Profile

John Daniel Bourland, Ph.D.Wake Forest School of Medicine

John Daniel Bourland, Ph.D.

Professor,



Clinical Interests

Dose Computation, Imaging in Radiation Treatment, Radiation Oncology Physics, Radiosurgery, Gamma Knife

Contact Information

Academic: 336-713-6503 | Department: 336-713-6503

Email: bourland@wakehealth.edu

Education & Training

  • B.S., University of North Carolina-Chapel Hill, 1978
  • M.S.P.H., University of North Carolina School of Public Hlth, 1981
  • Ph.D., University of North Carolina School of Public Hlth, 1990

Memberships

  • Am Assn Of Physicists In Med
  • Am Coll Of Radiology
  • Radiological Soc of North Amer
  • Am Soc Of Ther Rad & Oncology
  • Health Physics Society
John Daniel Bourland, Ph.D.

John Daniel Bourland, Ph.D.

Professor, Radiation Oncology
Comprehensive Cancer Center
Brain Tumor Center of Excellence
Biomedical Engineering

Research Interests

biotechnology, cancer/oncogenesis, cross(mult/tnslat/inter)discip, drugs/therapeutic agents pharm, environmental sciences, model development, surgery/trauma/burns/trauma

Contact Information

Academic: 336-713-6503 | Department: 336-713-6503

Email: bourland@wakehealth.edu

Recent Publications

Mu F, Lucas JT Jr, Watts JM, Johnson AJ, Daniel Bourland J, Laxton AW, Chan MD, Tatter SB. Tumor resection with carmustine wafer placement as salvage therapy after local failure of radiosurgery for brain metastasis. J Clin Neurosci. 2015;22(3):561-565.

Hanbury DB, Robbins ME [deceased], Bourland JD, Wheeler KT, Peiffer AM, Mitchell EL, Daunais JB, Deadwyler SA, Cline JM. Pathology of fractionated whole-brain irradiation in rhesus monkeys (Macaca mulatta). Radiat Res. 2015;183(3):367-374.

DeBo RJ, Register TC, Caudell DL, Sempowski GD, Dugan G, Gray S, Owzar K, Jiang C, Bourland JD, Chao NJ, Cline JM. Molecular and cellular profiling of acute responses to total body radiation exposure in ovariectomized female cynomolgus macaques. Int J Radiat Biol. 2015;91(6):510-518.

Tytell M, Robinson MB, Dorand JE, Gabard AR, Hurt JK, Anderson AM, Bourland JD, Liu J, Burnett LR. Ionizing radiation injury of the skin: histologic and metabolomic evaluation in the pig as a model for testing the potential benefits of topical treatments for cutaneous radiation injury [abstract]. F1000Research. 2015;4():197.

Willard SL, Uberseder B, Clark A, Daunais JB, Johnston WD, Neely D, Massey A, Williamson JD, Kraft RA, Bourland JD, Jones SR, Shively CA. Long term sertraline effects on neural structures in depressed and nondepressed adult female nonhuman primates. Neuropharmacology. 2015;():.

Lucas JT Jr, Colmer HG IV, White L, Fitzgerald N, Isom S, Bourland JD, Laxton AW, Tatter SB, Chan MD. Competing risk analysis of neurologic versus nonneurologic death in patients undergoing radiosurgical salvage after whole-brain radiation therapy failure: who actually dies of their brain metastases?. Int J Radiat Oncol Biol Phys. 2015;92(5):1008-1015.

Drzymala R, Alvarez P, Bednarz G, Bourland J, DeWerd L, Ma L, Meltsner S, Neyman G, Novotny J, Petti P, Rivard M, Shiu A, Goetsch S. TU-G-BRD-04: a round robin dosimetry intercomparison of gamma stereotactic radiosurgery calibration protocols. Med Phys. 2015;42(6):3627.

Triffo WJ, Bourland JD, Couture DE, McMullen KP, Tatter SB, Morris PP. Definitive treatment of vein of Galen aneurysmal malformation with stereotactic radiosurgery. J Neurosurg. 2014;120(1):120-125.

Lester SC, Taksler GB, Kuremsky JG, Lucas JT Jr, Ayala-Peacock DN, Randolph DM II, Bourland JD, Laxton AW, Tatter SB, Chan MD. Clinical and economic outcomes of patients with brain metastases based on symptoms: an argument for routine brain screening of those treated with upfront radiosurgery. Cancer. 2014;120(3):433-441.

Kilburn JM, Ellis TL [deceased], Lovato JF, Urbanic JJ, Bourland JD, Munley MT, Deguzman AF, McMullen KP, Shaw EG, Tatter SB, Chan MD. Local control and toxicity outcomes in brainstem metastases treated with single fraction radiosurgery: is there a volume threshold for toxicity?. J Neurooncol. 2014;117(1):167-174.

Weller M, Marshall K, Lovato JF, Bourland JD, deGuzman AF, Munley MT, Shaw EG, Tatter SB, Chan MD. Single-institution retrospective series of gamma knife radiosurgery in the treatment of multiple sclerosis-related trigeminal neuralgia: factors that predict efficacy. Stereotact Funct Neurosurg. 2014;92(1):53-58.

Rossmeisl JH Jr, Garcia PA, Daniel GB, Bourland JD, Debinski W, Dervisis N, Klahn S. Invited review-neuroimaging response assessment criteria for brain tumors in veterinary patients. Vet Radiol Ultrasound. 2014;55(2):115-132.

Lucas JT Jr, Nida AM, Isom S, Marshall K, Bourland JD, Laxton AW, Tatter SB, Chan MD. Predictive nomogram for the durability of pain relief from gamma knife radiation surgery in the treatment of trigeminal neuralgia. Int J Radiat Oncol Biol Phys. 2014;89(1):120-126.

Ayala-Peacock DN, Peiffer AM, Lucas JT, Isom S, Kuremsky JG, Urbanic JJ, Bourland JD, Laxton AW, Tatter SB, Shaw EG, Chan MD. A nomogram for predicting distant brain failure in patients treated with gamma knife stereotactic radiosurgery without whole brain radiotherapy. Neuro Oncol. 2014;16(9):1283-1288.

Neal MT, Chan MD, Lucas JT Jr, Loganathan A, Dillingham C, Pan E, Stewart JH IV, Bourland JD, Shaw EG, Tatter SB, Ellis TL. Predictors of survival, neurologic death, local failure, and distant failure after gamma knife radiosurgery for melanoma brain metastases. World Neurosurg. 2014;82(6):1250-1255.

Grimes K, Kratzer T, Russo K, Bourland D, Castellino S. Occult GI bleeding in a 15 year old pediatric cancer survivor. J Pediatr Gastroenterol Nutr. 2014;():.

Kuhn EN, Taksler GB, Dayton O, Loganathan A, Bourland D, Tatter SB, Laxton AW, Chan MD. Is there a tumor volume threshold for postradiosurgical symptoms? A single-institution analysis. Neurosurgery. 2014;75(5):536-545.

Forbes ME, Paitsel M, Bourland JD, Riddle DR. Early-delayed, radiation-induced cognitive deficits in adult rats are heterogeneous and age-dependent. Radiat Res. 2014;182(1):60-71.

Lucas JT, DiNotto J, Dolesh W, Jung Y, Whitlow CT, Maldjian JA, Chan MD, Bourland J. Safety assessment, artifact reduction, and description of geometric distortion associated with diffusion imaging (DWI) with rigid head frame immobilization for stereotactic radiosurgery [abstract]. Int J Radiat Oncol Biol Phys. 2014;90(1 Suppl):S903.

Dorand JE, Burnett LR, Tytell M, Bourland JD. A Sr-90 irradiation device for the study of cutaneous radiation injury [abstract]. In: Abstracts of the 56th American Association of Physicists in Medicine Annual Meeting & Exhibition; 2014 July 20-24; Austin (TX). 2014;():.

Tytell M, Robinson MB, Dorand JE, Gabard AR, Hurt JK, Anderson AM, Bourland JD, Burnett LR. Ionizing radiation injury of the skin: histologic and metabolomic evaluation in the pig as a model for testing the potential benefits of topical treatments for cutaneous radiation injury [abstract]. Mol Biol Cell. 2014;25(Meeting Abstract):P632.

Tytell M, Robinson MB, Dorand JE, Gabard AR, Hurt JK, Anderson AM, Bourland JD, Burnett L. Ionizing radiation injury of the skin: histologic and metabolomic evaluation in the pig [abstract]. In: Abstracts of the Assessment, Mitigation & Treatment of Radiation Injury Workshop; 2014 Oct. 8-10; Baltimore (MD). 2014;():12.

Gmeiner WH, Willingham MC, Bourland JD, Hatcher HC, Smith TL, D'Agostino RB Jr, Blackstock W. F10 inhibits growth of PC3 xenografts and enhances the effects of radiation therapy. J Clin Oncol Res. 2014;2(4):1028.

Willard S, Johnston WD, Clark A, Uberseder B, Neely D, Massey A, Daunais J, Williamson J, Register TC, Bourland JD, Shively C. Long term sertraline treatment decreases volumes of hippocampus and anterior cingulate cortex in an adult female primate model of depression [abstract]. Biol Psychiatry. 2013;73(9 Suppl):235S.

Forbes ME, Paitsel M, Bourland JD, Riddle DR. Systemic effects of fractionated, whole-brain irradiation in young adult and aging rats. Radiat Res. 2013;180(3):326-333.

Hopewell JW, Bourland JD, Shaw EG. Mike Robbins 1954-2013 [obituary]. Int J Radiat Biol. 2013;89(6):482-483.

Munley MT, Kagadis GC, McGee KP, Kirov AS, Jang S, Mutic S, Jeraj R, Xing L, Bourland JD. An introduction to molecular imaging in radiation oncology:aA report by the AAPM Working Group on Molecular Imaging in Radiation Oncology (WGMIR). Med Phys. 2013;40(10):101501.

Kuhn E, Taksler GB, Dayton O, Loganathan A, Bourland J, Ellis TL [deceased], Laxton AW, Shaw EG, Chan MD, Tatter SB. Adverse toxicity after stereotactic radiosurgery for treatment of meningiomas [abstract]. Int J Radiat Oncol Biol Phys. 2013;87(2 Suppl):S259.

Kuhn EN, Taksler GB, Dayton O, Loganathan AG, Vern-Gross TZ, Bourland JD, Laxton AW, Chan MD, Tatter SB. Patterns of recurrence after stereotactic radiosurgery for treatment of meningiomas. Neurosurg Focus. 2013;35(6):E14.

Kuremsky JG, Urbanic JJ, Petty WJ, Lovato JF, Bourland JD, Tatter SB, Ellis TL [deceased], McMullen KP, Shaw EG, Chan MD. Tumor histology predicts patterns of failure and survival in patients with brain metastases from lung cancer treated with gamma knife radiosurgery. Neurosurgery. 2013;73(4):641-647.

Hopewell JW, Bourland JD, Shaw EG. Michael E. Robbins, Ph.D. 1954-2012 [in memoriam]. Radiat Res. 2013;179(5):615-616.

Monjazeb AM, Ayala D, Jensen C, Case LD, Bourland JD, Ellis TL, McMullen KP, Chan MD, Tatter SB, Lesser GJ, Shaw EG. A phase I dose escalation study of hypofractionated IMRT field-in-field boost for newly diagnosed glioblastoma multiforme. Int J Radiat Oncol Biol Phys. 2012;82(2):743-748.

Marshall K, Chan MD, McCoy TP, Aubuchon AC, Bourland JD, McMullen KP, deGuzman AF, Munley MT, Shaw EG, Tatter SB, Ellis TL. Predictive variables for the successful treatment of trigeminal neuralgia with gamma knife radiosurgery. Neurosurgery. 2012;70(3):566-573.

Harris S, Chan MD, Lovato JF, Ellis TL, Tatter SB, Bourland JD, Munley MT, deGuzman AF, Shaw EG, Urbanic JJ, McMullen KP. Gamma knife stereotactic radiosurgery as salvage therapy after failure of whole-brain radiotherapy in patients with small-cell lung cancer. Int J Radiat Oncol Biol Phys. 2012;83(1):e53-e59.

Cochran DC, Chan MD, Aklilu M, Lovato JF, Alphonse NK, Bourland JD, Urbanic JJ, McMullen KP, Shaw EG, Tatter SB, Ellis TL. The effect of targeted agents on outcomes in patients with brain metastases from renal cell carcinoma treated with Gamma Knife surgery. J Neurosurg. 2012;116(5):978-983.

Attia A, Chan MD, Mott RT, Russell GB, Seif D, Bourland JD, Deguzman AF, Ellis TL, McMullen KP, Munley MT, Tatter SB, Shaw EG. Patterns of failure after treatment of atypical meningioma with gamma knife radiosurgery. J Neurooncol. 2012;108(1):179-185.

Bennett MC, Wiant DB, Gersh JA, Dolesh W, Ding X, Best RCM, Bourland JD. Mechanisms and prevention of thermal injury from gamma radiosurgery headframes during 3T MR imaging. J Appl Clin Med Phys. 2012;13(4):54-70.

Ding X, Bourland J, Dolesh W, Best R, Mcgowin I, Liu J. Small field output factor measurement using MAGIC gel dosimeter in 3T MRI [abstract]. Med Phys. 2012;39(6):3725.

Ding X, Bourland J, Dolesh W. Localization error in gamma radiosurgery with 3T MR due to fiducial box chemical shift from incorrect liquid filling materials [abstract]. Med Phys. 2012;39(6):3665.

Attia A, Tatter SB, Weller M, Marshall K, Lovato JF, Bourland JD, Ellis TL [deceased], McMullen KP, Shaw EG, Chan MD. CT-only planning for Gamma Knife radiosurgery in the treatment of trigeminal neuralgia: methodology and outcomes from a single institution. J Med Imaging Radiat Oncol. 2012;56(4):490-494.

Amponsah K, Ellis TL [deceased], Chan MD, Lovato JF, Bourland JD, deGuzman AF, Ekstrand KE, Munley MT, McMullen KP, Shaw EG, Tatter SB. Retrospective analysis of imaging techniques for treatment planning and monitoring of obliteration for gamma knife treatment of cerebral arteriovenous malformation. Neurosurgery. 2012;71(4):893-900.

Best R, Gersh J, Wiant D, Bourland J. Gamma knife perfexion dosimetry: a Monte Carlo model of one sector [abstract]. Med Phys. 2012;39(6):3812-3813.

Borras C, Bourland J, Brualla Gonzalez L, Bulychkin P, Ford E, Kazantsev P, Krylova T, Lopez Medina A, Prusova M, Romanov D, Rosello Ferrando J, Willoughby T, Yan D, Yu C, Zvereva A. Medical physics challenges for implementation of new technologies in external beam radiotherapy [abstract]. Med Phys. 2012;39(6):3955.

Squire SE, Chan MD, Furr RM, Lowell DA, Tatter SB, Ellis TL [deceased], Bourland JD, Deguzman AF, Munley MT, Ekstrand KE, Shaw EG, McMullen KP. Gamma knife radiosurgery in the treatment of tumor-related facial pain. Stereotact Funct Neurosurg. 2012;90(3):145-150.

Vern-Gross TZ, Lawrence JA, Case LD, McMullen KP, Bourland JD, Metheny-Barlow LJ, Ellis TL [deceased], Tatter SB, Shaw EG, Urbanic JJ, Chan MD. Breast cancer subtype affects patterns of failure of brain metastases after treatment with stereotactic radiosurgery. J Neurooncol. 2012;110(3):381-388.

Loganathan AG, Chan MD, Alphonse N, Peiffer AM, Johnson AJ, McMullen KP, Urbanic JJ, Saconn PA, Bourland JD, Munley MT, Shaw EG, Tatter SB, Ellis TL [deceased]. Clinical outcomes of brain metastases treated with Gamma Knife radiosurgery with 3.0T versus 1.5T MRI-based treatment planning: have we finally optimised detection of occult brain metastases?. J Med Imaging Radiat Oncol. 2012;56(5):554-560.

Ayala-Peacock D, Peiffer AM, Ellis TL [deceased], Tatter SB, Urbanic JJ, Bourland JD, Shaw EG, Chan MC. Predictive factors for distant brain failure after primary radiosurgical management of brain metastases [abstract]. Int J Radiat Oncol Biol Phys. 2012;84(3 Suppl):S296.

Lucas J, Marshall K, Bourland D, Shaw E, Ellis T [deceased], Tatter S, Chan MD. Predictors of durability of response for stereotactic radiosurgery in the treatment of trigeminal neuralgia [abstract]. Int J Radiat Oncol Biol Phys. 2012;84(3 Suppl):S37-S38.

Voytko ML, Murray RS, Bourland JD, Robbins ME [deceased]. Radiation-induced cognitive impairment in postmenopausal female nonhuman primates [abstract]. In: Abstracts of the International Cognition and Cancer Task Force Conference; 2012 Mar 15-17; Paris (France). 2012;():.

Robbins ME, Bourland JD, Cline JM, Wheeler KT, Deadwyler SA. A model for assessing cognitive impairment after fractionated whole-brain irradiation in nonhuman primates. Radiat Res. 2011;175(4):519-525.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Radiation Oncology

Clinical Interests

Dose Computation, Imaging in Radiation Treatment, Radiation Oncology Physics, Radiosurgery, Gamma Knife

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