Profile

Donald W. Bowden, Ph.D.Wake Forest School of Medicine

Donald W. Bowden, Ph.D.

Director,
Associate Director,
Professor,


Contact Information

Academic: 336-713-7507 | Department: 336-713-7500

Email: dbowden@wakehealth.edu

Education & Training

  • B.A., Vanderbilt University, 1972
  • Ph.D., University of California-Berkeley, 1978
  • Fellowship, Duke University Hospital, 1981

Memberships

  • Am Assn Of Advancement Of Scie
  • Am Diabetes Assn
  • Am Soc of Human Genetics
  • Fed Of Am Soc For Experimental
Donald W. Bowden, Ph.D.

Donald W. Bowden, Ph.D.

Director, Center for Diabetes Research
Associate Director, Center for Genomics and Personalized Medicine Research
Professor, Center for Genomics and Personalized Medicine Research
Biochemistry
Center on Diabetes, Obesity, and Metabolism

Research Interests

atherosclerosis/thrombosis, communication/speech/hearing, diabetes, genetics/genome, genomics and proteomics, metabolism, minority health issues, molecular biology/molecular me, vascular diseases

Contact Information

Academic: 336-713-7507 | Department: 336-713-7500

Email: dbowden@wakehealth.edu

Recent Publications

Raffield LM, Brenes GA, Cox AJ, Freedman BI, Hugenschmidt CE, Hsu FC, Xu J, Wagner BC, Williamson JD, Maldjian JA, Bowden DW. Associations between anxiety and depression symptoms and cognitive testing and neuroimaging in type 2 diabetes. J Diabetes Complications. 2016;30(1):143-149.

Freedman BI, Pastan SO, Israni AK, Schladt D, Julian BA, Gautreaux MD, Hauptfeld V, Bray RA, Gebel HM, Kirk AD, Gaston RS, Rogers J, Farney AC, Orlando G, Stratta RJ, Mohan S, Ma L, Langefeld CD, Bowden DW, Hicks PJ, Palmer ND,. APOL1 genotype and kidney transplantation outcomes from deceased African American donors. Transplantation. 2016;100(1):194-202.

Chien LC, Hsu FC, Bowden DW, Chiu YF. Generalization of rare variant association tests for longitudinal family studies. Genet Epidemiol. 2016;40(2):101-112.

Sharma NK, Sajuthi SP, Chou JW, Calles-Escandon J, Demons J, Rogers S, Ma L, Palmer ND, R McWilliams D, Beal J, Comeau M, Cherry K, Hawkins GA, Menon L, Kouba E, Davis D, Burris M, Byerly SJ, Easter L, Bowden DW, Freedman BI, Langefeld CD, Das SK. Tissue-specific and genetic regulation of insulin sensitivity-associated transcripts in African Americans. J Clin Endocrinol Metab. 2016;101(4):1455-1468.

Adams JN, Martelle SE, Raffield LM, Freedman BI, Langefeld CD, Hsu FC, Maldjian JA, Williamson JD, Hugenschmidt CE, Carr JJ, Cox AJ, Bowden DW. Analysis of advanced glycation end products in the DHS Mind Study. J Diabetes Complications. 2016;30(2):262-268.

Raffield LM, Cox AJ, Freedman BI, Hugenschmidt CE, Hsu FC, Wagner BC, Xu J, Maldjian JA, Bowden DW. Analysis of the relationships between type 2 diabetes status, glycemic control, and neuroimaging measures in the Diabetes Heart Study Mind. Acta Diabetol. 2016;53(3):439-447.

Adams JN, Raffield LM, Martelle SE, Freedman BI, Langefeld CD, Carr JJ, Cox AJ, Bowden DW. Genetic analysis of advanced glycation end products in the DHS MIND study. Gene. 2016;584(2):173-179.

Martelle SE, Raffield LM, Palmer ND, Cox AJ, Freedman BI, Hugenschmidt CE, Williamson JD, Bowden DW. Dopamine pathway gene variants may modulate cognitive performance in the DHS - Mind Study. Brain Behav. 2016;6(4):e00446.

Palmer ND, Divers J, Lu L, Register TC, Carr JJ, Hicks PJ, Smith SC, Xu J, Judd SE, Irvin MR, Gutierrez OM, Bowden DW, Wagenknecht LE, Langefeld CD, Freedman BI. Admixture mapping of serum vitamin D and parathyroid hormone concentrations in the African American-Diabetes Heart Study. Bone. 2016;87():71-77.

Ma L, Langefeld CD, Comeau ME, Bonomo JA, Rocco MV, Burkart JM, Divers J, Palmer ND, Hicks PJ, Bowden DW, Lea JP, Krisher JO, Clay MJ, Freedman BI. APOL1 renal-risk genotypes associate with longer hemodialysis survival in prevalent nondiabetic African American patients with end-stage renal disease. Kidney Int. 2016;():.

Williams RC, Elston RC, Kumar P, Knowler WC, Abboud HE, Adler S, Bowden DW, Divers J, Freedman BI, Igo RP Jr, Ipp E, Iyengar SK, Kimmel PL, Klag MJ, Kohn O, Langefeld CD, Leehey DJ, Nelson RG, Nicholas SB, Pahl MV, Parekh RS, Rotter JI, Schelling JR,. Selecting SNPs informative for African, American Indian and European Ancestry: application to the Family Investigation of Nephropathy and Diabetes (FIND). BMC Genomics. 2016;17(1):325.

Sajuthi SP, Sharma NK, Chou JW, Palmer ND, McWilliams DR, Beal J, Comeau ME, Ma L, Calles-Escandon J, Demons J, Rogers S, Cherry K, Menon L, Kouba E, Davis D, Burris M, Byerly SJ, Ng MC, Maruthur NM, Patel SR, Bielak LF, Lange LA, Guo X, Sale MM,. Mapping adipose and muscle tissue expression quantitative trait loci in African Americans to identify genes for type 2 diabetes and obesity. Hum Genet. 2016;():.

Liu CT, Raghavan S, Maruthur N, Kabagambe EK, Hong J, Ng MC, Hivert MF, Lu Y, An P, Bentley AR, Drolet AM, Gaulton KJ, Guo X, Armstrong LL, Irvin MR, Li M, Lipovich L, Rybin DV, Taylor KD, Agyemang C, Palmer ND, Cade BE, Chen WM, Dauriz M,. Trans-ethnic meta-analysis and functional annotation illuminates the genetic architecture of fasting glucose and insulin. Am J Hum Genet. 2016;99(1):56-75.

Ma J, Guan M, Bowden DW, Ng MC, Hicks PJ, Lea JP, Ma L, Gao C, Palmer ND, Freedman BI. Association analysis of the cubilin (CUBN) and megalin (LRP2) genes with ESRD in African Americans. Clin J Am Soc Nephrol. 2016;11(6):1034-1043.

Yuan M, Hsu FC, Bowden DW, Xu J, Carrie Smith S, Wagenknecht LE, Comeau ME, Divers J, Register TC, Jeffrey Carr J, Langefeld CD, Freedman BI. Relationships between measures of adiposity with subclinical atherosclerosis in patients with type 2 diabetes. Obesity (Silver Spring). 2016;():.

Freedman BI, Langefeld CD, Lu L, Palmer ND, Carrie Smith S, Bagwell BM, Hicks PJ, Xu J, Wagenknecht LE, Raffield LM, Register TC, Jeffrey Carr J, Bowden DW, Divers J. APOL1 associations with nephropathy, atherosclerosis, and all-cause mortality in African Americans with type 2 diabetes. Kidney Int. 2015;87(1):176-181.

Sink KM, Divers J, Whitlow CT, Palmer ND, Smith SC, Xu J, Hugenschmidt CE, Wagner BC, Williamson JD, Bowden DW, Maldjian JA, Freedman BI. Cerebral structural changes in diabetic kidney disease: African American-Diabetes Heart Study MIND. Diabetes Care. 2015;38(2):206-212.

Palmer ND, Ng MC, Langefeld CD, Divers J, Lea JP, Okusa MD, Kimberly RP, Bowden DW, Freedman BI. Lack of association of the APOL1 G3 haplotype in African Americans with ESRD. J Am Soc Nephrol. 2015;26(5):1021-1025.

Yeo NC, O'Meara CC, Bonomo JA, Veth KN, Tomar R, Flister MJ, Drummond IA, Bowden DW, Freedman BI, Lazar J, Link BA, Jacob HJ. Shroom3 contributes to the maintenance of the glomerular filtration barrier integrity. Genome Res. 2015;25(1):57-65.

Hellwege JN, Palmer ND, Brown MW, Ziegler JT, An SS, Guo X, Chen IY, Taylor K, Hawkins GA, Ng MC, Speliotes EK, Lorenzo C, Norris JM, Rotter JI, Wagenknecht LE, Langefeld CD, Bowden DW. Empirical characteristics of family-based linkage to a complex trait: the ADIPOQ region and adiponectin levels. Hum Genet. 2015;134(2):203-213.

Palmer ND, Goodarzi MO, Langefeld CD, Wang N, Guo X, Taylor KD, Fingerlin TE, Norris JM, Buchanan TA, Xiang AH , Haritunians T, Ziegler JT, Williams AH, Stefansovski D, Cui J, Mackay AW, Henkin LF, Bergman RN, Gao X, Gauderman J, Varma R, Hanis CL,. Genetic variants associated with quantitative glucose homeostasis traits translate to type 2 diabetes in Mexican Americans: the GUARDIAN (Genetics Underlying Diabetes in Hispanics) Consortium. Diabetes. 2015;64(5):1853-1866.

Raffield LM, Cox AJ, Hugenschmidt CE, Freedman BI, Langefeld CD, Williamson JD, Hsu F, Maldjian JA, Bowden DW. Heritability and genetic association analysis of neuroimaging measures in the Diabetes Heart Study. Neurobiol Aging. 2015;36(3):1602.e7-15.

Wessel J, Chu AY, Willems SM, Wang S, Yaghootkar H, Brody JA, Dauriz M, Hivert MF, Raghavan S, Lipovich L, Hidalgo B, Fox K, Huffman JE, An P, Lu Y, Rasmussen-Torvik LJ, Grarup N, Ehm MG, Li L, Baldridge AS, Stancakova A, Abrol R, Besse C,. Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility. Nat Commun. 2015;6():5897.

Raffield LM, Cox AJ, Carr JJ, Freedman BI, Hicks PJ, Langefeld CD, Hsu FC, Bowden DW. Analysis of a cardiovascular disease genetic risk score in the Diabetes Heart Study. Acta Diabetol. 2015;52(4):743-751.

Belalcazar LM, Papandonatos GD, McCaffery JM, Peter I, Pajewski NM, Erar B, Allred ND, Balasubramanyam A, Bowden DW, Brautbar A, Pi-Sunyer FX, Ballantyne CM, Huggins GS. A common variant in the CLDN7/ELP5 locus predicts adiponectin change with lifestyle intervention and improved fitness in obese individuals with diabetes. Physiol Genomics. 2015;47(6):215-224.

Dauriz M, Porneala BC, Guo X, Bielak LF, Peyser PA, Durant NH, Carnethon MR, Bonadonna RC, Bonora E, Bowden DW, Florez JC, Fornage M, Hivert MF, Jacobs DR Jr, Kabagambe EK, Lewis CE, Murabito JM, Rasmussen-Torvik LJ, Rich SS, Vassy JL, Yao J,. Association of a 62 variants type 2 diabetes genetic risk score with markers of subclinical atherosclerosis: a transethnic, multicenter study. Circ Cardiovasc Genet. 2015;8(3):507-515.

Il'yasova D, Wagenknecht LE, Spasojevic I, Watkins S, Bowden D, Wang F, D'Agostino RB Jr. Urinary F2-isoprostanes and metabolic markers of fat oxidation. Oxid Med Cell Longev. 2015;2015():729191.

Murea M, Hsu FC, Cox AJ, Hugenschmidt CE, Xu J, Adams JN, Raffield LM, Whitlow CT, Maldjian JA, Bowden DW, Freedman BI. Structural and functional assessment of the brain in European Americans with mild-to-moderate kidney disease: Diabetes Heart Study-MIND. Nephrol Dial Transplant. 2015;30(8):1322-1329.

Ma J, Divers J, Palmer ND, Julian BA, Israni AK, Schladt D, Pastan SO, Chattrabhuti K, Gautreaux MD, Hauptfeld V, Bray RA, Kirk AD, Brown WM, Gaston RS, Rogers J, Farney AC, Orlando G, Stratta RJ, Guan M, Palanisamy A, Reeves-Daniel AM, Bowden DW,. Deceased donor multidrug resistance protein 1 and caveolin 1 gene variants may influence allograft survival in kidney transplantation. Kidney Int. 2015;88(3):584-592.

Palmer ND, Stevens RD, Antinozzi PA, Anderson A, Bergman RN, Wagenknecht LE, Newgard CB, Bowden DW. Metabolomic profile associated with insulin resistance and conversion to diabetes in the Insulin Resistance Atherosclerosis Study. J Clin Endocrinol Metab. 2015;100(3):E463-E468.

Freedman BI, Smith SC, Bagwell BM, Xu J, Bowden DW, Divers J. Electrochemical skin conductance (ESC) associates with diabetic kidney disease (DKD) in European Americans (EAs) and African Americans (AAs) with type 2 diabetes mellitus (T2D) [abstract]. Diabetes. 2015;64(Suppl 1):A157.

Keaton JM, Ng MC, Palmer N, Pankow J, Fornage M, Wilson JG, Correa A, Rasmussen-Torvik LJ, Rotter JI, Rich SS, Wagenknecht LE, Freedman BI, Bowden DW. Genome-wide gene-gene interaction with insulin secretion loci reveals novel loci contributing to type 2 diabetes etiology in African Americans [abstract]. Diabetes. 2015;64(Suppl 1):A465.

Sajuthi S, Sharma N, McWilliams D, Chou J, Comeau M, Palmer ND, Ma L, Calles J, Demons J, Rogers S, Beal J, Menon L, Kouba E, Davis D, Byers J, Burris M, Byerly SJ, Easter L, Bowden DW, Freedman BI, Langefeld CD, Das SK. eQTL analysis of adipose and muscle in African Americans identifies genetic regulators for type 2 diabetes and obesity-associated genes [abstract]. Diabetes. 2015;64(Suppl 1):A82.

Sharma NK, Sajuthi S, Chou J, Ma L, Calles J, Demons J, Rogers S, McWilliams D, Beal J, Comeau M, Palmer ND, Menon L, Kouba E, Davis D, Byers J, Burris M, Byerly SJ, Easter L, Bowden DW, Freedman BI, Langefeld CD, Das SK. Transcriptional profiles of adipose and muscle tissue are associated with insulin sensitivity and influenced by genetic variation in African Americans [abstract]. Diabetes. 2015;64(Suppl 1):A456.

Raffield LM, Hsu FC, Cox AJ, Carr JJ, Freedman BI, Bowden DW. Predictors of all-cause and cardiovascular disease mortality in type 2 diabetes: Diabetes Heart Study. Diabetol Metab Syndr. 2015;7():58.

Hsu FC, Raffield LM, Hugenschmidt CE, Cox A, Xu J, Carr JJ, Freedman BI, Maldjian JA, Williamson JD, Bowden DW. Relationships between cognitive performance, neuroimaging and vascular disease: the DHS-MIND study. Neuroepidemiology. 2015;45(1):1-11.

Freedman BI, Divers J, Russell GB, Palmer ND, Wagenknecht LE, Smith SC, Xu J, Carr JJ, Bowden DW, Register T. Vitamin D associations with renal, bone, and cardiovascular phenotypes: African American-Diabetes Heart Study. J Clin Endocrinol Metab. 2015;100(10):3693-3701.

Whitlow CT, Sink KM, Divers J, Smith SC, Xu J, Palmer ND, Hugenschmidt CE, Williamson JD, Bowden DW, Freedman BI, Maldjian JA. Effects of type 2 diabetes on brain structure and cognitive function: African American-Diabetes Heart Study MIND. AJNR Am J Neuroradiol. 2015;36(9):1648-1653.

Freedman BI, Smith SC, Bagwell BM, Xu J, Bowden DW, Divers J. Electrochemical skin conductance in diabetic kidney disease. Am J Nephrol. 2015;41(6):438-447.

Iyengar SK, Sedor JR, Freedman BI, Kao WH, Kretzler M, Keller BJ, Abboud HE, Adler SG, Best LG, Bowden DW, Burlock A, Chen YD, Cole SA, Comeau ME, Curtis JM, Divers J, Drechsler C, Duggirala R, Elston RC, Guo X, Huang H, Hoffmann MM,. Genome-wide association and trans-ethnic meta-analysis for advanced diabetic kidney disease: Family Investigation of Nephropathy and Diabetes (FIND). PLoS Genet. 2015;11(8):e1005352.

Hawkins GA, Friedman DJ, Lu L, McWilliams DR, Chou JW, Sajuthi S, Divers J, Parekh RS, Li M, Genovese G, Pollack MR, Hicks PJ, Bowden DW, Ma L, Freedman BI, Langefeld CD. Re-sequencing of the APOL1-APOL4 and MYH9 gene regions in African Americans does not identify additional risks for CKD progression. Am J Nephrol. 2015;42(2):99-106.

Freedman BI, Divers J, Whitlow CT, Bowden DW, Palmer ND, Smith SC, Xu J, Register TC, Carr JJ, Wagner BC, Williamson JD, Sink KM, Maldjian JA. Subclinical atherosclerosis is inversely associated with gray matter volume in African Americans with type 2 diabetes. Diabetes Care. 2015;38(11):2158-2165.

Bonomo JA, Palmer ND, He JC, Fan Y, Hicks PJ, Lea JP, Okusa MD, Bowden DW, Freedman BI. Association analysis of the reticulon 1 gene in end-stage kidney disease. Am J Nephrol. 2015;42(4):259-264.

Freedman BI, Divers J, Russell GB, Palmer ND, Bowden DW, Carr JJ, Wagenknecht LE, Hightower RC, Xu J, Smith SC, Langefeld CD, Hruska KA, Register TC. Plasma FGF23 and calcified atherosclerotic plaque in African Americans with type 2 diabetes mellitus. Am J Nephrol. 2015;42(6):391-401.

Chien LC, Chiu YF, Hsu FC, Bowden D. Rare variant association tests for longitudinal family studies [abstract]. Genet Epidemiol. 2015;39(7):538.

Sink KM, Craft S, Smith SC, Maldjian JA, Bowden DW, Xu J, Freedman BI, Divers J. Montreal cognitive assessment and modified mini mental state examination in African Americans. J Aging Res. 2015;2015():872018.

Gao C, Wang N, Guo X, Ziegler JT, Taylor KD, Xiang AH, Hai Y, Kridel SJ, Nadler JL, Kandeel F, Raffel LJ, Chen YD, Norris JM, Rotter JI, Watanabe RM, Wagenknecht LE, Bowden DW, Speliotes EK, Goodarzi MO, Langefeld CD, Palmer ND. A comprehensive analysis of common and rare variants to identify adiposity loci in Hispanic Americans: the IRAS Family Study (IRASFS). PLoS One. 2015;10(11):e0134649.

Malhotra R, Mauer AC, Yao J, Guo X, Smith AV, Pechlivanis S, Hwang S-J, Wang J, Lu L, Lino-Cardenas C, Shelton G, O'Rourke C, Gupta A, Campbell CY, Johnson AD, Song C, Kalsch H, Nothen MM, Freedman BI, Bowden DW, Thanassoulis G,. Genetic associations with atherosclerotic abdominal aortic calcification [abstract]. Circulation. 2015;132(Suppl 3):A18116.

Register T, Carr JJ, Lenchik L, Divers J, Russell GB, Palmer ND, Wagenknecht LE, Smith SC, Xu J, Bowden DW, Freedman BI. Bone resorption assessed by serum type I collagen C-terminal telopeptide (crosslaps) is inversely associated with bone mineral density and change in BMD but not with change in calcified atherosclerotic plaque in African Americans. J Bone Miner Res. 2015;30(Suppl 1):.

Bonomo JA, Palmer ND, Fan Y, He JC, Bowden DW, Freedman BI. Associations between the reticulon 1 gene (RTN1) and end-stage kidney disease [abstract]. J Am Soc Nephrol. 2015;26(Abstract Suppl):738A.

All Publications

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For a list of earlier publications, visit the Carpenter Library Publication Search.

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