Profile

John Daniel Bourland, Ph.D.Wake Forest School of Medicine

John Daniel Bourland, Ph.D.

Professor,

Clinical Interests

Dose Computation, Imaging in Radiation Treatment, Radiation Oncology Physics, Radiosurgery, Gamma Knife

Contact Information

Academic: 336-713-6503 | Department: 336-713-6503

Email: bourland@wakehealth.edu

Education & Training

  • B.S., University of North Carolina-Chapel Hill, 1978
  • M.S.P.H., University of North Carolina School of Public Hlth, 1981
  • Ph.D., University of North Carolina School of Public Hlth, 1990

Memberships

  • Am Assn Of Physicists In Med
  • Am Coll Of Radiology
  • Radiological Soc of North Amer
  • Am Soc Of Ther Rad & Oncology
  • Health Physics Society
John Daniel Bourland, Ph.D.

John Daniel Bourland, Ph.D.

Professor, Radiation Oncology
Biomedical Engineering

Research Interests

Radiosurgery; Whole-Body Irradiation; Brain Neoplasms; Nomograms; Dog Diseases
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Contact Information

Academic: 336-713-6503 | Department: 336-713-6503

Email: bourland@wakehealth.edu

Recent Publications

Occult gastrointestinal bleeding in a 15-year-old pediatric cancer survivor. Grimes K, Kratzer T, Russo K, Bourland D, Castellino S.. J Pediatr Gastroenterol Nutr. 2016;62(6):e62-e63.

Emerging indications for fractionated gamma knife radiosurgery. McTyre E, Helis CA, Farris M, Wilkins L, Sloan D, Hinson WH, Bourland JD, Dezarn WA, Munley MT, Watabe K, Xing F, Laxton AW, Tatter SB, Chan MD.. Neurosurgery. 2016;():.

Tumor resection with carmustine wafer placement as salvage therapy after local failure of radiosurgery for brain metastasis. Mu F, Lucas JT Jr, Watts JM, Johnson AJ, Daniel Bourland J, Laxton AW, Chan MD, Tatter SB.. J Clin Neurosci. 2015;22(3):561-565.

Pathology of fractionated whole-brain irradiation in rhesus monkeys (Macaca mulatta). Hanbury DB, Robbins ME [deceased], Bourland JD, Wheeler KT, Peiffer AM, Mitchell EL, Daunais JB, Deadwyler SA, Cline JM.. Radiat Res. 2015;183(3):367-374.

Molecular and cellular profiling of acute responses to total body radiation exposure in ovariectomized female cynomolgus macaques. DeBo RJ, Register TC, Caudell DL, Sempowski GD, Dugan G, Gray S, Owzar K, Jiang C, Bourland JD, Chao NJ, Cline JM.. Int J Radiat Biol. 2015;91(6):510-518.

Ionizing radiation injury of the skin: histologic and metabolomic evaluation in the pig as a model for testing the potential benefits of topical treatments for cutaneous radiation injury [abstract]. Tytell M, Robinson MB, Dorand JE, Gabard AR, Hurt JK, Anderson AM, Bourland JD, Liu J, Burnett LR.. F1000Research. 2015;4():197.

Long term sertraline effects on neural structures in depressed and nondepressed adult female nonhuman primates. Willard SL, Uberseder B, Clark A, Daunais JB, Johnston WD, Neely D, Massey A, Williamson JD, Kraft RA, Bourland JD, Jones SR, Shively CA.. Neuropharmacology. 2015;99():369-378.

Competing risk analysis of neurologic versus nonneurologic death in patients undergoing radiosurgical salvage after whole-brain radiation therapy failure: who actually dies of their brain metastases?. Lucas JT Jr, Colmer HG IV, White L, Fitzgerald N, Isom S, Bourland JD, Laxton AW, Tatter SB, Chan MD.. Int J Radiat Oncol Biol Phys. 2015;92(5):1008-1015.

TU-G-BRD-04: a round robin dosimetry intercomparison of gamma stereotactic radiosurgery calibration protocols. Drzymala R, Alvarez P, Bednarz G, Bourland J, DeWerd L, Ma L, Meltsner S, Neyman G, Novotny J, Petti P, Rivard M, Shiu A, Goetsch S.. Med Phys. 2015;42(6):3627.

Impact of systemic targeted agents on the clinical outcomes of patients with brain metastases. Johnson AG, Ruiz J, Hughes R, Page BR, Isom S, Lucas JT, McTyre ER, Houseknecht KW, Ayala-Peacock DN, Bourland DJ, Hinson WH, Laxton AW, Tatter SB, Debinski W, Watabe K, Chan MD.. Oncotarget. 2015;6(22):18945-55.

Repeat radiosurgery for trigeminal neuralgia. Helis CA, Lucas JT Jr, Bourland JD, Chan MD, Tatter SB, Laxton AW.. Neurosurgery. 2015;77(5):755-761.

A round-robin gamma stereotactic radiosurgery dosimetry interinstitution comparison of calibration protocols. Drzymala RE, Alvarez PE, Bednarz G, Bourland JD, DeWerd LA, Ma L, Meltsner SG, Neyman G, Novotny J Jr, Petti PL, Rivard MJ, Shiu AS, Goetsch SJ.. Med Phys. 2015;42(11):6745-6756.

Distinct profiles of brain medullary metabolites detected by 1H-magnetic resonance spectroscopy correlate with indices of autonomic function and visceral fat in healthy adults [abstract]. Diz DI, Olson J, Bourland JD, Kitzman D, Carr JJ, Kritchevsky SB, Groban L, Shaltout HA.. Hypertension. 2015;66(Suppl 1):AP149.

Definitive treatment of vein of Galen aneurysmal malformation with stereotactic radiosurgery. Triffo WJ, Bourland JD, Couture DE, McMullen KP, Tatter SB, Morris PP.. J Neurosurg. 2014;120(1):120-125.

Clinical and economic outcomes of patients with brain metastases based on symptoms: an argument for routine brain screening of those treated with upfront radiosurgery. Lester SC, Taksler GB, Kuremsky JG, Lucas JT Jr, Ayala-Peacock DN, Randolph DM II, Bourland JD, Laxton AW, Tatter SB, Chan MD.. Cancer. 2014;120(3):433-441.

Local control and toxicity outcomes in brainstem metastases treated with single fraction radiosurgery: is there a volume threshold for toxicity?. Kilburn JM, Ellis TL [deceased], Lovato JF, Urbanic JJ, Bourland JD, Munley MT, Deguzman AF, McMullen KP, Shaw EG, Tatter SB, Chan MD.. J Neurooncol. 2014;117(1):167-174.

Single-institution retrospective series of gamma knife radiosurgery in the treatment of multiple sclerosis-related trigeminal neuralgia: factors that predict efficacy. Weller M, Marshall K, Lovato JF, Bourland JD, deGuzman AF, Munley MT, Shaw EG, Tatter SB, Chan MD.. Stereotact Funct Neurosurg. 2014;92(1):53-58.

Invited review-neuroimaging response assessment criteria for brain tumors in veterinary patients. Rossmeisl JH Jr, Garcia PA, Daniel GB, Bourland JD, Debinski W, Dervisis N, Klahn S.. Vet Radiol Ultrasound. 2014;55(2):115-132.

Predictive nomogram for the durability of pain relief from gamma knife radiation surgery in the treatment of trigeminal neuralgia. Lucas JT Jr, Nida AM, Isom S, Marshall K, Bourland JD, Laxton AW, Tatter SB, Chan MD.. Int J Radiat Oncol Biol Phys. 2014;89(1):120-126.

A nomogram for predicting distant brain failure in patients treated with gamma knife stereotactic radiosurgery without whole brain radiotherapy. Ayala-Peacock DN, Peiffer AM, Lucas JT, Isom S, Kuremsky JG, Urbanic JJ, Bourland JD, Laxton AW, Tatter SB, Shaw EG, Chan MD.. Neuro Oncol. 2014;16(9):1283-1288.

Predictors of survival, neurologic death, local failure, and distant failure after gamma knife radiosurgery for melanoma brain metastases. Neal MT, Chan MD, Lucas JT Jr, Loganathan A, Dillingham C, Pan E, Stewart JH IV, Bourland JD, Shaw EG, Tatter SB, Ellis TL.. World Neurosurg. 2014;82(6):1250-1255.

Is there a tumor volume threshold for postradiosurgical symptoms? A single-institution analysis. Kuhn EN, Taksler GB, Dayton O, Loganathan A, Bourland D, Tatter SB, Laxton AW, Chan MD.. Neurosurgery. 2014;75(5):536-545.

Early-delayed, radiation-induced cognitive deficits in adult rats are heterogeneous and age-dependent. Forbes ME, Paitsel M, Bourland JD, Riddle DR.. Radiat Res. 2014;182(1):60-71.

Safety assessment, artifact reduction, and description of geometric distortion associated with diffusion imaging (DWI) with rigid head frame immobilization for stereotactic radiosurgery [abstract]. Lucas JT, DiNotto J, Dolesh W, Jung Y, Whitlow CT, Maldjian JA, Chan MD, Bourland J.. Int J Radiat Oncol Biol Phys. 2014;90(1 Suppl):S903.

A Sr-90 irradiation device for the study of cutaneous radiation injury [abstract]. Dorand JE, Burnett LR, Tytell M, Bourland JD.. In: Abstracts of the 56th American Association of Physicists in Medicine Annual Meeting & Exhibition; 2014 July 20-24; Austin (TX). 2014;():.

Ionizing radiation injury of the skin: histologic and metabolomic evaluation in the pig as a model for testing the potential benefits of topical treatments for cutaneous radiation injury [abstract]. Tytell M, Robinson MB, Dorand JE, Gabard AR, Hurt JK, Anderson AM, Bourland JD, Burnett LR.. Mol Biol Cell. 2014;25(Meeting Abstract):P632.

Ionizing radiation injury of the skin: histologic and metabolomic evaluation in the pig [abstract]. Tytell M, Robinson MB, Dorand JE, Gabard AR, Hurt JK, Anderson AM, Bourland JD, Burnett L.. In: Abstracts of the Assessment, Mitigation & Treatment of Radiation Injury Workshop; 2014 Oct. 8-10; Baltimore (MD). 2014;():12.

F10 inhibits growth of PC3 xenografts and enhances the effects of radiation therapy. Gmeiner WH, Willingham MC, Bourland JD, Hatcher HC, Smith TL, D'Agostino RB Jr, Blackstock W.. J Clin Oncol Res. 2014;2(4):1028.

Long term sertraline treatment decreases volumes of hippocampus and anterior cingulate cortex in an adult female primate model of depression [abstract]. Willard S, Johnston WD, Clark A, Uberseder B, Neely D, Massey A, Daunais J, Williamson J, Register TC, Bourland JD, Shively C.. Biol Psychiatry. 2013;73(9 Suppl):235S.

Systemic effects of fractionated, whole-brain irradiation in young adult and aging rats. Forbes ME, Paitsel M, Bourland JD, Riddle DR.. Radiat Res. 2013;180(3):326-333.

Mike Robbins 1954-2013 [obituary]. Hopewell JW, Bourland JD, Shaw EG.. Int J Radiat Biol. 2013;89(6):482-483.

An introduction to molecular imaging in radiation oncology:aA report by the AAPM Working Group on Molecular Imaging in Radiation Oncology (WGMIR). Munley MT, Kagadis GC, McGee KP, Kirov AS, Jang S, Mutic S, Jeraj R, Xing L, Bourland JD.. Med Phys. 2013;40(10):101501.

Adverse toxicity after stereotactic radiosurgery for treatment of meningiomas [abstract]. Kuhn E, Taksler GB, Dayton O, Loganathan A, Bourland J, Ellis TL [deceased], Laxton AW, Shaw EG, Chan MD, Tatter SB.. Int J Radiat Oncol Biol Phys. 2013;87(2 Suppl):S259.

Patterns of recurrence after stereotactic radiosurgery for treatment of meningiomas. Kuhn EN, Taksler GB, Dayton O, Loganathan AG, Vern-Gross TZ, Bourland JD, Laxton AW, Chan MD, Tatter SB.. Neurosurg Focus. 2013;35(6):E14.

Tumor histology predicts patterns of failure and survival in patients with brain metastases from lung cancer treated with gamma knife radiosurgery. Kuremsky JG, Urbanic JJ, Petty WJ, Lovato JF, Bourland JD, Tatter SB, Ellis TL [deceased], McMullen KP, Shaw EG, Chan MD.. Neurosurgery. 2013;73(4):641-647.

Michael E. Robbins, Ph.D. 1954-2012 [in memoriam]. Hopewell JW, Bourland JD, Shaw EG.. Radiat Res. 2013;179(5):615-616.

A phase I dose escalation study of hypofractionated IMRT field-in-field boost for newly diagnosed glioblastoma multiforme. Monjazeb AM, Ayala D, Jensen C, Case LD, Bourland JD, Ellis TL, McMullen KP, Chan MD, Tatter SB, Lesser GJ, Shaw EG.. Int J Radiat Oncol Biol Phys. 2012;82(2):743-748.

Predictive variables for the successful treatment of trigeminal neuralgia with gamma knife radiosurgery. Marshall K, Chan MD, McCoy TP, Aubuchon AC, Bourland JD, McMullen KP, deGuzman AF, Munley MT, Shaw EG, Tatter SB, Ellis TL.. Neurosurgery. 2012;70(3):566-573.

Gamma knife stereotactic radiosurgery as salvage therapy after failure of whole-brain radiotherapy in patients with small-cell lung cancer. Harris S, Chan MD, Lovato JF, Ellis TL, Tatter SB, Bourland JD, Munley MT, deGuzman AF, Shaw EG, Urbanic JJ, McMullen KP.. Int J Radiat Oncol Biol Phys. 2012;83(1):e53-e59.

The effect of targeted agents on outcomes in patients with brain metastases from renal cell carcinoma treated with Gamma Knife surgery. Cochran DC, Chan MD, Aklilu M, Lovato JF, Alphonse NK, Bourland JD, Urbanic JJ, McMullen KP, Shaw EG, Tatter SB, Ellis TL.. J Neurosurg. 2012;116(5):978-983.

Patterns of failure after treatment of atypical meningioma with gamma knife radiosurgery. Attia A, Chan MD, Mott RT, Russell GB, Seif D, Bourland JD, Deguzman AF, Ellis TL, McMullen KP, Munley MT, Tatter SB, Shaw EG.. J Neurooncol. 2012;108(1):179-185.

Mechanisms and prevention of thermal injury from gamma radiosurgery headframes during 3T MR imaging. Bennett MC, Wiant DB, Gersh JA, Dolesh W, Ding X, Best RCM, Bourland JD.. J Appl Clin Med Phys. 2012;13(4):54-70.

Small field output factor measurement using MAGIC gel dosimeter in 3T MRI [abstract]. Ding X, Bourland J, Dolesh W, Best R, Mcgowin I, Liu J.. Med Phys. 2012;39(6):3725.

Localization error in gamma radiosurgery with 3T MR due to fiducial box chemical shift from incorrect liquid filling materials [abstract]. Ding X, Bourland J, Dolesh W.. Med Phys. 2012;39(6):3665.

CT-only planning for Gamma Knife radiosurgery in the treatment of trigeminal neuralgia: methodology and outcomes from a single institution. Attia A, Tatter SB, Weller M, Marshall K, Lovato JF, Bourland JD, Ellis TL [deceased], McMullen KP, Shaw EG, Chan MD.. J Med Imaging Radiat Oncol. 2012;56(4):490-494.

Retrospective analysis of imaging techniques for treatment planning and monitoring of obliteration for gamma knife treatment of cerebral arteriovenous malformation. Amponsah K, Ellis TL [deceased], Chan MD, Lovato JF, Bourland JD, deGuzman AF, Ekstrand KE, Munley MT, McMullen KP, Shaw EG, Tatter SB.. Neurosurgery. 2012;71(4):893-900.

Gamma knife perfexion dosimetry: a Monte Carlo model of one sector [abstract]. Best R, Gersh J, Wiant D, Bourland J.. Med Phys. 2012;39(6):3812-3813.

Medical physics challenges for implementation of new technologies in external beam radiotherapy [abstract]. Borras C, Bourland J, Brualla Gonzalez L, Bulychkin P, Ford E, Kazantsev P, Krylova T, Lopez Medina A, Prusova M, Romanov D, Rosello Ferrando J, Willoughby T, Yan D, Yu C, Zvereva A.. Med Phys. 2012;39(6):3955.

Gamma knife radiosurgery in the treatment of tumor-related facial pain. Squire SE, Chan MD, Furr RM, Lowell DA, Tatter SB, Ellis TL [deceased], Bourland JD, Deguzman AF, Munley MT, Ekstrand KE, Shaw EG, McMullen KP.. Stereotact Funct Neurosurg. 2012;90(3):145-150.

Breast cancer subtype affects patterns of failure of brain metastases after treatment with stereotactic radiosurgery. Vern-Gross TZ, Lawrence JA, Case LD, McMullen KP, Bourland JD, Metheny-Barlow LJ, Ellis TL [deceased], Tatter SB, Shaw EG, Urbanic JJ, Chan MD.. J Neurooncol. 2012;110(3):381-388.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Radiation Oncology

Clinical Interests

Dose Computation, Imaging in Radiation Treatment, Radiation Oncology Physics, Radiosurgery, Gamma Knife
John Daniel Bourland, Ph.D.

John Daniel Bourland, Ph.D.

Professor, Radiation Oncology
Biomedical Engineering

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