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Alain Bertoni, M.D.Wake Forest School of Medicine

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Education & Training

  • B.A., Yale University, 1990
  • M.D., Johns Hopkins University School of Medicine, 1995
  • M.P.H., Sch Hyg & PH,Johns Hopkins U, 1999
  • Residency, Internal Medicine, Johns Hopkins Hosp, 1998
  • Fellowship, Internal Medicine, Johns Hopkins University Schoo, 2001

NPI Number

  • 1558344259
Alain Bertoni, M.D.

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Alain Bertoni, M.D.

Chair, Epidemiology & Prevention
Professor, Epidemiology & Prevention
Maya Angelou Center for Health Equity
Center for Diabetes Research
Institute for Regenerative Medicine
General Internal Medicine
Translational Science Institute

Research Interests

cardiac function, diabetes, epidemiology, hypertension, prevention, vascular diseases

Contact Information

Academic: 336-716-2824 | Department: 336-716-2011

Email: abertoni@wakehealth.edu

Recent Publications

Ebong IA, Watson KE, Goff DC Jr, Bluemke DA, Srikanthan P, Horwich T, Bertoni AG. Association of menopause age and N-terminal pro brain natriuretic peptide: the Multi-Ethnic Study of Atherosclerosis. Menopause. 2015;22(5):527-533.

Kershaw KN, Diez Roux AV, Bertoni A, Carnethon MR, Everson-Rose SA, Liu K. Associations of chronic individual-level and neighbourhood-level stressors with incident coronary heart disease: the Multi-Ethnic Study of Atherosclerosis. J Epidemiol Community Health. 2015;69(2):136-141.

Mackey RH, Mora S, Bertoni AG, Wassel CL, Carnethon MR, Sibley CT, Goff DC Jr. Lipoprotein particles and incident type 2 diabetes in the Multi-Ethnic Study of Atherosclerosis. Diabetes Care. 2015;38(4):628-636.

Vasu S, Morgan TM, Kitzman DW, Bertoni A, Stacey RB, Hamilton C, Chiles C, Thohan V, Hundley WG. Abnormal stress-related measures of arterial stiffness in middle-aged and elderly men and women with impaired fasting glucose at risk for a first episode of symptomatic heart failure. J Am Heart Assoc. 2015;4(1):e000991.

Arnan MK, Hsieh TC, Yeboah J, Bertoni AG, Burke GL, Bahrainwala Z, Grega MA, Baumgartner WA, Gottesman RF. Postoperative blood urea nitrogen is associated with stroke in cardiac surgical patients. Ann Thorac Surg. 2015;99(4):1314-1320.

Ip EH, Efendi A, Molenberghs G, Bertoni AG. Comparison of risks of cardiovascular events in the elderly using standard survival analysis and multiple-events and recurrent-events methods. BMC Med Res Methodol. 2015;15(1):15.

Park SK, Adar SD, O'Neill MS, Auchincloss AH, Szpiro A, Bertoni AG, Navas-Acien A, Kaufman JD, Diez-Roux AV. Long-term exposure to air pollution and type 2 diabetes mellitus in a multiethnic cohort. Am J Epidemiol. 2015;181(5):327-336.

Latulipe C, Gatto A, Nguyen HT, Miller DP, Quandt SA, Bertoni AG, Smith A, Arcury TA. Design considerations for patient portal adoption by low-income, older adults. In: Proceedings of the 33rd Annual ACM Conference on Human Factors in Computing Systems (CHI); 2015 Crossings Apr 18-23; Seoul Korea. 2015;():3859-3868.

Effoe VS, Correa A, Chen H, Lacy ME, Bertoni AG. High-sensitivity C-reactive protein is associated with incident type 2 diabetes among African Americans: the Jackson Heart Study. Diabetes Care. 2015;():.

Christine PJ, Auchincloss AH, Bertoni AG, Carnethon MR, Sanchez BN, Moore K, Adar SD, Horwich TB, Watson KE, Diez Roux AV. Longitudinal associations between neighborhood physical and social environments and incident type 2 diabetes mellitus: the Multi-Ethnic Study of Atherosclerosis (MESA). JAMA Intern Med. 2015;175(8):1311-1320.

Fitzpatrick SL, Jeffery R, Johnson KC, Roche CC, Van Dorsten B, Gee M, Dotson K, Walkup MP, Espeland MA, Bahnson JL, Wagenknecht LE, Reboussin D, Rejeski WJ, Bertoni AG, Lang W, Lawlor MS, Lefkowitz D, Miller GD, Reynolds PS, Ribisl PM,. Baseline predictors of missed visits in the Look AHEAD study. Obesity (Silver Spring). 2014;22(1):131-140.

Chang PP, Chambless LE, Shahar E, Bertoni AG, Russell SD, Ni H, He M, Mosley TH, Wagenknecht LE, Samdarshi TE, Wruck LM, Rosamond WD. Incidence and survival of hospitalized acute decompensated heart failure in four US communities (from the Atherosclerosis Risk in Communities Study). Am J Cardiol. 2014;113(3):504-510.

Cox AJ, Azeem A, Yeboah J, Soliman EZ, Aggarwal SR, Bertoni AG, Carr JJ, Freedman BI, Herrington DM, Bowden DW. Heart rate-corrected QT interval is an independent predictor of all-cause and cardiovascular mortality in individuals with type 2 diabetes: the Diabetes Heart Study. Diabetes Care. 2014;37(5):1454-1461.

Bonds DE, Harrington M, Worrall BB, Bertoni AG, Eaton CB, Hsia J, Robinson J, Clemons TE, Fine LJ, Chew EY. Effect of long-chain omega-3 fatty acids and lutein+zeaxanthin supplements on cardiovascular outcomes: results of the Age-Related Eye Disease Study 2 (AREDS2) randomized clinical trial. JAMA Intern Med. 2014;174(5):763-771.

Ebong IA, Watson KE, Goff DC Jr, Bluemke DA, Srikanthan P, Horwich T, Bertoni AG. Age at menopause and incident heart failure: the Multi-Ethnic Study of Atherosclerosis. Menopause. 2014;21(6):585-591.

Yeboah J, Delaney JA, Nance R, McClelland RL, Polak JF, Sibley CT, Bertoni A, Burke GL, Carr JJ, Herrington DM. Mediation of cardiovascular risk factor effects through subclinical vascular disease: the Multi-Ethnic Study of Atherosclerosis. Arterioscler Thromb Vasc Biol. 2014;34(8):1778-1783.

Effoe VS, Rodriguez CJ, Wagenknecht LE, Evans GW, Chang PP, Mirabelli MC, Bertoni AG. Carotid intima-media thickness is associated with incident heart failure among middle-aged whites and backs: the Atherosclerosis Risk in Communities study. J Am Heart Assoc. 2014;3(3):e000797.

Unger E, Diez-Roux AV, Lloyd-Jones DM, Mujahid MS, Nettleton JA, Bertoni A, Badon SE, Ning H, Allen NB. Association of neighborhood characteristics with cardiovascular health in the Multi-Ethnic Study of Atherosclerosis. Circ Cardiovasc Qual Outcomes. 2014;7(4):524-531.

Espeland MA, Glick HA, Bertoni A, Brancati FL, Bray GA, Clark JM, Curtis JM, Egan C, Evans M, Foreyt JP, Ghazarian S, Gregg EW, Hazuda HP, Hill JO, Hire D, Horton ES, Hubbard VS, Jakicic JM, Jeffery RW, Johnson KC, Kahn SE, Killean T,. Impact of an intensive lifestyle intervention on use and cost of medical services among overweight and obese adults with type 2 diabetes: the action for health in diabetes. Diabetes Care. 2014;37(9):2548-2556.

Yeboah J, Erbel R, Delaney JC, Nance R, Guo M, Bertoni AG, Budoff M, Moebus S, Jockel KH, Burke GL, Wong ND, Lehmann N, Herrington DM, Mohlenkamp S, Greenland P. Development of a new diabetes risk prediction tool for incident coronary heart disease events: the Multi-Ethnic Study of Atherosclerosis and the Heinz Nixdorf Recall Study. Atherosclerosis. 2014;236(2):411-417.

Ebong IA, Goff DC Jr, Rodriguez CJ, Chen H, Bertoni AG. Mechanisms of heart failure in obesity. Obes Res Clin Pract. 2014;8(6):e540-e548.

Redheuil A, Wu CO, Kachenoura N, Ohyama Y, Yan RT, Bertoni AG, Hundley GW, Duprez DA, Jacobs DR Jr, Daniels LB, Darwin C, Sibley C, Bluemke DA, Lima JA. Proximal aortic distensibility is an independent predictor of all-cause mortality and incident CV events: the MESA study. J Am Coll Cardiol. 2014;64(24):2619-2629.

Knowler WC, Bahnson JL, Bantle JP, Bertoni AG, Bray GA, Chen H, Cheskin L, Clark JM, Egan C, Evans M, Foreyt JP, Glasser SP, Greenway FL, Gregg EW, Hazuda HP, Hill JO, Horton ES, Hubbard VS, Jakicic JM, Jeffery RW, Johnson KC, Kahn SE,. Effect of a long-term behavioural weight loss intervention on nephropathy in overweight or obese adults with type 2 diabetes: a secondary analysis of the Look AHEAD randomised clinical trial. Lancet Diabetes Endocrinol. 2014;2(10):801-809.

Azeem A, Yeboah J, Bertoni A, Burke G, Turkbey E, Szklo M, Herrington D. Association of hemoglobin A1C with cardiovascular disease and all-cause mortality in individuals without diabetes--the Multi-Ethnic Study of Atherosclerosis [abstract]. Circulation. 2013;127(12 Suppl):AP278.

Ng MCY, Saxena R, Li J, Palmer ND, Dimitrov L, Xu J, Rasmussen-Torvik LJ, Zmuda JM, Siscovick DS, Patel SR, Crook ED, Sims M, Chen YD, Bertoni AG, Li M, Grant SF, Dupuis J, Meigs JB, Psaty BM, Pankow JS, Langefeld CD,. Transferability and fine mapping of type 2 diabetes loci in African Americans: the Candidate Gene Association Resource Plus Study. Diabetes. 2013;62(3):965-976.

Divers J, Palmer ND, Lu L, Register TC, Carr JJ, Hicks PJ, Hightower RC, Smith SC, Xu J, Cox AJ, Hruska KA, Bowden DW, Lewis CE, Heiss G, Province MA, Borecki IB, Kerr KF, Chen YD, Palmas W, Rotter JI, Wassel CL, Bertoni AG,. Admixture mapping of coronary artery calcified plaque in African Americans with type 2 diabetes mellitus. Circ Cardiovasc Genet. 2013;6(1):97-105.

Lin SX, Berlin I, Younge R, Jin Z, Sibley CT, Schreiner P, Szklo M, Bertoni AG. Does elevated plasma triglyceride level independently predict impaired fasting glucose?: the Multi-Ethnic Study of Atherosclerosis (MESA). Diabetes Care. 2013;36(2):342-347.

Budoff MJ, Young R, Lopez VA, Kronmal RA, Nasir K, Blumenthal RS, Detrano RC, Bild DE, Guerci AD, Liu K, Shea S, Szklo M, Post W, Lima J, Bertoni A, Wong ND. Progression of coronary calcium and incident coronary heart disease events: MESA (Multi-Ethnic Study of Atherosclerosis). J Am Coll Cardiol. 2013;61(12):1231-1239.

Whitt-Glover MC, Hunter JC, Foy CG, Quandt SA, Vitolins MZ, Leng I, Hornbuckle LM, Sanya KA, Bertoni AG. Translating the Dietary Approaches to Stop Hypertension (DASH) diet for use in underresourced, urban African American communities, 2010. Prev Chronic Dis. 2013;10():120088.

Winston GJ, Palmas W, Lima J, Polak JF, Bertoni AG, Burke G, Eng J, Gottesman R, Shea S. Pulse pressure and subclinical cardiovascular disease in the Multi-Ethnic Study of Atherosclerosis. Am J Hypertens. 2013;26(5):636-642.

Ebong IA, Goff DC Jr, Rodriguez CJ, Chen H, Sibley CT, Bertoni AG. Association of lipids with incident heart failure among adults with and without diabetes mellitus: Multiethnic Study of Atherosclerosis. Circ Heart Fail. 2013;6(3):371-378.

Champaneri S, Xu X, Carnethon MR, Bertoni AG, Seeman T, DeSantis AS, Diez Roux A, Shrager S, Golden SH. Diurnal salivary cortisol is associated with body mass index and waist circumference: the Multiethnic Study of Atherosclerosis. Obesity (Silver Spring). 2013;21(1):E56-E63.

Abiemo EE, Alonso A, Nettleton JA, Steffen LM, Bertoni AG, Jain A, Lutsey PL. Relationships of the Mediterranean dietary pattern with insulin resistance and diabetes incidence in the Multi-Ethnic Study of Atherosclerosis (MESA). Br J Nutr. 2013;109(8):1490-1497.

Ebong IA, Goff DC Jr, Rodriguez CJ, Chen H, Bluemke DA, Szklo M, Bertoni AG. The relationship between measures of obesity and incident heart failure: the Multi-Ethnic Study of Atherosclerosis. Obesity (Silver Spring). 2013;21(9):1915-1922.

Redheuil A, Wu C, Yan RT, Bertoni AG, Hundley GW [sic] [Hundley WG], Duprez DA, Jacobs DR, Daniels LB, Bluemke DA, Lima JAC. Proximal aortic distensibility is an independent predictor of all-cause mortality and incident cardiovascular events in the multi-ethnic study of atherosclerosis [abstract]. Eur Heart J. 2013;34(Suppl 1):490.

Bertoni AG, Whitt-Glover MC. DASH for less cash? [invited commentary]. JAMA Intern Med. 2013;173(20):1924-1925.

McCaffery JM, Papandonatos GD, Huggins GS, Peter I, Kahn SE, Knowler WC, Hudnall GE, Lipkin EW, Kitabchi AE, Wagenknecht LE, Espeland MA, Bahnson JL, Reboussin D, Rejeski WJ, Bertoni A,. FTO predicts weight regain in the Look AHEAD clinical trial. Int J Obes (Lond). 2013;37(12):1545-1552.

Rasmussen-Torvik LJ, de Chavez P, Bertoni A, Bowden D, Dye A, Golden S, Meigs J, Pankow J, Liu K, Vassy J, Carnethon M. Association of SNP rs7903146 in TCF7L2 with incident type 2 diabetes in normal weight and overweight/obese individuals; a pooled analysis [abstract]. Circulation. 2013;127(12 Suppl):AP156.

Agarwal SK, Wruck L, Chang P, Yim E, Russell S, Bertoni A, Coresh J, Heiss G, Rosamond W. Heart failure case identification criteria and one year fatality following hospitalization - does a criterion matter? [abstract]. Circulation. 2013;128(22 Suppl):A17195.

Dharod A, Soliman EZ, Dawood F, Chen HY, Shea S, Nazarian S, Bertoni AG. Long-term outcomes of bradycardia in adults free of cardiovascular disease: the Multi-Ethnic Study of Atherosclerosis (MESA) [abstract]. Circulation. 2013;128(22 Suppl):A10726.

Effoe VS, Rodriguez CJ, Wagenknecht LE, Chang PP, Mirabelli MC, Bertoni AC. Carotid intima-media thickness is associated with incident heart failure among middle-aged whites and blacks the Atherosclerosis Risk in Communities study [abstract]. Circulation. 2013;128(22 Suppl):A10554.

Ebong IA, Watson KE, Goff DC, Bluemke DA, Srikanthan P, Horwich T, Bertoni AG. Age at menopause and incident heart failure: the Multi-Ethnic Study of Atherosclerosis [abstract]. Circulation. 2013;128(22 Suppl):A10384.

Allison MA, Jensky NE, Marshall SJ, Bertoni AG, Cushman M. Sedentary behavior and adiposity-associated inflammation: the Multi-Ethnic Study of Atherosclerosis. Am J Prev Med. 2012;42(1):8-13.

Yau JWY, Xie J, Lamoureux E, Klein R, Klein BEK, Cotch MF, Bertoni AG, Shea S, Wong TY. Retinal microvascular calibre and risk of incident diabetes: the Multi-Ethnic Study of Atherosclerosis. Diabetes Res Clin Pract. 2012;95(2):265-274.

Ebong IA, Bertoni AG, Soliman EZ, Guo M, Sibley CT, Chen YD, Rotter JI, Chen YC, Goff DC Jr. Electrocardiographic abnormalities associated with the metabolic syndrome and its components: the Multi-Ethnic Study of Atherosclerosis. Metab Syndr Relat Disord. 2012;10(2):92-97.

Mount DL, Davis C, Kennedy B, Raatz S, Dotson K, Gary-Webb TL, Thomas S, Johnson KC, Espeland MA, Bahnson J, Wagenknecht L, Reboussin D, Rejeski WJ, Lang W, Bertoni A, Vitolins M, Miller G, Ribisl P, Hodges A,. Factors influencing enrollment of African Americans in the Look AHEAD trial. Clin Trials. 2012;9(1):80-89.

de Oliveira Otto MC, Alonso A, Lee D-H, Delclos GL, Bertoni AG, Jiang R, Lima JA, Symanski E, Jacobs DR Jr, Nettleton JA. Dietary intakes of zinc and heme iron from red meat, but not from other sources, are associated with greater risk of metabolic syndrome and cardiovascular disease. J Nutr. 2012;142(3):526-533.

Rejeski WJ, Ip EH, Bertoni AG, Bray GA, Evans G, Gregg EW, Zhang Q. Lifestyle change and mobility in obese adults with type 2 diabetes. N Engl J Med. 2012;366(13):1209-1217.

Faulconbridge LF, Wadden TA, Rubin RR, Wing RR, Walkup MP, Fabricatore AN, Coday M, Van Dorsten B, Mount DL, Ewing LJ, Espeland MA, Bahnson JL, Wagenknecht L, Reboussin D, Rejeski WJ, Bertoni A, Lang W, Miller G, Lefkowitz D,. One-year changes in symptoms of depression and weight in overweight/obese individuals with type 2 diabetes in the Look AHEAD study. Obesity (Silver Spring). 2012;20(4):783-793.

Rosamond WD, Chang PP, Baggett C, Johnson A, Bertoni AG, Shahar E, Deswal A, Heiss G, Chambless LE. Classification of heart failure in the Atherosclerosis Risk in Communities (ARIC) Study: a comparison of diagnostic criteria. Circ Heart Fail. 2012;5(2):152-159.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Epidemiology & Prevention

Clinical Interests

General Internal Medicine

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