William B. Applegate, MD, MPH, MACPWake Forest School of Medicine

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William B. Applegate, MD, MPH, MACP


Contact Information

New Patient Appointments: 336-716-WAKE
Returning Patient Appointments: 336-713-8250
Department: 336-713-8570


Insurance Accepted »

Education & Training

  • B.A., University of Louisville, 1968
  • M.D., University of Louisville, 1972
  • M.P.H., Harvard School of Public Health, 1973
  • Internship, Internal Medicine, Boston Med Ctr, 1974
  • Residency, Internal Medicine, Boston Med Ctr, 1975
  • Residency, Internal Medicine, North Carolina Mem Hosp, 1976

NPI Number

  • 1730163197
William B. Applegate, MD, MPH, MACP

Doctor Rating

No Rating Available
Why No Ratings?

William B. Applegate, MD, MPH, MACP

Professor, Gerontology and Geriatric Medicine
Sticht Center on Aging

Research Interests

aging, fitness/physical

Contact Information

Academic: 336-713-8548 | Department: 336-713-8570


Recent Publications

Papademetriou V, Lovato L, Doumas M, Nylen E, Mottl A, Cohen RM, Applegate WB, Puntakee Z, Yale JF, Cushman WC. Chronic kidney disease and intensive glycemic control increase cardiovascular risk in patients with type 2 diabetes. Kidney Int. 2015;87(3):649-659.

Kalogeropoulos AP, Georgiopoulou VV, Murphy RA, Newman AB, Bauer DC, Harris TB, Yang Z, Applegate WB, Kritchevsky SB. Dietary sodium content, mortality, and risk for cardiovascular events in older adults: the Health, Aging, and Body Composition (Health ABC) study. JAMA Intern Med. 2015;175(3):410-419.

Ober KP, Applegate WB. The electronic health record. Are we the tools of our tools?. Pharos Alpha Omega Alpha Honor Med Soc. 2015;78(1):8-14.

Applegate WB, Sink KM, Williamson JD. Managing high blood pressure in older persons with decline in function [editorial]. Am J Kidney Dis. 2015;():.

Miller ME, Williamson JD, Gerstein HC, Byington RP, Cushman WC, Ginsberg HN, Ambrosius WT, Lovato L, Applegate WB. Effects of randomization to intensive glucose control on adverse events, cardiovascular disease, and mortality in older versus younger adults in the ACCORD trial. Diabetes Care. 2014;37(3):634-643.

Gencer B, Butler J, Bauer DC, Auer R, Kalogeropoulos A, Marques-Vidal P, Applegate WB, Satterfield S, Harris T, Newman A, Vittinghoff E, Rodondi N. Association of electrocardiogram abnormalities and incident heart failure events. Am Heart J. 2014;167(6):869-875.

Mandyam MC, Soliman EZ, Alonso A, Dewland TA, Heckbert SR, Vittinghoff E, Cummings SR, Ellinor PT, Chaitman BR, Stocke K, Applegate WB, Arking DE, Butler J, Loehr LR, Magnani JW, Murphy RA, Satterfield S, Newman AB, Marcus GM. The QT interval and risk of incident atrial fibrillation. Heart Rhythm. 2013;10(10):1562-1568.

Grimm RH, McNeil JJ, Applegate W, Beilin L, Espinoza S, Johnston CI, Kirpach B, Margolis K, Murray A, Nelson MR, Williamson J, et al. Study design of ASPirin in reducing events in the elderly (ASPREE): a randomized, controlled trial. Contemp Clin Trials. 2013;36(2):555-564.

McDermott MM, Applegate WB, Bonds DE, Buford TW, Church T, Espeland MA, Gill TM, Guralnik JM, Haskell W, Lovato LC, Pahor M, Pepine CJ, Reid KF, Newman A. Ankle brachial index values, leg symptoms, and functional performance among community-dwelling older men and women in the lifestyle interventions and independence for elders study. J Am Heart Assoc. 2013;2(6):e000257.

Callahan K, Gottlieb R, Applegate W, Atkinson H, Watkins F, Williamson J. Older adults receiving community-based services demonstrate high hospital utilization rates [abstract]. J Am Geriatr Soc. 2011;59(Suppl 1):S187-S188.

Demons JL, Sink KM, Applegate WB, Davis BR, Lambros MA, Lawlor JS, Williamson JD. Early outcomes of a novel senior mentor program utilizing Meals on Wheels volunteers [abstract]. J Am Geriatr Soc. 2011;59(Suppl 1):S85.

Sherman AM, Shumaker SA, Rejeski WJ, Morgan T, Applegate WB, Ettinger W. Social support, social integration, and health-related quality of life over time: results from the Fitness and Arthritis in Seniors Trial (FAST). Psychol Health. 2006;21(4):463-480.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

William B. Applegate, MD, MPH, MACP

William B. Applegate, MD, MPH, MACP

Professor, Gerontology and Geriatric Medicine
Sticht Center on Aging

CP concern for questions/worries
CP efforts to include in decisions
CP explanations of prob/condition
CP spoke using clear language
Friendliness/courtesy of CP
Likelihood of recommending CP
Patients' confidence in CP
Time CP spent with patient
Wait time at clinic

Patient Comments

Comments are taken from the Care Provider section of the Press Ganey Patient Satisfaction Survey. Comments are posted exactly as they are written. Comments are added weekly. To protect patient privacy and confidentiality, patient names are not included.


*Dr. Applegate is an excellent physician. He always listens to my concerns & gives me advice on what I can do. We talk about existing conditions and any changes in meds if needed.


Excellent care.


Already have. He is very professional. You can tell when you first meet a doctor if he is good or not. *Dr. Bill Applegate is excellent.


My son accompanied me for this visit and was astounded to meet such an awesome, caring "country doctor".


Definitely enjoyed the relationship we has as patient and Doctor.


Excellent dr.


*Dr. Applegate is an excellent doctor. He takes his time, explains things and discusses medication options. #9. Excellent.


Perfect mix of professional, pleasant & polite! Very respectful.

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