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Khalil N. Bitar, Ph.D.Wake Forest School of Medicine

Khalil N. Bitar, Ph.D.

Professor,


Contact Information

Academic: 336-713-1470

Email: kbitar@wakehealth.edu

Education & Training

  • B.S., Amer Univ of Beirut School of Medicine-Lebanon, 1968
  • Ph.D., Amer Univ of Beirut School of Medicine-Lebanon, 1976
  • M.B.A., University of Michigan/Ann Arbor, 2009

Memberships

  • Am Assn Of Advancement Of Scie
  • Am Federation Of Clinical Rese
  • Am Gastroenterological Assn
  • Am Motility Society
  • Am Physiological Society
Khalil N. Bitar, Ph.D.

Khalil N. Bitar, Ph.D.

Professor, Institute for Regenerative Medicine
Physiology & Pharmacology
Gastroenterology

Research Interests

Muscle, Smooth; Tissue Engineering; Myocytes, Smooth Muscle; Colon; Anal Canal
More »

Contact Information

Academic: 336-713-1470

Email: kbitar@wakehealth.edu

Recent Publications

Enteric neural differentiation in innervated, physiologically functional, smooth muscle constructs is modulated by bone morphogenic protein 2 secreted by sphincteric smooth muscle cells. Rego SL, Raghavan S, Zakhem E, Bitar KN.. J Tissue Eng Regen Med. 2017;11(4):1251-1261.

Tubular bioengineered smooth muscle structures. Bitar K, inventor; Wake Forest University Health Sciences, assignee.. United States patent US 9675646. 2017 Jun 13. 2017;():.

Successful treatment of passive fecal incontinence in an animal model using engineered biosphincters: a 3-month follow-up study. Bohl JL, Zakhem E, Bitar KN.. Stem Cells Transl Med. 2017;6(9):1795-1802.

Transplantation of a human tissue-engineered bowel in an athymic rat model. Zakhem E, Tamburrini R, Orlando G, Koch KL, Bitar KN.. Tissue Eng Part C Methods. 2017;23(11):652-660.

Successful transplantation of a human tissue engineered bowel (HTEB) in an athymic rat model [abstract]. Tamburrini R, Zakhem E, Orlando G, Koch KL, Bitar KN.. Transpl Int. 2017;30(Suppl 2):89.

Bioengineering functional human sphincteric and non-sphincteric gastrointestinal smooth muscle constructs. Rego SL, Zakhem E, Orlando G, Bitar KN.. Methods. 2016;99():128-134.

Bioengineered human pyloric sphincters using autologous smooth muscle and neural progenitor cells. Rego SL, Zakhem E, Orlando G, Bitar KN.. Tissue Eng Part A. 2016;22(1-2):151-160.

Bioengineering the gut: future prospects of regenerative medicine. Bitar KN, Zakhem E.. Nat Rev Gastroenterol Hepatol. 2016;13(9):543-556.

Biomechanical properties of an implanted engineered tubular gut-sphincter complex. Zakhem E, El Bahrawy M, Orlando G, Bitar KN.. J Tissue Eng Regen Med. 2016;():.

Successful treatment of passive fecal incontinence in an animal model using engineered biosphincters: a 12 month follow-up study [abstract]. Bohl JL, Zakhem E, Bitar KN.. Tissue Eng Part A. 2016;22(Suppl 1):S17-S18.

Development of a gut-sphincter complex that maintains biomechanical properties in vivo [abstract]. Zakhem E, Elbahrawy M, Orlando G, Bitar KN.. Tissue Eng Part A. 2016;22(Suppl 1):S41-S42.

Regarding 'perianal implantation of bioengineered human internal anal sphincter constructs intrinsically innervated with human neural progenitor cells' [letter]. Bitar KN.. Surgery. 2015;157(1):178.

Treatment of fecal incontinence: state of the science summary for the National Institute of diabetes and digestive and kidney diseases workshop. Whitehead WE, Rao SS, Lowry A, Nagle D, Varma M, Bitar KN, Bharucha AE, Hamilton FA.. Am J Gastroenterol. 2015;110(1):138-146.

The appendix as a viable source of neural progenitor cells to functionally innervate bioengineered gastrointestinal smooth muscle tissues. Zakhem E, Rego SL, Raghavan S, Bitar KN.. Stem Cells Transl Med. 2015;4(6):548-554.

In situ implantation of autologous biosphincter re-instates continence in a large animal model of passive fecal incontinence [abstract]. Bitar KN, Bohl J, Fortunato JE, Somara S, Raghavan S, Zakhem E, Rego SL, Koch KL.. Gastroenterology. 2015;148(4 Suppl 1):S-117.

The appendix as a viable source of neural progenitor cells to functionally innervate bioengineered gastrointestinal smooth muscle tissues [abstract]. Zakhem E, Rego SL, Raghavan S, Bitar KN.. Gastroenterology. 2015;148(4 Suppl 1):S-117.

Incorporation of interstitial cells of Cajal in bioengineered intrinsically innervated smooth muscle constructs [abstract]. Rego SL, Shannon B, Zakhem E, Bitar KN.. Gastroenterology. 2015;148(4 Suppl 1):S-535.

Human pyloric sphincters bioengineered using autologous pyloric smooth muscle cells and neural progenitor cells [abstract]. Rego SL, Zakhem E, Orlando G, Bitar KN.. Gastroenterology. 2015;148(4 Suppl 1):S-116-117.

Successful implantation of an engineered tubular neuromuscular tissue composed of human cells and chitosan scaffold. Zakhem E, Elbahrawy M, Orlando G, Bitar KN.. Surgery. 2015;158(6):1598-1608.

Chitosan-based neuromuscular tubular tissue with improved biomechanical properties suitable for gut lengthening in a rat model [abstract]. Bitar KN, Elbahrawy M, Zakhem E.. Tissue Eng Part A. 2015;21(Suppl 1):S79.

Is bioengineering a possibility in gastrointestinal disorders? [editorial]. Bitar KN, Zakhem E.. Expert Rev Gastroenterol Hepatol. 2015;9(12):1463-1465.

Development of chitosan scaffolds with enhanced mechanical properties for intestinal tissue engineering applications. Zakhem E, Bitar KN.. J Funct Biomater. 2015;6(4):999-1011.

Neo-innervation of a bioengineered intestinal smooth muscle construct around chitosan scaffold. Zakhem E, Raghavan S, Bitar KN.. Biomaterials. 2014;35(6):1882-1889.

Perianal implantation of bioengineered human internal anal sphincter constructs intrinsically innervated with human neural progenitor cells. Raghavan S, Miyasaka EA, Gilmont RR, Somara S, Teitelbaum DH, Bitar KN.. Surgery. 2014;155(4):668-674.

Tissue engineering in the gut: developments in neuromusculature. Bitar KN, Raghavan S, Zakhem E.. Gastroenterology. 2014;146(7):1614-1624.

Bioengineering of physiologically functional intrinsically innervated human internal anal sphincter constructs. Gilmont RR, Raghavan S, Somara S, Bitar KN.. Tissue Eng Part A. 2014;20(11-12):1603-1611.

Design strategies of biodegradable scaffolds for tissue regeneration. Bitar KN, Zakhem E.. Biomed Eng Comput Biol. 2014;6():13-20.

Stem cell therapy for GI neuromuscular disorders. Bitar KN, Raghavan S.. Curr Gastroenterol Rep. 2014;16(12):419.

Functional nitrergic neo-innervation of denervated colonic explants using tissue engineered innervated intestinal smooth muscle sheets [abstract]. Raghavan S, Bitar K.. Tissue Eng Part A. 2014;20(Suppl 1):S15.

Optimizing the differentiation of enteric neural progenitor cells in bioengineered gut derived smooth muscle cell constructs for implantation [abstract]. Rego SL, Raghavan S, Zakhem E, Bitar KN.. Tissue Eng Part A. 2014;20(Suppl 1):S108.

Surgical implantation of a bioengineered human smooth muscle tubular hollow organ [abstract]. Zakhem E, Elbahrawy M, Bitar KN.. Tissue Eng Part A. 2014;20(Suppl 1):S106.

The influence of extracellular matrix composition on the differentiation of neuronal subtypes in tissue engineered innervated intestinal smooth muscle sheets. Raghavan S, Bitar KN.. Biomaterials. 2014;35(26):7429-7440.

Cell and organ bioengineering technology as applied to gastrointestinal diseases. Orlando G, Bendala JD, Shupe T, Bergman C, Bitar KN, Booth C, Carbone M, Koch KL, Lerut JP, Neuberger JM, Petersen B, Ricordi C, Atala A, Stratta RJ, Soker S.. Gut. 2013;62(5):774-786.

Neuroglial differentiation of adult enteric neuronal progenitor cells as a function of extracellular matrix composition. Raghavan S, Gilmont RR, Bitar KN.. Biomaterials. 2013;34(28):6649-6658.

Tissue engineering and regenerative medicine as applied to the gastrointestinal tract. Bitar KN, Zakhem E.. Curr Opin Biotechnol. 2013;24(5):909-915.

Intestinal tissue engineering: current concepts and future vision of regenerative medicine in the gut. Bitar KN, Raghavan S.. Neurogastroenterol Motil. 2012;24(1):7-19.

Chitosan-based scaffolds for the support of smooth muscle constructs in intestinal tissue engineering. Zakhem E, Raghavan S, Gilmont RR, Bitar KN.. Biomaterials. 2012;33(19):4810-4817.

Artificial anal sphincter: a biologic plausibility [abstract]. Bitar KN.. Neurogastroenterol Motil. 2012;24(Suppl 2):5.

Tissue engineering for neuromuscular disorders of the gastrointestinal tract. Koch KL, Bitar KN, Fortunato JE.. World J Gastroenterol. 2012;18(47):6918-6925.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

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