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Susan E. Appt, D.V.M.Wake Forest School of Medicine

Susan E. Appt, D.V.M.

Associate Professor,

Contact Information

Academic: 336-716-1637 | Department: 336-716-1637

Email: sappt@wakehealth.edu

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Education & Training

  • B.Sc., Nova Scotia Agriculture College, 1990
  • D.V.M., Atlantic Veterinary College at University of PEI, 1994
  • Fellowship, Comparative Medicine, WFU School of Medicine, 2004

Memberships

  • North Am Menopause Soc
  • Am Veterinary Medical Assn
Susan E. Appt, D.V.M.

Susan E. Appt, D.V.M.

Associate Professor, Pathology-Comparative Medicine
Office of Women in Medicine and Science

Research Interests

Macaca fascicularis; Postmenopause; Ovarian Follicle; Estrogens, Conjugated (USP); Coronary Artery Disease
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Contact Information

Academic: 336-716-1637 | Department: 336-716-1637

Email: sappt@wakehealth.edu

Related Links

Recent Publications

Atherosclerosis and vascular biologic responses to estrogens: histologic, immunohistochemical, biochemical, and molecular methods. Register TC, Appt SE, Clarkson TB [deceased].. Methods Mol Biol. 2016;1366():517-532.

Sertraline inhibits increases in body fat and carbohydrate dysregulation in adult female cynomolgus monkeys. Silverstein-Metzler MG, Shively CA, Clarkson TB [deceased], Appt SE, Carr JJ, Kritchevsky SB, Jones SR, Register TC.. Psychoneuroendocrinology. 2016;68():29-38.

Corpus luteum as a novel target of weight changes that contribute to impaired female reproductive physiology and function. Kuokkanen S, Polotsky AJ, Chosich J, Bradford AP, Jasinska A, Phang T, Santoro N, Appt SE.. Syst Biol Reprod Med. 2016;62(4):227-242.

Decidualization of endometriosis in macaques. Atkins HM, Lombardini ED, Caudell DL, Appt SE, Dubois A, Cline JM.. Vet Pathol. 2016;():.

Beneficial effects of soy supplementation on postmenopausal atherosclerosis are dependent on pretreatment stage of plaque progression. Melendez GC, Register TC, Appt SE, Clarkson TB, Franke AA, Kaplan JR.. Menopause. 2015;22(3):289-296.

Vitamin D deficiency and cardiovascular disease in postmenopausal women: contributions from human and nonhuman primate studies. Schnatz PF, Nudy M, Jiang X, Demko JE, Appt SE.. Menopause. 2015;22(5):554-563.

Effects of long-term sertraline treatment and depression on coronary artery atherosclerosis in premenopausal female primates. Shively CA, Register TC, Appt SE, Clarkson TB.. Psychosom Med. 2015;77(3):267-278.

Joint MiRNA/mRNA expression profiling reveals changes consistent with development of dysfunctional corpus luteum after weight gain. Bradford AP, Jones K, Kechris K, Chosich J, Montague M, Warren WC, May MC, Al-Safi Z, Kuokkanen S, Appt SE, Polotsky AJ.. PLoS One. 2015;10(8):e0135163.

Myometrial artery calcification: significance for perimenopausal and postmenopausal women [editorial]. Susan E [sic] [Appt SE].. Menopause. 2015;22(12):1271-1272.

The association between common iliac artery vitamin D receptor expression and atherosclerosis in postmenopausal nonhuman primates [abstract]. Nudy MS, Jiang XZ, Appt SE, O'Sullivan DM, Kaplan JR, Schnatz PF.. Menopause. 2015;22(12):1392.

Common iliac artery vitamin D receptor expression patterns during the development of atherosclerosis in postmenopausal nonhuman primates [abstract]. Jiang XZ, Nudy MS, Appt SE, O'Sullivan DM, Kaplan JR, Schnatz PF.. Menopause. 2015;22(12):1392.

Effects of estradiol on transcriptional profiles in atherosclerotic iliac arteries in ovariectomized cynomolgus macaques. Eyster KM, Appt S, Chalpe A, Mark-Kappeler CJ, Register TC, Clarkson TB.. Menopause. 2014;21(2):143-152.

Characterization of ovarian aging and reproductive senescence in vervet monkeys (Chlorocebus aethiops sabaeus). Atkins HM, Willson CJ, Silverstein M, Jorgensen M, Floyd E, Kaplan JR, Appt SE.. Comp Med. 2014;64(1):55-62.

Effects of equol on gene expression in female cynomolgus monkey iliac arteries. Eyster K, Appt S, Chalpe A, Register T, Clarkson T.. Nutr Metab Cardiovasc Dis. 2014;24(4):423-427.

Effect of soy isoflavones on thyroid hormones in intact and ovariectomized cynomolgus monkeys (Macaca fascicularis). Silverstein MG, Kaplan JR, Appt SE, Register TC, Shively CA.. Menopause. 2014;21(10):1136-1142.

Identification of corpus luteum MicroRNAs regulated by weight gain in the vervet monkey [abstract]. Bradford A, Jones K, Chosich J, May M, Kechris K, Appt S, Polosky A.. Reprod Sci. 2014;21(3 Suppl):114A.

Effects of bazedoxifene, conjugated equine estrogens, and a tissue-selective estrogen complex containing both bazedoxifene and conjugated equine estrogens on cerebral artery atherosclerosis in postmenopausal monkeys. Clarkson TB, Ethun KF, Pajewski NM, Golden D, Floyd E, Appt SE.. Menopause. 2014;21(1):8-14.

Ovarian metabolomic profiles differ between monkeys consuming prudent and Western diets [abstract]. Appt SE, Dhungana S, McRitchie S, Sumner S.. Menopause. 2014;21(12):1334-1335.

Identification of antimullerian hormone protein expression in the arterial wall of premenopausal and postmenopausal monkeys [abstract]. Wellons M, Owens P, Caudell D, Appt SE.. Menopause. 2014;21(12):1334.

Dietary modification of physiological stress responses [abstract]. Shively CA, Register TC, Vitolins MZ, Wilson ME, Appt SE.. Am J Primatol. 2014;76(Suppl 1):71.

Effects of selective serotonin reuptake inhibitors and social stress on body composition and carbohydrate metabolism in female cynomolgus macaques (macaca fascicularis) [abstract]. Silverstein MG, Register TC, Appt SE, Shively CA.. Am J Primatol. 2014;76(Suppl 1):70.

Effects of bazedoxifene alone and with conjugated equine estrogens on coronary and peripheral artery atherosclerosis in postmenopausal monkeys. Clarkson TB, Ethun KF, Chen H, Golden D, Floyd E, Appt SE.. Menopause. 2013;20(3):274-281.

Timing hypothesis for postmenopausal hormone therapy: its origin, current status, and future. Clarkson TB, Melendez GC, Appt SE.. Menopause. 2013;20(3):342-353.

Assessment of luteal function in the vervet monkey as a means to develop a model for obesity-related reproductive phenotype. Kundu MC, May MC, Chosich J, Bradford AP, Lasley B, Gee N, Santoro N, Appt SE, Polotsky AJ.. Syst Biol Reprod Med. 2013;59(2):74-81.

Differential effects of estradiol on carotid artery inflammation when administered early versus late after surgical menopause. Sophonsritsuk A, Appt SE, Clarkson TB, Shively CA, Espeland MA, Register TC.. Menopause. 2013;20(5):540-547.

Endometrial profile of bazedoxifene acetate alone and in combination with conjugated equine estrogens in a primate model. Ethun KF, Wood CE, Cline JM, Register TC, Appt SE, Clarkson TB.. Menopause. 2013;20(7):777-784.

Premenopausal antimullerian hormone is a risk marker for postmenopausal coronary artery atherosclerosis progression in cynomolgus monkeys [abstract]. Appt SE, Kaplan JR, Clarkson TB.. Menopause. 2013;20(12):1324.

Weight fluctuations induce opposing changes in luteal molecular signals in vervet monkeys [abstract]. Kuokkanen S, Polotsky AJ, Chosich J, Bradford A, Jasinska A, Phang T, Santoro N, Appt S.. Reprod Sci. 2013;20(3 Suppl):252A.

Assessing the pulsatility of luteinizing hormone in female vervet monkeys (Chlorocebus aethiops sabaeus). Stephens SM, Pau FK, Yalcinkaya TM, May MC, Berga SL, Post MD, Appt SE, Polotsky AJ.. Comp Med. 2013;63(5):432-438.

Pharmacokinetics and in vivo potency of soluble epoxide hydrolase inhibitors in cynomolgus monkeys. Ulu A, Appt SE, Morisseau C, Hwang SH, Jones PD, Rose TE, Dong H, Lango J, Yang J, Tsai HJ, Miyabe C, Fortenbach C, Adams MR, Hammock BD.. Br J Pharmacol. 2012;165(5):1401-1412.

Effect of ovarian aging on androgen biosynthesis in a cynomolgus macaque model. Ethun KF, Wood CE, Parker CR, Kaplan JR, Chen H, Appt SE.. Climacteric. 2012;15(1):82-92.

Coronary artery vitamin D receptor expression and plasma concentrations of 25-hydroxyvitamin D: their association with atherosclerosis. Schnatz PF, Nudy M, O'Sullivan DM, Jiang X, Cline JM, Kaplan JR, Clarkson TB, Appt SE.. Menopause. 2012;19(9):967-973.

Response to an adequate dietary intake of vitamin D3 modulates the effect of estrogen therapy on bone density. Schnatz PF, Marakovits KA, O'Sullivan DM, Ethun K, Clarkson TB, Appt SE.. J Womens Health. 2012;21(8):858-864.

The association between plasma 25-hydroxyvitamin D3 concentrations, C-reactive protein levels, and coronary artery atherosclerosis in postmenopausal monkeys. Schnatz PF, Vila-Wright S, Jiang X, Register TC, Kaplan JR, Clarkson TB, Appt SE.. Menopause. 2012;19(10):1074-1080.

The quantification of vitamin D receptors in coronary arteries and their association with atherosclerosis. Schnatz PF, Nudy M, O'Sullivan DM, Jiang X, Cline JM, Kaplan JR, Clarkson TB, Appt SE.. Maturitas. 2012;73(2):143-147.

Premenopausal antimullerian hormone concentration is associated with subsequent atherosclerosis. Appt SE, Chen H, Clarkson TB, Kaplan JR.. Menopause. 2012;19(12):1353-1359.

Effects of bazedoxifene acetate with and without conjugated equine estrogens on the breast of postmenopausal monkeys. Ethun KF, Wood CE, Register TC, Cline JM, Appt SE, Clarkson TB.. Menopause. 2012;19(11):1242-1252.

Hippocampal responsiveness to 17 beta-estradiol and equol after long-term ovariectomy: implication for a therapeutic window of opportunity. Hamilton RT, Rettberg JR, Mao Z, To J, Zhao L, Appt SE, Register TC, Kaplan JR, Brinton RD.. Brain Res. 2011;1379():11-22.

The effect of dietary soy isoflavones before and after ovariectomy on hippocampal protein markers of mitochondrial bioenergetics and antioxidant activity in female monkeys. Rettberg JR, Hamilton RT, Mao Z, To J, Zhao L, Appt SE, Register TC, Kaplan JR, Brinton RD.. Brain Res. 2011;1379():23-33.

Identification of a mechanism for increased cardiovascular risk among individuals with low vitamin D concentrations. Schnatz PF, Nudy M, O'Sullivan DM, Ethun K, Appt SE, Clarkson TB.. Menopause. 2011;18(9):994-1000.

Gene expression signatures differ with extent of atherosclerosis in monkey iliac artery. Eyster KM, Appt SE, Mark-Kappeler CJ, Chalpe A, Register TC, Clarkson TB.. Menopause. 2011;18(10):1087-1095.

Pulse wave velocity is positively correlated with atherosclerosis extent in midlife female nonhuman primates [abstract]. Appt SE, Kavanagh K, Chen H, Kaplan JR, Lazar J, Clarkson TB.. Menopause. 2011;18(12):1348.

An inverse relationship between plasma vitamin D concentrations and C-reactive protein provides a potential mechanism for cardioprotection [abstract]. Schnatz PF, Vila-Wright S, Jiang X, Register TC, Appt SE, Kaplan JR, Clarkson TB.. Menopause. 2011;18(12):1352.

Endocrine profile of an ovariectomized cynomolgus monkey (Macaca fascicularis) with a supernumerary ovary. Ethun KF, Cline JM, Appt SE.. Comp Med. 2011;61(5):462-466.

Validation of multi-detector computed tomography as a non-invasive method for measuring ovarian volume in macaques (Macaca fascicularis). Jones JC, Appt SE, Werre SR, Tan JC, Kaplan JR.. Am J Primatol. 2010;72(6):530-538.

The effect of diet and cardiovascular risk on ovarian aging in cynomolgus monkeys (Macaca fascicularis). Appt SE, Chen H, Goode AK, Hoyer PB, Clarkson TB, Adams MR, Wilson ME, Franke AA, Kaplan JR.. Menopause. 2010;17(4):741-748.

Estrogen therapy and cardiovascular disease: could arterial expression of interleukin 17 provide some answers to the timing hypothesis? A study of early and late menopause in non-human primates [abstract]. Sophonsritsuk A, Appt SE, Clarkson TB, Register TC.. Fertil Steril. 2010;94(4 Suppl 1):S43-S44.

Experimental induction of reduced ovarian reserve in a nonhuman primate model (Macaca fascicularis). Appt SE, Clarkson TB, Hoyer PB, Kock ND, Goode AK, May MC, Persyn JT, Ethun KF, Chen H, Kaplan JR, et al.. Comp Med. 2010;60(5):380-388.

Impairment of ovarian function and associated health-related abnormalities are attributable to low social status in premenopausal monkeys and not mitigated by a high-isoflavone soy diet. Kaplan JR, Chen H, Appt SE, Lees CJ, Franke AA, Berga SL, Wilson ME, Manuck SB, Clarkson TB.. Hum Reprod. 2010;25(12):3083-3094.

Reproductive aging and risk for chronic disease: insights from studies of nonhuman primates. Appt SE, Ethun KF.. Maturitas. 2010;67(1):7-14.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Associate Professor, Pathology-Comparative Medicine

Susan E. Appt, D.V.M.

Susan E. Appt, D.V.M.

Associate Professor, Pathology-Comparative Medicine
Office of Women in Medicine and Science

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