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Eugene Bleecker, M.D.Wake Forest School of Medicine

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Eugene Bleecker, M.D.

Director,
Professor,


Clinical Interests

General Pulmonary Diseases, Chronic Obstructive Pulmonary Disease (COPD), Asthma

Contact Information

Department: 336-716-2011

Email: ebleeck@wakehealth.edu

Insurance Accepted »

Education & Training

  • B.A., New York University, 1964
  • M.D., SUNY Brooklyn College of Medicine, 1968
  • Internship, Kings Cnty Hosp Ctr, 1969
  • Residency, Kings Cnty Hosp Ctr, 1970
  • Residency, Johns Hopkins Hosp, 1973
  • Fellowship, Pulmonary Disease, University of California-San F, 1975

Board Certifications

  • American Board of Internal Medicine, Internal Medicine
  • American Board of Internal Medicine, Pulmonary Disease

Memberships

  • Johns Hopkins Medical & Surgic
  • Maryland Thoracic Society
  • Amer Coll Of Chest Physicians
  • Am Physiological Society
  • Am Soc of Human Genetics
  • Am Academy Of Allergy & Immuno
  • Gerontological Society Of Amer

NPI Number

  • 1811971104
Eugene Bleecker, M.D.

Doctor Rating

No Rating Available
Why No Ratings?

Eugene Bleecker, M.D.

Director, Center for Genomics and Personalized Medicine Research
Professor, Center for Genomics and Personalized Medicine Research
Pulmonary, Critical Care, Allergy, and Immunologic Medicine
Pediatrics

Research Interests

Asthma; Receptors, Adrenergic, beta-2; Adrenergic beta-Agonists; Anti-Asthmatic Agents; Pulmonary Disease, Chronic Obstructive
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Contact Information

Academic: 336-713-7500 | Department: 336-716-2011

Email: ebleeck@wakehealth.edu

Recent Publications

Understanding the impact of second-hand smoke exposure on clinical outcomes in participants with COPD in the SPIROMICS cohort. Putcha N, Barr RG, Han MK, Woodruff PG, Bleecker ER, Kanner RE, Martinez FJ, Smith BM, Tashkin DP, Bowler RP, Eisner MD, Rennard SI, Wise RA, Hansel NN.. Thorax. 2016;():.

Expression of asthma susceptibility genes in bronchial epithelial cells and bronchial alveolar lavage in the Severe Asthma Research Program (SARP) cohort. Li X, Hawkins GA, Moore WC, Hastie AT, Ampleford EJ, Milosevic J, Li H, Busse WW, Erzurum SC, Kaminski N, Wenzel SE, Bleecker ER, Meyers DA.. J Asthma. 2016;53(8):775-782.

Severe eosinophilic asthma treated with mepolizumab stratified by baseline eosinophil thresholds: a secondary analysis of the DREAM and MENSA studies. Ortega HG, Yancey SW, Mayer B, Gunsoy NB, Keene ON, Bleecker ER, Brightling CE, Pavord ID.. Lancet Respir Med. 2016;4(7):549-556.

Clinical significance of symptoms in smokers with preserved pulmonary function. Woodruff PG, Barr RG, Bleecker E, Christenson SA, Couper D, Curtis JL, Gouskova NA, Hansel NN, Hoffman EA, Kanner RE, Kleerup E, Lazarus SC, Martinez FJ, Paine R III, Rennard S, Tashkin DP, Han MK.. N Engl J Med. 2016;374(19):1811-1821.

Efficacy and safety of ipratropium bromide/albuterol compared with albuterol in patients with moderate-to-severe asthma: a randomized controlled trial. Donohue JF, Wise R, Busse WW, Garfinkel S, Zubek VB, Ghafouri M, Manuel RC, Schlenker-Herceg R, Bleecker ER.. BMC Pulm Med. 2016;16(1):65.

Exacerbation reduction in severe eosinophilic asthma based on eosinophil thresholds [abstract]. Yancey SW, Mayer B, Gunsoy N, Keene ON, Bleecker EG, Brightling C, Pavord I.. J Allergy Clin Immunol. 2016;137(2 Suppl):AB208.

Impact of age and sex on outcomes and hospital cost of acute asthma in the United States, 2011-2012. Zein JG, Udeh BL, Teague WG, Koroukian SM, Schlitz NK, Bleecker ER, Busse WB, Calhoun WJ, Castro M, Comhair SA, Fitzpatrick AM, Israel E, Wenzel SE, Holguin F, Gaston BM, Erzurum SC.. PLoS One. 2016;11(6):e0157301.

Plasma interleukin-6 concentrations, metabolic dysfunction, and asthma severity: a cross-sectional analysis of two cohorts. Peters MC, McGrath KW, Hawkins GA, Hastie AT, Levy BD, Israel E, Phillips BR, Mauger DT, Comhair SA, Erzurum SC, Johansson MW, Jarjour NN, Coverstone AM, Castro M, Holguin F, Wenzel SE, Woodruff PG, Bleecker ER, Fahy JV.. Lancet Respir Med. 2016;4(7):574-584.

SPIROMICS protocol for multicenter quantitative computed tomography to phenotype the lungs. Sieren JP, Newell JD Jr, Barr RG, Bleecker ER, Burnette N, Carretta EE, Couper D, Goldin J, Guo J, Han MK, Hansel NN, Kanner RE, Kazerooni EA, Martinez FJ, Rennard S, Woodruff PG, Hoffman EA.. Am J Respir Crit Care Med. 2016;194(7):794-806.

Efficacy and safety of benralizumab for patients with severe asthma uncontrolled with high-dosage inhaled corticosteroids and long-acting beta2-agonists (SIROCCO): a randomised, multicentre, placebo-controlled phase 3 trial. Bleecker ER, FitzGerald JM, Chanez P, Papi A, Weinstein SF, Barker P, Sproule S, Gilmartin G, Aurivillius M, Werkstrom V, Goldman M.. Lancet. 2016;():.

Inflammatory and co-morbid features of patients with severe asthma and frequent exacerbations. Denlinger LC, Phillips BR, Ramratnam S, Ross K, Bhakta NR, Cardet JC, Castro M, Peters SP, Phipatanakul W, Aujla S, Bacharier LB, Bleecker ER, Comhair SA, Coverstone A, DeBoer M, Erzurum SC, Fain SB, Fajt M, Fitzpatrick AM, Gaffin J, Gaston B,.. Am J Respir Crit Care Med. 2016;():.

Benralizumab, an anti-interleukin-5 receptor alpha monoclonal antibody, as add-on treatment for patients with severe, uncontrolled, eosinophilic asthma (CALIMA): a randomised, double-blind, placebo-controlled phase 3 trial. FitzGerald JM, Bleecker ER, Nair P, Korn S, Ohta K, Lommatzsch M, Ferguson GT, Busse WW, Barker P, Sproule S, Gilmartin G, Werkstrom V, Aurivillius M, Goldman M.. Lancet. 2016;():.

Biomarkers predictive of exacerbations in the SPIROMICS and COPDGene cohorts. Keene JD, Jacobson S, Kechris K, Kinney GL, Foreman MG, Doerschuk CM, Make BJ, Curtis JL, Rennard SI, Barr RG, Bleecker ER, Kanner RE, Kleerup EC, Hansel NN, Woodruff PG, Han MK, Paine Iii R, Martinez FJ, Bowler RP, O'Neal WK.. Am J Respir Crit Care Med. 2016;():.

Age and small airway imaging abnormalities in subjects with and without airflow obstruction in SPIROMICS. Martinez CH, Diaz AA, Meldrum C, Curtis JL, Cooper CB, Pirozzi C, Kanner RE, Paine Iii R, Woodruff PG, Bleecker ER, Hansel NN, Barr RG, Marchetti N, Criner GJ, Kazerooni EA, Hoffman EA, Ross BD, Galban CJ, Cigolle CT, Martinez FJ, Han MK.. Am J Respir Crit Care Med. 2016;():.

Serious asthma events with budesonide plus formoterol vs. budesonide alone. Peters SP, Bleecker ER, Canonica GW, Park YB, Ramirez R, Hollis S, Fjallbrant H, Jorup C, Martin UJ.. N Engl J Med. 2016;375(9):850-860.

Common genetic polymorphisms influence blood biomarker measurements in COPD. Sun W, Kechris K, Jacobson S, Drummond MB, Hawkins GA, Yang J, Chen TH, Quibrera PM, Anderson W, Barr RG, Basta PV, Bleecker ER, Beaty T, Casaburi R, Castaldi P, Cho MH, Comellas A, Crapo JD, Criner G, Demeo D, Christenson SA, Couper DJ,.. PLoS Genet. 2016;12(8):e1006011.

Meta-analysis of asthma-related hospitalization in mepolizumab studies of severe eosinophilic asthma. Yancey SW, Ortega HG, Keene ON, Mayer B, Gunsoy NB, Brightling CE, Bleecker ER, Haldar P, Pavord ID.. J Allergy Clin Immunol. 2016;():.

A continuum of admixture in the Western Hemisphere revealed by the African Diaspora genome. Mathias RA, Taub MA, Gignoux CR, Fu W, Musharoff S, O'Connor TD, Vergara C, Torgerson DG, Pino-Yanes M, Shringarpure SS, Huang L, Rafaels N, Boorgula MP, Johnston HR, Ortega VE, Levin AM, Song W, Torres R, Padhukasahasram B, Eng C,.. Nat Commun. 2016;7():12522.

Phenotypic and genotypic association of epithelial IL1RL1 to human TH2-like asthma. Traister RS, Uvalle CE, Hawkins GA, Meyers DA, Bleecker ER, Wenzel SE.. J Allergy Clin Immunol. 2015;135(1):92-99.e10.

Phenotype of asthmatics with increased airway S-nitrosoglutathione reductase activity. Marozkina NV, Wang XQ, Stsiapura V, Fitzpatrick A, Carraro S, Hawkins GA, Bleecker E, Meyers D, Jarjour N, Fain SB, Wenzel S, Busse W, Castro M, Panettieri RA Jr, Moore W, Lewis SJ, Palmer LA, Altes T, de Lange EE, Erzurum S, Teague WG, Gaston B.. Eur Respir J. 2015;45(1):87-97.

Genome-wide association study and admixture mapping reveal new loci associated with total IgE levels in Latinos. Pino-Yanes M, Gignoux CR, Galanter JM, Levin AM, Campbell CD, Eng C, Huntsman S, Nishimura KK, Gourraud PA, Mohajeri K, O'Roak BJ, Hu D, Mathias RA, Nguyen EA, Roth LA, Padhukasahasram B, Moreno-Estrada A, Sandoval K, Winkler CA, Lurmann F,.. J Allergy Clin Immunol. 2015;135(6):1502-1510.

Genetic variation in chitinase 3-like 1 (CHI3L1) contributes to asthma severity and airway expression of YKL-40. Gomez JL, Crisafi GM, Holm CT, Meyers DA, Hawkins GA, Bleecker ER, Jarjour N, Cohn L, Chupp GL.. J Allergy Clin Immunol. 2015;136(1):51-58.e10.

Tiotropium or salmeterol as add-on therapy to inhaled corticosteroids for patients with moderate symptomatic asthma: two replicate, double-blind, placebo-controlled, parallel-group, active-comparator, randomised trials. Kerstjens HA, Casale TB, Bleecker ER, Meltzer EO, Pizzichini E, Schmidt O, Engel M, Bour L, Verkleij CB, Moroni-Zentgraf P, Bateman ED.. Lancet Respir Med. 2015;3(5):367-376.

Asthma pharmacogenetics and the development of genetic profiles for personalized medicine. Ortega VE, Meyers DA, Bleecker ER.. Pharmgenomics Pers Med. 2015;8():9-22.

IL-6 trans-signaling increases expression of airways disease genes in airway smooth muscle. Robinson MB, Deshpande DA, Chou J, Cui W, Smith S, Langefeld C, Hastie AT, Bleecker ER, Hawkins GA.. Am J Physiol Lung Cell Mol Physiol. 2015;309(2):L129-L138.

Obstructive sleep apnea risk, asthma burden, and lower airway inflammation in adults in the Severe Asthma Research Program (SARP) II. Teodorescu M, Broytman O, Curran-Everett D, Sorkness RL, Crisafi G, Bleecker ER, Erzurum S, Gaston BM, Wenzel SE, Jarjour NN.. J Allergy Clin Immunol Pract. 2015;3(4):566-575.e1.

eQTL of bronchial epithelial cells and bronchial alveolar lavage deciphers GWAS-identified asthma genes. Li X, Hastie AT, Hawkins GA, Moore WC, Ampleford EJ, Milosevic J, Li H, Busse WW, Erzurum SC, Kaminski N, Wenzel SE, Meyers DA, Bleecker ER.. Allergy. 2015;70(10):1309-1318.

Asthma is more severe in older adults. Zein JG, Dweik RA, Comhair SA, Bleecker ER, Moore WC, Peters SP, Busse WW, Jarjour NN, Calhoun WJ, Castro M, Chung KF, Fitzpatrick A, Israel E, Teague WG, Wenzel SE, Love TE, Gaston BM, Erzurum SC.. PLoS One. 2015;10(7):e0133490.

Imputation from 328 African ancestry genomes reveals new associations with asthma in DPP10 [abstract]. Masuko H, Rafaels NM, Huang LL, Chavan S, Wilson JG, Williams LK, Ware LB, Ober C, Meyers DA, Hartert TV, Foreman M, Ford JG, Burchard EG, Bleecker ER, Dunston G, Taub M, Beaty TH, Ruczinski I, Mathias RA, Barnes KC.. J Allergy Clin Immunol. 2015;135(2 Suppl):AB162.

How well does whole genome sequencing improve ability to detect association with asthma in candidate genes compared to existing GWAS platforms in African American populations? [abstract]. Rafaels NM, Johnston HR, Huang L, Chavan S, Wilson JG, Williams LK, Ware LB, Ober C, Meyers DA, Hartert TV, Foreman M, Ford JG, Burchard EG, Bleecker ER, Taub M, Beaty TH, Ruczinski I, Mathias RA, Barnes KC.. J Allergy Clin Immunol. 2015;135(2 Suppl):AB164.

Blood eosinophil count and prospective annual asthma disease burden: a UK cohort study. Price DB, Rigazio A, Campbell JD, Bleecker ER, Corrigan CJ, Thomas M, Wenzel SE, Wilson AM, Small MB, Gopalan G, Ashton VL, Burden A, Hillyer EV, Kerkhof M, Pavord ID.. Lancet Respir Med. 2015;3(11):849-858.

Once-daily tiotropium respimat (R) add-on to at least ICS maintenance therapy reduces exacerbation risk in patients with uncontrolled symptomatic asthma [abstract]. Halpin D, Bateman ED, Paggiaro P, Bleecker ER, Engel M, Moroni-Zentgraf P, Schmidt H, Kerstjens HAM.. Thorax. 2015;70(Suppl 3):A151.

Clinical implications of having reduced mid forced expiratory flow rates (FEF25-75), independently of FEV1, in adult patients with asthma. Riley CM, Wenzel SE, Castro M, Erzurum SC, Chung KF, Fitzpatrick AM, Gaston B, Israel E, Moore WC, Bleecker ER, Calhoun WJ, Jarjour NN, Busse WW, Peters SP, Teague WG, Sorkness R, Holguin F.. PLoS One. 2015;10(12):e0145476.

State of the Union - an assessment of current asthmatics, their demographics, treatment and outcomes in 153 practices across the UK [abstract]. Price D, van Aalderen W, Bleecker E, Campbell J, Roche N, Skinner D, Thomas B.. Allergy. 2015;70(Suppl 101):166-167.

Reliability of multiplex-based blood biomarkers in COPD subjects enrolled in spiromics (subpopulation and intermediate outcome measures in COPD study) [abstract]. Anderson WH, Basta P, Carretta E, Cui G, Davis S, Doerschuk CM, Barr RG, Bleecker ER, Bowler RP, Curtis JL, Drummond MB, Han MK, Hansel NN, Kanner RE, Kleerup EC, Martinez FJ, Paine R, Peters SP, Woodruff PG, Rennard SI, Couper D, O'Neal WK.. Am J Respir Crit Care Med. 2015;191():A2935.

Pharmacodynamic effect of benralizumab on blood basophils and serum biomarkers in adults with chronic obstructive pulmonary disease and sputum eosinophilia [abstract]. Damera G, Brightling CE, Bleecker ER, She D, Van Der Merwe R, Ward CK.. Am J Respir Crit Care Med. 2015;191():A2711.

Circadian rhythm and clock gene expression are altered in asthmatic epithelium and bronchoalveolar lavage (bal) cells [abstract]. Fajt ML, Tedrow JR, Milosevic J, Trudeau JB, Bleecker ER, Meyers DA, Erzurum SC, Gaston BM, Busse WW, Jarjour NN, Kaminski N, Wenzel SE.. Am J Respir Crit Care Med. 2015;191():A3628.

Once-daily tiotropium respimat (R) add-on therapy improves symptom control across severities of symptomatic asthma, independent of allergic status [abstract]. FitzGerald JM, Engel M, Moroni-Zentgraf P, Luehmann R, Bleecker ER.. Am J Respir Crit Care Med. 2015;191():A4263.

Differential gene expression profiles in the bronchial epithelial cells of severe asthmatics treated with oral corticosteroids [abstract]. Gauthier M, Tedrow JR, Wu W, Milosevic J, Bleecker ER, Meyers DA, Erzurum SC, Gaston BM, Busse WW, Jarjour NN, Kaminski N, Ray A, Wenzel SE.. Am J Respir Crit Care Med. 2015;191():A2481.

The Rs12141494 polymorphism in Chi3l1 is associated with asthma severity and airway expression of Ykl-40 [abstract]. Gomez JL, Crisafi G, Holm C, Meyers DA, Hawkins GA, Bleecker ER, Jarjour NN, Cohn LE, Chupp GL.. Am J Respir Crit Care Med. 2015;191():A1057.

Analyses of COPD severity phenotypes and emphysema in spiromics subjects stratified By sputum granulocytes [abstract]. Hastie AT, Doerschuk CM, Alexis NE, Hansel NN, Peters SP, Barr RG, Couper D, Curtis JL, Han MK, Kanner RE, Kleerup EC, Martinez FJ, Putcha N, Rennard SI, Woodruff PG, Meyers DA, Bleecker ER.. Am J Respir Crit Care Med. 2015;191():A2861.

Blood biomarker quantitative trail loci in chronic obstructive pulmonary disease [abstract]. Jacobson S, Kechris K, Sun W, Yang J, Chen TH, Barr RG, Basta P, Bleecker ER, Couper D, Curtis JL, Doerschuk CM, Drummond MB, Han MK, Hansel NN, Hawkins G, Hoffman EA, Kanner R, Kleerup EC, Martinez FJ, Meyers DA, O'Neal WK, Peters SP,.. Am J Respir Crit Care Med. 2015;191():A3627.

Factor analysis of Chronic Obstructive Pulmonary Disease (COPD) related phenotypes in the subpopulations and intermediate outcome measures in COPD study (spiromics) [abstract]. Li X, Li H, Ampleford J, Dransfield MT, Barr RG, Couper D, Han MK, Hoffman EA, Kanner RE, Kleerup EC, Martinez FJ, Rennard SI, Woodruff PG, Meyers DA, Bleecker ER.. Am J Respir Crit Care Med. 2015;191():A2439.

Sarp clinical clusters predict steroid responsiveness and risk of asthma exacerbations in the Asthmanet Vida (Vitamin D In Asthma) Trial [abstract]. Moore WC, King TS, Bleecker ER, Meyers DA, Peters SP Wenzel SE.. Am J Respir Crit Care Med. 2015;191():A6055.

The very frequent exacerbator sub-phenotype is seen in all spectrums of asthma severity including milder disease in the Severe Asthma Research Program [abstract]. Opina MD, Bleecker ER, Meyers DA, Li H, Moore WC.. Am J Respir Crit Care Med. 2015;191():A4182.

African ancestry is associated with disease misclassification, airflow obstruction, and CT scan emphysema in African Americans from spiromics [abstract]. Ortega VE, Ampleford EJ, Hawkins G, Barr RG, Couper D, Han MK, Hoffman EA, Kanner RE, Kleerup EC, Martinez FJ, Rennard SI, Woodruff PG, Bleecker ER, Meyers DA.. Am J Respir Crit Care Med. 2015;191():A2297.

African ancestry is associated with lung function, healthcare utilization, and airways inflammation in African Americans with asthma [abstract]. Ortega VE, Moore WC, Zein J, Hastie AT, Ampleford E, Peters SP, Busse WW, Castro M, Erzurum SC, Israel E, Wenzel SE, Hawkins G, Bleecker ER, Meyers DA.. Am J Respir Crit Care Med. 2015;191():A1061.

Rare serpina1 variants are associated with lung function and health care utilization in a multi-ethnic population from the Severe Asthma Research Program (sarp) [abstract]. Pasha S, Orgega VE, Ampleford EJ, Bamshad MJ, Barnes KC, Busse WW, Castro M, Erzurum SC, Israel E, Mathias RA, Nickerson D, Wenzel SE, Hawkins G, Bleecker ER, Meyers DA.. Am J Respir Crit Care Med. 2015;191():A6057.

Understanding the impact of passive smoke exposure on outcomes in COPD [abstract]. Putcha N, Barr RG, Han M, Woodruff PG, Bleecker ER, Kanner RE, Martinez FJ, Tashkin DP, Rennard SI, Breysse P, Wise A, Hansel NN.. Am J Respir Crit Care Med. 2015;191():A3907.

The association between reduced mid-forced expiratory flow rates (fef25-75) with clinical outcomes in patients with asthma participating in the Severe Asthma Research Program (sarp) [abstract]. Riley C, Wenzel SE, Bleecker ER, Busse WW, Castro M, Erzurum SC, Fitzpatrick AM, Gaston BM, Israel E, Jarjour NN, Moore WC, Peters SP, Teague WG, Chung K, Holguin F.. Am J Respir Crit Care Med. 2015;191():A4188.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Center for Genomics and Personalized Medicine Research

Clinical Interests

General Pulmonary Diseases, Chronic Obstructive Pulmonary Disease (COPD), Asthma

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