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Research

Anthony J. Bleyer, M.D.

Professor, Nephrology

Clinical Specialties

Nephrology, Genetic Renal Disease, Diabetic Kidney Disease, Genetics, Clinical Nephrology, Dialysis

Contact Information

New Patient Appointments: 336-716-WAKE
Returning Patient Appointments: 336-716-4513
Department: 336-716-4650

Education & Training

M.D., Baylor College of Medicine , 1987
B.S., Rensselaer PolyTechnical Institute , 1982
Internship, Internal Medicine, Johns Hopkins Affil Hosps, 1988
Residency, Internal Medicine, Johns Hopkins Affil Hosps, 1990
Fellowship, University of Pennsylvania School of Medicine, 1992

Board Certifications

American Board of Internal Medicine, Nephrology
American Board of Internal Medicine, Internal Medicine

Memberships

Int'L Society Of Nephrology
Int'L Society Peritoneal Dialy
Nat'L Kidney Foundation
Am Soc Of Nephrology

NPI Number

1346225778

Anthony J. Bleyer, M.D.

Professor, Nephrology

Contact Information

Academic: 336-716-4513 | Department: 336-716-4650

Recent Publications

Kirby A, Gnirke A, Jaffe DB, Baresova V, Pochet N, Blumenstiel B, Ye C, Aird D, Stevens C, Robinson JT, Cabili MN, Gat-Viks I, Kelliher E, Daza R, DeFelice M, Hulkova H, Sovova J, Vylet'al P, Antignac C, Guttman M, Handsaker RE,. Mutations causing medullary cystic kidney disease type 1 lie in a large VNTR in MUC1 missed by massively parallel sequencing. Nat Genet. 2013;45(3):299-303.

Palmer BF, Glassock RJ, Bleyer AJ. Nephrology quiz and questionnaire: electrolytes. Clin J Am Soc Nephrol. 2012;7(6):1047-1052.

Bleyer AJ, Hawfield A. Cardiovascular disease: modifiable risk factors for sudden death in dialysis patients. Nat Rev Nephrol. 2012;8(6):323-324.

Hricik DE, Glassock RJ, Bleyer AJ. Nephrology quiz and questionnaire: transplantation. Clin J Am Soc Nephrol. 2012;7(7):1190-1194.

Golper TA, Glassock RJ, Bleyer AJ. Nephrology quiz and questionnaire: renal replacement therapy. Clin J Am Soc Nephrol. 2012;7(8):1347-1352.

Murea M, Moran T, Russell GB, Shihabi ZK, Byers JR, Andries L, Bleyer AJ, Freedman BI. Glycated albumin, not hemoglobin A1c, predicts cardiovascular hospitalization and length of stay in diabetic patients on dialysis. Am J Nephrol. 2012;36(5):488-496.

Bleyer AJ, Kmoch S. Gout: a step forward [editorial]. Adv Chronic Kidney Dis. 2012;19(6):356-357.

Stiburkova B, Bleyer AJ. Changes in serum urate and urate excretion with age. Adv Chronic Kidney Dis. 2012;19(6):372-376.

Murea M, Russell GB, Bleyer AJ, Freedman BI. Glycated albumin (GA), not hemoglobin A1c (HbA1c), predicts cardiovascular hospitalizations and length of stay (LOS) in dialysis patients with diabetes [abstract]. J Am Soc Nephrol. 2012;23():751A.

Bleyer AJ, Zivna M, Kmoch S. Uromodulin-associated kidney disease. Nephron Clin Pract. 2011;118(1):c31-c36.

Reeves-Daniel AM, DePalma JA, Bleyer AJ, Rocco MV, Murea M, Adams PL, Langefeld CD, Bowden DW, Hicks PJ, Stratta RJ, Lin J-J, Kiger DF, Gautreaux MD, Divers J, Freedman BI. The APOL1 gene and allograft survival after kidney transplantation. Am J Transplant. 2011;11(5):1025-1030.

Bleyer AJ, Hart PS. UMOD-associated kidney disease In: Pagon RA, Bird TD, Dolan CR, eds. GeneReviews [internet]. Seattle (WA): University of Washington;2011: NBK1356.

Kmoch S, Zivna M, Bleyer AJ. Familial juvenile hyperuricemic nephropathy type 2 In: Pagon RA, Bird TD, Dolan CR, eds. GeneReviews [internet]. Seattle (WA): University of Washington;2011: NBK53700.

Freedman BI, Andries L, Shihabi ZK, Rocco MV, Byers JR, Cardona CY, Graham AD, Mauck VL, Russell GB, Bleyer AJ, et al. Glycated albumin and risk of death and hospitalizations in diabetic dialysis patients. Clin J Am Soc Nephrol. 2011;6(7):1635-1643.

Glassock RJ, Bleyer AJ, Hricik DE, Palmer BF. The 2010 nephrology quiz and questionnaire: part 1. Clin J Am Soc Nephrol. 2011;6(9):2318-2327.

Glassock RJ, Bleyer AJ, Bargman JM, Fervenza FC. The 2010 nephrology quiz and questionnaire: part 2. Clin J Am Soc Nephrol. 2011;6(10):2534-2547.

Freedman BI, Hicks PJ, Langefeld CD, Lu L, Bleyer AJ, Divers J, Nachman PH, Derebail VK, Bowden DW. Sickle cell trait is not associated with ESRD susceptibility in African Americans [abstract]. J Am Soc Nephrol. 2011;22(Abstract Suppl):463A.

Bleyer AJ, Adams PL, Russell GB. Women are extremely disproportionately affected by high panel reactive antibody levels prior to kidney transplantation [abstract]. J Am Soc Nephrol. 2011;22(Abstract Suppl):956A.

Bleyer AJ, Murea M. Antimicrobial catheter locks: searching for the ideal solution [editorial]. J Am Soc Nephrol. 2011;22(10):1781-1782.

Bleyer AJ, Vidya S, Russell GB, Jones CM, Sujata L, Daeihagh P, Hire D. Longitudinal analysis of one million vital signs in patients in an academic medical center. Resuscitation. 2011;82(11):1387-1392.

Hicks PJ, Langefeld CD, Lu L, Bleyer AJ, Divers J, Nachman PH, Derebail VK, Bowden DW, Freedman BI. Sickle cell trait is not independently associated with susceptibility to end-stage renal disease in African Americans. Kidney Int. 2011;80(12):1339-1343.

Freedman BI, Shenoy RN, Planer JA, Clay KD, Shihabi ZK, Burkart JM, Sabio H, Byers JR, Russell GB, Bleyer AJ, et al. Comparison of glycated albumin and hemoglobin A1c concentrations in diabetic subjects on peritoneal and hemodialysis. Perit Dial Int. 2010;30(1):72-79.

Freedman BI, Shihabi ZK, Andries L, Cardona CY, Peacock TP, Byers JR, Russell GB, Stratta RJ, Bleyer AJ. Relationship between assays of glycemia in diabetic subjects with advanced chronic kidney disease. Am J Nephrol. 2010;31(5):375-379.

Grunfeld J-P, Zivna M, Hulkova H, Matignon M, Hodanova K, Vylet-al P, Kalbacova M, Baresova V, Sikora J, Bleyer AJ, et al. More on clinical renal genetics: dominant renin gene mutations associated with early-onset hyperuricemia, anemia, and chronic renal failure. Am J Hum Genet 85:204-213, 2009 [letter]. Clin J Am Soc Nephrol. 2010;5(4):565-566.

Bleyer AJ, Reddy SV, Sujata L, Russell GB, Akinnifesi D, Bleyer AJ Jr, Hire D, Shihabi Z, Knovich MA, Daeihagh P, Calles J, Freedman BI. Sickle cell trait and development of microvascular complications in diabetes mellitus. Clin J Am Soc Nephrol. 2010;5(6):1015-1020.

Jones CM, Bleyer AJ, Petree B. Evolution of a rapid response system from voluntary to mandatory activation. Jt Comm J Qual Patient Saf. 2010;36(6):266-270.

Schaffer P, Gombos E, Meichelbeck K, Kiss A, Hart PS, Bleyer AJ. Childhood course of renal insufficiency in a family with a uromodulin gene mutation. Pediatr Nephrol. 2010;25(7):1355-1360.

Bleyer AJ, Vidya S, Sujata L, Russell GB, Akinnifesi D, Hire D, Shihabi Z, Knovich MA, Daeihagh P, Calles J, Freedman BI. The impact of sickle cell trait on glycated haemoglobin in diabetes mellitus. Diabet Med. 2010;27(9):1012-1016.

Bleyer AJ, Hart PS, Kmoch S. Hereditary interstitial kidney disease. Semin Nephrol. 2010;30(4):366-373.

Reeves-Daniel A, Freedman BI, Assimos D, Hartmann EL, Bleyer A, Adams PL, Westcott C, Stratta RJ, Rogers J, Farney AC, Daniel KR. Short-term renal outcomes in African American and Caucasian donors following live kidney donation. Clin Transplant. 2010;24(5):717-722.

Bleyer AJ, Zivna M, Hulkova H, Hodanova K, Vyletal P, Sikora J, Zivny J, Sovova J, Hart TC, Adams JN, et al. Clinical and molecular characterization of a family with a dominant renin gene mutation and response to treatment with fludrocortisone. Clin Nephrol. 2010;74(6):411-422.

Vyletal P, Bleyer AJ, Kmoch S. Uromodulin biology and pathophysiology--an update. Kidney Blood Press Res. 2010;33(6):456-475.

Bleyer AJ, Zivna M, Hodanova K, Vyletal P, Hulkova H, Elleder M, Kmoch S. Novel renin gene mutation causes autosomal dominant chronic kidney failure and anemia and responds to fludrocortisone treatment in childhood [abstract]. J Am Soc Nephrol. 2010;21(Suppl):882A.

Bleyer AJ. Improving the recognition of hereditary interstitial kidney disease [commentary]. J Am Soc Nephrol. 2009;20(1):11-13.

Bleyer AJ, Hire D, Russell GB, Xu J, Divers J, Shihabi Z, Bowden DW, Freedman BI. Ethnic variation in the correlation between random serum glucose concentration and glycated haemoglobin. Diabet Med. 2009;26(2):128-133.

Bleyer AJ. Clues at the scene of the crime: sudden death in dialysis patients [commentary]. Perit Dial Int. 2009;29(1):23-25.

Zivna M, Hulkova H, Matignon M, Hodanova K, Vylet'al P, Kalbacova M, Baresova V, Sikora J, Blazkova H, Bleyer AJ, et al. Dominant renin gene mutations associated with early-onset hyperuricemia, anemia, and chronic kidney failure. Am J Hum Genet. 2009;85(2):204-213.

Freedman BI, Hicks PJ, Bostrom MA, Comeau ME, Divers J, Bleyer AJ, Kopp JB, Winkler CA, Langefeld CD, Bowden DW, et al. Non-muscle myosin heavy chain 9 gene MYH9 associations in African Americans with clinically diagnosed type 2 diabetes mellitus-associated ESRD. Nephrol Dial Transplant. 2009;24(11):3366-3371.

Freedman BI, Hicks PJ, Bostrom MA, Comeau ME, Divers J, Bleyer AJ, Kopp JB, Winkler CA, Langefeld CD, Bowden DW, et al. Non-muscle myosin heavy chain 9 gene MYH9 associations in African Americans (AA) with type 2 diabetes (T2DM)-associated ESRD [abstract]. J Am Soc Nephrol. 2009;20(Renal Week 2009 Abstract Issue):431A.

Freedman BI, Shihabi ZK, Andries L, Spainhour M, Byers JR, Russell GB, Stratta RJ, Calles J, Bleyer AJ. Accuracy of the glycated albumin (GA) and hemoglobin (Hb) A1c assays in diabetic subjects with advanced chronic kidney disease (CKD) [abstract]. J Am Soc Nephrol. 2009;20(Renal Week 2009 Abstract Issue):424A.

Bleyer AJ, Sedor JR, Freedman BI, O'Brien A, Russell GB, Graley J, Schelling JR. Risk factors for development and progression of diabetic kidney disease and treatment patterns among diabetic siblings of patients with diabetic kidney disease. Am J Kidney Dis. 2008;51(1):29-37.

Bleyer AJ. Prevention of sudden cardiac death in dialysis patients: a nephrologist's perspective. Dial Transplant. 2008;37(4):124-129.

Cao JJ, Biggs ML, Barzilay J, Konen J, Psaty BM, Kuller L, Bleyer AJ, Olson J, Wexler J, Summerson J, et al. Cardiovascular and mortality risk prediction and stratification using urinary albumin excretion in older adults ages 68-102: the Cardiovascular Health Study. Atherosclerosis. 2008;197(2):806-813.

Peacock TP, Shihabi ZK, Bleyer AJ, Dolbare EL, Byers JR, Knovich MA, Calles-Escandon J, Russell GB, Freedman BI. Comparison of glycated albumin and hemoglobin A1C levels in diabetic subjects on hemodialysis. Kidney Int. 2008;73(9):1062-1068.

Gupta K, Iskandar SS, Daeihagh P, Ratliff HL, Bleyer AJ. Distribution of pathologic findings in individuals with nephrotic proteinuria according to serum albumin. Nephrol Dial Transplant. 2008;23(5):1595-1599.

Reeves-Daniel A, Daniel K, Assimos D, Westcott C, Rogers J, Farney A, Stratta R, Hartmann E, Adams P, Bleyer A, Freedman B. Similar short-term renal outcomes among African Americans and caucasians following live kidney donation [abstract]. Am J Transplant. 2008;8(Suppl 2):191.

Freedman BI, Shenoy RN, Planer JA, Bleyer AJ, Cardona CY, Peacock TP, Andreis L, Byers JR, Russell GB, Shihabi ZK, et al. Glycated albumin more accurately reflects glycaemic control than HbA(1c) in diabetic subjects on peritoneal and hemodialysis [abstract]. Diabetologia. 2008;51(Suppl 1):S413-S414.

Thomas RL, Bleyer A, Kretzler M, Freedman BI, Iyengar SK, Schelling JR, Sedor JR. African American and European American diabetic sibs with normal GFR and family history of diabetic nephropathy (DN) lose GFR at equivalent rates but faster than diabetic subjects with no family history [abstract]. J Am Soc Nephrol. 2008;19():335A-336A.

Planer JA, Bleyer AJ, Shenoy RN, Clay KD, Cardona CY, Sabio H, Russell GB, Shihabi ZK, Freedman BI. Ethnic variation in hemoglobin (Hb) A1c and glycated albumin (GA) assays in patients on hemodialysis (HD) [abstract]. J Am Soc Nephrol. 2008;19():974A.

Shenoy RN, Planer JA, Clay KD, Bleyer AJ, Burkart JM, Cardona CY, Byers JR, Russell GB, Shihabi ZK, Freedman BI, et al. Evaluation of glycated albumin (GA), HbA1c and serum glucose concentrations in diabetic peritoneal (PD) and hemodialysis (HD) patients [abstract]. J Am Soc Nephrol. 2008;19():974A-975A.

Bleyer AJ. Hyperphosphatemia in the Calcium Acetate Renagel Evaluation-2 (CARE-2) Study [letter]. Am J Kidney Dis. 2008;52(5):1024.

Feely T, Copley A, Bleyer AJ. Catheter lock solutions to prevent bloodstream infections in high-risk hemodialysis patients. Am J Nephrol. 2007;27(1):24-29.

Delmez J, Block G, Bleyer A, Robertson J, Chasan-Taber S, Dillon M, Blair A. A randomized, double-blind, cross-over design study of sevelamer hydrochloride (SH, Renagel) and sevelamer carbonate (SC) in chronic kidney disease patients on hemodialysis [abstract]. Am J Kidney Dis. 2007;49(4):A36.

Mellen PB, Bleyer AJ, Herrington DM. Response to treatment of hyperuricemia in essential hypertension [letter]. Hypertension. 2007;49(6):e46.

Bleyer AJ. Use of antimicrobial catheter lock solutions to prevent catheter-related bacteremia. Clin J Am Soc Nephrol. 2007;2(5):1073-1078.

Bleyer AJ, Canaday O, El-Haddad H, Kiser RL, Klemmer PJ. Comparison of clinical characteristics between families with medullary cystic kidney disease type 2 and families with autosomal dominant interstitial kidney disease (medullary cystic kidney disease type 1) [abstract]. J Am Soc Nephrol. 2007;18(Abstracts Issue):366A.

Schelling JR, Bleyer AJ, Freedman BI, Sedor JR. Diabetic sibs with normal GFR and family history of diabetic nephropathy (DN) develop progressive nephropathy: a risk group for targeted intervention [abstract]. J Am Soc Nephrol. 2007;18(Abstracts Issue):571A.

Delmez J, Block G, Robertson J, Chasan-Taber S, Blair A, Dillon M, Bleyer AJ. A randomized, double-blind, crossover design study of sevelamer hydrochloride and sevelamer carbonate in patients on hemodialysis. Clin Nephrol. 2007;68():386-391.

Delmez J, Block G, Bleyer A, Robertson J, Chasan-Taber S, Dillon M, Blair A. Results of a randomized, double-blind, cross-over design study of sevelamer hydrochloride (Renagel((R))) and sevelamer carbonate in chronic kidney disease patients on hemodialysis [abstract]. Nephrol Dial Transplant. 2007;22(Suppl 6):361.

Bleyer AJ, Gupta K. UMOD-related kidney disease In: Pagon RA, ed. GeneReviews [internet]. Seattle (WA): University of Washington;2007: .

Codina J, Liu J, Bleyer AJ, Penn RB, DuBose TD Jr. Phosphorylation of S955 at the protein kinase A consensus promotes maturation of the alpha subunit of the colonic H+,K+-ATPase. J Am Soc Nephrol. 2006;17(7):1833-1840.

Cao JJ, Barzilay JI, Peterson D, Manolio TA, Psaty BM, Kuller L, Wexler J, Bleyer AJ, Cushman M. The association of microalbuminuria with clinical cardiovascular disease and subclinical atherosclerosis in the elderly: the Cardiovascular Health Study. Atherosclerosis. 2006;187(2):372-377.

Mellen PB, Bleyer AJ, Erlinger TP, Evans GW, Nieto FJ, Wagenknecht LE, Wofford MR, Herrington DM. Serum uric acid predicts incident hypertension in a biethnic cohort: the Atherosclerosis Risk in Communities Study. Hypertension. 2006;48(6):1037-1042.

Bleyer AJ, Sedor JR, Freedman BI, Schelling JR. Screening diabetic siblings of diabetic end-stage kidney disease patients reveals frequent uncontrolled hypertension, uncontrolled diabetes, and albuminuria [abstract]. J Am Soc Nephrol. 2006;17(Abstr Issue):82A.

Feely T, Bleyer AJ. Gentamicin/heparin and minocycline/EDTA catheter lock solutions prevent recurrent catheter related bactermia [abstract]. J Am Soc Nephrol. 2006;17(Abstr Issue):592A.

Codina J, Liu J, Bleyer AJ, Penn RB. A negatively charged amino acid at position 955 in the PKA consensus sequence promotes maturation of the alpha-subunit of the colonic H+,K+-ATPase (HKalpha2) [abstract]. J Am Soc Nephrol. 2006;17(Abstr Issue):551A.

Schelling JR, Sedor JR, Freedman BI, Rich SS, Iyengar SK, Bleyer AJ. The Family Investigation of Nephropathy and Diabetes (FIND) longitudinal follow-up study: design and preliminary results [abstract]. J Am Soc Nephrol. 2006;17(Abstr Issue):707A.