Allison Brashear, M.D.Wake Forest School of Medicine

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Allison Brashear, M.D.


Clinical Interests

Movement Disorders, Neuromuscular Diseases, Botulinum Toxin

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New Patient Appointments: 336-716-WAKE
Returning Patient Appointments: 336-716-4101
Department: 336-716-4101

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Education & Training

  • B.A., Depauw University, 1983
  • M.D., Indiana University School of Medicine, 1987
  • Internship, Medicine, Indiana Univ Med Ctr & Hosps, 1988
  • Residency, Neurology, Indiana Univ Med Ctr & Hosps, 1991

Board Certifications

  • American Board of Psychiatry and Neurology, Neurology


  • American Academy Of Neurology

NPI Number

  • 1881673713
Allison Brashear, M.D.

Doctor Rating

No Rating Available
Why No Ratings?

Allison Brashear, M.D.

Chair, Neurology
Professor, Neurology
Gerontology and Geriatric Medicine

Research Interests

drugs/therapeutic agents pharm, epidemiology, health services, research/outc, mental disorders/psychiatry/ps, neurosciences/behavior

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Academic: 336-716-3545 | Department: 336-716-4101

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Recent Publications

Sweadner KJ, Toro C, Whitlow CT, Snively BM, Cook JF, Ozelius LJ, Markello TC, Brashear A. ATP1A3 mutation in adult rapid-onset ataxia. PLoS One. 2016;11(3):e0151429.

Paciorkowski AR, McDaniel SS, Jansen LA, Tully H, Tuttle E, Ghoneim DH, Tupal S, Gunter SA, Vasta V, Zhang Q, Tran T, Liu YB, Ozelius LJ, Brashear A, Sweadner KJ, Dobyns WB, Hahn S. Novel mutations in ATP1A3 associated with catastrophic early life epilepsy, episodic prolonged apnea, and postnatal microcephaly. Epilepsia. 2015;56(3):422-430.

Gracies JM, Brashear A, Jech R, McAllister P, Banach M, Valkovic P, Walker H, Marciniak C, Deltombe T, Skoromets A, Khatkova S, Edgley S, Gul F, Catus F, De Fer BB, Vilain C, Picaut P. Safety and efficacy of abobotulinumtoxinA for hemiparesis in adults with upper limb spasticity after stroke or traumatic brain injury: a double-blind randomised controlled trial. Lancet Neurol. 2015;14(10):992-1001.

Liu YB, Tewari A, Salameh J, Arystarkhova E, Hampton TG, Brashear A, Ozelius LJ, Khodakhah K, Sweadner KJ. A dystonia-like movement disorder with brain and spinal neuronal defects is caused by mutation of the mouse laminin beta1 subunit, Lamb1. Elife. 2015;4():e11102.

Brashear A, Ozelius LJ, Sweadner KJ. ATP1A3 mutations: what is the phenotype? [editorial]. Neurology. 2014;82(6):468-469.

Cook JF, Hill DF, Snively BM, Boggs N, Suerken CK, Haq I, Stacy M, McCall WV, Ozelius LJ, Sweadner KJ, Brashear A. Cognitive impairment in rapid-onset dystonia-parkinsonism. Mov Disord. 2014;29(Suppl 3):344-350.

Heinzen EL, Arzimanoglou A, Brashear A, Clapcote SJ, Gurrieri F, Goldstein DB, Johannesson SH, Mikati MA, Neville B, Nicole S, Ozelius LJ, Poulsen H, Schyns T, Sweadner KJ, van den Maagdenberg A, Vilsen B. Distinct neurological disorders with ATP1A3 mutations. Lancet Neurol. 2014;13(5):503-514.

Saunders-Pullman R, Fuchs T, San Luciano M, Raymond D, Brashear A, Ortega R, Deik A, Ozelius LJ, Bressman SB. Heterogeneity in primary dystonia: lessons from THAP1, GNAL, and TOR1A in Amish-Mennonites. Mov Disord. 2014;29(6):812-818.

Oblak AL, Hagen MC, Sweadner KJ, Haq I, Whitlow CT, Maldjian JA, Epperson F, Cook JF, Stacy M, Murrell JR, Ozelius LJ, Brashear A, Ghetti B. Rapid-onset dystonia-parkinsonism associated with the I758S mutation of the ATP1A3 gene: a neuropathologic and neuroanatomical study of four siblings. Acta Neuropathol. 2014;128(1):81-98.

Tate J, Brashear A, Whitlow C, Snively B, Ozelius L, Sweadner K, Stacy M, Haq I. Rapid-onset dystonia-Parkinsonism presenting as tremor-dominant Parkinson's disease (PO4.161) [abstract]. Neurology. 2013;80(1 Meeting Abstracts):P04.

Doan QV, Gillard P, Brashear A, Halperin M, Hayward E, Varon S, Lu ZJ. Cost-effectiveness of onabotulinumtoxinA for the treatment of wrist and hand disability due to upper-limb post-stroke spasticity in Scotland. Eur J Neurol. 2013;20(5):773-780.

Brashear A. Commentary. Mov Disord. 2013;28(14):1939.

Evidente VG, Fernandez HH, LeDoux MS, Brashear A, Grafe S, Hanschmann A, Comella CL. A randomized, double-blind study of repeated incobotulinumtoxinA (Xeomin) in cervical dystonia. J Neural Transm. 2013;120(12):1699-1707.

Brashear A, Bushong L. Coding for the use of botulinum toxin for movement disorders. Continuum (Minneapolis, Minn.). 2013;19(5):1406-1415.

Truong DD, Gollomp SM, Jankovic J, LeWitt PA, Marx M, Hanschmann A, Fernandez HH, Brashear A. Sustained efficacy and safety of repeated incobotulinumtoxinA (Xeomin) injections in blepharospasm. J Neural Transm. 2013;120(9):1345-1353.

Brashear A. Treatment of cervical dystonia. Expert Opin Orphan Drugs. 2013;1(8):599-606.

Brashear A, Cook J, Amponsah A, Hill D, Snively B, Light L, Suerken C, McCall WV, Boggs N, Stacy M, Ozelius L, Sweadner K. Psychiatric and neurocognitive morbidity in rapid-onset dystonia Parkinsonism [abstract]. Neurology. 2012;78(Suppl 1):P01.225.

Brashear A, Ozelius LJ, Sweadner KJ. Rapid-onset dystonia-Parkinsonism: more than just dystonia In: Stacy MA, ed. Handbook of dystonia. 2nd ed. New York: Informa Healthcare;2012: 241-250.

Ghetti B, Brashear A, Hagen M, Sweadner K. Rapid onset dystonia-Parkinsonism associated with the I758S ATP1A3 mutation: a neuropathologic study of two affected siblings [abstract]. J Neuropathol Exp Neurol. 2012;71(6):592-593.

Barbano RL, Hill DF, Snively BM, Light LS, Boggs N, McCall WV, Stacy M, Ozelius L, Sweadner KJ, Brashear A. New triggers and non-motor findings in a family with rapid-onset dystonia-parkinsonism. Parkinsonism Relat Disord. 2012;18(6):737-741.

Doan QV, Brashear A, Gillard PJ, Varon SF, Vandenburgh AM, Turkel CC, Elovic EP. Relationship between disability and health-related quality of life and caregiver burden in patients with upper limb poststroke spasticity. PM R. 2012;4(1):4-10.

Esquenazi A, Mayer N, Lee S, Brashear A, Elovic E, Francisco GE, Yablon S. Patient registry of outcomes in spasticity care. Am J Phys Med Rehabil. 2012;91(9):729-746.

Brashear A, Cook JF, Hill DF, Amponsah A, Snively BM, Light L, Boggs N, Suerken CK, Stacy M, Ozelius L, Sweadner KJ, McCall WV. Psychiatric disorders in rapid-onset dystonia-parkinsonism. Neurology. 2012;79(11):1168-1173.

Charles D, Brashear A, Hauser RA, Li H-I, Boo L-M, Brin MF. Efficacy, tolerability, and immunogenicity of onabotulinumtoxinA in a randomized, double-blind, placebo-controlled trial for cervical dystonia. Clin Neuropharmacol. 2012;35(5):208-214.

Brashear A, Mink JW, Hill DF, Boggs N, McCall WV, Stacy MA, Snively B, Light LS, Sweadner KJ, Ozelius LJ, Morrison L. ATP1A3 mutations in infants: a new rapid-onset dystonia-Parkinsonism phenotype characterized by motor delay and ataxia. Dev Med Child Neurol. 2012;54(11):1065-1067.

Brashear A, Elovic E, eds. In: Spasticity: diagnosis and management. New York: Demos Medical Publishing;2011: .

Brashear A, Elovic E. Why is spasticity important? In: Brashear A, Elovic E, eds. Spasticity: diagnosis and management. New York: Demos Medical Publishing;2011: 3-4.

Brashear A. Botulinum toxin in the treatment of upper limb spasticity In: Brashear A, Elovic E, eds. Spasticity: diagnosis and management. New York: Demos Medical Publishing;2011: 131-140.

Chen R, Brashear A. A diagnostic test to distinguish psychogenic dystonia from organic dystonia? [editorial]. Neurology. 2011;76(7):590-591.

Brashear A, Hill DF, Boggs N, Ozelius L, Sweadner KJ, Light L, Stacy M, Snively BM, McCall WV. Psychosis: part of the rapid-onset dystonia-Parkinsonism (RDP) phenotype? [abstract]. Neurology. 2011;76(9 Suppl 4):A640.

Evidente VGH, Fernandez HH, LeDoux MS, Brashear A, Marx MW, Grafe SK, Comella CL. Flexible dosing with incobotulinumtoxin-A (Xeomin); botulinum neurotoxin type-A, free from accessory proteins) in cervical dystonia [abstract]. Eur J Neurol. 2011;18(Suppl 2):511.

Truong D, Brodsky M, Lew M, Brashear A, Jankovic J, Molho E, Orlova O, Timerbaeva S. Long-term efficacy and safety of botulinum toxin type A (Dysport) in cervical dystonia. Parkinsonism Relat Disord. 2010;16(5):316-323.

Brashear A, Hill D, Snively BM, Sweadner KJ, Ozelius L. De novo and recurrent mutations in ATP1A3 are common in rapid-onset dystonia-Parkinsonism [abstract]. Neurology. 2010;74(9 Suppl 2):A204.

Yablon SA, Simpson D, Gracies JM, Barbano R, Brashear A. Tizanidine improves geriatric depression scale scores in stroke and brain injury survivors with spastic hemiparesis: post-hoc analysis from a randomized, double-blind, placebo-controlled trial [abstract]. Neurology. 2010;74(9 Suppl 2):A409-A410.

Brashear A, Hill DF, Snively B, Sweadner KJ, Ozelius L. Now triggers in rapid-onset dystonia-Parkinsonism (RDP) [abstract]. Neurology. 2010;74(9 Suppl 2):A205.

Brashear A. Botulinum toxin type A: exploring new indications. Drugs Today (Barc). 2010;46(9):671-682.

Simpson DM, Gracies JM, Yablon SA, Barbano R, Brashear A. Botulinum neurotoxin versus tizanidine in upper limb spasticity: a placebo-controlled study. J Neurol Neurosurg Psychiatry. 2009;80(4):380-385.

Brashear A, Lambeth K. Spasticity. Curr Treat Options Neurol. 2009;11(3):153-161.

Brashear A. Botulinum toxin type A in the treatment of patients with cervical dystonia. Biologics. 2009;3():1-7.

Sacino A, Hampton TG, Lingrel JB, Brashear A, Sweadner KJ. Rapid onset dystonia-parkinsonism: symptoms in a mouse deficient in Na,K-ATPase alpha3 [abstract]. Mov Disord. 2009;24(Suppl 1):S112-S113.

Gracies J-M, Yablon S, Raghavan P, Barbano R, Brashear A, Simpson D. Relationship between active function and tone in a placebo-controlled study of botulinum neurotoxin vs tizanidine in upper limb spasticity [abstract]. Arch Phys Med Rehabil. 2009;90(10):e5-e6.

Barbano RL, Ozelius L, Hill DF, Brashear A. Variable phenotypic expression of rapid onset dystonia parkinsonism in a newly discovered Italian family with a T613M mutation in the ATP1A3 gene [abstract]. In: Abstracts of the 61st Annual Meeting of the American Academy of Neurology; 2009 April 25 - May 2; Seattle (WA). 2009;():IN2-1.003.

Simpson DM, Blitzer A, Brashear A, Comella C, Dubinsky R, Hallett M, Jankovic J, Karp B, Ludlow CL, Miyasaki JM, et al. Assessment: botulinum neurotoxin for the treatment of movement disorders (an evidence-based review): report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology. Neurology. 2008;70(19):1699-1706.

Elovic EP, Brashear A, Kaelin D, Liu J, Millis SR, Barron R, Turkel C. Repeated treatments with botulinum toxin type A produce sustained decreases in the limitations associated with focal upper-limb poststroke spasticity for caregivers and patients. Arch Phys Med Rehabil. 2008;89(5):799-806.

Brashear A. Clinical comparisons of botulinum neurotoxin formulations. Neurologist. 2008;14(5):289-298.

Brashear A, Dobyns WB, de Carvalho Aguiar P, Borg M, Frijns CJM, Gollamudi S, Green A, Guimaraes J, Haake B, Klein C, et al. The phenotypic spectrum of rapid-onset dystonia-parkinsonism (RDP) and mutations in the ATP1A3 gene. Brain. 2007;130(Pt 3):828-835.

Yablon SA, Brashear A, Gordon MF, Elovic DP, Turkel CC, Daggett S, Liu J, Brin MF. Formation of neutralizing antibodies in patients receiving botulinum toxin type A for treatment of poststroke spasticity: a pooled-data analysis of three clinical trials. Clin Ther. 2007;29(4):683-690.

Brashear A, Farmer D, Wood F, Bressman SB, Dobyns WB, Ozelius LO. ATP1A3 mutations in rapid-onset dystonia Parkinsonism: is there more to the story? [abstract]. Ann Neurol. 2006;60(Suppl 10):S11.

Jankovic J, Hunter C, Dolimbek BZ, Dolimbek GS, Adler CH, Brashear A, Comella CL, Gordon M, Riley DE, Sethi K, et al. Clinico-immunologic aspects of botulinum toxin type B treatment of cervical dystonia. Neurology. 2006;67(12):2233-2235.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Neurology

Clinical Interests

Movement Disorders, Neuromuscular Diseases, Botulinum Toxin
Allison Brashear, M.D.

Allison Brashear, M.D.

Chair, Neurology
Professor, Neurology
Gerontology and Geriatric Medicine

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