Profile

Eugene Bleecker, M.D.Wake Forest Baptist Health

Eugene Bleecker, M.D.

Director,
Shared Resource Director,
Professor,



Clinical Specialties

General Pulmonary Diseases, Chronic Obstructive Pulmonary Disease (COPD), Asthma

Contact Information

Department: 336-716-2011

Email: ebleeck@wakehealth.edu

Insurance Accepted »

Education & Training

  • B.A., New York University , 1964
  • M.D., SUNY Brooklyn College of Medicine , 1968
  • Internship, Kings Cnty Hosp Ctr, 1969
  • Residency, Kings Cnty Hosp Ctr, 1970
  • Residency, Johns Hopkins Hosp, 1973
  • Fellowship, Pulmonary Disease, University of California-San F, 1975

Board Certifications

  • American Board of Internal Medicine, Internal Medicine, Internal Medicine - Internal Medicine

Memberships

  • Johns Hopkins Medical & Surgic
  • Maryland Thoracic Society
  • Amer Coll Of Chest Physicians
  • Am Physiological Society
  • Am Soc Of Human Genetics
  • Am Academy Of Allergy & Immuno
  • Gerontological Society Of Amer

NPI Number

  • 1811971104
Eugene Bleecker, M.D.Wake Forest Baptist Health

Eugene Bleecker, M.D.

Director, Center for Genomics and Personalized Medicine Research
Shared Resource Director, Translational Science Institute
Professor, Translational Science Institute
Translational Science Institute
Center for Genomics and Personalized Medicine Research
Pulmonary, Critical Care, Allergy, and Immunologic Medicine

Research Interests

aging, drugs/therapeutic agents pharm, genetics/genome, genomics and proteomics, immunology/allergy/inflammatio, molecular biology/molecular me

Contact Information

Academic: 336-713-7500 | Department: 336-716-2011

Email: ebleeck@wakehealth.edu

Recent Publications

Chung KF, Wenzel SE, Brozek JL, Bush A, Castro M, Sterk PJ, Adcock IM, Bateman ED, Bel EH, Bleecker ER, Boulet LP, Brightling C, Chanez P, Dahlen SE, Djukanovic R, Frey U, Gaga M, Gibson P, Hamid Q, Jajour NN, Mauad T, Sorkness RL, Teague WG. International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma. Eur Respir J. 2014;43(2):343-373.

Arron JR, Choy DF, Laviolette M, Kelsen SG, Hatab A, Leigh R, Thomson NC, Bleecker ER, Olivenstein R, Avila PC, Jarjour NN, Castro M, Gauvreau GM, Good JT, Kline JN, Mansur A, Mayers I, Heaney LG, Hamid Q, Harris JM. Disconnect between sputum neutrophils and other measures of airway inflammation in asthma [letter]. Eur Respir J. 2014;43(2):627-629.

Lotvall J, Bleecker ER, Busse WW, O'Byrne PM, Woodcock A, Kerwin EM, Stone S, Forth R, Jacques L, Bateman ED. Efficacy and safety of fluticasone furoate 100 mcg once-daily in patients with persistent asthma: a 24-week placebo and active-controlled randomised trial. Respir Med. 2014;108(1):41-49.

Ortega VE, Hawkins GA, Moore WC, Hastie AT, Ampleford EJ, Busse WW, Castro M, Chardon D,Erzurum SC, Israel E, Montealegre F, Wezel SE, Peters SP, Meyers DA, Bleecker ER. Effect of rare variants in ADRB2 on risk of severe exacerbations and symptom control during longacting beta agonist treatment in a multiethnic asthma population: a genetic study. Lancet Respir Med. 2014;2(3):204-213.

Moore WC, Bleecker ER. Asthma heterogeneity and severity-why is comprehensive phenotyping important?. Lancet Respir Med. 2014;2(1):10-11.

Denlinger LC, Manthei DM, Seibold MA, Ahn K, Bleecker E, Boushey HA, Calhoun WJ, Castro M, Chinchili VM, Fahy JV, Hawkins GA, Icitovic N, Israel E, Jarjour NN, King T, Kraft M, Lazarus SC, Lehman E, Martin RJ, Meyers DA,. P2X7-regulated protection from exacerbations and loss of control is independent of asthma maintenance therapy. Am J Respir Crit Care Med. 2013;187(1):28-33.

Holguin F, Comhair SA, Hazen SL, Powers RW, Khatri SS, Bleecker ER, Busse WW, Calhoun WJ, Castro M, Fitzpatrick AM, Gaston B, Israel E, Jarjour NN, Moore WC, Peters SP, Teague WG, Chung KF, Erzurum SC, Wenzel SE. An association between L-arginine/asymmetric dimethyl arginine balance, obesity, and the age of asthma onset phenotype. Am J Respir Crit Care Med. 2013;187(2):153-159.

Himes BE, Sheppard K, Berndt A, Leme AS, Myers RA, Gignoux CR, Levin AM, Gauderman WJ, Yang JJ, Mathias RA, Romieu I, Torgerson DG, Roth LA, Huntsman S, Eng C, Klanderman B, Ziniti J, Senter-Sylvia J, Szefler SJ, Lemanske RF Jr,. Integration of mouse and human genome-wide association data identifies KCNIP4 as an asthma gene. PLoS One. 2013;8(2):e56179.

Romeo J, Hastie AT, Foster S, Moore W, Peters SP, Bleecker ER, Dykewicz MS. LIGHT is associated with increased cellular infiltrate and levels of TH1 cytokines as well as well as [sic] reduced lung function in human asthma [abstract]. J Allergy Clin Immunol. 2013;131(2 Suppl):AB203.

Fu W, O'Connor TD, Jun G, Kang HM, Abecasis G, Leal SM, Gabriel S, Rieder MJ, Altshuler D, Shendure J, Nickerson DA, Bamshad MJ, Bowden DW, Burke G, Carr J, Goff D, Herrington DM, Liu Y, Bleecker E, Meyers D,. Analysis of 6,515 exomes reveals the recent origin of most human protein-coding variants. Nature. 2013;493(7431):216-220.

Rao CK, Moore CG, Bleecker E, Busse WW, Calhoun W, Castro M, Chung KF, Erzurum SC, Israel E, Curran-Everett D, Wenzel SE. Characteristics of perimenstrual asthma and its relation to asthma severity and control: data from the Severe Asthma Research Program. Chest. 2013;143(4):984-992.

Levin AM, Mathias RA, Huang L, Roth LA, Daley D, Myers RA, Himes BE, Romieu I, Yang M, Eng C, Park JE, Zoratti K, Gignoux CR, Torgerson DG, Galanter JM, Huntsman S, Nguyen EA, Becker AB, Chan-Yeung M, Kozyrskyj AL,. A meta-analysis of genome-wide association studies for serum total IgE in diverse study populations. J Allergy Clin Immunol. 2013;131(4):1176-1184.


Hastie AT, Moore WC, Li H, Rector BM, Ortega VE, Pascual RM, Peters SP, Meyers DA, Bleecker ER. Biomarker surrogates do not accurately predict sputum eosinophil and neutrophil percentages in asthmatic subjects. J Allergy Clin Immunol. 2013;132(1):72-80.

Li X, Hawkins GA, Ampleford EJ, Moore WC, Li H, Hastie AT, Howard TD, Boushey HA, Busse WW, Calhoun WJ, Castro M, Erzurum SC, Israel E, Lemanske RF Jr, Szefler SJ, Wasserman SI, Wenzel SE, Peters SP, Meyers DA, Bleecker ER. Genome-wide association study identifies TH1 pathway genes associated with lung function in asthmatic patients. J Allergy Clin Immunol. 2013;132(2):313-320.

Peters SP, Bleecker ER, Kunselman SJ, Icitovic N, Moore WC, Pascual R, Ameredes BT, Boushey HA, Calhoun WJ, Castro M, Cherniack RM, Craig T, Denlinger LC, Engle LL, Dimango EA, Israel E, Kraft M, Lazarus SC, Lemanske RF Jr,. Predictors of response to tiotropium versus salmeterol in asthmatic adults. J Allergy Clin Immunol. 2013;132(5):1068-1074.

Woodcock A, Bleecker ER, Lotvall J, O'Byrne PM, Bateman ED, Medley H, Ellsworth A, Jacques L, Busse WW. Efficacy and safety of fluticasone furoate/vilanterol compared with fluticasone propionate/salmeterol combination in adult and adolescent patients with persistent asthma: a randomized trial. Chest. 2013;144(4):1222-1229.

Moore WC, Fitzpatrick AM, Li X, Hastie AT, Li H, Meyers DA, Bleecker ER. Clinical heterogeneity in the severe asthma research program. Ann Am Thorac Soc. 2013;10(Suppl):S118-S124.

O'Connor TD, Kiezun A, Bamshad M, Rich SS, Smith JD, Turner E, Bleecker ER, Bowden DW. Fine-scale patterns of population stratification confound rare variant association tests. PLoS One. 2013;8(7):e65834.

Busse WW, Bleecker ER, Bateman ED, Lotvall J, Forth R, Davis AM, Jacques L, Haumann B, Woodcock A. Fluticasone furoate demonstrates efficacy in patients with asthma symptomatic on medium doses of inhaled corticosteroid therapy: an 8-week, randomised, placebo-controlled trial. Thorax. 2012;67(1):35-41.

Li X, Ampleford EJ, Howard TD, Moore WC, Li H, Busse WW, Castro M, Erzurum SC, Fitzpatrick AM, Gaston B, Israel E, Jarjour NN, Teague WG, Wenzel SE, Hawkins GA, Bleecker ER, Meyers DA. The C11orf30-LRRC32 region is associated with total serum IgE levels in asthmatic patients [letter]. J Allergy Clin Immunol. 2012;129(2):575-578.

Hartman JM, Hastie A, Moore WC, Rector B, Peters SP, Bleecker ER, Dykewicz MS. Thioredoxin is positively associated with eosinophils in induced sputum from patients with asthma [abstract]. J Allergy Clin Immunol. 2012;129(2 Suppl):AB209.

Jarjour NN, Erzurum SC, Bleecker ER, Calhoun WJ, Castro M, Comhair SAA, Chung KF, Curran-Everett D, Dweik RA, Fain SB, Fitzpatrick AM, Gaston BM, Israel E, Hastie A, Hoffman EA, Holguin F, Levy BD, Meyers DA, Moore WC, Peters SP,. Severe asthma: lessons learned from the National Heart, Lung, and Blood Institute Severe Asthma Research Program. Am J Respir Crit Care Med. 2012;185(4):356-362.

Torgerson DG, Capurso D, Mathias RA, Graves PE, Hernandez RD, Beaty TH, Bleecker ER, Raby BA, Meyers DA, Barnes KC, Weiss ST, Martinez FD, Nicolae DL, Ober C. Resequencing candidate genes implicates rare variants in asthma susceptibility. Am J Hum Genet. 2012;90(2):273-281.

Ortega VE, Hawkins G, Moore WC, Sadeghnejad A, Busse WW, Erzurum SC, Wenzel SE, Peters SP, Meyers DA, Bleecker ER. Characterization of rare variants in the Adam33 gene in asthma cases from two ethnic groups [abstract]. Am J Respir Crit Care Med. 2012;185(Meeting Abstracts):A5609.

Bellinger C, Pascual R, Krings J, Smith R, Burmudez R, Peters SP, Bleecker ER, Moore WC. Similar decrements in FEV1 and FVC in not severe and severe asthma subjects following investigative bronchoscopy [abstract]. Am J Respir Crit Care Med. 2012;185(Meeting Abstracts):A4178.

Li X, Moore WC, Li H, Ampleford EJ, Busse WW, Erzurum SC, Wenzel SE, Howard TD, Hawkins GA, Meyers DA, Bleecker ER. Phenotype determinants for asthma severity clusters and genetic association for cluster-based asthma severity in Severe Asthma Research Program (SARP) [abstract]. Am J Respir Crit Care Med. 2012;185(Meeting Abstracts):A2501.

Slager RE, Moore WC, Peters SP, Busse WW, Erzurum SC, Wenzel SE, Meyers DA, Bleecker ER. Rare TH1 and TH2 pathway genetic variants contribute to severe allergic asthma [abstract]. Am J Respir Crit Care Med. 2012;185(Meeting Abstracts):A2509.

Hawkins G, Li X, Slager R, Moore WC, Peters SP, Bleecker ER, Meyers DA. Exome sequencing of asthma candidate genes in chromosome 2q11-12 and 2q33 [abstract]. Am J Respir Crit Care Med. 2012;185(Meeting Abstracts):A4904.

Moore WC, Hastie AT, Li H, Li X, Busse WW, Wenzel SE, Peters SP, Meyers DA, Bleecker ER. The addition of sputum inflammatory cell counts to the SARP cluster analysis results in similar clinical asthma phenotypes with biologic heterogeneity [abstract]. Am J Respir Crit Care Med. 2012;185(Meeting Abstracts):A3625.

Ortega VE, Hawkins G, Hastie AT, Moore WC, Sadeghnejad A, Busse WW, Erzurum SC, Wenzel SE, Peters SP, Meyers DA, Bleecker ER. Effects of rare beta2-adrenergic receptor gene variants and long-acting beta agonists on healthcare utilization and corticosteroid use in two multi-ethnic asthma populations [abstract]. Am J Respir Crit Care Med. 2012;185(Meeting Abstracts):A2514.

Hastie AT, Moore WC, Li H, Rector BM, Pascual RM, Peters SP, Meyers DA, Bleecker ER. Blood eosinophils, exhaled nitric oxide, and IGE do not accurately predict sputum eosinophils [abstract]. Am J Respir Crit Care Med. 2012;185(Meeting Abstracts):A3926.

Bateman ED, Bleecker ER, Lotvall J, Woodcock A, Forth R, Medley H, Davis AM, Jacques L, Haumann B, Busse WW. Dose effect of once-daily fluticasone furoate in persistent asthma: a randomized trial. Respir Med. 2012;106(5):642-650.

Bousquet J, Anto JM, Demoly P, Schunemann HJ, Togias A, Akdis M, Auffray C, Bachert C, Bieber T, Bousquet PJ, Carlsen KH, Casale TB, Cruz AA, Keil T, Lodrup Carlsen KC, Maurer M, Ohta K, Papadopoulos NG, Roman Rodriguez M,. Severe chronic allergic (and related) diseases: a uniform approach - A MeDALL - GA(2)LEN - ARIA position paper. Int Arch Allergy Immunol. 2012;158(3):216-231.

Herrington DM, Meyers DA, Xu J, Zheng SL, Bleecker ER, Isaacs WB, Walsh PC, inventors; Wake Forest University Health Sciences, assignee. Mutations in the macrophage scavenger receptor 1 gene alter risk of prostate cancer, asthma, and cardiovascular disease. United States patent US 8,192,928. 2012 June 5. 2012;():.

Hawkins GA, Robinson MB, Hastie AT, Li X, Li H, Moore WC, Howard TD, Busse WW, Erzurum SC, Wenzel SE, Peters SP, Meyers DA, Bleecker ER. The IL6R variation Asp358 Ala is a potential modifier of lung function in subjects with asthma. J Allergy Clin Immunol. 2012;130(2):510-515.

Slager RE, Otulana BA, Hawkins GA, Yen YP, Peters SP, Wenzel SE, Meyers DA, Bleecker ER. IL-4 receptor polymorphisms predict reduction in asthma exacerbations during response to an anti-IL-4 receptor alpha antagonist. J Allergy Clin Immunol. 2012;130(2):516-522.

Chipps BE, Zeiger RS, Borish L, Wenzel SE, Yegin A, Hayden ML, Miller DP, Bleecker ER, Simons FER, Szefler SJ, Weiss ST, Haselkorn T. Key findings and clinical implications from The Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens (TENOR) study. J Allergy Clin Immunol. 2012;130(2):332-342.

Himes BE, Jiang X, Hu R, Wu AC, Lasky-Su JA, Klanderman BJ, Ziniti J, Senter-Sylvia J, Lima JJ, Irvin CG, Peters SP, Meyers DA, Bleecker ER, Kubo M, Tamari M, Nakamura Y, Szefler SJ, Lemanske RF Jr, Zeiger RS, Strunk RC, Martinez FD,. Genome-wide association analysis in asthma subjects identifies SPATS2L as a novel bronchodilator response gene. PLoS Genet. 2012;8(7):e1002824.

Pavord ID, Korn S, Howarth P, Bleecker ER, Buhl R, Keene ON, Ortega H, Chanez P. Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial. Lancet. 2012;380(9842):651-659.

Slager RE, Hawkins GA, Li X, Postma DS, Meyers DA, Bleecker ER. Genetics of asthma susceptibility and severity. Clin Chest Med. 2012;33(3):431-443.

Bleecker ER, Meyers DA, Bailey WC, Sims AM, Bujac SR, Goldman M, Martin UJ. ADRB2 polymorphisms and budesonide/formoterol responses in COPD. Chest. 2012;142(2):320-328.


Calhoun WJ, Ameredes BT, King TS, Icitovic N, Bleecker ER, Castro M, Cherniack RM, Chinchilli VM, Craig T, Denlinger L, DiMango EA, Engle LL, Fahy JV, Grant JA, Israel E, Jarjour N, Kazani SD, Kraft M, Kunselman SJ, Lazarus SC, Lemanske RF,. Comparison of physician-, biomarker-, and symptom-based strategies for adjustment of inhaled corticosteroid therapy in adults with asthma: the BASALT randomized controlled trial. JAMA. 2012;308(10):987-997.

Torgerson DG, Capurso D, Ampleford EJ, Li X, Moore WC, Gignoux CR, Hu D, Eng C, Mathias RA, Busse WW, Castro M, Erzurum SC, Fitzpatrick AM, Gaston B, Israel E, Jarjour NN, Teague WG, Wenzel SE, Rodriguez-Santana JR,. Genome-wide ancestry association testing identifies a common European variant on 6q14.1 as a risk factor for asthma in African American subjects. J Allergy Clin Immunol. 2012;130(3):622-629.

Bleecker ER, Bateman ED, Busse WW, Woodcock A, Frith L, House KW, Jacques L, Davis AM, Haumann B, Lotvall J. Once-daily fluticasone furoate is efficacious in patients with symptomatic asthma on low-dose inhaled corticosteroids. Ann Allergy Asthma Immunol. 2012;109(5):353-358.

Lotvall J, Bateman ED, Bleecker ER, Busse WW, Woodcock A, Follows R, Lim J, Stone S, Jacques L, Haumann B. 24-h duration of the novel LABA vilanterol trifenatate in asthma patients treated with inhaled corticosteroids. Eur Respir J. 2012;40(3):570-579.

Kader AK, Sun J, Reck BH, Newcombe PJ, Kim ST, Hsu FC, D'Agostino RB Jr, Tao S, Zhang Z, Turner AR, Platek GT, Spraggs CF, Whittaker JC, Lane BR, Isaacs WB, Meyers DA, Bleecker ER, Torti FM, Trent JM, McConnell JD,. Potential impact of adding genetic markers to clinical parameters in predicting prostate biopsy outcomes in men following an initial negative biopsy: findings from the REDUCE trial. Eur Urol. 2012;62(6):953-961.

Li X, Ampleford EJ, Howard TD, Moore WC, Torgerson DG, Li H, Busse WW, Castro M, Erzurum SC, Israel E, Nicolae DL, Ober C, Wenzel SE, Hawkins GA, Bleecker ER, Meyers DA. Genome-wide association studies of asthma indicate opposite immunopathogenesis direction from autoimmune diseases. J Allergy Clin Immunol. 2012;130(4):861-868.

Mattheisen M, Bunyavanich S, Himes BE, Gauderman WJ, Bleecker ER, Meyers DA, London SJ, Gilliland FD, Burchard EG, Martinez FD, Williams LK, Barnes KC, Ober C, Nicolae DL, Laird NM, Raby BA, Lasky-Su J, Lange C, Weiss ST. Integrative analysis of case-control and family based association studies--lessons we have learned [abstract]. Ann Hum Genet. 2012;76(Pt 5):419.

Myers RA, Himes BE, Gignoux CR, Yang JJ, Gauderman WJ, Rebordosa C, Xie J, Torgerson DG, Levin AM, Baurley J, Graves PE, Mathias RA, Romieu I, Roth LA, Conti D, Avila L, Eng C, Vora H, LeNoir MA, Soto-Quiros M, Liu J, Celedon JC,. Further replication studies of the EVE Consortium meta-analysis identifies 2 asthma risk loci in European Americans. J Allergy Clin Immunol. 2012;130(6):1294-301.

Ortega VE, Bleecker ER. The pharmacogenetics of asthma and the road to personlized medicine. Pulmao RJ. 2012;21(2):41-52.

Ortega VE, Bleecker ER. The safety of long-acting beta-agonists and the development of combination therapies for asthma and COPD In: Lotvall J, Busse WW, eds. Advances in combination therapy for asthma and COPD. Chichester, West Sussex: John Wiley & Sons;2012: 102-134.

Luyster FS, Teodorescu M, Bleecker E, Busse W, Calhoun W, Castro M, Chung KF, Erzurum S, Israel E, Strollo PJ, Wenzel SE. Sleep quality and asthma control and quality of life in non-severe and severe asthma. Sleep Breath. 2012;16(4):1129-1137.

Chipps BE, Zeiger RS, Dorenbaum A, Borish L, Wenzel SE, Miller DP, Hayden ML, Bleecker ER, Simons FE, Szefler SJ, Weiss ST, Haselkorn T. Assessment of asthma control and asthma exacerbations in the epidemiology and natural history of asthma: outcomes and treatment regimens (TENOR) observational cohort. Curr Respir Care Rep. 2012;1(4):259-269.

Busse WW, Peters SP, Fenton MJ, Mitchell H, Bleecker ER, Castro M, Wenzel S, Erzurum SC, Fitzpatrick AM, Moore WC, et al. Vaccination of patients with mild and severe asthma with a 2009 pandemic H1N1 influenza virus vaccine. J Allergy Clin Immunol. 2011;127(1):130-137.

Balzar S, Fajt ML, Comhair SAA, Erzurum SC, Bleecker E, Busse WW, Castro M, Gaston B, Israel E, Schwartz LB, et al. Mast cell phenotype, location, and activation in severe asthma: data from the Severe Asthma Research Program. Am J Respir Crit Care Med. 2011;183(3):299-309.

Duan QL, Gaume BR, Hawkins GA, Himes BE, Bleecker ER, Klanderman B, Irvin CG, Peters SP, Meyers DA, Hanrahan JP, et al. Regulatory haplotypes in ARG1 are associated with altered bronchodilator response. Am J Respir Crit Care Med. 2011;183(4):449-454.

Fitzpatrick AM, Teague WG, Meyers DA, Peters SP, Li X, Li H, Wenzel SE, Aujla S, Bleecker ER, Moore WC, et al. Heterogeneity of severe asthma in childhood: confirmation by cluster analysis of children in the National Institutes of Health/National Heart, Lung, and Blood Institute Severe Asthma Research Program. J Allergy Clin Immunol. 2011;127(2):382-389.

Liu L, Teague WG, Erzurum S, Fitzpatrick A, Mantri S, Dweik RA, Bleecker ER, Meyers D, Moore W, Peters SP, et al. Determinants of exhaled breath condensate pH in a large population with asthma. Chest. 2011;139(2):328-336.

Ortega VE, Hastie A, Sadeghnejad A, Moore W, Hawkins GA, Peters SP, Busse WW, Calhoun WJ, Meyers DA, Bleecker ER, et al. Rare beta2-adrenergic receptor gene polymorphisms in asthma cases and controls from the Severe Asthma Research Program [abstract]. Am J Respir Crit Care Med. 2011;183(Meeting Abstracts):A1357.


Holguin F, Bleecker ER, Busse WW, Calhoun WJ, Castro M, Erzurum SC, Fitzpatrick AM, Gaston B, Moore WC, Peters SP, et al. Obesity and asthma: an association modified by age of asthma onset. J Allergy Clin Immunol. 2011;127(6):1486-1493.

Li X, Howard TD, Moore WC, Ampleford EJ, Li H, Busse WW, Peters SP, Hawkins GA, Bleecker ER, Meyers DA, et al. Importance of hedgehog interacting protein and other lung function genes in asthma. J Allergy Clin Immunol. 2011;127(6):1457-1465.

Comhair SAA, Gaston BM, Ricci KS, Hammel J, Dweik RA, Meyers D, Ampleford EJ, Bleecker ER, Moore W, Peters SP, et al. Detrimental effects of environmental tobacco smoke in relation to asthma severity. PLoS ONE. 2011;6(5):e18574.

Slager RE, Hawkins G, Otulana B, Yen Y, Wenzel SE, Meyers DA, Bleecker ER. Interleukin 4 receptor polymorphisms predict therapeutic pitrakinra treatment response in moderate to severe asthma [abstract]. Am J Respir Crit Care Med. 2011;183():A6178.

Slager RE, Li H, Moore W, Hawkins G, Peters SP, Busse WW, Chung K, Erzurum SC, Meyers DA, Bleecker ER, et al. Predictive model of severe atopic asthma phenotypes using interleukin 4/13 pathway polymorphisms [abstract]. Am J Respir Crit Care Med. 2011;183():A1332.

Silverman EK, Vestbo J, Agusti A, Anderson W, Bakke PS, Barnes KC, Barr RG, Bleecker ER, Boezen HM, Burkart KM, et al. Opportunities and challenges in the genetics of COPD 2010: an International COPD Genetics Conference report. COPD. 2011;8(2):121-135.

Moore WC, Evans MD, Bleecker ER, Busse WW, Calhoun WJ, Castro M, Chung KF, Erzurum SC, Pascual RM, Peters SP, et al. Safety of investigative bronchoscopy in the Severe Asthma Research Program. J Allergy Clin Immunol. 2011;128(2):328-336.

Torgerson DG, Ampleford EJ, Chiu GY, Gauderman WJ, Gignoux CR, Graves PE, Himes BE, Li X, Bleecker ER, Meyers DA, et al. Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. Nat Genet. 2011;43(9):887-892.

Bleecker ER, Siler T, Owen R, Kramer B. Bronchodilator efficacy and safety of indacaterol 150 mcg once daily in patients with COPD: an analysis of pooled data. Int J Chron Obstruct Pulmon Dis. 2011;6():431-438.

Bleecker ER, Busse WW, Donohue JF, Garfinkel S, Lystig T, Manuel RC, Schlenker-Herceg R, Wise RA. Comparison of ipratropium bromide and albuterol sulfate chlorofluorocarbon metered-dose inhaler and albuterol hydrofluoroalkane metered-dose inhaler in a crossover trial in patients with moderate-to-severe asthma [abstract]. J Allergy Clin Immunol. 2011;127(2):AB83.

Woodcock A, Bateman ED, Busse WW, Lotvall J, Snowise NG, Forth R, Jacques L, Haumann B, Bleecker ER. Efficacy in asthma of once-daily treatment with fluticasone furoate: a randomized, placebo-controlled trial. Respir Res. 2011;12():132.

Wechsler ME, Castro M, Lehman E, Chinchilli VM, Sutherland ER, Denlinger L, Lazarus SC, Peters SP, Israel E, Bleecker E, et al. Impact of race on asthma treatment failures in the asthma clinical research network. Am J Respir Crit Care Med. 2011;184(11):1247-1253.

Woodcock A, Bleecker ER, Busse WW, Lotvall J, Snowise NG, Frith L, Jacques L, Haumann B, Bateman ED. Fluticasone furoate: once-daily evening treatment versus twice-daily treatment in moderate asthma. Respir Res. 2011;12():160.

Hawkins GA, Robinson MB, Moore W, Hastie A, Pascual RM, Peters SP, Meyers DA, Bleecker ER. Correlation of serum IL6 with lung function and phenotypic asthma clusters: data from the Severe Asthma Research Program (SARP) [abstract]. Am J Respir Crit Care Med. 2011;183(Meeting Abstracts):A6169.

Hatzis CE, Hastie A, Moore W, Rector B, Sousa A, Knowles R, Peters SP, Meyers DA, Bleecker ER. BAL cell lysate IL1b synthesis and processing correlates with blood eosinophil levels in subjects with asthma [abstract]. Am J Respir Crit Care Med. 2011;183(Meeting Abstracts):A4453.

Robinson MB, Deshpande DA, Pascual RM, Panettieri RA, Penn R, Meyers DA, Bleecker ER, Hawkins GA. IL6 signaling in human airway smooth muscle (hasm): distinct signaling effected by the soluble IL6 receptor and functional consequences [abstract]. Am J Respir Crit Care Med. 2011;183():A2074.

Li X, Howard TD, Zheng SL, Haselkorn T, Peters SP, Meyers DA, Bleecker ER. Genome-wide association study of asthma identifies RAD50-IL13 and HLA-DR/DQ regions. J Allergy Clin Immunol. 2010;125(2):328-335.

Moore WC, Meyers DA, Wenzel SE, Teague WG, Li H, Li X, D'Agostino R Jr, Castro M, Peters SP, Bleecker ER, et al. Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program. Am J Respir Crit Care Med. 2010;181(4):315-323.


Bleecker ER, Nelson HS, Kraft M, Corren J, Meyers DA, Yancey SW, Anderson WH, Emmett AH, Ortega HA. Meeting the obligation to balance bioethics and clinical trial design in asthma [editorial]. Am J Respir Crit Care Med. 2010;181(7):648-650.

Bleecker ER, Nelson HS, Kraft M, Corren J, Meyers DA, Yancey SW, Anderson WH, Emmett AH, Ortega HG. Beta2-receptor polymorphisms in patients receiving salmeterol with or without fluticasone propionate. Am J Respir Crit Care Med. 2010;181(7):676-687.

Hastie AT, Moore WC, Meyers DA, Vestal PL, Li H, Peters SP, Bleecker ER. Analyses of asthma severity phenotypes and inflammatory proteins in subjects stratified by sputum granulocytes. J Allergy Clin Immunol. 2010;125(5):1028-1036.

Ohar JA, Sadeghnejad A, Meyers DA, Donohue JF, Bleecker ER. Do symptoms predict COPD in smokers?. Chest. 2010;137(6):1345-1353.

Dweik RA, Sorkness RL, Wenzel S, Hammel J, Curran-Everett D, Comhair SAA, Bleecker E, Busse W, Moore W, Peters S, et al. Use of exhaled nitric oxide measurement to identify a reactive, at-risk phenotype among patients with asthma. Am J Respir Crit Care Med. 2010;181(10):1033-1041.

Ohar JA, Hamilton RF Jr, Zheng S, Sadeghnejad A, Sterling DA, Xu J, Meyers DA, Bleecker ER, Holian A. COPD is associated with a macrophage scavenger receptor-1 gene sequence variation. Chest. 2010;137(5):1098-1107.

O'Connor RD, Bleecker ER, Long A, Tashkin D, Peters S, Klingman D, Gutierrez B. Subacute lack of asthma control and acute asthma exacerbation history as predictors of subsequent acute asthma exacerbations: evidence from managed care data. J Asthma. 2010;47(4):422-428.

Bottema RW, Nolte IM, Howard TD, Koppelman GH, Dubois AE, de Meer G, Kerkhof M, Bleecker ER, Meyers DA, Postma DS. Interleukin 13 and interleukin 4 receptor-alpha polymorphisms in rhinitis and asthma. Int Arch Allergy Immunol. 2010;153(3):259-267.

Hawkins GA, Moore WC, Robinson MB, Peters SP, Meyers D, Bleecker ER. IL6R polymorphisms predict measures of lung function in caucasian asthmatics: data from the Severe Asthma Research Program (SARP) [abstract]. Am J Respir Crit Care Med. 2010;181(1 Meeting Abstracts):A1298.

Sadeghnejad A, Ohar JA, Bleecker ER, Meyers D. Replication of an association of the interleukin-1 receptor antagonist gene with asthma in an adult urban admixed population [abstract]. Am J Respir Crit Care Med. 2010;181(1 Meeting Abstracts):A3877.

Slager RE, Pascual RM, Moore WC, Hawkins GA, Peters SP, Meyers D, Bleecker ER. GATA3 polymorphisms are predictors of steroid use and atopic asthma in the Severe Asthma Research Program [abstract]. Am J Respir Crit Care Med. 2010;181(1 Meeting Abstracts):A1301.

Ortega VE, Hawkins GA, Montealegre F, Chardon D, Sadeghnejad A, Moore WC, Peters SP, Meyers D, Bleecker ER. Rare beta2 adrenergic receptor gene polymorphisms in asthma cases and controls from different ethnic groups [abstract]. Am J Respir Crit Care Med. 2010;181(1 Meeting Abstracts):A1316.

Ortega VE, Liggett SB, Pascual R, Diallo A, Moore WC, Meyers D, Bleecker ER, Hawkins GA. Epigenetics of the beta2-adrenergic receptor gene [abstract]. Am J Respir Crit Care Med. 2010;181(1 Meeting Abstracts):A1306.

Ortega VE, Hawkins GA, Sadeghnejad A, Moore WC, Meyers D, Bleecker ER. Characterization of asthma cases and controls with rare ADAM33 gene polymorphisms in a multi-ethnic population [abstract]. Am J Respir Crit Care Med. 2010;181(1 Meeting Abstracts):A1315.

Li X, Howard TD, Ampleford EJ, Peters SP, Bleecker ER, Meyers DA. Genome-wide association study of asthma severity using proportional odds model identifies TMEM154 [abstract]. Am J Respir Crit Care Med. 2010;181(1 Meeting Abstracts):A3728.

Ohar JA, Howard TD, Ampleford EJ, Bleecker ER, Meyers DA. Genome wide association study in mesothelioma [abstract]. Am J Respir Crit Care Med. 2010;181(1 Meeting Abstracts):A4340.

Hastie AT, Albon D, Moore WC, Krings J, Smith RV, Meyers DA, Peters SP, Bleecker ER. Inflammatory protein microarray analysis of sputum from obese subjects with asthma compared with nonobese subjects with asthma [abstract]. Am J Respir Crit Care Med. 2010;181(1 Meeting Abstracts):A6801.

Pascual RM, Moore WC, Peters SP, Li H, Wenzel SE, Meyers DA, Weiss ST, Litonjua AA, Bleecker ER. Serum vitamin D levels are inversely correlated with FEV1 and FVC in asthma [abstract]. Am J Respir Crit Care Med. 2010;181(1 Meeting Abstracts):A6800.

Pascual RM, Bleecker ER. Pharmacogenetics of asthma. Curr Opin Pharmacol. 2010;10(3):226-235.

Loza MJ, Foster S, Bleecker ER, Peters SP, Penn RB. Asthma and gender impact accumulation of T cell subtypes. Respir Res. 2010;11():art. 103.

Brasier AR, Victor S, Ju H, Busse WW, Curran-Everett D, Bleecker E, Castro M, Chung KF, Gaston B, Israel E, et al. Predicting intermediate phenotypes in asthma using bronchoalveolar lavage-derived cytokines. Clin Transl Sci. 2010;3(4):147-157.

Djukanovic R, Wilson SJ, Moore WC, Koenig SM, Laviolette M, Bleecker ER, Davis WB, Doherty DE, Olivenstein R, Israel E, et al. Montelukast added to fluticasone propionate does not alter inflammation or outcomes. Respir Med. 2010;104(10):1425-1435.

Bhatti SK, Hastie AT, Moore WC, Peters SP, Dykewicz MS, Bleecker ER. Increased numbers of macrophages and neutrophils are associated with decreased interleukin-33 (IL-33) levels in asthmatic sputum [abstract]. J Allergy Clin Immunol. 2010;125(2 Suppl 1):AB109.

Hawkins GA, Robinson MB, Moore WC, Hastie AT, Peters SP, Meyers DA, Bleecker ER. Serum levels of soluble IL6R are genetically regulated and correlate with lung function in asthmatics: Severe Asthma Research Program (SARP) [abstract]. J Allergy Clin Immunol. 2010;125(2 Suppl 1):AB357.

Peters SP, Kunselman SJ, Icitovic N, Moore WC, Pascual R, Ameredes BT, Boushey HA, Calhoun WJ, Meyers DA, Bleecker ER, et al. Tiotropium bromide step-up therapy for adults with uncontrolled asthma. N Engl J Med. 2010;363(18):1715-1726.

Slager RE, Hawkins GA, Ampleford EJ, Bowden A, Stevens LE, Morton MT, Tomkinson A, Wenzel SE, Bleecker ER, Meyers DA, et al. IL-4 receptor alpha polymorphisms are predictors of a pharmacogenetic response to a novel IL-4/IL-13 antagonist [letter]. J Allergy Clin Immunol. 2010;126(4):875-878.

Slager RE, Hawkins GA, Ampleford EJ, Bowden A, Stevens LE, Morton MT, Tomkinson A, Wenzel SE, Bleecker ER, Meyers DA, et al. The need for standardization in exercise challenge testing for exercise-induced asthma/bronchoconstriction [letter]. J Allergy Clin Immunol. 2010;126(4):878-880.

Sutherland ER, King TS, Icitovic N, Ameredes BT, Bleecker E, Boushey HA, Calhoun WJ, Castro M, cherniack RM, Peters SP, et al. A trial of clarithromycin for the treatment of suboptimally controlled asthma. J Allergy Clin Immunol. 2010;126(4):747-753.

Bousquet J, Mantzouranis E, Cruz AA, Ait-Khaled N, Baena-Cagnani CE, Bleecker ER, Brightling CE, Burney P, Bush A, Busse WW, et al. Uniform definition of asthma severity, control, and exacerbations: document presented for the World Health Organization Consultation on Severe Asthma. J Allergy Clin Immunol. 2010;126(5):926-938.

Gamble C, Talbott E, Youk A, Holguin F, Pitt B, Silveira L, Bleecker E, Busse W, Calhoun W, Castro M, et al. Racial differences in biologic predictors of severe asthma: data from the Severe Asthma Research Program. J Allergy Clin Immunol. 2010;126(6):1149-1156.

Goldman M, Lawrance RM, Bleecker ER, Meyers DA, Ambrose HJ. Effect of polymorphisms in the ADRB2 3 ' untranslated region (3 ' UTR) on response to inhaled corticosteroid and long-acting beta(2)-adrenergic agonist (ICS/LABA) combination therapy [abstract]. J Allergy Clin Immunol. 2009;123(2 Suppl):S137.

Haselkorn T, Fish JE, Zeiger RS, Szefler SJ, Miller DP, Chipps BE, Weiss ST, Wenzel SE, Borish L, Bleecker ER. Asthma control and risk of future asthma exacerbations: evaluation of the impairment domain of the NHLBI guidelines in the TENOR Cohort [abstract]. J Allergy Clin Immunol. 2009;123(2 Suppl):S80.

Sadeghnejad A, Ohar JA, Zheng SL, Sterling DA, Hawkins GA, Meyers DA, Bleecker ER. Adam33 polymorphisms are associated with COPD and lung function in long-term tobacco smokers. Respir Res. 2009;10():article 21.

Sadeghnejad A, Bleecker E, Meyers DA. Principles of genetics in allergic diseased and asthma In: Adkinson NF Jr, Bochner BS, Busse WW, Holgate ST, Lemanske RF Jr, Simons FER, eds. Middleton's allergy: principles & practice. 7th ed. Philadelphia: Mosby/Elsevier;2009: 59-72.

Wenzel SE, Barnes PJ, Bleecker ER, Bousquet J, Busse W, Dahlen S-E, Holgate ST, Meyers DA, Rabe KF, Antczak A, et al. A randomized, double-blind, placebo-controlled study of tumor necrosis factor-alpha blockade in severe persistent asthma. Am J Respir Crit Care Med. 2009;179(7):549-558.

Sadeghnejad A, Koppelman GH, Ohar JA, Postma DS, Bleecker ER, Meyers DA. Role of SERPINE2 in asthma and COPD [abstract]. Am J Respir Crit Care Med. 2009;179(Online Abstr Issue):A2741.

Ohar JA, Sadeghnejad A, Meyers DA, Bleecker ER. Symptoms poorly predict the presence of COPD in at-risk smokers [abstract]. Am J Respir Crit Care Med. 2009;179(Online Abstr Issue):A1471.

Hastie AT, Moore WC, Meyers DA, Vestal PL, Krings JO, Smith RA, Li H, Peters SP, Bleecker ER. Inflammatory protein analyses of sputum from human subjects with severe or nonsevere asthma [abstract]. Am J Respir Crit Care Med. 2009;179(Online Abstr Issue):A3925.

Breit JS, Hastie AT, Vestal PL, Moore WC, Peters SP, Bleecker ER. Stem cell factor and cKit from asthmatic and normal subjects' epithelial cells and fibroblasts in response to inflammatory mediators [abstract]. Am J Respir Crit Care Med. 2009;179(Online Abstr Issue):A5444.

Laber DM, Hastie AT, Peters SP, Bleecker ER. Quantitative skin testing in asthmatic subjects enrolled in the Severe Asthma Research Program [abstract]. J Allergy Clin Immunol. 2009;123(3):730.

Hawkins GA, Lazarus R, Smith RS, Tantisira KG, Meyers DA, Peters SP, Weiss ST, Bleecker ER. The glucocorticoid receptor heterocomplex gene STIP1 is associated with improved lung function in asthmatic subjects treated with inhaled corticosteroids. J Allergy Clin Immunol. 2009;123(6):1376-1383.

Haselkorn T, Fish JE, Zeiger RS, Szefler SJ, Miller DP, Chipps BE, Simons FER, Weiss ST, Wenzel SE, Bleecker ER, et al. Consistently very poorly controlled asthma, as defined by the impairment domain of the Expert Panel Report 3 guidelines, increases risk for future severe asthma exacerbations in The Epidemiology and Natural History of Asthma:. J Allergy Clin Immunol. 2009;124(5):895-902.

Koppelman GH, Meyers DA, Howard TD, Zheng SL, Hawkins GA, Ampleford EJ, Xu J, Koning H, Bruinenberg M, Bleecker ER, et al. Identification of PCDH1 as a novel susceptibility gene for bronchial hyperresponsiveness. Am J Respir Crit Care Med. 2009;180(10):929-935.

Wechsler ME, Kunselman SJ, Chinchilli VM, Bleecker E, Boushey HA, Calhoun WJ, Ameredes BT, Castro M, Craig TJ, Peters SP, et al. Effect of beta2-adrenergic receptor polymorphism on response to longacting beta2 agonist in asthma (LARGE trial): a genotype-stratified, randomised, placebo-controlled, crossover trial. Lancet. 2009;374(9703):1754-1764.

Ortega VE, Hawkins GA, Meyers DA, Bleecker ER. Characterization of asthma cases and controls with rare beta2 adrenergic receptor gene polymorphisms in a multi-ethnic population [abstract]. Am J Respir Crit Care Med. 2009;179(1 Meeting Abstracts):A5434.

Koppelman GH, Meyers DA, Howard TD, Zheng SL, Hawkins GA, Ampleford EA, Xu J, Koning H, Bruinenberg M, Bleecker ER, et al. Identification of protocadherin-1 as a novel susceptibility gene for bronchial hyperresponsiveness and asthma [abstract]. Am J Respir Crit Care Med. 2009;179(1 Meeting Abstracts):A2447.

Moore WC, Meyers DA, Li H, D'Agostino R, Peters SP, Bleecker ER. Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program [abstract]. Am J Respir Crit Care Med. 2009;179(1 Meeting Abstracts):A2522.

Crowley MB, Moore WC, Smith RV, Meyers DA, Peters SP, Bleeker ER [sic] [Bleecker ER]. The effect of specific air pollutants on FEV1 variability in the Severe Asthma Research Program [abstract]. Am J Respir Crit Care Med. 2009;179(1 Meeting Abstracts):A1291.

Moore WC, Meyers DA, Li H, Peters SP, Bleecker ER. The importance of the 3rd controller medication in the Severe Asthma Research Program [abstract]. Am J Respir Crit Care Med. 2009;179(1 Meeting Abstracts):A2806.

Pascual RM, Slager RE, Li H, Hawkins GA, Peters SP, Moore WC, Meyers DA, Bleecker ER. GATA3 polymorphisms are associated with baseline and maximal post-bronchodilator FEV1 in Severe Asthma Research Program (SARP) asthmatics [abstract]. Am J Respir Crit Care Med. 2009;179(1 Meeting Abstracts):A2449.

Slager RE, Diallo A, Hawkins GA, Bowden A, Stevens L, Morton M, Tomkinson A, Longphre M, Bleecker ER, Meyers DA. IL4R polymorphisms are associated with response to IL4/IL13 receptor antagonist (Aerovant) in human asthmatics and non-human primates [abstract]. Am J Respir Crit Care Med. 2009;179(1 Meeting Abstracts):A5417.

Xu J, Zheng SL, Herrington DM, Bleecker E, Meyers D, Isaacs W, Walsh P, inventors; Wake Forest University Health Sciences, assignee. Mutations in the macrophage scavenger receptor 1 gene alter risk of prostate cancer, asthma, and cardiovascular disease. United States patent US 7,579,147. 2009 Aug 25. 2009;():.

Ortega VE, Meyers DA, Bleecker ER, Hawkins GA. Methylation-specific sequencing of the beta2 adrenergic receptor gene in asthma cases and controls [abstract]. Am J Respir Crit Care Med. 2009;179(Meeting Abstracts):A5433.

Giaccaglia V, Nicklas B, Kritchevsky S, Mychalecky J, Messier S, Bleecker E, Pahor M. Interaction between angiotensin converting enzyme insertion/deletion genotype and exercise training on knee extensor strength in older individuals. Int J Sports Med. 2008;29(1):40-44.

Hawkins GA, Weiss ST, Bleecker ER. Clinical consequences of ADRbeta2 polymorphisms. Pharmacogenomics. 2008;9(3):349-358.

Zheng SL, Sun J, Smith S, Li G, Hsu F-C, Zhu Y, Kader AK, Turner AR, Liu W, Bleecker ER, Meyers DA, Chang B-L, Xu J, et al. Cumulative association of five genetic variants with prostate cancer. N Engl J Med. 2008;358(9):910-919.

Brasier AR, Victor S, Boetticher G, Ju H, Lee C, Bleecker ER, Castro M, Busse WW, Calhoun WJ. Molecular phenotyping of severe asthma using pattern recognition of bronchoalveolar lavage-derived cytokines. J Allergy Clin Immunol. 2008;121(1):30-37.

Panebra A, Schwarb MR, Swift SM, Weiss ST, Bleecker ER, Hawkins GA, Liggett SB. Variable-length poly-C tract polymorphisms of the beta2-adrenergic receptor 3 '-UTR alter expression and agonist regulation. Am J Physiol Lung Cell Mol Physiol. 2008;294(2):L190-L195.

Sorkness RL, Bleecker ER, Busse WW, Calhoun WJ, Castro M, Chung KF, Curran-Everett D, Erzurum SC, Moore WC, Peters SP, et al. Lung function in adults with stable but severe asthma: air trapping and incomplete reversal of obstruction with bronchodilation. J Appl Physiol. 2008;104(2):394-403.

Anderson W, Bleecker ER, Nelson H, Corren J, Emmett A, Reilly D, Yancey S, Ortega H. Lack of effect of promoter, coding and 3' polymorphisms of the beta2-adrenergic receptor (ADRB2) on the clinical response to salmeterol alone or with fluticasone propionate in subjects with asthma [abstract]. J Allergy Clin Immunol. 2008;121(2 Suppl 1):S143.

Bleecker ER, Nelson H, Corren J, Kraft M, Yancey S, Ortega H, Reilly D, Emmett A, Anderson W. Ary16Gly polymorphism of the beta2-adrenergic receptor gene does not modulate clinical response to salmeterol in subjects with asthma [abstract]. J Allergy Clin Immunol. 2008;121(2 Suppl 1):S143.

Meyers DA, Hawkins GA, Wenzel SA, Lo K, Watt R, Bleecker ER. Pharmacogenetic identification of increased responsiveness in severe asthma with anti-TNF (Golimumab) therapy [abstract]. J Allergy Clin Immunol. 2008;121(3):798.

Nelson H, Bleecker ER, Corren J, Yancey S, Ortega H, Reilly D, Emmett A, Anderson W. Characterization of asthma exacerbations by Arg16Gly genotype in subjects with asthma receiving salmeterol alone or with fluticasone propionate [abstract]. J Allergy Clin Immunol. 2008;121(2 Suppl 1):S131.

Chen H, Blanc PD, Hayden ML, Bleecker ER, Chawla A, Lee JH. Assessing productivity loss and activity impairment in severe or difficult-to-treat asthma. Value Health. 2008;11(2):231-239.


Hite RD, Hastie AT, Seeds MC, Grier BL, Peters SP, Moore WC, Bleecker ER. Surfactant alterations in asthmatics from the Wake Forest Severe Asthma Research Program Center [abstract]. Am J Respir Crit Care Med. 2008;177(Abstr Issue):A100.

Wang WCH, Mihlbachler KA, Bleecker ER, Weiss ST, Liggett SB. A polymorphism of G-protein coupled receptor kinase5 alters agonist-promoted desensitization of beta2-adrenergic receptors. Pharmacogenet Genomics. 2008;18(8):729-732.


Lara A, Khatri SB, Wang Z, Comhair SAA, Xu W, Dweik RA, Bodine M, Bleecker E, Moore W, Peters SP, et al. Alterations of the arginine metabolome in asthma. Am J Respir Crit Care Med. 2008;178(7):673-681.

Litonjua AA, Lasky-Su J, Schneiter K, Tantisira KG, Lazarus R, Klanderman B, Peters SP, Hawkins GA, Meyers DA, Bleecker ER, et al. ARG1 is a novel bronchodilator response gene: screening and replication in four asthma cohorts. Am J Respir Crit Care Med. 2008;178(7):688-694.

Planaguma A, Kazani S, Marigowda G, Haworth O, Mariani TJ, Israel E, Bleecker ER, Curran-Everett D, Erzurum SC, Calhoun WJ, et al. Airway lipoxin A4 generation and lipoxin A4 receptor expression are decreased in severe asthma. Am J Respir Crit Care Med. 2008;178(6):574-582.

Reijmerink NE, Postma DS, Bruinenberg M, Nolte IM, Meyers DA, Bleecker ER, Koppelman GH. Association of IL1RL1, IL18R1, and IL18RAP gene cluster polymorphisms with asthma and atopy [letter]. J Allergy Clin Immunol. 2008;122(3):651-654.

Smith AK, Lange LA, Ampleford EJ, Meyers DA, Bleecker ER, Howard TD. Association of polymorphisms in CASP10 and CASP8 with FEV1/FVC and bronchial hyperresponsiveness in ethnically diverse asthmatics. Clin Exp Allergy. 2008;38(11):1738-1744.

Walter MJ, Castro M, Kunselman SJ, Chinchilli VM, Reno M, Ramkumar TP, Avila PC, Boushey HA, Bleecker ER, Peters SP, et al. Predicting worsening asthma control following the common cold. Eur Respir J. 2008;32(6):1548-1554.

Ohar JA, Holian A, Sadeghnejad A, Hamilton RF, Zheng SL, Xu J, Meyers DA, Bleecker ER. Polymorphisms in MSR1 gene affect macrophage function [abstract]. Am J Respir Crit Care Med. 2008;177(Online Abstr Issue):A503.

Sadeghnejad A, Ohar JA, Zheng SL, Hawkins GA, Meyers DA, Bleecker ER. ADAM33 polymorphisms are associated with COPD and lung function in long-term tobacco smokers [abstract]. Am J Respir Crit Care Med. 2008;177(Online Abstr Issue):A504.

Perry CD, Hawkins GA, Hastie AT, Cauthen CG, Diallo A, Li H, Moore WC, Meyers DA, Peters SP, Bleecker ER. Genetic variation in pulmonary and activation-regulated chemokine (PARC/CCL18) in asthma [abstract]. Am J Respir Crit Care Med. 2008;177(Online Abstr Issue):A338.

Cauthen CG, Hastie AT, Wu M, Vestal PL, Moore WC, Krings J, Smith RV, Bleecker ER, Peters SP. Collagen type I fragments associate with cytokines and cell counts in sputum of severe and nonsevere asthmatics [abstract]. Am J Respir Crit Care Med. 2008;177(Online Abstr Issue):A813.

Hastie AT, Vestal PL, Moore WC, Krings J, Smith RV, Peters SP, Bleecker ER. Proteomic microarray analyses of sputum from subjects with asthma compared to subjects with chronic obstructive pulmonary disease (COPD) [abstract]. Am J Respir Crit Care Med. 2008;177(Online Abstr Issue):A960.

Bleecker ER. Pharmacogenetics of asthma. US Respir Dis. 2008;4():39-44.

Ortega VE, Hawkins GA, Harkins M, Meyers DA, Bleecker ER. Sequencing of the beta2 adrenergic receptor gene and association with asthma susceptibility in a US Hispanic population from New Mexico [abstract]. Am J Respir Crit Care Med. 2008;177(Meeting Abstracts):A334.

Surka AE, McCallister JW, Hastie AT, Moore WC, Vestel [sic] PL [Vestal PL], Krings J, Smith R, Peters SP, Bleecker ER. Levels of tumor necrosis factor alpha (TNFa) and brain derived neurotrophic factor (BDNF) correlate in sputum but not in serum [abstract]. Am J Respir Crit Care Med. 2007;175(Abstr Issue):A681.

Moore WC, Bleecker ER, Curran-Everett D, Erzurum SC, Ameredes BT, Bacharier L, Calhoun WJ, Castro M, Peters SP, Meyers DA, et al. Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research Program. J Allergy Clin Immunol. 2007;119(2):405-413.


Wenzel SE, Balzar S, Ampleford E, Hawkins GA, Busse WW, Calhoun WJ, Castro M, Chung KF, Meyers DA, Bleecker ER, et al. IL4R alpha mutations are associated with asthma exacerbations and mast cell/IgE expression. Am J Respir Crit Care Med. 2007;175(6):570-576.

Bleecker ER, Postma DS, Lawrance R, Meyers DA, Ambrose H, Goldman M. Effect of polymorphisms in the beta2-adrenergic receptor gene (ADRB2) on response to long-acting beta2-agonist (LABA) therapy [abstract]. J Allergy Clin Immunol. 2007;119(2):524-525.

Smith RS, Meyers DA, Peters SP, Moore WC, Wenzel SA, Bleecker ER, Hawkins GA. Sequence analysis of HSPA1A and HSPA1B in a multi-ethnic study population. DNA Seq. 2007;18(1):47-53.

Surka AE, Hastie AT, Moore WC, Wu M, Krings J, Smith R, Peters SP, Bleecker ER. Corticosteroid effect on brain derived neurotrophic factor (BDNF) in serum and sputum of asthmatics in vivo, and in asthmatic sputum cells and airway fibroblasts in vitro [abstract]. Am J Respir Crit Care Med. 2007;175(Abstr Issue):A56.

Hastie AT, Wenzel SE, Chung KF, Busse WW, Bleecker ER. Relationship of sputum cells with pulmonary function, symptoms and health-care utilization as a function of asthma severity [abstract]. Am J Respir Crit Care Med. 2007;175(Abstr Issue):A153.

Berger WE, Bleecker ER, O'Dowd L, Miller CJ, Mezzanotte WS. Efficacy of once-daily budesonide (BUD) and formoterol (FM) administered via one pressurized metered-dose inhaler (pMDI) in asthma patients [abstract]. Am J Respir Crit Care Med. 2007;175(Abstr Issue):A188.

Bleecker ER, Berger WE, O'Dowd L, Miller CJ, Mezzanotte WS. Safety of once-daily budesonide (BUD) and formoterol (FM) administered via one pressurized metered-dose inhaler (pMDI) in patients with asthma [abstract]. Am J Respir Crit Care Med. 2007;175(Abstr Issue):A190.

Berger WE, Bleecker ER, O'Dowd L, Miller CJ, Mezzanotte WS. Asthma control with once-daily budesonide/formoterol (BUD/FM) pressurized metered-dose inhaler [abstract]. Am J Respir Crit Care Med. 2007;175(Abstr Issue):A191.

Ortega VE, Montealegre F, Chardon D, Meyers DA, Diallo AF, Ampleford EJ, Hawkins GA, Bleecker ER. Sequencing of the beta2 adrenergic receptor gene in Puerto Ricans with asthma [abstract]. Am J Respir Crit Care Med. 2007;175(Abstr Issue):A461.

McCallister JW, Moore WC, Hastie AT, Vestal PL, Ampleford EJ, Hawkins GA, Wenzel SE, Meyers DA, Bleecker ER. Association of polymorphisms in the tumor necrosis factor-alpha (TNFalpha) gene with levels of TNFalpha and pulmonary function in asthma [abstract]. Am J Respir Crit Care Med. 2007;175(Abstr Issue):A462.

Sadeghnejad A, Meyers DA, Bleeker [sic] ER [Bleecker ER], Ohar JA. IL13 promoter polymorphism enhances the adverse effect of smoking on lung function [abstract]. Am J Respir Crit Care Med. 2007;175(Abstr Issue):A563.

McCallister JW, Hastie AT, Moore WC, Vestal PL, Krings JO, Smith RV, Peters SP, Bleecker ER. Lack of correlation between sputum, exhaled breath condensate and serum levels of tumor necrosis factor-alpha (TNFalpha) in asthma [abstract]. Am J Respir Crit Care Med. 2007;175(Abstr Issue):A684.

Moore WC, Everett DC, Bleecker ER, Wenzel SE. Racial differences in health care utilization in the Severe Asthma Research Program [abstract]. Am J Respir Crit Care Med. 2007;175(Abstr Issue):A829.

Smith RS, Li H, Ampleford EA, Peters SP, Moore WC, Meyers DA, Bleecker ER, Hawkins GA. Steroid complex immunophilia FKBP4 is associated with severe asthma [abstract]. Am J Respir Crit Care Med. 2007;175(Abstr Issue):A833.

Meyers DA, Wenzel SE, Hawkins GA, Bleecker ER. ADAM33: association with asthma severity phenotypes, pulmonary function and air trapping in CT scans [abstract]. Am J Respir Crit Care Med. 2007;175(Abstr Issue):A969.

Penn RB, Ortega VE, Bleecker ER. A roadmap to functional genomics. Physiol Genomics. 2007;30(1):82-88.

Bleecker E, Tashkin D, Peters S, Long A, O'Connor R, Parasuraman B, Boggs R. A 4-year assessment of severe and non-severe asthma in a real-world setting [abstract]. Value Health. 2007;10(3):A111.

Long A, Bleecker E, O'Connor R, Tashkin D, Peters S, Silkoff P, Parasuraman B, Boggs R. A 4-year assessment of sub-acute lack of asthma control in a real-world setting [abstract]. Value Health. 2007;10(3):A112.

Sadeghnejad A, Meyers DA, Bottai M, Sterling DA, Bleecker ER, Ohar JA. IL13 promoter polymorphism -1112C/T modulates the adverse effect of tobacco smoking on lung function. Am J Respir Crit Care Med. 2007;176(8):748-752.

Bleecker ER, Anderson WH, Dorinsky PM. Beta-adrenergic receptor genotype and response to salmeterol [reply to letter]. J Allergy Clin Immunol. 2007;120(1):219-220.

Ortega VE, Hawkins GA, Peters SP, Bleecker ER. Pharmacogenetics of the beta2-adrenergic receptor gene. Immunol Allergy Clin North Am. 2007;27(4):665-684.

Bleecker ER, Postma DS, Lawrance RM, Meyers DA, Ambrose HJ, Goldman M. Effect of ADRB2 polymorphisms on response to longacting beta2-agonist therapy: a pharmacogenetic analysis of two randomised studies. Lancet. 2007;370(9605):2118-2125.

Duggan D, Zheng SL, Dimitrov L, Cheng Y, Li G, Sun J, Chang B-L, Liu W, Kim JW, Bleecker ER, Meyers DA, Xu J, et al. Two genome-wide association studies of aggressive prostate cancer implicate putative prostate tumor suppressor gene DAB21P. J Natl Cancer Inst. 2007;99(24):1836-1844.

Bleecker E, Yancey S, Ortega H, Anderson W. Arginine 16 genotype does not modulate clinical response to salmeterol in subjects with asthma [abstract]. Chest. 2007;132(4 Suppl):436S.

Meyers DA, Bleecker ER. Asthma In: Rimoin DL, Connor JM, Pyeritz R, Korf B, eds. Emery and Rimoin's principles and practice of medical genetics, vol II. 5th ed. Philadephia: Chruchill Livingstone Elsevier;2007: 1395-1405.

Zheng SL, Liu W, Dimitrov L, Sun J, Sun J, Chang B, Loza M, Turner AR, Bleecker ER, Meyers DA, Xu J, et al. A comprehensive association study for genes in inflammation pathway provides support for their roles in prostate cancer risk in the CAPS Study. Prostate. 2006;66(14):1556-1564.

Hawkins GA, Tantisira K, Meyers DA, Ampleford EJ, Moore WC, Klanderman B, Liggett SB, Peters SP, Weiss ST, Bleecker ER. Sequence, haplotype and association analysis of ADRbeta2 in a multiethnic asthma case-control study. Am J Respir Crit Care Med. 2006;174(10):1101-1109.

Bleecker ER, Yancey SW, Baitinger LA, Edwards LD, Klotsman M, Anderson WH, Dorinsky PM. Salmeterol response is not affected by beta2-adrenergic receptor genotype in subjects with persistent asthma. J Allergy Clin Immunol. 2006;118(4):809-816.

Weiss ST, Litonjua AA, Lange C, Lazarus R, Liggett SB, Bleecker ER, Tantisira KG. Overview of the pharmacogenetics of asthma treatment. Pharmacogenomics J. 2006;6(5):311-326.

Ohar JA, Ampleford EJ, Sterling DA, Bleecker ER, Meyers DA. ADAM33 is associated with COPD in a large US population [abstract]. In: American Thoracic Society International Conference Abstracts; 2006 May 19-24; San Diego (CA). 2006;():A620.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Translational Science Institute

Clinical Specialties

General Pulmonary Diseases, Chronic Obstructive Pulmonary Disease (COPD), Asthma

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