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William B. Applegate, MD, MPH, MACPWake Forest Baptist Health

Doctor Rating

4.8 out of 5

48 Ratings

William B. Applegate, MD, MPH, MACP


Clinical Interests

Geriatrics, Hypertension

Contact Information

Returning Patient Appointments: 336-713-8250
Department: 336-713-8570


Insurance Accepted »

Education & Training

  • B.A., University of Louisville, 1968
  • M.D., University of Louisville, 1972
  • M.P.H., Harvard School of Public Health, 1973
  • Internship, Internal Medicine, Boston Med Ctr, 1974
  • Residency, Internal Medicine, Boston Med Ctr, 1975
  • Residency, Internal Medicine, North Carolina Mem Hosp, 1976

Board Certifications

  • American Board of Internal Medicine, Internal Medicine

NPI Number

  • 1730163197
William B. Applegate, MD, MPH, MACP

Doctor Rating

4.8 out of 5

48 Ratings

William B. Applegate, MD, MPH, MACP

Professor, Gerontology and Geriatric Medicine

Research Interests

Hypertension; Antihypertensive Agents; Blood Pressure; Geriatrics; Diuretics
More »

Contact Information

Academic: 336-713-8548 | Department: 336-713-8570


Recent Publications

Effects of high density lipoprotein raising therapies on cardiovascular outcomes in patients with type 2 diabetes mellitus, with or without renal impairment: the Action to Control Cardiovascular Risk in Diabetes study. Papademetriou V, Lovato L, Tsioufis C, Cushman W, Applegate WB, Mottle A, Punthakee Z, Nylen E, Doumas M.. Am J Nephrol. 2017;45(2):136-145.

Across the pond [editorial]. Applegate WB.. J Am Geriatr Soc. 2017;65(5):901-902.

Social participation modifies the effect of a structured physical activity program on major mobility disability among older adults: results from the LIFE study. Corbett DB, Rejeski WJ, Tudor-Locke C, Glynn NW, Kritchevsky SB, McDermott MM, Church TS, Fielding RA, Gill TM, King AC, Miller ME, Chen H, Pahor M, Manini TM, Pahor M, Guralnik JM, Leeuwenburgh C, Caudle C, Crump L, Holmes L, Lee J,.. J Gerontol B Psychol Sci Soc Sci. 2017;():.

Pharmacologic treatment of hypertension in adults aged 60 years or older [letter]. Cushman WC, Johnson KC, Applegate WB, Cutler JA.. Ann Intern Med. 2017;167(4):290-291.

Effect of intensive blood-pressure treatment on patient-reported outcomes. Berlowitz DR, Foy CG, Kazis LE, Bolin LP, Conroy MB, Fitzpatrick P, Gure TR, Kimmel PL, Kirchner K, Morisky DE, Newman J, Olney C, Oparil S, Pajewski NM, Powell J, Ramsey T, Simmons DL, Snyder J, Supiano MA, Weiner DE, Whittle J, Rocco M,.. N Engl J Med. 2017;377(8):733-744.

Reply to: language matters, so geriatricians should talk of declining health and death [letter]. Lundebjerg NE, Trucil DE, Applegate WB.. J Am Geriatr Soc. 2017;65(12):2743-2744.

Blood pressure trajectory, gait speed, and outcomes: the Health, Aging, and Body Composition study. Odden MC, Wu C, Shlipak MG, Psaty BM, Katz R, Applegate WB, Harris T, Newman AB, Peralta CA.. J Gerontol A Biol Sci Med Sci. 2016;71(12):1688-1694.

Intensive vs standard blood pressure control and cardiovascular disease outcomes in adults aged greater than or equal to 75 years: a randomized clinical trial. Williamson JD, Supiano MA, Applegate WB, Berlowitz DR, Campbell RC, Chertow GM, Fine LJ, Haley WE, Hawfield AT, Ix JH, Kitzman DW, Kostis JB, Krousel-Wood MA, Launer LJ, Oparil S, Rodriguez CJ, Roumie CL, Shorr RI, Sink KM, Wadley VG,.. JAMA. 2016;315(24):2673-2682.

Hospitalizations during a physical activity intervention in older adults at risk of mobility disability: analyses from the Lifestyle Interventions and Independence for Elders randomized clinical trial. Marsh AP, Applegate WB, Guralnik JM, Jack Rejeski W, Church TS, Fielding RA, Gill TM, King AC, Kritchevsky SB, Manini TM, McDermott MM, Newman AB, Stowe CL, Walkup MP, Pahor M, Miller ME.. J Am Geriatr Soc. 2016;64(5):933-943.

Journal of the American Geriatrics Society in transition: 15 years of innovation and excellence paves the way for a bright future [editorial]. Applegate WB, Ouslander JG.. J Am Geriatr Soc. 2016;64(7):1399.

Cardiovascular outcomes in action to control cardiovascular risk in diabetes: impact of blood pressure level and presence of kidney disease. Papademetriou V, Zaheer M, Doumas M, Lovato L, Applegate WB, Tsioufis C, Mottle A, Punthakee Z, Cushman WC.. Am J Nephrol. 2016;43(4):271-280.

JAGS evolves: creating a proactive forum [editorial]. Applegate WB.. J Am Geriatr Soc. 2016;64(9):1769.

Influence of studies published by the Journal of the American Geriatrics Society: top 20 articles from 2000-2015. Yoshikawa TT, Ouslander JG, Applegate WB.. J Am Geriatr Soc. 2016;64(9):1763-1768.

The evolving taxonomy of health in older persons. Applegate WB, Ip E.. JAMA. 2016;316(23):2487-2488.

Chronic kidney disease and intensive glycemic control increase cardiovascular risk in patients with type 2 diabetes. Papademetriou V, Lovato L, Doumas M, Nylen E, Mottl A, Cohen RM, Applegate WB, Puntakee Z, Yale JF, Cushman WC.. Kidney Int. 2015;87(3):649-659.

Dietary sodium content, mortality, and risk for cardiovascular events in older adults: the Health, Aging, and Body Composition (Health ABC) study. Kalogeropoulos AP, Georgiopoulou VV, Murphy RA, Newman AB, Bauer DC, Harris TB, Yang Z, Applegate WB, Kritchevsky SB.. JAMA Intern Med. 2015;175(3):410-419.

The electronic health record. Are we the tools of our tools?. Ober KP, Applegate WB.. Pharos Alpha Omega Alpha Honor Med Soc. 2015;78(1):8-14.

Managing high blood pressure in older persons with decline in function [editorial]. Applegate WB, Sink KM, Williamson JD.. Am J Kidney Dis. 2015;66(5):745-747.

Self-reported gastrointestinal symptoms in type 2 diabetes improve with an intensive lifestyle intervention: results from the Action for Health in Diabetes (Look AHEAD) clinical trial. Neiberg RH, Rejeski JJ, Applegate WB, Clark JM, Knowler WC, Bray GA, Espeland MA, Cheskin LJ.. Clin Diabetes. 2015;33(4):181-188.

Effects of randomization to intensive glucose control on adverse events, cardiovascular disease, and mortality in older versus younger adults in the ACCORD trial. Miller ME, Williamson JD, Gerstein HC, Byington RP, Cushman WC, Ginsberg HN, Ambrosius WT, Lovato L, Applegate WB.. Diabetes Care. 2014;37(3):634-643.

Association of electrocardiogram abnormalities and incident heart failure events. Gencer B, Butler J, Bauer DC, Auer R, Kalogeropoulos A, Marques-Vidal P, Applegate WB, Satterfield S, Harris T, Newman A, Vittinghoff E, Rodondi N.. Am Heart J. 2014;167(6):869-875.

The QT interval and risk of incident atrial fibrillation. Mandyam MC, Soliman EZ, Alonso A, Dewland TA, Heckbert SR, Vittinghoff E, Cummings SR, Ellinor PT, Chaitman BR, Stocke K, Applegate WB, Arking DE, Butler J, Loehr LR, Magnani JW, Murphy RA, Satterfield S, Newman AB, Marcus GM.. Heart Rhythm. 2013;10(10):1562-1568.

Study design of ASPirin in reducing events in the elderly (ASPREE): a randomized, controlled trial. Grimm RH, McNeil JJ, Applegate W, Beilin L, Espinoza S, Johnston CI, Kirpach B, Margolis K, Murray A, Nelson MR, Williamson J, et al.. Contemp Clin Trials. 2013;36(2):555-564.

Ankle brachial index values, leg symptoms, and functional performance among community-dwelling older men and women in the lifestyle interventions and independence for elders study. McDermott MM, Applegate WB, Bonds DE, Buford TW, Church T, Espeland MA, Gill TM, Guralnik JM, Haskell W, Lovato LC, Pahor M, Pepine CJ, Reid KF, Newman A.. J Am Heart Assoc. 2013;2(6):e000257.

Older adults receiving community-based services demonstrate high hospital utilization rates [abstract]. Callahan K, Gottlieb R, Applegate W, Atkinson H, Watkins F, Williamson J.. J Am Geriatr Soc. 2011;59(Suppl 1):S187-S188.

Early outcomes of a novel senior mentor program utilizing Meals on Wheels volunteers [abstract]. Demons JL, Sink KM, Applegate WB, Davis BR, Lambros MA, Lawlor JS, Williamson JD.. J Am Geriatr Soc. 2011;59(Suppl 1):S85.

Social support, social integration, and health-related quality of life over time: results from the Fitness and Arthritis in Seniors Trial (FAST). Sherman AM, Shumaker SA, Rejeski WJ, Morgan T, Applegate WB, Ettinger W.. Psychol Health. 2006;21(4):463-480.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Gerontology and Geriatric Medicine

Clinical Interests

Geriatrics, Hypertension
William B. Applegate, MD, MPH, MACP

William B. Applegate, MD, MPH, MACP

Professor, Gerontology and Geriatric Medicine

Doctor Rating

4.8 out of 5

William B. Applegate, MD, MPH, MACP48 Ratings


Doctor Ratings

The overall Patient Rating score is the average of responses to the nine questions listed below. The questions are from the Press Ganey Patient Satisfaction Survey. Responses are measured on a 1 to 5 scale, where 1 represents "very poor" and 5 represents "very good."
Press Ganey Patient Satisfaction Survey

CP concern for questions/worries
CP efforts to include in decisions
CP explanations of prob/condition
CP spoke using clear language
Friendliness/courtesy of CP
Likelihood of recommending CP
Patients' confidence in CP
Time CP spent with patient
Wait time at clinic

Patient Comments

Comments are taken from the Care Provider section of the Press Ganey Patient Satisfaction Survey. Comments are posted exactly as they are written. Comments are added weekly. To protect patient privacy and confidentiality, patient names are not included.


Excellent Dr. Always address all health issues and together decide on a plan to address them.


*Dr. Applegate is a very good doctor because he listens!


Me and my family greatly appreciate the excellent care that we receive from Dr. Applegate and his team.


Dr. Applegate is without a doubt one of the finest experiences (medically and personally) that i have had at Baptist Hospital. (My husband was seriously ill with multiple problems (organ removals, quadruple heart surgery, etc) over ten years. No experience (some exceedingly good, some not so good) has exceeded the unfailing quality of care given by Dr. Applegate. The institution should consider him a treasure!


*Dr. Applegate is a great asset to WFB & the patients, that visit the Geriatric Clinic. He brings many years of experience to the job - arm draws _____ that... to give his patients the best care possible. Wish more doctors were like that. We... but we deserve respect & The... we could get if we were 30.


*Dr. Applegate is an excellent doctor and I have total confidence in him taking care of my medical needs.


*Dr. Applegate is an excellent Doctor.


He's the best, I believe he's in charge - he runs a great office. Very professional. He DOESN'T TALK ABOUT SERVICE he DOES it!

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