Profile

Kathleen B. Brosnihan Simmons, Ph.D.Wake Forest School of Medicine

Education & Training

  • B.S., College of St Mary , 1965
  • M.S., Creighton University , 1970
  • Ph.D., Case Western Reserve , 1974
  • Fellowship, Cleveland Clinic Foundation, 1976

Memberships

  • Am Heart Association
  • Am Physiological Society
  • Cons for SE Hypertension Contr
  • Endocrine Society
  • Inter-Amer Soc of Hypertension
Kathleen B. Brosnihan Simmons, Ph.D.

Kathleen B. Brosnihan Simmons, Ph.D.

Professor, Surgical Sciences-Hypertension
Hypertension and Vascular Research Center
Office of Women in Medicine and Science
Institute for Regenerative Medicine
Obstetrics & Gynecology
Physiology & Pharmacology
Translational Science Institute

Research Interests

hormones/cytokines/signalling, maternal & child health, model development, women's health issues

Contact Information

Academic: 336-716-2795 | Department: 336-716-2795

Email: bbrosnih@wakehealth.edu

Recent Publications

Washburn LK, Brosnihan KB, Chappell MC, Diz DI, Gwathmey TM, Nixon PA, Russell GB, Snively BM, O'Shea TM. The renin-angiotensin-aldosterone system in adolescent offspring born prematurely to mothers with preeclampsia. J Renin Angiotensin Aldosterone Syst. 2014;():.

Pulgar VM, Yamaleyeva LM, Varagic J, McGee CM, Bader M, Dechend R, Howlett AC, Brosnihan KB. Increased angiotensin II contraction of the uterine artery at early gestation in a transgenic model of hypertensive pregnancy is reduced by inhibition of endocannabinoid hydrolysis. Hypertension. 2014;64(3):619-625.

Yamaleyeva LM, Merrill DC, Ebert TJ, Smith TL, Mertz HL, Brosnihan KB. Hemodynamic responses to angiotensin-(1-7) in women in their third trimester of pregnancy. Hypertens Pregnancy. 2014;33(4):375-388.

Yamaleyeva LM, Brosnihan KB, Anton L, McGee C, Mertz HL, Gallagher PE, Merrill DC. Opposing interactions between angiotensin II and apelin in human placental chorionic villi [abstract]. Reprod Sci. 2014;21(3 Suppl):393A.

Schaich C, Howlett A, Brosnihan K, Diz D. Differential blood pressure response in normotensive rats and rats with angiotensin II-dependent hypertension following systemic cannabinoid CB1 receptor blockade [abstract]. FASEB J. 2014;28(1 Suppl):1140.11.


Miller GD, Isom S, Morgan TM, Vitolins MZ, Blackwell C, Brosnihan KB, Diz DI, Katula J, Goff D. Effects of a community-based weight loss intervention on adipose tissue circulating factors. Diabetes Metab Syndr. 2014;():.

Moniwa N, Varagic J, Ahmad S, Voncannon JL, Simington SW, Wang H, Groban L, Brosnihan KB, Nagata S, Kato J, Kitamura K, Gomez RA, Lopez ML, Ferrario CM. Hemodynamic and hormonal changes to dual Renin-Angiotensin system inhibition in experimental hypertension. Hypertension. 2013;61(2):417-424.

Valdes G, Corthorn J, Bharadwaj MS, Joyner J, Schneider D, Brosnihan KB. Utero-placental expression of angiotensin-(1-7) and ACE2 in the pregnant guinea-pig. Reprod Biol Endocrinol. 2013;11():5.

Yamaleyeva LM, Neves LA, Coveleskie K, Diz DI, Gallagher PE, Brosnihan KB. AT1, AT2, and AT1-7 receptor expression in the uteroplacental unit of normotensive and hypertensive rats during early and late pregnancy. Placenta. 2013;34(6):497-502.

Varagic J, Ahmad S, VonCannon JL, Moniwa N, Brosnihan KB, Wysocki J, Batlle D, Ferrario CM. Predominance of AT(1) blockade over mas-mediated angiotensin-(1-7) mechanisms in the regulation of blood pressure and renin-angiotensin system in mRen2.Lewis rats. Am J Hypertens. 2013;26(5):583-590.

Americao A, Pirro N, Brosnihan KB, Chappell M. Processing of angiotensinogen to angiotensin-(1-12) by a non-renin enzyme in the salt-sensitive mRen2.Lewis rat [abstract]. FASEB J. 2013;27():909.1.

Brosnihan KB, Yamaleyeva LM, Gallagher PE, Pulgar VM, Neves LA. Local uterine Ang-(1-7) infusion augments expression of cannabinoid receptors and differentially alters endocannabinoid metabolizing enzymes in the decidualized uterus of pseudopregnant rats [abstract]. Hypertension. 2013;62(3 Suppl):543.

Pulgar VM, Yamaleyeva LM, Varagic J, Bader M, Dechend R, Brosnihan KB. Inhibition of metabolism of endogenous AEA and 2-AG reduces Ang II induced uterine artery contraction at early pregnancy in a transgenic model of preeclampsia [abstract]. Hypertension. 2013;62(3 Suppl):416.

Yamaleyeva LM, Brosnihan KB, Anton L, McGee CM, Mertz HL, Merrill DC. Angiotensin II attenuates apelin-36 release from human placental chorionic villi [abstract]. Hypertension. 2013;62(3 Suppl):549.

Miller G, Blackwell CS, Vitolins M, Isom S, Morgan TM, Brosniham KB, Diz DI, Katula JA, Goff DC. A community-based weight loss intervention in obese adults improves adipose tissue circulating factors independently of baseline glucose tolerance [abstract]. In: Obesityweek 2013 November 11-16; Atlanta (GA). 2013;():S86.

Brosnihan KB, Yamaleyeva L, Gallagher PE, Pulgar V, Neves LAA. Local uterine Ang-(1-7) infusion augments the expression of CB1R, CB2 receptor and MAGL but not FAAH in the decidualized uterus of pseudopregnant rats [abstract]. In: Conference Program of the 2013 Carolina Cannabinoid Collaborative Conference; 2013 Oct 25-27; Richmond (VA). 2013;():.

Brosnihan KB, Bharadwaj MS, Yamaleyeva LM, Neves LAA. Decidualized pseudopregnant rat uterus shows marked reduction in Ang II and Ang-(1-7) levels. Placenta. 2012;33(1):17-23.

Yamaleyeva LM, Gilliam-Davis S, Almeida I, Brosnihan KB, Lindsey SH, Chappell MC. Differential regulation of circulating and renal ACE2 and ACE in hypertensive mRen2.Lewis rats with early-onset diabetes. Am J Physiol Renal Physiol. 2012;302(11):F1374-84.

Varagic J, Ahmad S, Voncannon JL, Moniwa N, Simington SW Jr, Brosnihan BK, Gallagher PE, Habibi J, Sowers JR, Ferrario CM. Nebivolol reduces cardiac angiotensin II, associated oxidative stress and fibrosis but not arterial pressure in salt-loaded spontaneously hypertensive rats. J Hypertens. 2012;30(9):1766-1774.

Yamaleyeva LM, Lindsey SH, Pulgar VM, Yamane L, daSilva M, Bonfa P, Brosnihan KB. ACE2 deficiency enhances angiotensin II-induced vasoconstriction of the uterine artery at mid-gestation in mice [abstract]. Hypertension. 2012;60(Suppl 3):317.

Alzayadneh EM, Brosnihan KB, Diz DI. Nuclear renin-angiotensin system in renal proximal tubule cells [abstract]. Hypertension. 2012;60(3 Suppl):238.

Varagic J, Ahmad S, Moniwa N, Brosnihan KB, Wysocki J, Batlle D, Ferrario CM. Predominance of angiotensin II type 1 receptor blockade over antiotensin-(1-7) mechanisms in the regulation of blood pressure and renin angiotensin system in mRen.Lewis rats [abstract]. Hypertension. 2012;60(Suppl 3):283.

Varagic J, Ahmad S, Moniwa N, Brosnihan KB, Ferrario CM. Olmesartan reduces angiotensin II without affecting ACE activity in kidneys of mRen2.Lewis rats [abstract]. FASEB J. 2011;25(Meeting Abstracts):1b358.

Bharadwaj MS, Brosnihan KB. Role of endogenous angiotensin-(1-7) in the regulation of prostaglandin synthetic enzymes in the uteroplacental unit in late gestation [abstract]. FASEB J. 2011;25(Meeting Abstracts):1b540.

Lindsey SH, Yamaleyeva LM, Brosnihan KB, Gallagher PE, Chappell MC. Estrogen receptor GPR30 reduces oxidative stress and proteinuria in the salt-sensitive female mRen2.Lewis rat. Hypertension. 2011;58(4):665-671.

Bharadwaj MS, Strawn WB, Groban L, Yamaleyeva LM, Chappell MC, Horta C, Atkins K, Firmes L, Gurley SB, Brosnihan KB. Angiotensin-converting enzyme 2 deficiency is associated with impaired gestational weight gain and fetal growth restriction. Hypertension. 2011;58(5):852-858.

Hering L, Herse F, Brosnihan KB, Muller DN, Dechend R. Effects of circulating and local angiotensin II on maternal and fetal hearts during pregnancy [abstract]. Placenta. 2011;32(9):A40.

Bharadwaj MS, Joyner J, Corthorn J, Valdes G, Brosnihan KB. Angiotensin-(1-7) and ACE2 uteroplacental expression in guinea-pig pregnancy [abstract]. Hypertension. 2011;58(5):e171.

Firmes L, Brosnihan B, dos Reis A. Effect of ovariectomy on renin angiotensin system in aged rats [abstract]. Hypertension. 2011;58(5):e147.

Gwathmey TM, Nixon PA, O'Shea TM, Brosnihan KB, Chappell MC, Washburn LK. Premature birth is associated with higher diastolic blood pressure and reduced vitamin D in African American adolescents [abstract]. Hypertension. 2011;58(5):e165.

Muller C, Shewale S, Pirro N, Gurley SB, Brosnihan KB, Fiorino P, Chappell MC. Sex and species differences in ACE, ACE2 and neprilysin of the renal brush border [abstract]. Hypertension. 2011;58(5):e153.

Yokoyama H, Averill DB, Brosnihan KB, Smith RD, Schiffrin EL, Ferrario CM. Role of blood pressure reduction in prevention of cardiac and vascular hypertrophy. Russ J Cardiol. 2011;4():102-108.

Yamaleyeva L, Bharadwaj M, Strawn W, Chappell M, Groban L, Atkins K, Horta C, Firmes L, Farah L, Gurly S, Brosnihan KB. ACE2 deficiency is associated with impaired gestational weight gain and fetal growth restriction [abstract]. Physiologist. 2011;54(6):22.

Wysocki J, Ye M, Rodriguez E, Gonzalez-Pacheco FR, Barrios C, Evora K, Schuster M, Brosnihan KB, Ferrario CM, et al. Targeting the degradation of angiotensin II with recombinant angiotensin-convertng enzyme 2: prevention of angiotensin II-dependent hypertension. Hypertension. 2010;55(1):90-98.

Brosnihan KB, Hering L, Dechend R, Chappell MC, Herse F. Increased angiotensin II in the mesometrial triangle of a transgenic rat model of preeclampsia. Hypertension. 2010;55(2 Pt 2):562-566.

Varagic J, Ahmad S, Brosnihan KB, Groban L, Chappell MC, Tallant EA, Gallagher PE, Ferrario CM. Decreased cardiac Ang-(1-7) is associated with salt-induced cardiac remodeling and dysfunction. Ther Adv Cardiovasc Dis. 2010;4(1):17-25.

Senador D, Key M, Brosnihan KB, Irigoyen MC, Elased KM, Morris M. Cardiovascular interactions between losartan and fructose in mice. J Cardiovasc Pharmacol Ther. 2010;15(1):68-77.

Bharadwaj MS, Brosnihan KB. Decidualization results in the polarization of Ang-(1-7), Ang II, and ACE2 to the antimesometrial pole [abstract]. FASEB J. 2010;24(Meeting Abstracts):1040.8.

Bushnell C, Archer D, Brosnihan B. Vascular cell adhesion molecule-1 (VCAM-1) levels in patients at risk for stroke: the impact of gender and risk factor load [abstract]. Stroke. 2010;41(4):E302.

Cohen JA, Lindsey SH, Pirro NT, Brosnihan KB, Gallagher PE, Chappell MC. Influence of estrogen depletion and salt loading on renal angiotensinogen expression in the mRen(2).Lewis strain. Am J Physiol Renal Physiol. 2010;299(1):F35-F42.

Hering L, Herse F, Geusens N, Verlohren S, Wenzel K, Staff AC, Brosnihan KB, Huppertz B, Luft FC, Muller DN, et al. Effects of circulating and local uteroplacental angiotensin II in rat pregnancy. Hypertension. 2010;56(2):311-318.

Anton L, Merrill DC, Neves LAA, Gruver C, Moorefield C, Brosnihan KB. Angiotensin II and angiotensin-(1-7) decrease sFlt1 release in normal but not preeclamptic chorionic villi: an in vitro study. Reprod Biol Endocrinol. 2010;8():art. 135.

Bharadwaj MS, Brosnihan KB. Decidualization results: in the polarization of Ang-(1-7), Ang II, and ACE2 to the antimesometrial pole [abstract]. Hypertension. 2010;56(5):e114.

Brosnihan KB, Bharadwaj MS, Strawn WB, Busalacchi K, Horta CO, Gurley SB. Restricted maternal and fetal growth in angiotensin converting enzyme 2 knock out mice is associated with elevated placental angiotensin II levels [abstract]. Hypertension. 2010;56(5):e113.

Smith RD, Yokoyama H, Averill DB, Cooke L, Brosnihan KB, Schiffrin EL, Ferrario CM. Protective effects of angiotensin II blockade with olmesartan medoxomil on resistance vessel remodeling. Russ J Cardiol. 2010;5():83-90.

Varagic J, Ahmad S, Brosnihan KB, Habibi J, Sowers JR, Ferrario CM. The effects of nebivolol on salt-induced renal injury [abstract]. Hypertension. 2010;56(5):e155.

Varagic J, Ahmad S, Brosnihan KB, Habibi J, Tilmon RD, Sowers JR, Ferrario CM. Salt-induced renal injury in spontaneously hypertensive rats: effects of nebivolol. Am J Nephrol. 2010;32(6):557-566.

Mellen PB, Daniel KR, Brosnihan KB, Hansen KJ, Herrington DM. Effect of muscadine grape seed supplementation on vascular function in subjects with or at risk for cardiovascular disease: a randomized crossover trial. J Am Coll Nutr. 2010;29(5):469-475.

Alfany-Frenandez I, Casillas-Ramirez A, Bintanel-Morcillo M, Brosnihan KB, Ferrario CM, Serafin A, Rimola A, Rodes J, Rosello-Catafau J, Peralta C. Therapeutic targets in liver transplantation: angiotensin II in nonsteatotic grafts and angiotensin-(1-7) in steatotic grafts. Am J Transplant. 2009;9(3):439-451.

Schindler C, Ferrario CM, Brosnihan KB, Idelevich E, Siegert J, Bocking W, Kirch W. Atorvastatin increases plasma levels of the pleiotropic RAS-peptide angiotensin-(1-7) in hypercholesterolemic patients [abstract]. Basic Clin Pharmacol Toxicol. 2009;104(6):517.

Alfany-Fernandez I, Casillas-Ramirez A, Bintanel-Morcillo M, Brosnihan KB, Ferrario CM, Rimola A, Arroyo V, Rodes J, Rosello-Catafau J, Peralta C. Therapeutic targets in liver transplantation: angiotensin II in non-steatotic grafts and angiotensin-(1-7) in steatotic grafts [abstract]. J Hepatol. 2009;50(Suppl 1):S63.

Schindler C, Ferrario CM, Brosnihan BK [sic] [Brosnihan KB], Idelevich E, Siegert J, Kirch W. Atorvastatin mediates pleiotropic effects in hypercholesterolemic patients via the Renin-Angiotensin-System (RAS) by increasing angiotensin-(1-7) [abstract]. Naunyn Schmiedebergs Arch Pharmacol. 2009;379(Suppl 1):92.

Sugulle M, Dechend R, Herse F, Weedon-Fekjaer MS, Johnsen GM, Brosnihan KB, Anton L, Luft FC, Wollert KC, Kempf T, et al. Circulating and placental growth-differentiation factor 15 in preeclampsia and in pregnancy complicated by diabetes mellitus. Hypertension. 2009;54(1):106-112.

Lindsey SH, Cohen JA, Brosnihan KB, Gallagher PE, Chappell MC. Chronic treatment with the G protein-coupled receptor 30 agonist G-1 decreases blood pressure in ovariectomized mRen2.Lewis rats. Endocrinology. 2009;150(8):3753-3758.

Anton L, Merrill DC, Neves LAA, Diz DI, Corthorn J, Stovall K, Gallagher PE, Moorefield C, Gruver C, Brosnihan KB, et al. The uterine placental bed renin-angiotensin system in normal and preeclamptic pregnancy. Endocrinology. 2009;150(9):4316-4325.

Valdes G, Kaufmann P, Corthorn J, Erices R, Brosnihan KB, Joyner-Grantham J. Vasodilator factors in the systemic and local adaptations to pregnancy. Reprod Biol Endocrinol. 2009;7():article 79.

Brosnihan KB, Dechend R, Hering L. Enhanced expression of human RAS mRNA in association with increased Ang II suggests a critical role for the maternal placenta in preeclampsia [abstract]. Hypertension. 2009;54(4):e111.

Dechend R, Hering L, Herse F, Verlohren S, Geusens N, Luft FC, Muller DN, Pijnenborg R, Brosnihan BK [sic] [Brosnihan KB], Cartwright JE. Different effects of circulating and local uteroplacental angiotensin II in pregnancy [abstract]. Hypertension. 2009;54(4):e108-e109.

Gilliam-Davis S, Tommasi EN, Garcia-Espinosa MA, Chappell MC, Brosnihan KB, Diz DI. Bilateral renal denervation prevents age-related proteinuria without altering excretion of intrarenal angiotensin peptides in Sprague-Dawley rats [abstract]. Hypertension. 2009;54(4):e76.

Varagic J, Ahmad S, Brosnihan KB, Ferrario CM. Spironolactone and angiotensin-(1-7) in salt-induced cardiac injury [abstract]. Hypertension. 2009;54(4):e26.

Brosnihan KB, Anton L, Merrill DC. Contrasting roles of the renin-angiotensin system in maternal uterus and fetal placenta in normal and preeclamptic pregnancy [abstract]. In: Meeting Program and Abstracts of the 2009 American Physiological Society Conference: Sex Steroids and Gender in Cardiovascular-Renal Physiology and Pathology; 2009 July 15-18; Broomfield (CO). 2009;():14.

Levy PJ, Strawn WB, Brosnihan KB, Moore LC, Holbrook JB, Hansen KJ, Ferrario CM. Angiotensin II receptor blockade increases endothelial repair potential in younger adults with severe peripheral arterial disease (PAD) [abstract]. J Thromb Haemost. 2009;7(Suppl 2):918.

Neves LAA, Stovall K, Joyner J, Valdes G, Gallagher PE, Ferrario CM, Merrill DC, Brosnihan KB. ACE2 and ANG-(1-7) in the rat uterus during early and late gestation. Am J Physiol Regul Integr Comp Physiol. 2008;294(1):R151-R161.

Schindler C, Ferrario CM, Jatzke C, Ahner K, Brosnihan KB, Bramlage P, Maywald U, Oertel R, Boecking W, Kirch W. Characterization of vascular reactivity in dorsal hand veins after oral rosiglitazone treatment in healthy subjects. Int J Clin Pharmacol Ther. 2008;46(1):30-39.

Lakoski SG, Liu Y, Brosnihan KB, Herrington DM. Interleukin-10 concentration and coronary heart disease (CHD) event risk in the Estrogen Replacement and Atherosclerosis (ERA) study. Atherosclerosis. 2008;197(1):443-447.

Anton L, Merrill DC, Neves LAA, Stovall K, Gallagher PE, Diz DI, Moorefield C, Gruver C, Ferrario CM, Brosnihan KB. Activation of local chorionic villi angiotensin II levels but not angiotensin (1-7) in preelampsia. Hypertension. 2008;51(4):1066-1072.

Joyner J, Neves LAA, Stovall K, Ferrario CM, Brosnihan KB. Angiotensin-(1-7) serves as an aquaretic by increasing water intake and diuresis in association with downregulation of aquaporin-1 during pregnancy in rats. Am J Physiol Regul Integr Comp Physiol. 2008;294(3):R1073-1080.

Jessup JA, Brosnihan KB, Gallagher PE, Chappell MC, Ferrario CM. Differential effect of low-dose thiazides on the renin angiotensin system in genetically hypertensive and normotensive rats. J Am Soc Hypertens. 2008;2(2):106-115.

Brosnihan KB, Li P, Figueroa JP, Ganten D, Ferrario CM. Estrogen, nitric oxide, and hypertension differentially modulate agonist-induced contractile responses in female transgenic (mRen2)27 hypertensive rats. Am J Physiol Heart Circ Physiol. 2008;294(5):H1995-2001.


Brosnihan KB, Anton L, Neves LAA, Moorefield C, Gruver C, Ferrario CM, Merrill DC. Ang II and Ang-(1-7) decrease sFlt1 release in normal but not preeclamptic chorionic villi [abstract]. J Hypertens. 2008;26(Suppl 1):S16.

Pendergrass KD, Pirro NT, Westwood BM, Ferrario CM, Brosnihan KB, Chappell MC. Sex differences in circulating and renal angiotensins of hypertensive mRen(2).Lewis but not normotensive Lewis rats. Am J Physiol Heart Circ Physiol. 2008;295(1):H10-H20.

Anton L, Merrill DC, Diz D, Neves LA, Gallagher PE, Stovall K, Moorefield C, Gruver C, Ferrario CM, Brosnihan KB. Elevation of maternal uterine placental bed angiotensin II levels is associated with increased renin and ACE mRNA in preeclampsia [abstract]. Hypertension. 2008;52(4):e49.

Brosnihan KB, Pazzine M, Neves LA, Ferrario CM. Pregnancy stimulates a differential contribution of AT1 and AT1-7 receptors to renal and uterine blood flow [abstract]. Hypertension. 2008;52(4):e92.

Zhou P, Cheng H-J, Cross M, Callahan MF, Brosnihan B, Little WC, Cheng C-P. Functional effect of chronic urotensin II receptor antagonist on L-type Ca2+ current in mouse model of progressive heart failure [abstract]. Circulation. 2008;118(18 Suppl 2):S398.

Joyner J, Neves LAA, Ferrario CM, Brosnihan KB. Administration of D-alanine-[Ang-(1-7)] (A-779) prior to pregnancy in Sprague Dawley rats produces antidiuresis in late gestation. J Am Soc Hypertens. 2008;2(6):425-430.

Anton L, Merrill D, Diz D, Neves L, Gallagher P, Stovall K, Moorefield C, Gruver C, Ferrario C, Brosnihan KB. Does the activated RAS with suppression of all Ang receptors in the preeclamptic maternal uterus play an endocrine role on the placenta? [abstract]. Hypertens Pregnancy. 2008;27(4):508.

Brosnihan KB, Anton L, Neves L, Moorefield C, Gruver C, Ferrario C, Merrill D. Ang II and Ang-(1-7) decrease sFlt1 release in normal but not preeclamptic chorionic villi [abstract]. Hypertens Pregnancy. 2008;27(4):510.

Yeboah J, Klein K, Brosnihan B, Reboussin D, Herrington DM. Effects of hormone therapy on soluble cell adhesion molecules in postmenopausal women with coronary artery disease. Menopause. 2008;15(6):1060-1064.

Anton L, Brosnihan KB. Systemic and uteroplacental renin--angiotensin system in normal and pre-eclamptic pregnancies. Ther Adv Cardiovasc Dis. 2008;2(5):349-362.

Jessup JA, Brosnihan KB, Gallagher PE, Chappell MC, Ferrario CM. Differential effect of low dose thiazides on the renin angiotensin system in genetically hypertensive and normotensive rats. J Am Soc Hypertens. 2008;2(2):106-115.

Schindler C, Brosnihan KB, Ferrario CM, Bramlage P, Maywald U, Koch R, Oertel R, Kirch W. Comparison of inhibitory effects of irbesartan and atorvastatin treatment on the renin angiotensin system (RAS) in veins: a randomized double-blind crossover trial in healthy subjects. J Clin Pharmacol. 2007;47(1):112-120.

Lakoski SG, Li L, Langefeld CD, Liu Y, Howard TD, Brosnihan KB, Xu J, Bowden DW, Herrington DM. The association between innate immunity gene (IRAK1) and C-reactive protein in the Diabetes Heart Study. Exp Mol Pathol. 2007;82(3):280-283.

Joyner J, Neves LA, Stovall K, Ferrario CM, Brosnihan KB. Angiotensin-(1-7) increases water intake and produces diuresis in association with down-regulation of aquaporin-1 during pregnancy in rats [abstract]. FASEB J. 2007;21(6 Pt II):A1245.

Brosnihan KB, Neves LAA, Stovall K, Ferrario CM. Decidualization of pseduopregnant uterus is associated with marked reduction in Ang II and Ang-(1-7) content [abstract]. FASEB J. 2007;21(6 Pt II):A1252.

Pendergrass KD, Brosnihan KB, Chappell MC. An enhanced intrarenal remin angiotensin system contributes to the gender disparity in blood pressure of the hypertensive mRen2.Lewis rat [abstract]. FASEB J. 2007;21(6):A1415.

Joyner J, Neves LAA, Granger JP, Alexander BT, Merrill DC, Chappell MC, Ferrario CM, Davis WP, Brosnihan KB. Temporal-spatial expression of ANG-(1-7) and angiotensin-converting enzyme 2 in the kidney of normal and hypertensive pregnant rats. Am J Physiol Regul Integr Comp Physiol. 2007;293(1):R169-R177.

Pignone A, Del Rosso A, Brosnihan KB, Perfetto F, Livi R, Fiori G, Guiducci S, Cinelli M, Rogai V, Ferrario CM, et al. Reduced circulating levels of angiotensin-(1-7) in systemic sclerosis: a new pathway in the dysregulation of endothelial-dependent vascular tone control. Ann Rheum Dis. 2007;66(10):1305-1310.

Prime DD, Brosnihan KB, Herrington DM. Effects of hormone therapy on blood pressure and the renin-angiotensin system in postmenopausal women. Minerva Cardioangiol. 2007;55(4):477-485.

Grigore D, Ojeda NB, Robertson EB, Dawson AS, Huffman CA, Bourassa EA, Speth RC, Brosnihan KB, Alexander BT. Placental insufficiency results in temporal alterations in the renin angiotensin system in male hypertensive growth restricted offspring. Am J Physiol Regul Integr Comp Physiol. 2007;293(2):R804-811.

Anton L, Merrill DC, Diz DI, Neves LA, Stovall K, Gallagher PE, Moorefield C, Gruver C, Ferrario CM, Brosnihan KB. The increased shift of the Ang II/Ang-(1-7) balance in the chorionic villi from preeclamptic subjects is mediated by the AT1 receptor [abstract]. Hypertension. 2007;50(4):e79.

Brosnihan KB, Stovell K, Gallagher PE, Ferrario CM, Neves LA. Intrauterine Ang-(1-7) infusion attenuates PGE2 and PGF1 alpha but not TXB2 in decidualized uterus of pseudopregnant rats [abstract]. Hypertension. 2007;50(4):e102.

Joyner J, Neves LA, Stovall K, Ferrario CM, Brosnihan KB. Angiotensin-(1-7) increases urine volume excretion without changing plasma volume or blood pressure during pregnancy [abstract]. Hypertension. 2007;50(4):e78.

Varagic J, Brosnihan KB, Groban L, Gallagher PE, Ferrario CM. Decreased expression of cardiac ACE2 is associated with salt-induced cardiac remodeling and dysfunction [abstract]. Hypertension. 2007;50(4):e150.

Gironacci MM, Brosnihan KB, Ferrario CM, Gorzalczany S, Verrilli MAL, Pascual M, Taira C, Pena C. Increased hypothalamic angiotensin-(1-7) levels in rats with aortic coarctation-induced hypertension. Peptides. 2007;28(8):1580-1585.


Brosnihan KB, Anton L, Merrill DC. Ang-(1-7) and ACE2 in human pregnancy [abstract]. Physiologist. 2007;50(6):23.

Ferrario CM, Averill DB, Brosnihan KB, Chappell MC, Diz DI, Gallagher PE, Neves L, Tallant EA. Regulation of cardiovascular control mechanisms by angiotensin (1-7) and angiotensin-converting enzyme 2 In: Carey RM, ed. Hypertension and hormone mechanisms. Totowa (NJ): Humana Press;2007: 43-59.

Neves LAA, Chappell MC, Ferrario CM, Gallagher PE, Ganten D, Brosnihan KB. Effect of estrogen on neprilysin expression in uterus and kidney of Sprague-Dawley normotensive and heterozygous (mRen2)27-transgenic hypertensive rats. Peptides. 2006;27(11):2912-2918.

Joyner J, Neves LAA, Gallagher PE, Chappell MC, Ferrario CM, Brosnihan KB. Kidney ACE2 mRNA and activity in virgin and normal pregnant Sprague Dawley rats [abstract]. J N C Acad Sci. 2006;122(2):80.

Neves LA, Stovall K, Gallagher PE, Valdes G, Ferrario CM, Merrill DC, Brosnihan KB. Ang-(1-7) concentration and ACE2 mRNA levels are downregulated during the process of implantation and decidualization in Sprague-Dawley rats [abstract]. Hypertens Pregnancy. 2006;25(Suppl 1):20.

Lange LA, Burdon K, Langefeld CD, Liu Y, Beck SR, Rich SS, Freedman BI, Brosnihan KB, Herrington DM, Wagenknecht LE, Bowden DW. Heritability and expression of C-reactive protein in type 2 diabetes in the Diabetes Heart Study. Ann Hum Genet. 2006;70(Pt 6):717-725.

Jessup JA, Gallagher PE, Averill DB, Brosnihan KB, Tallant EA, Chappell MC, Ferrario CM. Effect of angiotensin II blockade on a new congenic model of hypertension derived from transgenic Ren-2 rats. Am J Physiol Heart Circ Physiol. 2006;291(5):H2166-2172.

Smith RD, Yokoyama H, Averill DB, Cooke L, Brosnihan KB, Schiffrin EL, Ferrario CM. The protective effects of angiotensin II blockade with olmesartan medoxomil on resistance vessel remodeling (The VIOS study) : rationale and baseline characteristics. Am J Cardiovasc Drugs. 2006;6(5):335-342.

Lakoski SG, Brosnihan KB, Herrington DM. Interleukin-10 concentration and coronary heart disease (CHD) event risk in the Estrogen Replacement and Atherosclerosis (ERA) Study [abstract]. Circulation. 2006;114(18 Suppl):871.

Anton L, Merrill DC, Neves LA, Gallagher PE, Moorefield C, Gruver C, Ferrario CM, Brosnihan KB. Increased expression of AT1 receptor and angiotensinogen mRNA and Ang II in human placental chorionic villi of preeclamptic pregnant subjects [abstract]. Hypertension. 2006;48(4):e95.

Brosnihan KB, Neves LA, Gallagher P, Hodgin JB, Smithies O, Maeda N. Differential regulation by ER alpha and ER beta for ACE and ACE2 [abstract]. Hypertension. 2006;48(4):e49.

Joyner J, Neves L, Gallagher P, Merrill D, Ferrario C, Brosnihan KB. Counter-regulation of ACE and ACE2 gene expression in the kidney of normal pregnant rats [abstract]. Hypertension. 2006;48(4):e95.

Smith RD, Yokoyama H, Brosnihan KB, Ferrario CM. Inflammatory markers (IM) in uncomplicated hypertension [abstract]. J Hypertens. 2006;24(Suppl 6):111.

Smith RD, Averill DB, Brosnihan KB, Ferrario CM. Effects of antihypertensive therapy on insulin sensitivity and leptin values [abstract]. J Hypertens. 2006;24(Suppl 6):112-113.

Smith RD, Brosnihan KB, Owen J. Cross talk of the angiotensin AT1 receptor and the thromboxane receptor [abstract]. J Hypertens. 2006;24(Suppl 6):252.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

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