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Eugene Bleecker, M.D.Wake Forest School of Medicine

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Eugene Bleecker, M.D.

Director,
Professor,


Clinical Interests

General Pulmonary Diseases, Chronic Obstructive Pulmonary Disease (COPD), Asthma

Contact Information

Department: 336-716-2011

Email: ebleeck@wakehealth.edu

Insurance Accepted »

Education & Training

  • B.A., New York University, 1964
  • M.D., SUNY Brooklyn College of Medicine, 1968
  • Internship, Kings Cnty Hosp Ctr, 1969
  • Residency, Kings Cnty Hosp Ctr, 1970
  • Residency, Johns Hopkins Hosp, 1973
  • Fellowship, Pulmonary Disease, University of California-San F, 1975

Board Certifications

  • American Board of Internal Medicine, Internal Medicine
  • American Board of Internal Medicine, Pulmonary Disease

Memberships

  • Johns Hopkins Medical & Surgic
  • Maryland Thoracic Society
  • Amer Coll Of Chest Physicians
  • Am Physiological Society
  • Am Soc of Human Genetics
  • Am Academy Of Allergy & Immuno
  • Gerontological Society Of Amer

NPI Number

  • 1811971104
Eugene Bleecker, M.D.

Doctor Rating

No Rating Available
Why No Ratings?

Eugene Bleecker, M.D.

Director, Center for Genomics and Personalized Medicine Research
Professor, Center for Genomics and Personalized Medicine Research
Pulmonary, Critical Care, Allergy, and Immunologic Medicine
Pediatrics

Research Interests

Asthma; Anti-Asthmatic Agents; Androstadienes; Adrenal Cortex Hormones; Polymorphism, Single Nucleotide
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Contact Information

Academic: 336-713-7500 | Department: 336-716-2011

Email: ebleeck@wakehealth.edu

Recent Publications

Inflammatory and comorbid features of patients with severe asthma and frequent exacerbations. Denlinger LC, Phillips BR, Ramratnam S, Ross K, Bhakta NR, Cardet JC, Castro M, Peters SP, Phipatanakul W, Aujla S, Bacharier LB, Bleecker ER, Comhair SA, Coverstone A, DeBoer M, Erzurum SC, Fain SB, Fajt M, Fitzpatrick AM, Gaffin J, Gaston B,.. Am J Respir Crit Care Med. 2017;195(3):302-313.

Effects of bronchoscopy on lung function in asthmatics. Bellinger C, Bleecker ER, Peters SP, Pascual RM, Krings J, Smith RV, Hasties A [sic] [Hastie A], Moore WC.. J Asthma. 2017;():.

Understanding the impact of second-hand smoke exposure on clinical outcomes in participants with COPD in the SPIROMICS cohort. Putcha N, Barr RG, Han MK, Woodruff PG, Bleecker ER, Kanner RE, Martinez FJ, Smith BM, Tashkin DP, Bowler RP, Eisner MD, Rennard SI, Wise RA, Hansel NN.. Thorax. 2016;():.

Expression of asthma susceptibility genes in bronchial epithelial cells and bronchial alveolar lavage in the Severe Asthma Research Program (SARP) cohort. Li X, Hawkins GA, Moore WC, Hastie AT, Ampleford EJ, Milosevic J, Li H, Busse WW, Erzurum SC, Kaminski N, Wenzel SE, Bleecker ER, Meyers DA.. J Asthma. 2016;53(8):775-782.

Severe eosinophilic asthma treated with mepolizumab stratified by baseline eosinophil thresholds: a secondary analysis of the DREAM and MENSA studies. Ortega HG, Yancey SW, Mayer B, Gunsoy NB, Keene ON, Bleecker ER, Brightling CE, Pavord ID.. Lancet Respir Med. 2016;4(7):549-556.

Clinical significance of symptoms in smokers with preserved pulmonary function. Woodruff PG, Barr RG, Bleecker E, Christenson SA, Couper D, Curtis JL, Gouskova NA, Hansel NN, Hoffman EA, Kanner RE, Kleerup E, Lazarus SC, Martinez FJ, Paine R III, Rennard S, Tashkin DP, Han MK.. N Engl J Med. 2016;374(19):1811-1821.

Efficacy and safety of ipratropium bromide/albuterol compared with albuterol in patients with moderate-to-severe asthma: a randomized controlled trial. Donohue JF, Wise R, Busse WW, Garfinkel S, Zubek VB, Ghafouri M, Manuel RC, Schlenker-Herceg R, Bleecker ER.. BMC Pulm Med. 2016;16(1):65.

Exacerbation reduction in severe eosinophilic asthma based on eosinophil thresholds [abstract]. Yancey SW, Mayer B, Gunsoy N, Keene ON, Bleecker EG, Brightling C, Pavord I.. J Allergy Clin Immunol. 2016;137(2 Suppl):AB208.

Impact of age and sex on outcomes and hospital cost of acute asthma in the United States, 2011-2012. Zein JG, Udeh BL, Teague WG, Koroukian SM, Schlitz NK, Bleecker ER, Busse WB, Calhoun WJ, Castro M, Comhair SA, Fitzpatrick AM, Israel E, Wenzel SE, Holguin F, Gaston BM, Erzurum SC.. PLoS One. 2016;11(6):e0157301.

Plasma interleukin-6 concentrations, metabolic dysfunction, and asthma severity: a cross-sectional analysis of two cohorts. Peters MC, McGrath KW, Hawkins GA, Hastie AT, Levy BD, Israel E, Phillips BR, Mauger DT, Comhair SA, Erzurum SC, Johansson MW, Jarjour NN, Coverstone AM, Castro M, Holguin F, Wenzel SE, Woodruff PG, Bleecker ER, Fahy JV.. Lancet Respir Med. 2016;4(7):574-584.

SPIROMICS protocol for multicenter quantitative computed tomography to phenotype the lungs. Sieren JP, Newell JD Jr, Barr RG, Bleecker ER, Burnette N, Carretta EE, Couper D, Goldin J, Guo J, Han MK, Hansel NN, Kanner RE, Kazerooni EA, Martinez FJ, Rennard S, Woodruff PG, Hoffman EA.. Am J Respir Crit Care Med. 2016;194(7):794-806.

Efficacy and safety of benralizumab for patients with severe asthma uncontrolled with high-dosage inhaled corticosteroids and long-acting beta2-agonists (SIROCCO): a randomised, multicentre, placebo-controlled phase 3 trial. Bleecker ER, FitzGerald JM, Chanez P, Papi A, Weinstein SF, Barker P, Sproule S, Gilmartin G, Aurivillius M, Werkstrom V, Goldman M.. Lancet. 2016;388(10056):2115-2127.

Benralizumab, an anti-interleukin-5 receptor alpha monoclonal antibody, as add-on treatment for patients with severe, uncontrolled, eosinophilic asthma (CALIMA): a randomised, double-blind, placebo-controlled phase 3 trial. FitzGerald JM, Bleecker ER, Nair P, Korn S, Ohta K, Lommatzsch M, Ferguson GT, Busse WW, Barker P, Sproule S, Gilmartin G, Werkstrom V, Aurivillius M, Goldman M.. Lancet. 2016;388(10056):2128-2141.

Biomarkers predictive of exacerbations in the SPIROMICS and COPDGene cohorts. Keene JD, Jacobson S, Kechris K, Kinney GL, Foreman MG, Doerschuk CM, Make BJ, Curtis JL, Rennard SI, Barr RG, Bleecker ER, Kanner RE, Kleerup EC, Hansel NN, Woodruff PG, Han MK, Paine Iii R, Martinez FJ, Bowler RP, O'Neal WK.. Am J Respir Crit Care Med. 2016;():.

Age and small airway imaging abnormalities in subjects with and without airflow obstruction in SPIROMICS. Martinez CH, Diaz AA, Meldrum C, Curtis JL, Cooper CB, Pirozzi C, Kanner RE, Paine Iii R, Woodruff PG, Bleecker ER, Hansel NN, Barr RG, Marchetti N, Criner GJ, Kazerooni EA, Hoffman EA, Ross BD, Galban CJ, Cigolle CT, Martinez FJ, Han MK.. Am J Respir Crit Care Med. 2016;():.

Serious asthma events with budesonide plus formoterol vs. budesonide alone. Peters SP, Bleecker ER, Canonica GW, Park YB, Ramirez R, Hollis S, Fjallbrant H, Jorup C, Martin UJ.. N Engl J Med. 2016;375(9):850-860.

Common genetic polymorphisms influence blood biomarker measurements in COPD. Sun W, Kechris K, Jacobson S, Drummond MB, Hawkins GA, Yang J, Chen TH, Quibrera PM, Anderson W, Barr RG, Basta PV, Bleecker ER, Beaty T, Casaburi R, Castaldi P, Cho MH, Comellas A, Crapo JD, Criner G, Demeo D, Christenson SA, Couper DJ,.. PLoS Genet. 2016;12(8):e1006011.

Meta-analysis of asthma-related hospitalization in mepolizumab studies of severe eosinophilic asthma. Yancey SW, Ortega HG, Keene ON, Mayer B, Gunsoy NB, Brightling CE, Bleecker ER, Haldar P, Pavord ID.. J Allergy Clin Immunol. 2016;():.

A continuum of admixture in the Western Hemisphere revealed by the African Diaspora genome. Mathias RA, Taub MA, Gignoux CR, Fu W, Musharoff S, O'Connor TD, Vergara C, Torgerson DG, Pino-Yanes M, Shringarpure SS, Huang L, Rafaels N, Boorgula MP, Johnston HR, Ortega VE, Levin AM, Song W, Torres R, Padhukasahasram B, Eng C,.. Nat Commun. 2016;7():12522.

Journal of thoracic disease (impact and influence of real-life respiratory research abstracts from the respiratory effectiveness group 2016 Summit) abstracts. Nibber A, Thomas M, Thomas V, van Aalderen W, Bleecker E, Campbell J, Roche N, Haughney J, Van Ganse E, Park HY, Rhee CK, Skinner D, Chisholm A, van Boven JFM, Soriano JB, Price D.. J Thorac Dis. 2016;8(Suppl 5):.

Gene expression correlated to severe asthma characteristics reveals heterogeneous mechanisms of severe disease. Modena BD, Bleecker ER, Busse WW, Erzurum SC, Gaston BM, Jarjour NN, Meyers DA, Milosevic J, Tedrow JR, Wu W, Kaminski N, Wenzel SE.. Am J Respir Crit Care Med. 2016;():.

Effects of age and disease severity on systemic corticosteroid responses in asthma. Phipatanakul W, Mauger DT, Sorkness RL, Gaffin JM, Holguin F, Woodruff PG, Ly NP, Bacharier LB, Bhakta NR, Moore WC, Bleecker ER, Hastie AT, Meyers DA, Castro M, Fahy J, Fitzpatrick A, Gaston BM, Jarjour NN, Levy BD, Peters SP, Teague WG,.. Am J Respir Crit Care Med. 2016;():.

Asthma heterogeneity and severity. Carr TF, Bleecker E.. World Allergy Organ J. 2016;9(1):41.

Functional small airway abnormalities increase with age among never and ever-smokers without airflow obstruction. An analysis of the Spiromics Cohort [abstract]. Martinez CH, Diaz AA, Curtis JL, Cooper CB, Pirozzi C, Kanner R, Paine R III, Woodruff PG, Bleecker E, Hansel NN, Barr RG, Kazerooni E, Hoffman EA, Ross BD, Galban C, Cigolle CT, Martinez FJ, Han MK.. Am J Respir Crit Care Med. 2016;193():A4277.

Small airway disease is associated with patient-centered outcomes among smokers with moderate obstructive lung disease. An analysis of the Spiromics Cohort [abstract]. Martinez CH, Diaz AA, Curtis JL, Cooper CB, Pirozzi C, Kanner R, Paine R III, Woodruff PG, Bleecker E, Hansel NN, Barr RG, Kazerooni E, Hoffman EA, Ross BD, Galban C, Martinez FJ, Han MK.. Am J Respir Crit Care Med. 2016;193():A3511.

Impact of comorbid insomnia on asthma control and asthma-related healthcare utilization [abstract]. Luyster FS, Strollo PJ, Holguin F, Bleecker E, Castro M, Fahy JV, Gaston B, Israel E, Jarjour NN, Mauger D, Wenzel SE.. Am J Respir Crit Care Med. 2016;193():A6429.

Common airway variants and risk of chronic obstructive pulmonary disease. The subpopulations and intermediate outcome measures in COPD Study (spiromics) [abstract]. Smith BM, Hoffman EA, Bleecker ER, Couper DJ, Han MK, Hansel NN, Kanner R, Kleerup E, Martinez FJ, Rennard SI, Woodruff PG, Barr RG.. Am J Respir Crit Care Med. 2016;193():A6611.

Clinical and molecular characterization of the Chi3l1/ykl-40 severe asthma endotypes [abstract]. Gomez JL, Crisafi G, Holm C, Jarjour NN, Hawkins GA, Meyers DA, Bleecker E, Reibman J, Cohn LE, Chupp GL.. Am J Respir Crit Care Med. 2016;193():A4346.

Multiscale imaging-based clusters in the COPD cohort associates with clinical characteristics: the subpopulations and intermediate outcome measures in COPD Study (spiromics) [abstract]. Haghighi B, Choi S, Hoffman EA, Newell J, Barr RG, Han MK, Cooper CB, O'Neal WK, Woodruff PG, Bleecker ER, Martinez FJ, Lin CL.. Am J Respir Crit Care Med. 2016;193():A6612.

Prevalence and risk factors for persistent very poorly controlled (vpc) asthma after more than a decade in the tenor Ii cohort [abstract]. Haselkorn T, Zeiger RS, Borish L, Paknis B, Bleecker ER, Foreman A, Kianifard F, Weiss ST, Chipps BE, Szefler SJ.. Am J Respir Crit Care Med. 2016;193():A1025.

Analysis of changes in the lung microbiome and host parameters in current and former smokers with and without COPD in the spiromics cohort [abstract]. Erb-Downward JR, Han MK, Freeman CM, Brown JP, Christenson S, Cooper CB, Barr RG, Hansel NN, Kanner R, Zeidler M, Moore W, Bleecker E, Falkowski N, Farr D, Paine R III, Woodruff PG, Martinez FJ, Curtis JL, Huffnagle GB.. Am J Respir Crit Care Med. 2016;193():A4065.

Pubertal changes associated with estrogen and not androgens are more strongly associated with lower lung function and fixed airflow obstruction: a cross-sectional analysis of children and adolescents in Sarp Iii [abstract]. Gaston B, Myers RE, Phillips B, Mauger D, Bacharier LB, Ross K, Chmiel JF, Marozkina N, Fitzpatrick AM, Bleecker E, Castro M, Fahy JV, Ly N, Jarjour NN, Ramratnam S, Zein JG, Irani AM, Levy BD, Phipatanakul W, Holguin F, Aujla S, Wenzel SE,.. Am J Respir Crit Care Med. 2016;193():A2176.

Blood eosinophils poorly correlate with sputum eosinophils, and have few associations with spirometry, clinical and quantitated computed tomography measures compared to sputum eosinophils in the spiromics cohort [abstract]. Hastie AT, Alexis NE, Doerschuk C, Hansel NN, Christenson S, Putcha N, Ortega VE, Peters SP, Barr RG, Couper DJ, Hoffman EA, Kanner R, Kleerup E, Martinez FJ, Woodruff PG, Han MK, Meyers DA, Curtis JL, Bleecker ER.. Am J Respir Crit Care Med. 2016;193():A6168.

Fissure integrity and rate of emphysema progression: subpopulations and intermediate outcome measures in COPD Study (spiromics) [abstract]. Dougherty TM, Newell JD Jr, Yin Y, Schirm JA, Sieren JP, Barr RG, Bleecker E, Bowler RP, Comellas AP, Cooper CB, Criner GJ, Dransfield MT, Hansel NN, Han MK, Kanner R, Lazarus SC, Martinez FJ, Woodruff PG, Chan KS, Hoffman EA.. Am J Respir Crit Care Med. 2016;193():A5817.

Characterization of smokers with COPD exacerbations despite preserved spirometry in the subpopulations and intermediate outcome measures in COPD Study (spiromics) [abstract]. Christenson SA, Barr RG, Bleecker ER, Bowler RP, Cooper CB, Criner GJ, Dransfield MT, Hansel NN, Han MK, Hoffman EA, Kanner R, Lazarus SC, Martinez FJ, Paine R III, Wells JM, Woodruff PG.. Am J Respir Crit Care Med. 2016;193():A4276.

A blood eosinophil count of greater than 150 cells/ul predicts sputum eosinophilia greater than or equal to 3% in patients with severe asthma with other markers of inflammatory lung disease [abstract]. Austin D, Pouliquen I, Yancey S, Bleeker E [sic] [Bleecker E].. Am J Respir Crit Care Med. 2016;193():A4338.

Biomarker characterization of a debilitated phenotype in spiromics [abstract]. Barjaktarevic I, Martinez CH, Curtis JL, Bowler RP, O'Neal WK, Hoffman EA, Carretta EE, Quibrera M, Barr RG, Bleecker E, Couper DJ, Criner GJ, Dransfield MT, Han MK, Hansel NN, Kanner R, Lazarus SC, Martinez FJ, Paine R III, Tashkin DP,.. Am J Respir Crit Care Med. 2016;193():A1426.

Identification of a debilitated phenotype in spiromics [abstract]. Barjaktarevic I, Martinez CH, Curtis JL, Hoffman EA, Carretta EE, Bowler RP, O'Neal WK, Quibrera M, Barr RG, Martinez FJ, Couper DJ, Criner GJ, Dransfield MT, Han MK, Hansel NN, Kanner R, Lazarus SC, Bleecker ER, Paine R III, Tashkin DP,.. Am J Respir Crit Care Med. 2016;193():A3519.

Association between blood biomarkers, CT phenotype and COPD stage in spiromics [abstract]. Taylor J, Degtiar I, Murray S, Wang X, Martinez CH, Erb-Downward JR, Marchetti N, Criner GJ, O'Neal WK, Couper DJ, Bowler RP, Scholand M, Pirozzi C, Cooper CB, Kanner R, Paine R III, Barr RG, Bleecker E, Hansel NN, Woodruff PG, Hoffman EA,.. Am J Respir Crit Care Med. 2016;193():A4066.

Clinical significance of symptoms in smokers with preserved spirometry [abstract]. Woodruff PG, Barr RG, Bleecker ER, Christenson SA, Couper DJ, Curtis JL, Gouskova N, Hansel NN, Hoffman EA, Kanner R, Kleerup E, Lazarus SC, Martinez FJ, Paine R III, Rennard SI, Tashkin DP, Han MK,.. Am J Respir Crit Care Med. 2016;193():A7779.

Genetic ancestry is associated with baseline lung function, CT-scan emphysema, and COPD risk in African Americans and Hispanics from spiromics [abstract]. Ortega VE, Hoffman EA, Ampleford EJ, Hawkins GA, Barr RG, Couper DJ, Han MK, Kanner R, Kleerup E, Martinez FJ, Rennard SI, Woodruff PG, Meyers DA, Bleecker ER.. Am J Respir Crit Care Med. 2016;193():A6164.

Short-term stability of pulmonary function and clinical measures in COPD using a cohort from spiromics (subpopulations and intermediate outcome measures in COPD Study) [abstract]. Anderson WH, O'Neal WK, Doerschuk CM, Carretta EE, Couper DJ, Tashkin D, Paine R III, Cooper B, Bleecker ER, Barr RG, Hansel NN, Han MK, Martinez FJ, Curtis JL, Woodruff PG, Kleerup E, Kanner R.. Am J Respir Crit Care Med. 2016;193():A3515.

How 'stable' is stable COPD? Daily symptom variability of subjects enrolled in the Spiromics Exacerbation Sub-Study [abstract]. Ancy KM, Leidy NK, Malley KG, Anderson WH, Barr RG, Bleeker E [sic] [Bleecker E], Bowler RP, Carretta EE, Cooper CB, Couper DJ, Doerschuk CM, Dransfield MT, Hansel NN, Hoffman EA, Kanner R, O'Neal WK, Paine R III, Peter SP, Scholand M,.. Am J Respir Crit Care Med. 2016;193():A3527.

Age and gender-specific protective effects of superoxide dismutase in asthma severity [abstract]. Comhair SAA, Baicker-McKee SM, Bleeker E [sic] [Bleecker E], Castro M, Fahy JV, Israel E, Jarour N, Levy BD, Mauger D, Wenzel SE, Teague WG, Gaston B, Erzurum SC.. Am J Respir Crit Care Med. 2016;193():A3171.

Sex hormones impact asthma severity and lung function in adult men and women [abstract]. Zein JG, DeBoer MD, Teague WG, Comhair S, Castro M, Busse WW, Jarjour NN, Bleecker ER, Moore WC, Wenzel SE, Calhoun WJ, Gaston B, Erzurum SC.. Am J Respir Crit Care Med. 2016;193():A1436.

The bitter taste receptor gene Tas2r42 is a novel asthma severity gene [abstract]. Hawkins GA, Deshpande DA, Ampleford EJ, Li X, Li H, Moore WC, Meyers DA, Bleecker ER.. Am J Respir Crit Care Med. 2016;193():A6681.

Cluster analysis of chronic obstructive pulmonary disease (COPD) related phenotypes in the subpopulations and intermediate outcome measures in COPD Study (spiromics) [abstract]. Li X, Han MK, Ortega VA, Dransfield MT, Li H, Barr RG, Couper DJ, Hoffman EA, Kanner R, Kleerup E, Martinez FJ, Woodruff PG, Meyers DA, Bleecker ER.. Am J Respir Crit Care Med. 2016;193():A3509.

Genome-wide association identifies Rs28929474 (glu342lys) in serpina1 associated with post-bronchodilator Fev1/FVC and percent predicted Fev1 in spiromics [abstract]. Li X, Ortega VE, Ampleford EJ, Barr RG, Couper DJ, Han MK, Hoffman EA, Kanner R, Kleerup E, Martinez FJ, Woodruff PG, Hawkins GA, Bleecker ER, Meyers DA.. Am J Respir Crit Care Med. 2016;193():A4431.

Phenotypic/genetic characteristics of COPD, asthma, and asthma-COPD overlap syndrome (acos) in spiromics and sarp [abstract]. Li X, Ortega VE, Nadia H, Christenson S, Moore WC, Li H, Barr RG, Couper DJ, Hoffman EA, Han MK, Kanner R, Kleerup E, Martinez FJ, Hawkins GA, Woodruff PG, Bleecker ER, Meyers DA.. Am J Respir Crit Care Med. 2016;193():A6237.

Role of tumor necrosis factor-related apoptosis inducing ligand and Th1, Th2 and Th17 inflammation in asthma [abstract]. Marks M, Hastie AT, Steele C, Moore WC, Ampleford EJ, Meyers DA, Bleecker ER.. Am J Respir Crit Care Med. 2016;193():A1336.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Center for Genomics and Personalized Medicine Research

Clinical Interests

General Pulmonary Diseases, Chronic Obstructive Pulmonary Disease (COPD), Asthma

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