility in older, obese adults in poor cardiovascular health. Rejeski WJ, Brubaker PH, Goff DC Jr, Bearon LB, McClelland JW, Perri MG, Ambrosius WT.. Arch Intern Med. 2011;171(10):880-886.

Lack of association between thiazolidinediones and macular edema in type 2 diabetes: the ACCORD eye substudy. Ambrosius WT, Danis RP, Goff DC Jr, Greven CM, Gerstein HC, Cohen RM, Riddle MC, Miller ME, Buse JB, Perdue LH, et al.. Arch Ophthalmol. 2010;128(3):312-318.

Epidemiologic relationships between A1C and all-cause mortality during a median 3.4-year follow-up of glycemic treatment in the ACCORD trial. Riddle MC, Ambrosius WT, Brillon DJ, Buse JB, Byington RP, Cohen RM, Goff DC Jr, Malozowski S, Margolis KL, Probstfield JL, et al.. Diabetes Care. 2010;33(5):983-990.

Power for studies with random group sizes. Ambrosius WT, Mahnken JD.. Stat Med. 2010;29(10):1137-1144.

Weight loss and self-regulatory eating efficacy in older adults: the Cooperative Lifestyle Intervention Program [abstract]. Rejeski WJ, Mihalko SL, Ambrosius WT, Bearon LB, Gaukstern JE, McClelland JW, Perri MG.. Ann Behav Med. 2010;39(Suppl 1):199.

Effects of medical therapies on retinopathy progression in type 2 diabetes. Chew EY, Ambrosius WT, Davis MD, Danis RP, Gangaputra S, Greven CM, Hubbard L, Lovato JF, Perdue LH, Goff DC Jr, et al.. N Engl J Med. 2010;363(3):233-244.

Macular edema and thiazolidinediones [reply to letter]. Ambrosius WT, Danis RP, Riddle MC, Goff DC Jr, Gerstein HC, Greven CM, Chew EY.. Arch Ophthalmol. 2010;128(12):1631-1632.

Retinopathy progression in type 2 diabetes [reply to letter]. Chew EY, Ambrosius WT, Danis RP.. N Engl J Med. 2010;363(22):2173-2174.

Substrate utilization during and after exercise in mild cystic fibrosis. Wideman L, Baker CF, Brown PK, Consitt LA, Ambrosius WT, Schechter MS.. Med Sci Sports Exerc. 2009;41(2):270-278.

Age, body mass index, and gender differences in sacroiliac joint pathology. Irwin RW, Watson T, Minick RP, Ambrosius WT.. Am J Phys Med Rehabil. 2007;86(1):37-44.

Controlling prescription drug expenditures: a report of success. Miller DP, Furberg CD, Small RH, Millman FM, Ambrosius WT, Harshbarger JS, Ohl CA.. Am J Manag Care. 2007;13(8):473-480.

Power and sample size. Case LD, Ambrosius WT.. Methods Mol Biol. 2007;404():377-408.

Controlling prescription drug expenditures: a case report of success [abstract]. Miller DP, Furberg CD, Small RH, Millman FM, Ambrosius WT, Harshbarger JS, Ohl CA.. J Gen Intern Med. 2007;22(Suppl 1):64.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Walter T. Ambrosius, Ph.D.

Walter T. Ambrosius, Ph.D.

Professor, Biostatistical Sciences
Director, Design and Analysis Unit
Professor, Biostatistical Sciences
Translational Science Institute

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