Khalil N. Bitar, Ph.D.Wake Forest School of Medicine

Khalil N. Bitar, Ph.D.


Contact Information

Academic: 336-713-1470 | Department: 336-716-2011


Education & Training

  • B.S., Amer Univ of Beirut School of Medicine-Lebanon, 1968
  • Ph.D., Amer Univ of Beirut School of Medicine-Lebanon, 1976
  • M.B.A., University of Michigan/Ann Arbor, 2009


  • Am Assn Of Advancement Of Scie
  • Am Federation Of Clinical Rese
  • Am Gastroenterological Assn
  • Am Motility Society
  • Am Physiological Society
Khalil N. Bitar, Ph.D.

Khalil N. Bitar, Ph.D.

Professor, Institute for Regenerative Medicine
Sticht Center on Aging
Physiology & Pharmacology

Research Interests

aging, biotechnology, cell growth, differentiation,d, degenerative disorders, diabetes, engineering/bioengineering, molecular biology/molecular me

Contact Information

Academic: 336-713-1470 | Department: 336-716-2011


Recent Publications

Whitehead WE, Rao SS, Lowry A, Nagle D, Varma M, Bitar KN, Bharucha AE, Hamilton FA. Treatment of fecal incontinence: state of the science summary for the National Institute of diabetes and digestive and kidney diseases workshop. Am J Gastroenterol. 2015;110(1):138-146.

Zakhem E, Raghavan S, Bitar KN. Neo-innervation of a bioengineered intestinal smooth muscle construct around chitosan scaffold. Biomaterials. 2014;35(6):1882-1889.

Raghavan S, Miyasaka EA, Gilmont RR, Somara S, Teitelbaum DH, Bitar KN. Perianal implantation of bioengineered human internal anal sphincter constructs intrinsically innervated with human neural progenitor cells. Surgery. 2014;155(4):668-674.

Bitar KN, Raghavan S, Zakhem E. Tissue engineering in the gut: developments in neuromusculature. Gastroenterology. 2014;146(7):1614-1624.

Gilmont RR, Raghavan S, Somara S, Bitar KN. Bioengineering of physiologically functional intrinsically innervated human internal anal sphincter constructs. Tissue Eng Part A. 2014;20(11-12):1603-1611.

Bitar KN, Zakhem E. Design strategies of biodegradable scaffolds for tissue regeneration. Biomed Eng Comput Biol. 2014;6():13-20.

Bitar KN, Raghavan S. Stem cell therapy for GI neuromuscular disorders. Curr Gastroenterol Rep. 2014;16(12):419.

Raghavan S, Bitar K. Functional nitrergic neo-innervation of denervated colonic explants using tissue engineered innervated intestinal smooth muscle sheets [abstract]. Tissue Eng Part A. 2014;20(Suppl 1):S15.

Rego SL, Raghavan S, Zakhem E, Bitar KN. Optimizing the differentiation of enteric neural progenitor cells in bioengineered gut derived smooth muscle cell constructs for implantation [abstract]. Tissue Eng Part A. 2014;20(Suppl 1):S108.

Zakhem E, Elbahrawy M, Bitar KN. Surgical implantation of a bioengineered human smooth muscle tubular hollow organ [abstract]. Tissue Eng Part A. 2014;20(Suppl 1):S106.

Orlando G, Bendala JD, Shupe T, Bergman C, Bitar KN, Booth C, Carbone M, Koch KL, Lerut JP, Neuberger JM, Petersen B, Ricordi C, Atala A, Stratta RJ, Soker S. Cell and organ bioengineering technology as applied to gastrointestinal diseases. Gut. 2013;62(5):774-786.

Bitar KN, Zakhem E. Tissue engineering and regenerative medicine as applied to the gastrointestinal tract. Curr Opin Biotechnol. 2013;24(5):909-915.

Bitar KN, Raghavan S. Intestinal tissue engineering: current concepts and future vision of regenerative medicine in the gut. Neurogastroenterol Motil. 2012;24(1):7-19.

Zakhem E, Raghavan S, Gilmont RR, Bitar KN. Chitosan-based scaffolds for the support of smooth muscle constructs in intestinal tissue engineering. Biomaterials. 2012;33(19):4810-4817.

Bitar KN. Artificial anal sphincter: a biologic plausibility [abstract]. Neurogastroenterol Motil. 2012;24(Suppl 2):5.

Koch KL, Bitar KN, Fortunato JE. Tissue engineering for neuromuscular disorders of the gastrointestinal tract. World J Gastroenterol. 2012;18(47):6918-6925.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

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