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Alain Bertoni, M.D.Wake Forest School of Medicine

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Alain Bertoni, M.D.


Ctr for Vaccines at Extremes

Clinical Interests

General Internal Medicine

Contact Information

Department: 336-716-2011


Insurance Accepted »

Education & Training

  • B.A., Yale University, 1990
  • M.D., Johns Hopkins University School of Medicine, 1995
  • M.P.H., Sch Hyg & PH;Johns Hopkins U, 1999
  • Residency, Internal Medicine, Johns Hopkins Hosp, 1998
  • Fellowship, Internal Medicine, Johns Hopkins University Schoo, 2001

Board Certifications

  • American Board of Internal Medicine, Internal Medicine

NPI Number

  • 1558344259
Alain Bertoni, M.D.

Doctor Rating

No Rating Available
Why No Ratings?

Alain Bertoni, M.D.

Chair, Epidemiology & Prevention
Director, Maya Angelou Center for Health Equity
Professor, Epidemiology & Prevention
Center on Diabetes, Obesity, and Metabolism
Ctr for Vaccines at Extremes

Research Interests

Atherosclerosis; Heart Failure; Diabetes Mellitus, Type 2; Cardiovascular Diseases; Ethnic Groups
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Contact Information

Academic: 336-716-2824 | Department: 336-716-2011


Recent Publications

Left ventricular hypertrophy by ECG versus cardiac MRI as a predictor for heart failure. Oseni AO, Qureshi WT, Almahmoud MF, Bertoni AG, Bluemke DA, Hundley WG, Lima JA, Herrington DM, Soliman EZ.. Heart. 2017;103(1):49-54.

Percent emphysema and daily motor activity levels in the general population: Multi-Ethnic Study of Atherosclerosis. Lo Cascio CM, Quante M, Hoffman EA, Bertoni AG, Aaron CP, Schwartz JE, Avdalovic MV, Fan VS, Lovasi GS, Kawut SM, Austin JH, Redline S, Barr RG.. Chest. 2017;151(5):1039-1050.

Sex differences in the association between insulin resistance and incident coronary heart disease and stroke among blacks without diabetes mellitus: the Jackson Heart Study. Effoe VS, Wagenknecht LE, Echouffo Tcheugui JB, Chen H, Joseph JJ, Kalyani RR, Bell RA, Wu WH, Casanova R, Bertoni AG.. J Am Heart Assoc. 2017;6(2):e004229.

Geographic information systems to assess external validity in randomized trials. Savoca MR, Ludwig DA, Jones ST, Jason Clodfelter K, Sloop JB, Bollhalter LY, Bertoni AG.. Am J Prev Med. 2017;():.

High-sensitive cardiac troponin T as an early biochemical signature for clinical and subclinical heart failure: MESA (Multi-Ethnic Study of Atherosclerosis). Seliger SL, Hong SN, Christenson RH, Kronmal R, Daniels LB, Lima JA, de Lemos JA, Bertoni AG, deFilippi CR.. Circulation. 2017;135(16):1494-1505.

Diabetes status modifies the association between carotid intima-media thickness and incident heart failure: the Atherosclerosis Risk in Communities Study. Effoe VS, McClendon EE, Rodriguez CJ, Wagenknecht LE, Evans GW, Chang PP, Bertoni AG.. Diabetes Res Clin Pract. 2017;128():58-66.

Diabetes, depressive symptoms, and functional disability in African Americans: the Jackson Heart Study. Kalyani RR, Ji N, Carnethon M, Bertoni AG, Selvin E, Gregg EW, Sims M, Golden SH.. J Diabetes Complications. 2017;():.

Changes in metabolic risk factors over 10 years and their associations with late-life cognitive performance: the Multi-Ethnic Study of Atherosclerosis. Hughes TM, Craft S, Baker LD, Espeland MA, Rapp SR, Sink KM, Bertoni AG, Burke GL, Gottesman RF, Michos ED, Luchsinger JA, Fitzpatrick AL, Hayden KM.. Alzheimers Dement (Amst). 2017;8():18-25.

Genome-wide physical activity interactions in adiposity - a meta-analysis of 200,452 adults. Graff M, Scott RA, Justice AE, Young KL, Feitosa MF, Barata L, Winkler TW, Chu AY, Mahajan A, Hadley D, Xue L, Workalemahu T, Heard-Costa NL, den Hoed M, Ahluwalia TS, Qi Q, Ngwa JS, Renstrom F, Quaye L, Eicher JD, Hayes JE, Cornelis M,.. PLoS Genet. 2017;13(4):e1006528.

Association of asymptomatic bradycardia with incident cardiovascular disease and mortality: the Multi-Ethnic Study of Atherosclerosis (MESA). Dharod A, Soliman EZ, Dawood F, Chen H, Shea S, Nazarian S, Bertoni AG.. JAMA Intern Med. 2016;176(2):219-227.

Aldosterone, renin and diabetes mellitus in African Americans: the Jackson Heart Study. Joseph JJ, Echouffo-Tcheugui JB, Kalyani RR, Yeh HC, Bertoni AG, Effoe VS, Casanova R, Sims M, Correa A, Wu WC, Wand GS, Golden SH.. J Clin Endocrinol Metab. 2016;101(4):1770-1778.

The obesity and heart failure epidemics among African Americans: insights from the Jackson Heart Study. Krishnamoorthy A, Greiner MA, Bertoni AG, Eapen ZJ, O'Brien EC, Curtis LH, Hernandez AF, Mentz RJ.. J Card Fail. 2016;22(8):589-597.

Cardiovascular risk factor targets and cardiovascular disease event risk in diabetes: a pooling project of the Atherosclerosis Risk in Communities Study, Multi-Ethnic Study of Atherosclerosis, and Jackson Heart Study. Wong ND, Zhao Y, Patel R, Patao C, Malik S, Bertoni AG, Correa A, Folsom AR, Kachroo S, Mukherjee J, Taylor H, Selvin E.. Diabetes Care. 2016;39(5):668-676.

Ambulatory blood pressure monitoring phenotypes among individuals with and without diabetes taking antihypertensive medication: the Jackson Heart Study. Bromfield SG, Shimbo D, Bertoni AG, Sims M, Carson AP, Muntner P.. J Hum Hypertens. 2016;30(12):731-736.

Nine-year effects of 3.7 years of intensive glycemic control on cardiovascular outcomes. Gerstein HC, Beavers DP, Bertoni AG, Bigger JT, Buse JB, Craven TE, Cushman WC, Fonseca V, Geller NL, Giddings SJ, Grimm RH, Genuth S, Hramiak I, Ismail-Beigi F, Jimenez CRL, Kirby R, Probsfield J, Riddle MC, Seaquist ER, Friedewald WT.. Diabetes Care. 2016;39(5):701-708.

Predictors of longitudinal change in insulin resistance and beta-cell function in African Americans without diabetes: the Jackson Heart Study [abstract]. Effoe VS, Chen H, Echouffo-Tcheugui JB, Bell RA, Correa A, Joseph JJ, Hairston KG, Kalyani RR, Bertoni AG.. In: Abstracts of the 2016 Annual Meeting of the American Diabetes Association; 2016 June 10-14; New Orleans (LA). 2016;():1563-P.

The association of ideal cardiovascular health with incident type 2 diabetes mellitus: the Multi-Ethnic Study of Atherosclerosis. Joseph JJ, Echouffo-Tcheugui JB, Carnethon MR, Bertoni AG, Shay CM, Ahmed HM, Blumenthal RS, Cushman M, Golden SH.. Diabetologia. 2016;59(9):1893-1903.

Immigrant status and cardiovascular risk over time: results from the Multi-Ethnic Study of Atherosclerosis. Le-Scherban F, Albrecht SS, Bertoni A, Kandula N, Mehta N, Diez Roux AV.. Ann Epidemiol. 2016;26(6):429-435.e1.

Physical activity, sedentary behaviors and the incidence of type 2 diabetes mellitus: the Multi-Ethnic Study of Atherosclerosis (MESA). Joseph JJ, Echouffo-Tcheugui JB, Golden SH, Chen H, Jenny NS, Carnethon MR, Jacobs D Jr, Burke GL, Vaidya D, Ouyang P, Bertoni AG.. BMJ Open Diabetes Res Care. 2016;4(1):e000185.

Neighborhood environments and incident hypertension in the Multi-Ethnic Study of Atherosclerosis. Kaiser P, Diez Roux AV, Mujahid M, Carnethon M, Bertoni A, Adar SD, Shea S, McClelland R, Lisabeth L.. Am J Epidemiol. 2016;183(11):988-997.

Left ventricular area on non-contrast cardiac computed tomography as a predictor of incident heart failure - The Multi-Ethnic Study of Atherosclerosis. Bittencourt MS, Blankstein R, Mao S, Rivera JJ, Bertoni AG, Shaw LJ, Blumenthal RS, Budoff MJ, Nasir K.. J Cardiovasc Comput Tomogr. 2016;10(6):500-506.

Body fat distribution, menopausal hormone therapy and incident type 2 diabetes in postmenopausal women of the MESA study. Ebong IA, Watson KE, Hairston KG, Carnethon MR, Ouyang P, Szklo M, Bertoni AG.. Maturitas. 2016;91():147-152.

Development and validation of risk prediction models for cardiovascular events in black adults: the Jackson Heart Study cohort. Fox ER, Samdarshi TE, Musani SK, Pencina MJ, Sung JH, Bertoni AG, Xanthakis V, Balfour PC Jr, Shreenivas SS, Covington C, Liebson PR, Sarpong DF, Butler KR, Mosley TH, Rosamond WD, Folsom AR, Herrington DM, Vasan RS, Taylor HA.. JAMA Cardiol. 2016;1(1):15-25.

Prediction of incident diabetes in the Jackson Heart Study using high-dimensional machine learning. Casanova R, Saldana S, Simpson SL, Lacy ME, Subauste AR, Blackshear C, Wagenknecht L, Bertoni AG.. PLoS One. 2016;11(10):e0163942.

Diabetes and clinical and subclinical CVD. Bertoni AG, Kramer H, Watson K, Post WS.. Glob Heart. 2016;11(3):337-342.

Actigraphy measured sleep indices and adiposity: the Multi-Ethnic Study of Atherosclerosis (MESA). Ogilvie RP, Redline S, Bertoni AG, Chen X, Ouyang P, Szklo M, Lutsey PL.. Sleep. 2016;39(9):1701-1708.

The use of electronic medical records for recruitment in clinical trials: findings from the Lifestyle Intervention for Treatment of Diabetes trial. Effoe VS, Katula JA, Kirk JK, Pedley CF, Bollhalter LY, Brown WM, Savoca MR, Jones ST, Baek J, Bertoni AG, Faust D, Gower E, Freehill K, Logan K, Bell RA, Espeland M, et al.. Trials. 2016;17(1):496.

Pedal edema as an indicator of early heart failure in the community: prevalence and associations with cardiac structure/function and natriuretic peptides (MESA [Multiethnic Study of Atherosclerosis]). Yeboah J, Bertoni A, Qureshi W, Aggarwal S, Lima JA, Kawel-Boehm N, Bluemke DA, Shah SJ.. Circ Heart Fail. 2016;9(12):e003415.

The Lifestyle Intervention for the Treatment of Diabetes study (LIFT Diabetes): design and baseline characteristics for a randomized translational trial to improve control of cardiovascular disease risk factors. Katula JA, Kirk JK, Pedley CF, Savoca MR, Effoe VS, Bell RA, Bertoni AG.. Contemp Clin Trials. 2016;53():89-99.

Metabolic syndrome is associated with increased cardiac fibrosis and impaired diastolic function: a potential role for inflammation [abstract]. Ladeiras-Lopes R, Turin-Moreira H, Bettencourt N, Fontes-Carvalho R, Sampaio F, Ambale-Venkatesh B, Wu C, Liu K, Bertoni A, Ouyang P, Bluemke D, Lima J.. Eur Heart J. 2016;37(Suppl 1):399.

New statin use and left ventricular structure: estimating long-term associationsin the Multi-Ethnic Study of Atherosclerosis (MESA) [abstract]. Strand LN, Young RL, Delaney JA, Bertoni AG, Bluemke DA, Burke GL, Lima JA, Sotoodehnia N, Psaty BM, Heckbert SR, McClelland RL.. Pharmacoepidemiol Drug Saf. 2016;25(Suppl 3):568-569.

Factors associated with maintenance of body mass index in the Jackson Heart Study [abstract]. Auerbach B, Katz R, Boyko EJ, Drewnowski A, Tucker KL, Bertoni A, Dubbert PM, Hickson D, Correa A, Young B.. J Gen Intern Med. 2016;31(Suppl 2):S222-S223.

Association of menopause age and N-terminal pro brain natriuretic peptide: the Multi-Ethnic Study of Atherosclerosis. Ebong IA, Watson KE, Goff DC Jr, Bluemke DA, Srikanthan P, Horwich T, Bertoni AG.. Menopause. 2015;22(5):527-533.

Associations of chronic individual-level and neighbourhood-level stressors with incident coronary heart disease: the Multi-Ethnic Study of Atherosclerosis. Kershaw KN, Diez Roux AV, Bertoni A, Carnethon MR, Everson-Rose SA, Liu K.. J Epidemiol Community Health. 2015;69(2):136-141.

Lipoprotein particles and incident type 2 diabetes in the Multi-Ethnic Study of Atherosclerosis. Mackey RH, Mora S, Bertoni AG, Wassel CL, Carnethon MR, Sibley CT, Goff DC Jr.. Diabetes Care. 2015;38(4):628-636.

Abnormal stress-related measures of arterial stiffness in middle-aged and elderly men and women with impaired fasting glucose at risk for a first episode of symptomatic heart failure. Vasu S, Morgan TM, Kitzman DW, Bertoni A, Stacey RB, Hamilton C, Chiles C, Thohan V, Hundley WG.. J Am Heart Assoc. 2015;4(1):e000991.

Postoperative blood urea nitrogen is associated with stroke in cardiac surgical patients. Arnan MK, Hsieh TC, Yeboah J, Bertoni AG, Burke GL, Bahrainwala Z, Grega MA, Baumgartner WA, Gottesman RF.. Ann Thorac Surg. 2015;99(4):1314-1320.

Comparison of risks of cardiovascular events in the elderly using standard survival analysis and multiple-events and recurrent-events methods. Ip EH, Efendi A, Molenberghs G, Bertoni AG.. BMC Med Res Methodol. 2015;15(1):15.

Long-term exposure to air pollution and type 2 diabetes mellitus in a multiethnic cohort. Park SK, Adar SD, O'Neill MS, Auchincloss AH, Szpiro A, Bertoni AG, Navas-Acien A, Kaufman JD, Diez-Roux AV.. Am J Epidemiol. 2015;181(5):327-336.

Design considerations for patient portal adoption by low-income, older adults. Latulipe C, Gatto A, Nguyen HT, Miller DP, Quandt SA, Bertoni AG, Smith A, Arcury TA.. In: Proceedings of the 33rd Annual ACM Conference on Human Factors in Computing Systems (CHI); 2015 Crossings Apr 18-23; Seoul Korea. 2015;():3859-3868.

High-sensitivity C-reactive protein is associated with incident type 2 diabetes among African Americans: the Jackson Heart Study. Effoe VS, Correa A, Chen H, Lacy ME, Bertoni AG.. Diabetes Care. 2015;38(9):1694-1700.

Longitudinal associations between neighborhood physical and social environments and incident type 2 diabetes mellitus: the Multi-Ethnic Study of Atherosclerosis (MESA). Christine PJ, Auchincloss AH, Bertoni AG, Carnethon MR, Sanchez BN, Moore K, Adar SD, Horwich TB, Watson KE, Diez Roux AV.. JAMA Intern Med. 2015;175(8):1311-1320.

Relation of physical activity and incident atrial fibrillation (from the Multi-Ethnic Study of Atherosclerosis). Bapat A, Zhang Y, Post WS, Guallar E, Soliman EZ, Heckbert SR, Lima J, Bertoni AG, Alonso A, Nazarian S.. Am J Cardiol. 2015;116(6):883-888.

Effect of an intensive lifestyle intervention on atrial fibrillation risk in individuals with type 2 diabetes: the Look AHEAD randomized trial. Alonso A, Bahnson JL, Gaussoin SA, Bertoni AG, Johnson KC, Lewis CE, Vetter M, Mantzoros CS, Jeffery RW, Soliman EZ, Espeland MA.. Am Heart J. 2015;170(4):770-777.e5.

Everything in moderation - dietary diversity and quality, central obesity and risk of diabetes. de Oliveira Otto MC, Padhye NS, Bertoni AG, Jacobs DR Jr, Mozaffarian D.. PLoS One. 2015;10(10):e0141341.

Serial measurement of N-terminal pro-B-type natriuretic peptide and cardiac troponin T for cardiovascular disease risk assessment in the Multi-Ethnic Study of Atherosclerosis (MESA). Daniels LB, Clopton P, deFilippi CR, Sanchez OA, Bahrami H, Lima JA, Tracy RP, Siscovick D, Bertoni AG, Greenland P, Cushman M, Maisel AS, Criqui MH.. Am Heart J. 2015;170(6):1170-1183.

Acculturation is associated with left ventricular mass in a multiethnic sample: the Multi-Ethnic Study of Atherosclerosis. Effoe VS, Chen H, Moran A, Bertoni AG, Bluemke DA, Seeman T, Darwin C, Watson KE, Rodriguez CJ.. BMC Cardiovasc Disord. 2015;15(1):161.

Prediabetes and the association with unrecognized myocardial infarction in the Multi-Ethnic Study of Atherosclerosis. Stacey RB, Leaverton PE, Schocken DD, Peregoy AJ, Bertoni AG.. Am Heart J. 2015;170(5):923-928.

Baseline predictors of missed visits in the Look AHEAD study. Fitzpatrick SL, Jeffery R, Johnson KC, Roche CC, Van Dorsten B, Gee M, Dotson K, Walkup MP, Espeland MA, Bahnson JL, Wagenknecht LE, Reboussin D, Rejeski WJ, Bertoni AG, Lang W, Lawlor MS, Lefkowitz D, Miller GD, Reynolds PS, Ribisl PM,.. Obesity (Silver Spring). 2014;22(1):131-140.

Incidence and survival of hospitalized acute decompensated heart failure in four US communities (from the Atherosclerosis Risk in Communities Study). Chang PP, Chambless LE, Shahar E, Bertoni AG, Russell SD, Ni H, He M, Mosley TH, Wagenknecht LE, Samdarshi TE, Wruck LM, Rosamond WD.. Am J Cardiol. 2014;113(3):504-510.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Epidemiology & Prevention

Clinical Interests

General Internal Medicine

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