Eugene Bleecker, M.D.Wake Forest School of Medicine

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Eugene Bleecker, M.D.


Clinical Interests

Asthma, Chronic Obstructive Pulmonary Disease (COPD), General Pulmonary Diseases

Contact Information

Department: 336-716-2011


Insurance Accepted »

Education & Training

  • B.A., New York University, 1964
  • M.D., SUNY Brooklyn College of Medicine, 1968
  • Internship, Kings Cnty Hosp Ctr, 1969
  • Residency, Kings Cnty Hosp Ctr, 1970
  • Residency, Johns Hopkins Hosp, 1973
  • Fellowship, Pulmonary Disease, University of California-San F, 1975

Board Certifications

  • American Board of Internal Medicine, Internal Medicine


  • Am Academy Of Allergy & Immuno
  • Am Physiological Society
  • Am Soc of Human Genetics
  • Amer Coll Of Chest Physicians
  • Gerontological Society Of Amer
  • Johns Hopkins Medical & Surgic
  • Maryland Thoracic Society

NPI Number

  • 1811971104
Eugene Bleecker, M.D.

Doctor Rating

No Rating Available
Why No Ratings?

Eugene Bleecker, M.D.

Director, Center for Genomics and Personalized Medicine Research
Professor, Center for Genomics and Personalized Medicine Research
Center for Genomics and Personalized Medicine Research
Pulmonary, Critical Care, Allergy, and Immunologic Medicine

Research Interests

cardiac function, drugs/therapeutic agents pharm, epidemiology, genetics/genome, genomics and proteomics, immunology/allergy/inflammatio, infectious diseases, molecular biology/molecular me

Contact Information

Academic: 336-713-7500 | Department: 336-716-2011


Recent Publications

Putcha N, Barr RG, Han MK, Woodruff PG, Bleecker ER, Kanner RE, Martinez FJ, Smith BM, Tashkin DP, Bowler RP, Eisner MD, Rennard SI, Wise RA, Hansel NN. Understanding the impact of second-hand smoke exposure on clinical outcomes in participants with COPD in the SPIROMICS cohort. Thorax. 2016;():.

Traister RS, Uvalle CE, Hawkins GA, Meyers DA, Bleecker ER, Wenzel SE. Phenotypic and genotypic association of epithelial IL1RL1 to human TH2-like asthma. J Allergy Clin Immunol. 2015;135(1):92-99.e10.

Marozkina NV, Wang XQ, Stsiapura V, Fitzpatrick A, Carraro S, Hawkins GA, Bleecker E, Meyers D, Jarjour N, Fain SB, Wenzel S, Busse W, Castro M, Panettieri RA Jr, Moore W, Lewis SJ, Palmer LA, Altes T, de Lange EE, Erzurum S, Teague WG, Gaston B. Phenotype of asthmatics with increased airway S-nitrosoglutathione reductase activity. Eur Respir J. 2015;45(1):87-97.

Pino-Yanes M, Gignoux CR, Galanter JM, Levin AM, Campbell CD, Eng C, Huntsman S, Nishimura KK, Gourraud PA, Mohajeri K, O'Roak BJ, Hu D, Mathias RA, Nguyen EA, Roth LA, Padhukasahasram B, Moreno-Estrada A, Sandoval K, Winkler CA, Lurmann F,. Genome-wide association study and admixture mapping reveal new loci associated with total IgE levels in Latinos. J Allergy Clin Immunol. 2015;135(6):1502-1510.

Ortega VE, Meyers DA, Bleecker ER. Asthma pharmacogenetics and the development of genetic profiles for personalized medicine. Pharmgenomics Pers Med. 2015;8():9-22.

Robinson MB, Deshpande DA, Chou J, Cui W, Smith S, Langefeld C, Hastie AT, Bleecker ER, Hawkins GA. IL-6 trans-signaling increases expression of airways disease genes in airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2015;309(2):L129-L138.

Teodorescu M, Broytman O, Curran-Everett D, Sorkness RL, Crisafi G, Bleecker ER, Erzurum S, Gaston BM, Wenzel SE, Jarjour NN. Obstructive sleep apnea risk, asthma burden, and lower airway inflammation in adults in the Severe Asthma Research Program (SARP) II. J Allergy Clin Immunol Pract. 2015;3(4):566-575.e1.

Li X, Hastie AT, Hawkins GA, Moore WC, Ampleford EJ, Milosevic J, Li H, Busse WW, Erzurum SC, Kaminski N, Wenzel SE, Meyers DA, Bleecker ER. eQTL of bronchial epithelial cells and bronchial alveolar lavage deciphers GWAS-identified asthma genes. Allergy. 2015;70(10):1309-1318.

Zein JG, Dweik RA, Comhair SA, Bleecker ER, Moore WC, Peters SP, Busse WW, Jarjour NN, Calhoun WJ, Castro M, Chung KF, Fitzpatrick A, Israel E, Teague WG, Wenzel SE, Love TE, Gaston BM, Erzurum SC. Asthma is more severe in older adults. PLoS One. 2015;10(7):e0133490.

Gomez JL, Crisafi GM, Holm CT, Meyers DA, Hawkins GA, Bleecker ER, Jarjour N, Cohn L, Chupp GL. Genetic variation in chitinase 3-like 1 (CHI3L1) contributes to asthma severity and airway expression of YKL-40. J Allergy Clin Immunol. 2015;136(1):51-58.e10.

Kerstjens HA, Casale TB, Bleecker ER, Meltzer EO, Pizzichini E, Schmidt O, Engel M, Bour L, Verkleij CB, Moroni-Zentgraf P, Bateman ED. Tiotropium or salmeterol as add-on therapy to inhaled corticosteroids for patients with moderate symptomatic asthma: two replicate, double-blind, placebo-controlled, parallel-group, active-comparator, randomised trials. Lancet Respir Med. 2015;3(5):367-376.

Masuko H, Rafaels NM, Huang LL, Chavan S, Wilson JG, Williams LK, Ware LB, Ober C, Meyers DA, Hartert TV, Foreman M, Ford JG, Burchard EG, Bleecker ER, Dunston G, Taub M, Beaty TH, Ruczinski I, Mathias RA, Barnes KC. Imputation from 328 African ancestry genomes reveals new associations with asthma in DPP10 [abstract]. J Allergy Clin Immunol. 2015;135(2 Suppl):AB162.

Rafaels NM, Johnston HR, Huang L, Chavan S, Wilson JG, Williams LK, Ware LB, Ober C, Meyers DA, Hartert TV, Foreman M, Ford JG, Burchard EG, Bleecker ER, Taub M, Beaty TH, Ruczinski I, Mathias RA, Barnes KC. How well does whole genome sequencing improve ability to detect association with asthma in candidate genes compared to existing GWAS platforms in African American populations? [abstract]. J Allergy Clin Immunol. 2015;135(2 Suppl):AB164.

Price DB, Rigazio A, Campbell JD, Bleecker ER, Corrigan CJ, Thomas M, Wenzel SE, Wilson AM, Small MB, Gopalan G, Ashton VL, Burden A, Hillyer EV, Kerkhof M, Pavord ID. Blood eosinophil count and prospective annual asthma disease burden: a UK cohort study. Lancet Respir Med. 2015;3(11):849-858.

Halpin D, Bateman ED, Paggiaro P, Bleecker ER, Engel M, Moroni-Zentgraf P, Schmidt H, Kerstjens HAM. Once-daily tiotropium respimat (R) add-on to at least ICS maintenance therapy reduces exacerbation risk in patients with uncontrolled symptomatic asthma [abstract]. Thorax. 2015;70(Suppl 3):A151.

Riley CM, Wenzel SE, Castro M, Erzurum SC, Chung KF, Fitzpatrick AM, Gaston B, Israel E, Moore WC, Bleecker ER, Calhoun WJ, Jarjour NN, Busse WW, Peters SP, Teague WG, Sorkness R, Holguin F. Clinical implications of having reduced mid forced expiratory flow rates (FEF25-75), independently of FEV1, in adult patients with asthma. PLoS One. 2015;10(12):e0145476.

Price D, van Aalderen W, Bleecker E, Campbell J, Roche N, Skinner D, Thomas B. State of the Union - an assessment of current asthmatics, their demographics, treatment and outcomes in 153 practices across the UK [abstract]. Allergy. 2015;70(Suppl 101):166-167.

Chung KF, Wenzel SE, Brozek JL, Bush A, Castro M, Sterk PJ, Adcock IM, Bateman ED, Bel EH, Bleecker ER, Boulet LP, Brightling C, Chanez P, Dahlen SE, Djukanovic R, Frey U, Gaga M, Gibson P, Hamid Q, Jajour NN, Mauad T, Sorkness RL, Teague WG. International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma. Eur Respir J. 2014;43(2):343-373.

Arron JR, Choy DF, Laviolette M, Kelsen SG, Hatab A, Leigh R, Thomson NC, Bleecker ER, Olivenstein R, Avila PC, Jarjour NN, Castro M, Gauvreau GM, Good JT, Kline JN, Mansur A, Mayers I, Heaney LG, Hamid Q, Harris JM. Disconnect between sputum neutrophils and other measures of airway inflammation in asthma [letter]. Eur Respir J. 2014;43(2):627-629.

Lotvall J, Bleecker ER, Busse WW, O'Byrne PM, Woodcock A, Kerwin EM, Stone S, Forth R, Jacques L, Bateman ED. Efficacy and safety of fluticasone furoate 100 mcg once-daily in patients with persistent asthma: a 24-week placebo and active-controlled randomised trial. Respir Med. 2014;108(1):41-49.

Ortega VE, Hawkins GA, Moore WC, Hastie AT, Ampleford EJ, Busse WW, Castro M, Chardon D,Erzurum SC, Israel E, Montealegre F, Wezel SE, Peters SP, Meyers DA, Bleecker ER. Effect of rare variants in ADRB2 on risk of severe exacerbations and symptom control during longacting beta agonist treatment in a multiethnic asthma population: a genetic study. Lancet Respir Med. 2014;2(3):204-213.

Moore WC, Bleecker ER. Asthma heterogeneity and severity-why is comprehensive phenotyping important?. Lancet Respir Med. 2014;2(1):10-11.

Wysocki K, Park SY, Bleecker E, Busse W, Castro M, Chung KF, Gaston B, Erzurum S, Israel E, Teague WG, Moore CG, Wenzel S. Characterization of factors associated with systemic corticosteroid use in severe asthma: data from the Severe Asthma Research Program [letter]. J Allergy Clin Immunol. 2014;133(3):915-918.

O'Byrne PM, Bleecker ER, Bateman ED, Busse WW, Woodcock A, Forth R, Toler WT, Jacques L, Lotvall J. Once-daily fluticasone furoate alone or combined with vilanterol in persistent asthma. Eur Respir J. 2014;43(3):773-782.

Wu W, Bleecker E, Moore W, Busse WW, Castro M, Chung KF, Calhoun WJ, Erzurum S, Gaston B, Israel E, Curran-Everett D, Wenzel SE. Unsupervised phenotyping of Severe Asthma Research Program participants using expanded lung data. J Allergy Clin Immunol. 2014;133(5):1280-1288.

Castro M, King TS, Kunselman SJ, Cabana MD, Denlinger L, Holguin F, Kazani SD, Moore WC, Moy J, Sorkness CA, Avila P, Bacharier LB, Bleecker E, Boushey HA, Chmiel J, Fitzpatrick AM, Gentile D, Hundal M, Israel E, Kraft M, Krishnan JA,. Effect of vitamin D3 on asthma treatment failures in adults with symptomatic asthma and lower vitamin D levels: the VIDA randomized clinical trial. JAMA. 2014;311(20):2083-2091.

Hosking L, Bleecker E, Ghosh S, Yeo A, Jacques L, Mosteller M, Meyers D. GLCCI1 rs37973 does not influence treatment response to inhaled corticosteroids in white subjects with asthma [letter]. J Allergy Clin Immunol. 2014;133(2):587-589.

Meyers DA, Bleecker ER, Holloway JW, Holgate ST. Asthma genetics and personalised medicine. Lancet Respir Med. 2014;2(5):405-415.

O'Neal WK, Anderson W, Basta PV, Carretta EE, Doerschuk CM, Barr RG, Bleecker ER, Christenson SA, Curtis JL, Han MK, Hansel NN, Kanner RE, Kleerup EC, Martinez FJ, Miller BE, Peters SP, Rennard SI, Scholand MB, Tal-Singer R,. Comparison of serum, EDTA plasma and P100 plasma for luminex-based biomarker multiplex assays in patients with chronic obstructive pulmonary disease in the SPIROMICS study. J Transl Med. 2014;12():9.

Moore WC, Hastie AT, Li X, Li H, Busse WW, Jarjour NN, Wenzel SE, Peters SP, Meyers DA, Bleecker ER. Sputum neutrophil counts are associated with more severe asthma phenotypes using cluster analysis. J Allergy Clin Immunol. 2014;133(6):1557-1563.

Myers RA, Scott NM, Gauderman WJ, Qiu W, Mathias RA, Romieu I, Levin AM, Pino-Yanes M, Graves PE, Villarreal AB, Beaty TH, Carey VJ, Croteau-Chonka DC, Del Rio Navarro B, Edlund C, Hernandez-Cadena L, Navarro-Olivos E, Padhukasahasram B,. Genome-wide interaction studies reveal sex-specific asthma risk alleles. Hum Mol Genet. 2014;23(19):5251-5259.

Ortega VE, Bleecker ER. The beta2-adrenergic receptor gene: its influence on inhaled beta agonist responsiveness In: Dalby RN, Byron PR, Peart J, Suman JD, Farr SJ, Young PM, Traini D, eds. Respiratory drug delivery. RDD online;2014: 61-74.

Slager RE, Li X, Meyers DA, Bleecker ER. Genetics and asthma In: Bernstein JA, Levy ML, eds. Clinical asthma: theory and practice. Boca Raton: CRC Press;2014: 21-28.

Voraphani N, Gladwin MT, Contreras AU, Kaminski N, Tedrow JR, Milosevic J, Bleecker ER, Meyers DA, Ray A, Ray P, Erzurum SC, Busse WW, Zhao J, Trudeau JB, Wenzel SE. An airway epithelial iNOS-DUOX2-thyroid peroxidase metabolome drives Th1/Th2 nitrative stress in human severe asthma. Mucosal Immunol. 2014;7(5):1175-1185.

Hawkins G, Robinson MB, Bleecker ER, Meyers DA, Peters SP. RNAseq analysis of gene expression in human airway smooth muscle cells: comparison of classical IL6 signaling and IL6 trans-signaling [abstract]. Am J Respir Crit Care Med. 2014;189():A6384.

Steele C, Dunaway CW, Hastie AT, Ampleford EJ, Bleecker ER, Meyers DA. Defining fungal asthma severity via immune mediator differences in bronchoalveolar lavage fluid and induced sputum from fungal skin test-positive vs. skin test-negative asthmatics [abstract]. Am J Respir Crit Care Med. 2014;189():A2176.

Hawkins G, Robinson MB, Moore WC, Hastie AT, Peters SP, Meyers DA, Bleecker ER, Berry M. Serum soluble IL6 receptor levels are elevated in subjects with COPD and are associated with the IL6R coding variation Asp358Ala [abstract]. Am J Respir Crit Care Med. 2014;189():A4288.

Li X, Moore WC, Hastie AT, Ampleford EJ, Li H, Hawkins GA, Busse WW, Erzurum SC, Kaminski N, Wenzel SE, Meyers DA, Bleecker ER. Deciphering functional variants for genes associated with asthma susceptibility using eQTL of bronchial epithelial cells and bronchial alveolar lavage [abstract]. Am J Respir Crit Care Med. 2014;189(Meeting Abstracts):A1001.

Martinez CH, Kleerup EC, Woodruff PG, Kanner RE, Barr RG, Bleecker ER, Rennard SI, Couper D, Martinez FJ, Han MK. GOLD and COPD foundation guideline concordance in the SPIROMICS population [abstract]. Am J Respir Crit Care Med. 2014;189():A5941.

Ortega VE, Moore WC, Hawkins G, Ampleford EJ, Busse WW, Castro M, Erzurum SC, Israel E, Wenzel SE, Peters SP, Bleecker ER, Meyers DA. African ancestry is associated with lower baseline lung function, misclassification of disease severity, and healthcare utilization in African Americans with severe asthma [abstract]. Am J Respir Crit Care Med. 2014;189():A6366.

Coverstone AM, Zheng J, Bacharier LB, Fitzpatrick AM, Teague WG, Meyers DA, Peters SP, Li X, Li H, Wenzel SE, Aujla S, Gaston BM, Bleecker ER, Moore WC, Castro M. Predictors of response to bronchodilators in children with severe asthma [abstract]. Am J Respir Crit Care Med. 2014;189():A3839.

Smith BM, Hoffman EA, Rabinowitz D, Han MK, Donohue KM, Christenson SA, Hansel N, Kleerup EC, Bleecker ER, Couper D, Kanner RE, Rennard SI, Barr RG. Thinner airway walls In COPD: a comparison of spatially matched airways In SPIROMICS [abstract]. Am J Respir Crit Care Med. 2014;189():A4333.

Zein J, Comhair S, Dweik RA, Moore WC, Bleecker ER, Busse WW, Calhoun W, Castro M, Chung K, Israel E, Jarjour NN, Teague WG, Wenzel SE, Gaston B, Fitzpatrick AM, Erzurum SC. The distinctive role of age and asthma duration on asthma severity [abstract]. Am J Respir Crit Care Med. 2014;189():A2425.

Han MK, Wang X, Murray S, O'Neal WK, Doerschuk CM, Anderson WH, Basta P, Couper D, Bowler RP, Weir M, Scholand M, Pirozzi CS, Kleerup E, Kanner RE, Barr G, Bleecker ER, Martinez FJ, Woodruff PG, Hoffman EA. Blood biomarkers and CT phenotypes in the subpopulations and intermediate outcome measures In COPD study (SPIROMICS) [abstract]. Am J Respir Crit Care Med. 2014;189():A5915.

Hastie AT, Dunaway CW, Moore WC, Foster S, Rector BM, Ampleford E, Bleecker ER, Steele C, Meyers DA. Complex patterns of Th1 inflammatory biomarker associations with cellular constituents of induced sputum in asthma [abstract]. Am J Respir Crit Care Med. 2014;189():A4236.

Han MK, Tayob N, Kim V, Murray S, Barr G, Rennard SI, Woodruff PG, Kleerup E, Kanner RE, Bleecker ER, Hersh CP, Wendt CH, Washko GR, Dransfield MT, Curtis JL, Foreman MG, Casaburi R, Make BJ, Criner GJ, Regan EA, Hokanson JE, Beaty T,. CT emphysema score (EMPHysema, age, smoking, SIZE - EMPHASIZE) identifies clinically significant COPD [abstract]. Am J Respir Crit Care Med. 2014;189():A4336.

Bateman ED, O'Byrne PM, Busse WW, Lotvall J, Bleecker ER, Andersen L, Jacques L, Frith L, Lim J, Woodcock A. Once-daily fluticasone furoate (FF)/vilanterol reduces risk of severe exacerbations in asthma versus FF alone. Thorax. 2014;69(4):312-319.

Couper D, LaVange LM, Han M, Barr RG, Bleecker E, Hoffman EA, Kanner R, Kleerup E, Martinez FJ, Woodruff PG, Rennard S. Design of the subpopulations and intermediate outcomes in COPD Study (SPIROMICS). Thorax. 2014;69(5):491-494.

Smith BM, Hoffman EA, Rabinowitz D, Bleecker E, Christenson S, Couper D, Donohue KM, Han MK, Hansel NN, Kanner RE, Kleerup E, Rennard S, Barr RG. Comparison of spatially matched airways reveals thinner airway walls in COPD. The Multi-Ethnic Study of Atherosclerosis (MESA) COPD Study and the subpopulations and intermediate outcomes in COPD Study (SPIROMICS). Thorax. 2014;69(11):987-996.

Kerstjens H, Bleecker E, Meltzer E, Casale T, Pizzichini E, Schmidt O, Engel M, Bour L, Bateman E, Moroni-Zentgraf P, Hoz A de la. Tiotropium as add-on to inhaled corticosteroids significantly improves asthma control as reflected by the ACQ responder rate [abstract]. Respirology. 2014;19(Suppl 2):78.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Center for Genomics and Personalized Medicine Research

Clinical Interests

Asthma, Chronic Obstructive Pulmonary Disease (COPD), General Pulmonary Diseases

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