Profile

Donald W. Bowden, Ph.D.Wake Forest School of Medicine

Education & Training

  • B.A., Vanderbilt University, 1972
  • Ph.D., University of California-Berkeley, 1978
  • Fellowship, Duke University Hospital, 1981

Memberships

  • Am Assn Of Advancement Of Scie
  • Am Diabetes Assn
  • Am Soc of Human Genetics
  • Fed Of Am Soc For Experimental
Donald W. Bowden, Ph.D.

Donald W. Bowden, Ph.D.

Director, Center for Diabetes Research
Associate Director, Center for Genomics and Personalized Medicine Research
Professor, Center for Genomics and Personalized Medicine Research
Biochemistry
Office of Women in Medicine and Science
Center on Diabetes, Obesity, and Metabolism

Research Interests

Diabetes Mellitus, Type 2; Polymorphism, Single Nucleotide; African Americans; Diabetic Nephropathies; Kidney Failure, Chronic
More »

Contact Information

Academic: 336-713-7507 | Department: 336-713-7500

Email: dbowden@wakehealth.edu

Recent Publications

Associations between anxiety and depression symptoms and cognitive testing and neuroimaging in type 2 diabetes. Raffield LM, Brenes GA, Cox AJ, Freedman BI, Hugenschmidt CE, Hsu FC, Xu J, Wagner BC, Williamson JD, Maldjian JA, Bowden DW.. J Diabetes Complications. 2016;30(1):143-149.

APOL1 genotype and kidney transplantation outcomes from deceased African American donors. Freedman BI, Pastan SO, Israni AK, Schladt D, Julian BA, Gautreaux MD, Hauptfeld V, Bray RA, Gebel HM, Kirk AD, Gaston RS, Rogers J, Farney AC, Orlando G, Stratta RJ, Mohan S, Ma L, Langefeld CD, Bowden DW, Hicks PJ, Palmer ND,.. Transplantation. 2016;100(1):194-202.

Generalization of rare variant association tests for longitudinal family studies. Chien LC, Hsu FC, Bowden DW, Chiu YF.. Genet Epidemiol. 2016;40(2):101-112.

Tissue-specific and genetic regulation of insulin sensitivity-associated transcripts in African Americans. Sharma NK, Sajuthi SP, Chou JW, Calles-Escandon J, Demons J, Rogers S, Ma L, Palmer ND, R McWilliams D, Beal J, Comeau M, Cherry K, Hawkins GA, Menon L, Kouba E, Davis D, Burris M, Byerly SJ, Easter L, Bowden DW, Freedman BI, Langefeld CD, Das SK.. J Clin Endocrinol Metab. 2016;101(4):1455-1468.

Analysis of advanced glycation end products in the DHS Mind Study. Adams JN, Martelle SE, Raffield LM, Freedman BI, Langefeld CD, Hsu FC, Maldjian JA, Williamson JD, Hugenschmidt CE, Carr JJ, Cox AJ, Bowden DW.. J Diabetes Complications. 2016;30(2):262-268.

Analysis of the relationships between type 2 diabetes status, glycemic control, and neuroimaging measures in the Diabetes Heart Study Mind. Raffield LM, Cox AJ, Freedman BI, Hugenschmidt CE, Hsu FC, Wagner BC, Xu J, Maldjian JA, Bowden DW.. Acta Diabetol. 2016;53(3):439-447.

Genetic analysis of advanced glycation end products in the DHS MIND study. Adams JN, Raffield LM, Martelle SE, Freedman BI, Langefeld CD, Carr JJ, Cox AJ, Bowden DW.. Gene. 2016;584(2):173-179.

Dopamine pathway gene variants may modulate cognitive performance in the DHS - Mind Study. Martelle SE, Raffield LM, Palmer ND, Cox AJ, Freedman BI, Hugenschmidt CE, Williamson JD, Bowden DW.. Brain Behav. 2016;6(4):e00446.

Admixture mapping of serum vitamin D and parathyroid hormone concentrations in the African American-Diabetes Heart Study. Palmer ND, Divers J, Lu L, Register TC, Carr JJ, Hicks PJ, Smith SC, Xu J, Judd SE, Irvin MR, Gutierrez OM, Bowden DW, Wagenknecht LE, Langefeld CD, Freedman BI.. Bone. 2016;87():71-77.

APOL1 renal-risk genotypes associate with longer hemodialysis survival in prevalent nondiabetic African American patients with end-stage renal disease. Ma L, Langefeld CD, Comeau ME, Bonomo JA, Rocco MV, Burkart JM, Divers J, Palmer ND, Hicks PJ, Bowden DW, Lea JP, Krisher JO, Clay MJ, Freedman BI.. Kidney Int. 2016;90(2):389-395.

Selecting SNPs informative for African, American Indian and European Ancestry: application to the Family Investigation of Nephropathy and Diabetes (FIND). Williams RC, Elston RC, Kumar P, Knowler WC, Abboud HE, Adler S, Bowden DW, Divers J, Freedman BI, Igo RP Jr, Ipp E, Iyengar SK, Kimmel PL, Klag MJ, Kohn O, Langefeld CD, Leehey DJ, Nelson RG, Nicholas SB, Pahl MV, Parekh RS, Rotter JI, Schelling JR,.. BMC Genomics. 2016;17(1):325.

Mapping adipose and muscle tissue expression quantitative trait loci in African Americans to identify genes for type 2 diabetes and obesity. Sajuthi SP, Sharma NK, Chou JW, Palmer ND, McWilliams DR, Beal J, Comeau ME, Ma L, Calles-Escandon J, Demons J, Rogers S, Cherry K, Menon L, Kouba E, Davis D, Burris M, Byerly SJ, Ng MC, Maruthur NM, Patel SR, Bielak LF, Lange LA, Guo X, Sale MM,.. Hum Genet. 2016;135(8):869-880.

Trans-ethnic meta-analysis and functional annotation illuminates the genetic architecture of fasting glucose and insulin. Liu CT, Raghavan S, Maruthur N, Kabagambe EK, Hong J, Ng MC, Hivert MF, Lu Y, An P, Bentley AR, Drolet AM, Gaulton KJ, Guo X, Armstrong LL, Irvin MR, Li M, Lipovich L, Rybin DV, Taylor KD, Agyemang C, Palmer ND, Cade BE, Chen WM, Dauriz M,.. Am J Hum Genet. 2016;99(1):56-75.

Association analysis of the cubilin (CUBN) and megalin (LRP2) genes with ESRD in African Americans. Ma J, Guan M, Bowden DW, Ng MC, Hicks PJ, Lea JP, Ma L, Gao C, Palmer ND, Freedman BI.. Clin J Am Soc Nephrol. 2016;11(6):1034-1043.

Relationships between measures of adiposity with subclinical atherosclerosis in patients with type 2 diabetes. Yuan M, Hsu FC, Bowden DW, Xu J, Carrie Smith S, Wagenknecht LE, Comeau ME, Divers J, Register TC, Jeffrey Carr J, Langefeld CD, Freedman BI.. Obesity (Silver Spring). 2016;24(8):1810-1818.

Improved performance of dynamic measures of insulin response over surrogate indices to identify genetic contributors of type 2 diabetes: the GUARDIAN Consortium. Palmer ND, Wagenknecht LE, Langefeld CD, Wang N, Buchanan TA, Xiang AH, Allayee H, Bergman RN, Raffel LJ, Chen YD, Haritunians T, Fingerlin T, Goodarzi MO, Taylor KD, Rotter JI, Watanabe RM, Bowden DW.. Diabetes. 2016;65(7):2072-2080.

APOL1 renal-risk variants associate with reduced cerebral white matter lesion volume and increased gray matter volume. Freedman BI, Gadegbeku CA, Bryan RN, Palmer ND, Hicks PJ, Ma L, Rocco MV, Smith SC, Xu J, Whitlow CT, Wagner BC, Langefeld CD, Hawfield AT, Bates JT, Lerner AJ, Raj DS, Sadaghiani MS, Toto RD, Wright JT Jr, Bowden DW, Williamson JD, Sink KM,.. Kidney Int. 2016;90(2):440-449.

The genetic architecture of type 2 diabetes. Fuchsberger C, Flannick J, Teslovich TM, Mahajan A, Agarwala V, Gaulton KJ, Ma C, Fontanillas P, Moutsianas L, McCarthy DJ, Rivas MA, Perry JR, Sim X, Blackwell TW, Robertson NR, Rayner NW, Cingolani P, Locke AE, Fernandez Tajes J, Highland HM,.. Nature. 2016;536(7614):41-47.

Association of kidney structure-related gene variants with type 2 diabetes-attributed end-stage kidney disease in African Americans. Guan M, Ma J, Keaton JM, Dimitrov L, Mudgal P, Stromberg M, Bonomo JA, Hicks PJ, Freedman BI, Bowden DW, Ng MC.. Hum Genet. 2016;135(11):1251-1262.

Genome-wide interaction with insulin secretion loci reveals novel loci for type 2 diabetes in African Americans. Keaton JM, Hellwege JN, Ng MC, Palmer ND, Pankow JS, Fornage M, Wilson JG, Correa A, Rasmussen-Torvik LJ, Rotter JI, Chen YD, Taylor KD, Rich SS, Wagenknecht LE, Freedman B, Bowden DW.. PLoS One. 2016;11(7):e0159977.

Novel genetic variants associated with increased vertebral volumetric BMD, reduced vertebral fracture risk, and increased expression of SLC1A3 and EPHB2. Nielson CM, Liu CT, Smith AV, Ackert-Bicknell CL, Reppe S, Jakobsdottir J, Wassel C, Register TC, Oei L, Alonso N, Oei EH, Parimi N, Samelson EJ, Nalls MA, Zmuda J, Lang T, Bouxsein M, Latourelle J, Claussnitzer M, Siggeirsdottir K, Srikanth P,.. J Bone Miner Res. 2016;():.

Genome-wide linkage and association analysis of cardiometabolic phenotypes in Hispanic Americans. Hellwege JN, Palmer ND, Dimitrov L, Keaton JM, Tabb KL, Sajuthi S, Taylor KD, Ng MC, Speliotes EK, Hawkins GA, Long J, Ida Chen YD, Lorenzo C, Norris JM, Rotter JI, Langefeld CD, Wagenknecht LE, Bowden DW.. J Hum Genet. 2016;():.

Bone mineral density and progression of subclinical atherosclerosis in African Americans with type 2 diabetes. Wagenknecht LE, Divers J, Register TC, Russell GB, Bowden DW, Xu J, Langefeld CD, Lenchik L, Hruska KA, Carr JJ, Freedman BI.. J Clin Endocrinol Metab. 2016;101(11):4135-4141.

Adiposity is inversely associated with hippocampal volume in African Americans and European Americans with diabetes. Hsu FC, Yuan M, Bowden DW, Xu J, Smith SC, Wagenknecht LE, Langefeld CD, Divers J, Register TC, Carr JJ, Williamson JD, Sink KM, Maldjian JA, Freedman BI.. J Diabetes Complications. 2016;30(8):1506-1512.

APOE genotypes associate with cognitive performance but not cerebral structure: Diabetes Heart Study MIND. Palmer Allred ND, Raffield LM, Hardy JC, Hsu FC, Divers J, Xu J, Smith SC, Hugenschmidt CE, Wagner BC, Whitlow CT, Sink KM, Maldjian JA, Williamson JD, Bowden DW, Freedman BI.. Diabetes Care. 2016;():.

NAT 2 and coronary artery calcification in African and European Americans with type 2 diabetes [abstract]. Conway BN, Allred ND, Freedman BI, Bowden DW.. In: Abstracts of the 2016 Annual Meeting of the American Diabetes Association; 2016 June 10-14; New Orleans (LA). 2016;():1655.

Omics analysis of adiponectin in African Americans to elucidate the biology underlying metabolic disease [abstract]. Palmer ND, Sajuthi S, Sharma N, Chou J, Bowden DW, Freedman BI, Langefeld CD, Das SK.. In: Abstracts of the 2016 Annual Meeting of the American Diabetes Association; 2016 June 10-14; New Orleans (LA). 2016;():2461.

Increased intestinal permeability as a risk factor for type 2 diabetes. Cox AJ, Zhang P, Bowden DW, Devereaux B, Davoren PM, Cripps AW, West NP.. Diabetes Metab. 2016;():.

Genome-Wide association of CKD progression: the chronic renal insufficiency cohort study. Parsa A, Kanetsky PA, Xiao R, Gupta J, Mitra N, Limou S, Xie D, Xu H, Anderson AH, Ojo A, Kusek JW, Lora CM, Hamm LL, He J, Sandholm N, Jeff J, Raj DE, Boger CA, Bottinger E, Salimi S, Parekh RS, Adler SG, Langefeld CD, Bowden DW, Groop PH,.. J Am Soc Nephrol. 2016;():.

APOL1 associations with nephropathy, atherosclerosis, and all-cause mortality in African Americans with type 2 diabetes. Freedman BI, Langefeld CD, Lu L, Palmer ND, Carrie Smith S, Bagwell BM, Hicks PJ, Xu J, Wagenknecht LE, Raffield LM, Register TC, Jeffrey Carr J, Bowden DW, Divers J.. Kidney Int. 2015;87(1):176-181.

Cerebral structural changes in diabetic kidney disease: African American-Diabetes Heart Study MIND. Sink KM, Divers J, Whitlow CT, Palmer ND, Smith SC, Xu J, Hugenschmidt CE, Wagner BC, Williamson JD, Bowden DW, Maldjian JA, Freedman BI.. Diabetes Care. 2015;38(2):206-212.

Lack of association of the APOL1 G3 haplotype in African Americans with ESRD. Palmer ND, Ng MC, Langefeld CD, Divers J, Lea JP, Okusa MD, Kimberly RP, Bowden DW, Freedman BI.. J Am Soc Nephrol. 2015;26(5):1021-1025.

Shroom3 contributes to the maintenance of the glomerular filtration barrier integrity. Yeo NC, O'Meara CC, Bonomo JA, Veth KN, Tomar R, Flister MJ, Drummond IA, Bowden DW, Freedman BI, Lazar J, Link BA, Jacob HJ.. Genome Res. 2015;25(1):57-65.

Empirical characteristics of family-based linkage to a complex trait: the ADIPOQ region and adiponectin levels. Hellwege JN, Palmer ND, Brown MW, Ziegler JT, An SS, Guo X, Chen IY, Taylor K, Hawkins GA, Ng MC, Speliotes EK, Lorenzo C, Norris JM, Rotter JI, Wagenknecht LE, Langefeld CD, Bowden DW.. Hum Genet. 2015;134(2):203-213.

Genetic variants associated with quantitative glucose homeostasis traits translate to type 2 diabetes in Mexican Americans: the GUARDIAN (Genetics Underlying Diabetes in Hispanics) Consortium. Palmer ND, Goodarzi MO, Langefeld CD, Wang N, Guo X, Taylor KD, Fingerlin TE, Norris JM, Buchanan TA, Xiang AH , Haritunians T, Ziegler JT, Williams AH, Stefansovski D, Cui J, Mackay AW, Henkin LF, Bergman RN, Gao X, Gauderman J, Varma R, Hanis CL,.. Diabetes. 2015;64(5):1853-1866.

Heritability and genetic association analysis of neuroimaging measures in the Diabetes Heart Study. Raffield LM, Cox AJ, Hugenschmidt CE, Freedman BI, Langefeld CD, Williamson JD, Hsu F, Maldjian JA, Bowden DW.. Neurobiol Aging. 2015;36(3):1602.e7-15.

Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility. Wessel J, Chu AY, Willems SM, Wang S, Yaghootkar H, Brody JA, Dauriz M, Hivert MF, Raghavan S, Lipovich L, Hidalgo B, Fox K, Huffman JE, An P, Lu Y, Rasmussen-Torvik LJ, Grarup N, Ehm MG, Li L, Baldridge AS, Stancakova A, Abrol R, Besse C,.. Nat Commun. 2015;6():5897.

Analysis of a cardiovascular disease genetic risk score in the Diabetes Heart Study. Raffield LM, Cox AJ, Carr JJ, Freedman BI, Hicks PJ, Langefeld CD, Hsu FC, Bowden DW.. Acta Diabetol. 2015;52(4):743-751.

A common variant in the CLDN7/ELP5 locus predicts adiponectin change with lifestyle intervention and improved fitness in obese individuals with diabetes. Belalcazar LM, Papandonatos GD, McCaffery JM, Peter I, Pajewski NM, Erar B, Allred ND, Balasubramanyam A, Bowden DW, Brautbar A, Pi-Sunyer FX, Ballantyne CM, Huggins GS.. Physiol Genomics. 2015;47(6):215-224.

Association of a 62 variants type 2 diabetes genetic risk score with markers of subclinical atherosclerosis: a transethnic, multicenter study. Dauriz M, Porneala BC, Guo X, Bielak LF, Peyser PA, Durant NH, Carnethon MR, Bonadonna RC, Bonora E, Bowden DW, Florez JC, Fornage M, Hivert MF, Jacobs DR Jr, Kabagambe EK, Lewis CE, Murabito JM, Rasmussen-Torvik LJ, Rich SS, Vassy JL, Yao J,.. Circ Cardiovasc Genet. 2015;8(3):507-515.

Urinary F2-isoprostanes and metabolic markers of fat oxidation. Il'yasova D, Wagenknecht LE, Spasojevic I, Watkins S, Bowden D, Wang F, D'Agostino RB Jr.. Oxid Med Cell Longev. 2015;2015():729191.

Structural and functional assessment of the brain in European Americans with mild-to-moderate kidney disease: Diabetes Heart Study-MIND. Murea M, Hsu FC, Cox AJ, Hugenschmidt CE, Xu J, Adams JN, Raffield LM, Whitlow CT, Maldjian JA, Bowden DW, Freedman BI.. Nephrol Dial Transplant. 2015;30(8):1322-1329.

Deceased donor multidrug resistance protein 1 and caveolin 1 gene variants may influence allograft survival in kidney transplantation. Ma J, Divers J, Palmer ND, Julian BA, Israni AK, Schladt D, Pastan SO, Chattrabhuti K, Gautreaux MD, Hauptfeld V, Bray RA, Kirk AD, Brown WM, Gaston RS, Rogers J, Farney AC, Orlando G, Stratta RJ, Guan M, Palanisamy A, Reeves-Daniel AM, Bowden DW,.. Kidney Int. 2015;88(3):584-592.

Metabolomic profile associated with insulin resistance and conversion to diabetes in the Insulin Resistance Atherosclerosis Study. Palmer ND, Stevens RD, Antinozzi PA, Anderson A, Bergman RN, Wagenknecht LE, Newgard CB, Bowden DW.. J Clin Endocrinol Metab. 2015;100(3):E463-E468.

Electrochemical skin conductance (ESC) associates with diabetic kidney disease (DKD) in European Americans (EAs) and African Americans (AAs) with type 2 diabetes mellitus (T2D) [abstract]. Freedman BI, Smith SC, Bagwell BM, Xu J, Bowden DW, Divers J.. Diabetes. 2015;64(Suppl 1):A157.

Genome-wide gene-gene interaction with insulin secretion loci reveals novel loci contributing to type 2 diabetes etiology in African Americans [abstract]. Keaton JM, Ng MC, Palmer N, Pankow J, Fornage M, Wilson JG, Correa A, Rasmussen-Torvik LJ, Rotter JI, Rich SS, Wagenknecht LE, Freedman BI, Bowden DW.. Diabetes. 2015;64(Suppl 1):A465.

eQTL analysis of adipose and muscle in African Americans identifies genetic regulators for type 2 diabetes and obesity-associated genes [abstract]. Sajuthi S, Sharma N, McWilliams D, Chou J, Comeau M, Palmer ND, Ma L, Calles J, Demons J, Rogers S, Beal J, Menon L, Kouba E, Davis D, Byers J, Burris M, Byerly SJ, Easter L, Bowden DW, Freedman BI, Langefeld CD, Das SK.. Diabetes. 2015;64(Suppl 1):A82.

Transcriptional profiles of adipose and muscle tissue are associated with insulin sensitivity and influenced by genetic variation in African Americans [abstract]. Sharma NK, Sajuthi S, Chou J, Ma L, Calles J, Demons J, Rogers S, McWilliams D, Beal J, Comeau M, Palmer ND, Menon L, Kouba E, Davis D, Byers J, Burris M, Byerly SJ, Easter L, Bowden DW, Freedman BI, Langefeld CD, Das SK.. Diabetes. 2015;64(Suppl 1):A456.

Predictors of all-cause and cardiovascular disease mortality in type 2 diabetes: Diabetes Heart Study. Raffield LM, Hsu FC, Cox AJ, Carr JJ, Freedman BI, Bowden DW.. Diabetol Metab Syndr. 2015;7():58.

Relationships between cognitive performance, neuroimaging and vascular disease: the DHS-MIND study. Hsu FC, Raffield LM, Hugenschmidt CE, Cox A, Xu J, Carr JJ, Freedman BI, Maldjian JA, Williamson JD, Bowden DW.. Neuroepidemiology. 2015;45(1):1-11.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Quick Reference

Request an Appointment
New Patients

336-716-WAKE
888-716-WAKE

Existing patients may contact the clinic directly.
Find a Doctor Ways to Give
Comprehensive Cancer Centers National Designation is RenewedMagnet Hospital RecognitionConsumer Choice2015 Best DoctorsJoint Commission Report

Disclaimer: The information on this website is for general informational purposes only and SHOULD NOT be relied upon as a substitute for sound professional medical advice, evaluation or care from your physician or other qualified health care provider.

© Wake Forest Baptist Medical Center, Medical Center Boulevard, Winston-Salem, NC 27157. All Rights Reserved.