Profile

Khalil N. Bitar, Ph.D.Wake Forest School of Medicine

Khalil N. Bitar, Ph.D.

Professor,



Contact Information

Academic: 336-713-1470 | Department: 336-716-2011

Email: kbitar@wakehealth.edu

Education & Training

  • B.S., Amer Univ of Beirut School of Medicine-Lebanon, 1968
  • Ph.D., Amer Univ of Beirut School of Medicine-Lebanon, 1976
  • M.B.A., University of Michigan/Ann Arbor, 2009

Memberships

  • Am Assn Of Advancement Of Scie
  • Am Federation Of Clinical Rese
  • Am Gastroenterological Assn
  • Am Motility Society
  • Am Physiological Society
Khalil N. Bitar, Ph.D.

Khalil N. Bitar, Ph.D.

Professor, Institute for Regenerative Medicine
Sticht Center on Aging
Gastroenterology
Physiology & Pharmacology

Research Interests

aging, biotechnology, degenerative disorders, molecular biology/molecular me

Contact Information

Academic: 336-713-1470 | Department: 336-716-2011

Email: kbitar@wakehealth.edu

Recent Publications

Bitar KN. Regarding 'perianal implantation of bioengineered human internal anal sphincter constructs intrinsically innervated with human neural progenitor cells' [letter]. Surgery. 2015;157(1):178.

Whitehead WE, Rao SS, Lowry A, Nagle D, Varma M, Bitar KN, Bharucha AE, Hamilton FA. Treatment of fecal incontinence: state of the science summary for the National Institute of diabetes and digestive and kidney diseases workshop. Am J Gastroenterol. 2015;110(1):138-146.

Zakhem E, Rego SL, Raghavan S, Bitar KN. The appendix as a viable source of neural progenitor cells to functionally innervate bioengineered gastrointestinal smooth muscle tissues. Stem Cells Transl Med. 2015;4(6):548-554.

Rego SL, Raghavan S, Zakhem E, Bitar KN. Enteric neural differentiation in innervated, physiologically functional, smooth muscle constructs is modulated by bone morphogenic protein 2 secreted by sphincteric smooth muscle cells. J Tissue Eng Regen Med. 2015;():.

Bitar KN, Bohl J, Fortunato JE, Somara S, Raghavan S, Zakhem E, Rego SL, Koch KL. In situ implantation of autologous biosphincter re-instates continence in a large animal model of passive fecal incontinence [abstract]. Gastroenterology. 2015;148(4 Suppl 1):S-117.

Zakhem E, Rego SL, Raghavan S, Bitar KN. The appendix as a viable source of neural progenitor cells to functionally innervate bioengineered gastrointestinal smooth muscle tissues [abstract]. Gastroenterology. 2015;148(4 Suppl 1):S-117.

Rego SL, Shannon B, Zakhem E, Bitar KN. Incorporation of interstitial cells of Cajal in bioengineered intrinsically innervated smooth muscle constructs [abstract]. Gastroenterology. 2015;148(4 Suppl 1):S-535.

Rego SL, Zakhem E, Orlando G, Bitar KN. Human pyloric sphincters bioengineered using autologous pyloric smooth muscle cells and neural progenitor cells [abstract]. Gastroenterology. 2015;148(4 Suppl 1):S-116-117.

Zakhem E, Elbahrawy M, Orlando G, Bitar KN. Successful implantation of an engineered tubular neuromuscular tissue composed of human cells and chitosan scaffold. Surgery. 2015;():.

Zakhem E, Raghavan S, Bitar KN. Neo-innervation of a bioengineered intestinal smooth muscle construct around chitosan scaffold. Biomaterials. 2014;35(6):1882-1889.

Raghavan S, Miyasaka EA, Gilmont RR, Somara S, Teitelbaum DH, Bitar KN. Perianal implantation of bioengineered human internal anal sphincter constructs intrinsically innervated with human neural progenitor cells. Surgery. 2014;155(4):668-674.

Bitar KN, Raghavan S, Zakhem E. Tissue engineering in the gut: developments in neuromusculature. Gastroenterology. 2014;146(7):1614-1624.

Gilmont RR, Raghavan S, Somara S, Bitar KN. Bioengineering of physiologically functional intrinsically innervated human internal anal sphincter constructs. Tissue Eng Part A. 2014;20(11-12):1603-1611.

Bitar KN, Zakhem E. Design strategies of biodegradable scaffolds for tissue regeneration. Biomed Eng Comput Biol. 2014;6():13-20.

Bitar KN, Raghavan S. Stem cell therapy for GI neuromuscular disorders. Curr Gastroenterol Rep. 2014;16(12):419.

Raghavan S, Bitar K. Functional nitrergic neo-innervation of denervated colonic explants using tissue engineered innervated intestinal smooth muscle sheets [abstract]. Tissue Eng Part A. 2014;20(Suppl 1):S15.

Rego SL, Raghavan S, Zakhem E, Bitar KN. Optimizing the differentiation of enteric neural progenitor cells in bioengineered gut derived smooth muscle cell constructs for implantation [abstract]. Tissue Eng Part A. 2014;20(Suppl 1):S108.

Zakhem E, Elbahrawy M, Bitar KN. Surgical implantation of a bioengineered human smooth muscle tubular hollow organ [abstract]. Tissue Eng Part A. 2014;20(Suppl 1):S106.

Raghavan S, Bitar KN. The influence of extracellular matrix composition on the differentiation of neuronal subtypes in tissue engineered innervated intestinal smooth muscle sheets. Biomaterials. 2014;35(26):7429-7440.

Orlando G, Bendala JD, Shupe T, Bergman C, Bitar KN, Booth C, Carbone M, Koch KL, Lerut JP, Neuberger JM, Petersen B, Ricordi C, Atala A, Stratta RJ, Soker S. Cell and organ bioengineering technology as applied to gastrointestinal diseases. Gut. 2013;62(5):774-786.

Raghavan S, Gilmont RR, Bitar KN. Neuroglial differentiation of adult enteric neuronal progenitor cells as a function of extracellular matrix composition. Biomaterials. 2013;34(28):6649-6658.

Bitar KN, Zakhem E. Tissue engineering and regenerative medicine as applied to the gastrointestinal tract. Curr Opin Biotechnol. 2013;24(5):909-915.

Bitar KN, Raghavan S. Intestinal tissue engineering: current concepts and future vision of regenerative medicine in the gut. Neurogastroenterol Motil. 2012;24(1):7-19.

Zakhem E, Raghavan S, Gilmont RR, Bitar KN. Chitosan-based scaffolds for the support of smooth muscle constructs in intestinal tissue engineering. Biomaterials. 2012;33(19):4810-4817.

Bitar KN. Artificial anal sphincter: a biologic plausibility [abstract]. Neurogastroenterol Motil. 2012;24(Suppl 2):5.

Koch KL, Bitar KN, Fortunato JE. Tissue engineering for neuromuscular disorders of the gastrointestinal tract. World J Gastroenterol. 2012;18(47):6918-6925.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

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