Profile

John Daniel Bourland, Ph.D.

John Daniel Bourland, Ph.D.

Contact Information
Appointment:
336-713-3600
Office:
336-713-6503
Fax:
336-713-6565
Clinical Specialties
Dose Computation, Imaging in Radiation Treatment, Radiation Oncology Physics, Radiosurgery, Gamma Knife
Education & Training
  BSUniversity of North Carolina-Chapel Hill1978
  MSPHUniversity of North Carolina School of Public Hlth1981
  PhDUniversity of North Carolina School of Public Hlth1990
Memberships
American Association of Physicists In Medicine
American Coll of Radiology
Radiological Society of North Amer
American Society of Therapeutic Rad & Onc
Health Physics Society
John Daniel Bourland, Ph.D.

John Daniel Bourland, Ph.D.

Contact Information
Appointment:
336-713-3600
Office:
336-713-6503
Fax:
336-713-6565
Research Interests
other
Recent Publications
Monjazeb AM, Ayala D, Jensen C, Case LD, Bourland JD, Ellis TL, McMullen KP, Chan MD, Tatter SB, Lesser GJ, Shaw EG. A phase I dose escalation study of hypofractionated IMRT field-in-field boost for newly diagnosed glioblastoma multiforme. Int J Radiat Oncol Biol Phys. 2012; 82(2):743-748.

Marshall K, Chan MD, McCoy TP, Aubuchon AC, Bourland JD, McMullen KP, deGuzman AF, Munley MT, Shaw EG, Tatter SB, Ellis TL. Predictive variables for the successful treatment of trigeminal neuralgia with gamma knife radiosurgery. Neurosurgery. 2012; 70(3):566-573.

Robbins ME, Bourland JD, Cline JM, Wheeler KT, Deadwyler SA. A model for assessing cognitive impairment after fractionated whole-brain irradiation in nonhuman primates. Radiat Res. 2011; 175(4):519-525.

Jensen CA, Chan MD, McCoy TP, Bourland JD, deGuzman AF, Ellis TL, Ekstrand KE, McMullen KP, Munley MT, Shaw EG, Urbanic JJ, Tatter SB. Cavity-directed radiosurgery as adjuvant therapy after resection of a brain metastasis. J Neurosurg. 2011; 114(6):1585-1591.

Schindler MK, Bourland JD, Forbes ME, Hua K, Riddle DR. Neurobiological responses to stereotactic focal irradiation of the adult rodent hippocampus. J Neurol Sci. 2011; 306(1-2):129-137.

Aubuchon AC, Chan MD, Lovato JF, Balamucki CJ, Ellis TL, Tatter SB, McMullen KP, Munley MT, Deguzman AF, Ekstrand KE, Bourland JD, Shaw EG. Repeat gamma knife radiosurgery for trigeminal neuralgia. Int J Radiat Oncol Biol Phys. 2011; 81(4):1059-1065.

Ding X, Singh R, Burke A, Hatcher H, Olson J, Kraft RA, Schmid M, Carroll D, Bourland JD, Akman S, Torti FM, Torti SV. Development of iron-containing multiwalled carbon nanotubes for MR-guided laser-induced thermotherapy. Nanomedicine (Lond). 2011; 6(8):1341-1352.

Lowell D, Tatter SB, Bourland JD, DeGuzman AF, Ekstrand KE, Ellis TL, Lovato JF, McMullen KP, Munley MT, Shaw EG, Urbanic JJ, Chan MD. Toxicity of gamma knife radiosurgery in the treatment of intracranial tumors in patients with collagen vascular diseases or multiple sclerosis. Int J Radiat Oncol Biol Phys. 2011; 81(4):e519-e524.

Yoshizumi T, Brady SL, Robbins ME, Bourland JD. Specific issues in small animal dosimetry and irradiator calibration. Int J Radiat Biol. 2011; 87(10):1001-1010.

Amponsah K, Ellis TL, Chan MD, Bourland JD, Glazier SS, McMullen KP, Shaw EG, Tatter SB. Staged gamma knife radiosurgery for large cerebral arteriovenous malformations. Stereotact Funct Neurosurg. 2011; 89(6):365-371.

Diz DI, Garcia-Espinosa MA, Shaltout HA, Olson J, Bourland JD, Groban L. Correlation of the brain medullary metabolites N-acetyl aspartic acid and N-acetyl aspartyl glutamate with the age related decline in sensitivity for baroreflex control of heart rate in humans [abstract]. Hypertension. 2011; 58(5):e116.

Kilburn JM, Ellis TL, Urbanic JJ, Bourland JD, Munley MT, deGuzman AF, McMullen KP, Shaw EG, Tatter SB, Chan MD. Outcomes for gamma knife radiosurgery for brainstem metastases [abstract]. Int J Radiat Oncol Biol Phys. 2011; 81(2 Suppl):S302.

Kuremsky JG, Urbanic JJ, Petty WJ, Lovato JF, Bourland JD, Tatter SB, Ellis TL, McMullen KP, Shaw EG, Chan MD. Tumor histology predicts patterns of failure and survival in patients with lung cancer treated with gamma knife radiosurgery [abstract]. Int J Radiat Oncol Biol Phys. 2011; 81(2 Suppl):S595.

Loganathan AG, Chan MD, Alphonse N, Peiffer AM, Johnson A, McMullen KP, Urbanic JJ, Saconn PA, Bourland JD, Munley MT, Shaw EG, Tatter SB, Ellis TL. Clinical outcomes of brain metastases treated with gamma knife radiosurgery with 3.0 T vs. 1.5 T MRI-based treatment planning [abstract]. Neuro Oncol. 2011; 13(Suppl 3):129.

Vern-Gross TZ, McMullen KP, Case LD, Bourland JD, Ellis TL, Lawrence JA, Tatter SB, Shaw EG, Urbanic JJ, Chan MD. Patterns of failure in patients receiving gamma knife radiosurgery for breast carcinoma to the brain [abstract]. Int J Radiat Oncol Biol Phys. 2011; 81(2 Suppl):S216-S217.

Vern-Gross TZ, McMullen KP, Case LD, Bourland JD, Ellis TL, Lawrence JA, Tatter SB, Shaw EG, Urbanic JJ, Chan MD. Patterns of failure in patients receiving gamma knife radiosurgery for breast carcinoma to the brain [abstract]. Neuro Oncol. 2011; 13(Suppl 3):127.

Willey JS, Livingston EW, Robbins ME, Bourland JD, Tirado-Lee L, Smith-Sielicki H, Bateman TA. Risedronate prevents early radiation-induced osteoporosis in mice at multiple skeletal locations. Bone. 2010; 46(1):101-111.

Wiant D, Gersh JA, Bennett M, Bourland JD. Evaluation of the spatial dependence of the point spread function in 2D PET image reconstruction using LOR-OSEM. Med Phys. 2010; 37(3):1169-1182.

Chen BJ, Deoliveira D, Spasojevic I, Sempowski GD, Jiang C, Owzar K, Wang X, Cline JM, Bourland JD, Dugan G, et al. Growth hormone mitigates against lethal irradiation and enhances hematologic and immune recovery in mice and nonhuman primates. PLoS ONE. 2010; 5(6):e11056.

Saconn PA, Shaw EG, Chan MD, Squire SE, Johnson AJ, McMullen KP, Tatter SB, Ellis TL, Lovato J, Bourland JD, Ekstrand KE, DeGuzman AF, Munley MT. Use of 3.0-T MRI for stereotactic radiosurgery planning for treatment of brain metastases: a single-institution retrospective review. Int J Radiat Oncol Biol Phys. 2010; 78(4):1142-1146.

Lowell DA, Shaw EG, Bourland JD, de Guzman AF, Ekstrand KE, Ellis TL, McMullen KP, Munley MT, Tatter SB, Chan MD. Analysis of toxicity in patients with collagen vascular diseases or multiple sclerosis treated with gamma knife radiosurgery for intracranial tumors [abstract]. Int J Radiat Oncol Biol Phys. 2010; 78(3 Suppl):S269-S270.

Marshall KM, Chan MD, Ellis TL, Aubuchon A, Balamucki CJ, Bourland JD, McCoy TP, McMullen KP, Shaw EG, Tatter SB. Predictive variables for successful treatment of trigeminal neuralgia with radiosurgery [abstract]. Int J Radiat Oncol Biol Phys. 2010; 78(3 Suppl):S8.

McMullen KP, Harris S, Lovato J, Ellis TL, Tatter SB, Urbanic J, Bourland JD, Shaw EG, Chan MD. Salvage radiosurgery for patients with small cell lung cancer after previous whole brain radiations [abstract]. Int J Radiat Oncol Biol Phys. 2010; 78(3 Suppl):S274-S275.

Lawrence MV, Rossi P, Powell D, Ekstrand KE, deGuzman AF, Munley MT, Ellis TL, Tatter SB, Stieber VW, McMullen KP, Shaw EG, Bourland JD. Relationship between radiosurgery conformity indices and acoustic neuroma tumor volume. In: McDermott MW, ed. Radiosurgery. New York: Karger; 2010: 95-99.

Wentworth S, Pinn M, Bourland JD, DeGuzman AF, Ekstrand K, Ellis TL, Glazier SS, McMullen KP, Munley M, Stieber VW, Tatter SB, Shaw EG. Clinical experience with radiation therapy in the management of neurofibromatosis-associated central nervous system tumors. Int J Radiat Oncol Biol Phys. 2009; 73(1):208-213.

Sintay BJ, Bourland JD. A PDE approach for quantifying and visualizing tumor progression and regression. In: Miga MI, Wong KH, eds. Medical imaging 2009: visualization, image-guided procedures, and modeling. Proceedings of SPIE--The International Society for Optical Engineering; 2009 Feb 8; Lake Buena Vista (FL). Bellingham (WA): SPIE--The International Society for Optical Engineering; 2009: 72612F.

Wiant D, Bourland JD. Simulated gamma knife head frame placement for radiosurgical pre-planning. Technol Cancer Res Treat. 2009; 8(4):265-270.

Zhu X, Bourland JD, Yuan Y, Zhuang T, O'Daniel J, Thongphiew D, Wu QJ, Das SK, Yoo S, Yin FF. Tradeoffs of integrating real-time tracking into IGRT for prostate cancer treatment. Phys Med Biol. 2009; 54(17):N393-N401.

Wiant D, Atwood TF, Olson J, Papagikos M, Forbes ME, Riddle DR, Bourland JD. Gamma knife radiosurgery treatment planning for small animals using high-resolution 7T micro-magnetic resonance imaging. Radiat Res. 2009; 172(5):625-631.

Bharkhada D, Yu H, Dixon R, Wei Y, Carr JJ, Bourland JD, Best R, Hogan R, Wang G. Demonstration of dose and scatter reductions for interior computed tomography. J Comput Assist Tomogr. 2009; 33(6):967-972.

Attia A, Chan M, Seif D, Russell GB, Bourland JD, Deguzman A, Ellis T, McMullen K, Tatter S, Shaw EG. Treatment of atypical meningiomas with gamma knife radiosurgery: the role of conformality index and margin dose [abstract]. Int J Radiat Oncol Biol Phys. 2009; 75(3 Suppl 1):S226-S227.

Aubuchon AC, Chan M, Lovano J, McMullen K, Ellis T, Tatter S, Bourland J, Deguzman A, Munley M, Shaw E. Dorsal root entry zone dose predicts efficacy and toxicity for patients receiving a second radiosurgical treatment for recurrent trigeminal neuralgia [abstract]. Int J Radiat Oncol Biol Phys. 2009; 75(3 Suppl 1):S240.

Jensen CA, Chan MD, McCoy TP, Shaw EG, McMullen KP, Ellis TL, Munley MT, Bourland JD, De Guzman AF, Tatter SB. Adjuvant radiosurgery after resection of a brain metastasis allows for the delay or elimination of whole brain radiotherapy [abstract]. Int J Radiat Oncol Biol Phys. 2009; 75(3 Suppl 1):S226.

Spillman WB Jr, Robertson JL, Meissner KE, Jesselli J, Bourland JD, Robbins ME, Shaw EG. Shape factor analysis of progressive rat hepatoma images. J Biomed Opt. 2008; 13(1):art.014030.

Hinson WH, Kearns WT, deGuzman AF, Bourland JD. Photon spectral characteristics of dissimilar 6 MV linear accelerators. Med Phys. 2008; 35(5):1698-1702.

Monjazeb AM, Bourland JD, Case LD, Ellis TL, Lesser GJ, McMullen KP, Munley M, Tatter SB, Shaw EG. A phase I dose escalation study of IMRT field-in-field boost for newly diagnosed glioblastoma multiforme (GBM) [abstract]. Int J Radiat Oncol Biol Phys. 2008; 72(1 Suppl 1):S227.

Willey JS, Lloyd SAJ, Robbins ME, Bourland JD, Smith-Sielicki H, Bowman LC, Norrdin RW, Bateman TA. Early increase in osteoclast number in mice after whole-body irradiation with 2 Gy X rays. Radiat Res. 2008; 170(3):388-392.

Riddle DR, Schindler MK, Forbes ME, Hua K, Bourland JD. Low dose Gamma Knife irradiation of the adult rodent hippocampus: aging affects the development of in- and out-of-field effects [abstract]. Soc Neurosci Abstr. 2008; 2008(Neuroscience Meeting Planner):.

Lloyd SAJ, Bandstra ER, Travis ND, Nelson GA, Bourland JD, Pecaut MJ, Gridley DS, Willey JS, Bateman TA. Spaceflight-relevant types of ionizing radiation and cortical bone: potential LET effect?. Adv Space Res. 2008; 42(12):1889-1897.

Bowman LC, Livingston EW, Willey JS, Robbins ME, Bourland JD, Bateman TA. Radiation-induced bone loss: description of dose, time course, age, strain and sex variables [abstract]. J Bone Miner Res. 2008; 23(Suppl):S335.

Willey JS, Livingston EW, Bowman LC, Robbins ME, Bourland JD, Bateman TA. Risedronate prevents early radiation-induced bone loss at multiple skeletal sites [abstract]. J Bone Miner Res. 2008; 23(Suppl):S20.

Wiant D, Rossmeisl J, Robertson J, Bourland J. Ex post facto addition of headframes to DICOM image sets for radiosurgery treatment planning [abstract]. Med Phys. 2008; 35(6):2699.

Lawrence M, Bourland J. Positron emission tomography phantom studies for radiation therapy target delineation [abstract]. Med Phys. 2008; 35(6):2666.

Atwood TF, Zhu J-M, Bourland JD. Bioanatomic MR imaging for characterization of brain tumor and radiation response in the rat brain [abstract]. Med Phys. 2008; 35(6):2855.

Sintay B, Bourland J. Tumor shape analysis using Poisson's equation [abstract]. Med Phys. 2008; 35(6):2661.

Bourland JD. Hybrid power [newsmagazine article]. Advance for Imaging & Radiation Oncology. 2008; 18(2):50-56.

Bourland JD. Image-guided radiation treatment. In: Wolbarst AB, Massman KL, Hendee WR, eds. Advances in medical physics 2008. Madison (WI): Medical Physics Publishing; 2008: 179-192.

Ekstrand KE, Hinson WH, Kearns W, Bourland JD, deGuzman AF, McMullen KP, Stieber VW. Optically guided linac radiosurgery with a Leksell head frame as an adjunct to gamma knife treatment. Technol Cancer Res Treat. 2007; 6(2):123-126.

Gmeiner WH, Garg S, Hatcher HC, Smith TL, Bourland JD, Garg PK. MicroPET imaging to monitor tumor response to single agent and combined ionizing radiation therapy and FdUMP treatment [abstract]. J Nucl Med. 2007; 48(6 Suppl 2):83P.

Bourland J, Jeraj R. CE: functional/molecular imaging: PET for planning/assessment [abstract]. Med Phys. 2007; 34(6):2541.

Havnen A, Munley M, Bourland J. A model to evaluate the spatial and dosimetric resolutions of IMRT for desired high-gradient dose distributions [abstract]. Med Phys. 2007; 34(6):2405.

Hinson WH, Kearns WT, deGuzman AF, Bourland JD. Photon spectral characteristics of dissimilar 6MV linear accelerators [abstract]. Med Phys. 2007; 34(6):2481.

Kearns WT, Bourland JD, Hinson WH, Hampton CJ, Munley MT. Implementation and special considerations for dedicated PET/CT simulation in radiation oncology [abstract]. Med Phys. 2007; 34(6):2398.

Stieber V, Robbins M, deGuzman A, Tatter S, Ekstrand K, McMullen K, Branch C, Shaw E, Bourland JD, Lovato J, Munley M, Ellis T, et al. Determination of a clinical value for the repair half-time (T1/2) of the trigeminal nerve based on outcome data from gamma knife radiosurgery for facial pain. Radiat Res. 2007; 168(2):143-148.

Jones JC, Appt SE, Bourland JD, Hoyer PB, Clarkson TB, Kaplan JR. Multidetector computed tomographic morphology of ovaries in cynomolgus macaques (Macaca fascicularis). J Am Assoc Lab Anim Sci. 2007; 46(5):54-63.

Pinn M, Bourland JD, Ellis T, Deguzman A, Ekstrand K, McMullen K, Glazier S, Munley M, Stieber V, Tatter S, Shaw E, et al. Results of stereotactic radiosurgery for NF2 patients with acoustic neuroma [abstract]. Neuro Oncol. 2007; 9(4):587.

Bourland J. Functional imaging for radiotherapy guidance--quantitative biological imaging and the oncologic target [abstract]. Med Phys. 2006; 33(6):2255.

Bourland J, Flowers K, Huey K, Shaw E. Dedicated PET-CT and MR-simulators in a state-of-the-art radiation treatment facility [abstract]. Med Phys. 2006; 33(6):2165.

Bourland J. Positron emission tomography for oncologic imaging and treatment [abstract]. Med Phys. 2006; 33(6):2178-2179.

Fullerton G, Bourland J, Pelizzari C, Ling C, Jaffray D, Eckelman W, Patt B, Hendee W, Mulvaney J, Mackie T, et al. BIROW--Biomedical Imaging Research Opportunities Workshop: intersociety project to accelerate biomedical imaging discovery and application [abstract]. Med Phys. 2006; 33(6):2279-2280.

Balamucki CJ, Stieber VW, Ellis TL, Tatter SB, DeGuzman AF, McMullen KP, Lovato J, Shaw EG, Ekstrand KE, Bourland JD, Munley MT, Robbins M, Branch C. Does dose rate affect efficacy? The outcomes of 256 gamma knife surgery procedures for trigeminal neuralgia and other types of facial pain as they relate to the half-life of cobalt. J Neurosurg. 2006; 105(5):730-735.

Kim PK, Ellis TL, Stieber VW, McMullen KP, Shaw EG, McCoy TP, D'Agostino RB, Bourland JD, Deguzman AF, Ekstrand KE, Raber MR, Tatter SB. Gamma Knife surgery targeting the resection cavity of brain metastasis that has progressed after whole-brain radiotherapy. J Neurosurg. 2006; 105(Suppl):75-78.

Powell, DF, Rossi PJ, Lawrence MV, Kavanagh K, McMullen KP, Stieber VW, Ellis TL, deGuzman AF, Bourland JD, Tatter SB. Stereotactic radiosurgery improves pre-treatment symptoms in patients with acoustic neuroma [abstract]. Int J Radiat Oncol Biol Phys. 2006; 66(3 Suppl):S198.
All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Last Updated 4/17/2012
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