Profile

Kathleen B. Brosnihan Simmons, Ph.D.Wake Forest School of Medicine

Education & Training

  • B.S., College of St Mary, 1965
  • M.S., Creighton University, 1970
  • Ph.D., Case Western Reserve, 1974
  • Fellowship, Cleveland Clinic Foundation, 1976

Memberships

  • Am Heart Association
  • Am Physiological Society
  • Cons for SE Hypertension Contr
  • Endocrine Society
  • Inter-Amer Soc of Hypertension
Kathleen B. Brosnihan Simmons, Ph.D.

Kathleen B. Brosnihan Simmons, Ph.D.

Professor, Hypertension
Hypertension and Vascular Research Center
Office of Women in Medicine and Science
Institute for Regenerative Medicine
Obstetrics & Gynecology
Physiology & Pharmacology
Translational Science Institute

Research Interests

hormones/cytokines/signalling, hypertension, maternal & child health, model development, radiology imaging/nuclear medi, women's health issues

Contact Information

Academic: 336-716-2795 | Department: 336-716-2795

Email: bbrosnih@wakehealth.edu

Recent Publications

Brosnihan KB, Pulgar VM, Gallagher PE, Neves LA, Yamaleyeva LM. Local uterine Ang-(1-7) infusion augments the expression of cannabinoid receptors and differentially alters endocannabinoid metabolizing enzymes in the decidualized uterus of pseudopregnant rats. Reprod Biol Endocrinol. 2015;13(1):5.

Pulgar VM, Yamaleyeva LM, Varagic J, McGee CM, Bader M, Dechend R, Howlett AC, Brosnihan KB. Vasoactive lipid mediators control uterine vascular reactivity at early pregnancy in the transgenic hAGNxhREN rat [abstract]. Pregnancy Hypertens. 2015;5(1):8.

Yamaleyeva LM, Chappell MC, Bridget Brosnihan K, Anton L, Pirro N, McGee C, Merrill DC, Mertz HL. Apelin as a novel therapeutic target in preeclampsia [abstract]. Pregnancy Hypertens. 2015;5(1):140-141.

Yamaleyeva LM, Pulgar VM, Lindsey SH, Yamane L, Varagic J, McGee C, daSilva M, Bonfa PL, Gurley SB, Brosnihan KB. Uterine artery dysfunction in pregnant ACE2 knockout mice is associated with placental hypoxia and reduced umbilical blood flow velocity. Am J Physiol Endocrinol Metab. 2015;309(1):E84-E94.

Washburn LK, Brosnihan KB, Chappell MC, Diz DI, Gwathmey TM, Nixon PA, Russell GB, Snively BM, O'Shea TM. The renin-angiotensin-aldosterone system in adolescent offspring born prematurely to mothers with preeclampsia. J Renin Angiotensin Aldosterone Syst. 2014;():.

Pulgar VM, Yamaleyeva LM, Varagic J, McGee CM, Bader M, Dechend R, Howlett AC, Brosnihan KB. Increased angiotensin II contraction of the uterine artery at early gestation in a transgenic model of hypertensive pregnancy is reduced by inhibition of endocannabinoid hydrolysis. Hypertension. 2014;64(3):619-625.

Yamaleyeva LM, Merrill DC, Ebert TJ, Smith TL, Mertz HL, Brosnihan KB. Hemodynamic responses to angiotensin-(1-7) in women in their third trimester of pregnancy. Hypertens Pregnancy. 2014;33(4):375-388.

Yamaleyeva LM, Brosnihan KB, Anton L, McGee C, Mertz HL, Gallagher PE, Merrill DC. Opposing interactions between angiotensin II and apelin in human placental chorionic villi [abstract]. Reprod Sci. 2014;21(3 Suppl):393A.

Schaich C, Howlett A, Brosnihan K, Diz D. Differential blood pressure response in normotensive rats and rats with angiotensin II-dependent hypertension following systemic cannabinoid CB1 receptor blockade [abstract]. FASEB J. 2014;28(1 Suppl):1140.11.

Schaich CL, Shaltout HA, Brosnihan KB, Howlett AC, Diz DI. Acute and chronic systemic CB1 cannabinoid receptor blockade improves blood pressure regulation and metabolic profile in hypertensive (mRen2)27 rats. Physiol Rep. 2014;2(8):e12108.

Miller GD, Isom S, Morgan TM, Vitolins MZ, Blackwell C, Brosnihan KB, Diz DI, Katula J, Goff D. Effects of a community-based weight loss intervention on adipose tissue circulating factors. Diabetes Metab Syndr. 2014;8(4):205-211.

Pulgar VM, Yamaleyeva LM, Varagic J, McGee CM, Bader M, Delbruck M, Dechend R, Brosnihan KB. Increased role of COX-derived prostanoids in regulating Ang II induced uterine artery contraction at early pregnancy in a transgenic model of preeclampsia [abstract]. Hypertension. 2014;64(Suppl 1):A579.

Yamaleyeva LM, Pulgar VM, Lindsey SH, Varagic J, McGee CM, Yamane L, Brosnihan KB. Uterine artery dysfunction in ACE2 deficient mice is associated with placental hypoxia and reduced umbilical flow [abstract]. Hypertension. 2014;64(Suppl 1):A092.

Brosnihan KB, Pulgar VM, Varagic J, Oliva K, Bader M, Delbruck M, Dechend R, Gallagher P, Thomas BF, Grabenauer M, Yamaleyeva LM. Increased uterine interimplantation levels of Ang II, AT1R, and CB1R are associated with reduced uterine permeability at early pregnancy in a transgenic model of preeclampsia [abstract]. Hypertension. 2014;64(Suppl 1):A577.

Yamaleyeva LM, Chappell MC, Brosnihan KB, Anton L, Pirro N, McGee C, Merrill DC, Mertz HL. Apelin as a novel therapeutic target in preeclampsia [abstract]. Hypertension. 2014;64(Suppl 1):A634.

Moniwa N, Varagic J, Ahmad S, Voncannon JL, Simington SW, Wang H, Groban L, Brosnihan KB, Nagata S, Kato J, Kitamura K, Gomez RA, Lopez ML, Ferrario CM. Hemodynamic and hormonal changes to dual Renin-Angiotensin system inhibition in experimental hypertension. Hypertension. 2013;61(2):417-424.

Valdes G, Corthorn J, Bharadwaj MS, Joyner J, Schneider D, Brosnihan KB. Utero-placental expression of angiotensin-(1-7) and ACE2 in the pregnant guinea-pig. Reprod Biol Endocrinol. 2013;11():5.

Yamaleyeva LM, Neves LA, Coveleskie K, Diz DI, Gallagher PE, Brosnihan KB. AT1, AT2, and AT1-7 receptor expression in the uteroplacental unit of normotensive and hypertensive rats during early and late pregnancy. Placenta. 2013;34(6):497-502.

Varagic J, Ahmad S, VonCannon JL, Moniwa N, Brosnihan KB, Wysocki J, Batlle D, Ferrario CM. Predominance of AT(1) blockade over mas-mediated angiotensin-(1-7) mechanisms in the regulation of blood pressure and renin-angiotensin system in mRen2.Lewis rats. Am J Hypertens. 2013;26(5):583-590.

Americao A, Pirro N, Brosnihan KB, Chappell M. Processing of angiotensinogen to angiotensin-(1-12) by a non-renin enzyme in the salt-sensitive mRen2.Lewis rat [abstract]. FASEB J. 2013;27():909.1.

Brosnihan KB, Yamaleyeva LM, Gallagher PE, Pulgar VM, Neves LA. Local uterine Ang-(1-7) infusion augments expression of cannabinoid receptors and differentially alters endocannabinoid metabolizing enzymes in the decidualized uterus of pseudopregnant rats [abstract]. Hypertension. 2013;62(3 Suppl):543.

Pulgar VM, Yamaleyeva LM, Varagic J, Bader M, Dechend R, Brosnihan KB. Inhibition of metabolism of endogenous AEA and 2-AG reduces Ang II induced uterine artery contraction at early pregnancy in a transgenic model of preeclampsia [abstract]. Hypertension. 2013;62(3 Suppl):416.

Yamaleyeva LM, Brosnihan KB, Anton L, McGee CM, Mertz HL, Merrill DC. Angiotensin II attenuates apelin-36 release from human placental chorionic villi [abstract]. Hypertension. 2013;62(3 Suppl):549.

Miller G, Blackwell CS, Vitolins M, Isom S, Morgan TM, Brosniham KB, Diz DI, Katula JA, Goff DC. A community-based weight loss intervention in obese adults improves adipose tissue circulating factors independently of baseline glucose tolerance [abstract]. In: Obesityweek 2013 November 11-16; Atlanta (GA). 2013;():S86.

Brosnihan KB, Yamaleyeva L, Gallagher PE, Pulgar V, Neves LAA. Local uterine Ang-(1-7) infusion augments the expression of CB1R, CB2 receptor and MAGL but not FAAH in the decidualized uterus of pseudopregnant rats [abstract]. In: Conference Program of the 2013 Carolina Cannabinoid Collaborative Conference; 2013 Oct 25-27; Richmond (VA). 2013;():.

Brosnihan KB, Bharadwaj MS, Yamaleyeva LM, Neves LAA. Decidualized pseudopregnant rat uterus shows marked reduction in Ang II and Ang-(1-7) levels. Placenta. 2012;33(1):17-23.

Yamaleyeva LM, Gilliam-Davis S, Almeida I, Brosnihan KB, Lindsey SH, Chappell MC. Differential regulation of circulating and renal ACE2 and ACE in hypertensive mRen2.Lewis rats with early-onset diabetes. Am J Physiol Renal Physiol. 2012;302(11):F1374-84.

Varagic J, Ahmad S, Voncannon JL, Moniwa N, Simington SW Jr, Brosnihan BK, Gallagher PE, Habibi J, Sowers JR, Ferrario CM. Nebivolol reduces cardiac angiotensin II, associated oxidative stress and fibrosis but not arterial pressure in salt-loaded spontaneously hypertensive rats. J Hypertens. 2012;30(9):1766-1774.

Yamaleyeva LM, Lindsey SH, Pulgar VM, Yamane L, daSilva M, Bonfa P, Brosnihan KB. ACE2 deficiency enhances angiotensin II-induced vasoconstriction of the uterine artery at mid-gestation in mice [abstract]. Hypertension. 2012;60(Suppl 3):317.

Alzayadneh EM, Brosnihan KB, Diz DI. Nuclear renin-angiotensin system in renal proximal tubule cells [abstract]. Hypertension. 2012;60(3 Suppl):238.

Varagic J, Ahmad S, Moniwa N, Brosnihan KB, Wysocki J, Batlle D, Ferrario CM. Predominance of angiotensin II type 1 receptor blockade over antiotensin-(1-7) mechanisms in the regulation of blood pressure and renin angiotensin system in mRen.Lewis rats [abstract]. Hypertension. 2012;60(Suppl 3):283.

Varagic J, Ahmad S, Moniwa N, Brosnihan KB, Ferrario CM. Olmesartan reduces angiotensin II without affecting ACE activity in kidneys of mRen2.Lewis rats [abstract]. FASEB J. 2011;25(Meeting Abstracts):1b358.

Bharadwaj MS, Brosnihan KB. Role of endogenous angiotensin-(1-7) in the regulation of prostaglandin synthetic enzymes in the uteroplacental unit in late gestation [abstract]. FASEB J. 2011;25(Meeting Abstracts):1b540.

Lindsey SH, Yamaleyeva LM, Brosnihan KB, Gallagher PE, Chappell MC. Estrogen receptor GPR30 reduces oxidative stress and proteinuria in the salt-sensitive female mRen2.Lewis rat. Hypertension. 2011;58(4):665-671.

Bharadwaj MS, Strawn WB, Groban L, Yamaleyeva LM, Chappell MC, Horta C, Atkins K, Firmes L, Gurley SB, Brosnihan KB. Angiotensin-converting enzyme 2 deficiency is associated with impaired gestational weight gain and fetal growth restriction. Hypertension. 2011;58(5):852-858.

Hering L, Herse F, Brosnihan KB, Muller DN, Dechend R. Effects of circulating and local angiotensin II on maternal and fetal hearts during pregnancy [abstract]. Placenta. 2011;32(9):A40.

Bharadwaj MS, Joyner J, Corthorn J, Valdes G, Brosnihan KB. Angiotensin-(1-7) and ACE2 uteroplacental expression in guinea-pig pregnancy [abstract]. Hypertension. 2011;58(5):e171.

Firmes L, Brosnihan B, dos Reis A. Effect of ovariectomy on renin angiotensin system in aged rats [abstract]. Hypertension. 2011;58(5):e147.

Gwathmey TM, Nixon PA, O'Shea TM, Brosnihan KB, Chappell MC, Washburn LK. Premature birth is associated with higher diastolic blood pressure and reduced vitamin D in African American adolescents [abstract]. Hypertension. 2011;58(5):e165.

Muller C, Shewale S, Pirro N, Gurley SB, Brosnihan KB, Fiorino P, Chappell MC. Sex and species differences in ACE, ACE2 and neprilysin of the renal brush border [abstract]. Hypertension. 2011;58(5):e153.

Yokoyama H, Averill DB, Brosnihan KB, Smith RD, Schiffrin EL, Ferrario CM. Role of blood pressure reduction in prevention of cardiac and vascular hypertrophy. Russ J Cardiol. 2011;4():102-108.

Yamaleyeva L, Bharadwaj M, Strawn W, Chappell M, Groban L, Atkins K, Horta C, Firmes L, Farah L, Gurly S, Brosnihan KB. ACE2 deficiency is associated with impaired gestational weight gain and fetal growth restriction [abstract]. Physiologist. 2011;54(6):22.

Wysocki J, Ye M, Rodriguez E, Gonzalez-Pacheco FR, Barrios C, Evora K, Schuster M, Brosnihan KB, Ferrario CM, et al. Targeting the degradation of angiotensin II with recombinant angiotensin-convertng enzyme 2: prevention of angiotensin II-dependent hypertension. Hypertension. 2010;55(1):90-98.

Brosnihan KB, Hering L, Dechend R, Chappell MC, Herse F. Increased angiotensin II in the mesometrial triangle of a transgenic rat model of preeclampsia. Hypertension. 2010;55(2 Pt 2):562-566.

Varagic J, Ahmad S, Brosnihan KB, Groban L, Chappell MC, Tallant EA, Gallagher PE, Ferrario CM. Decreased cardiac Ang-(1-7) is associated with salt-induced cardiac remodeling and dysfunction. Ther Adv Cardiovasc Dis. 2010;4(1):17-25.

Senador D, Key M, Brosnihan KB, Irigoyen MC, Elased KM, Morris M. Cardiovascular interactions between losartan and fructose in mice. J Cardiovasc Pharmacol Ther. 2010;15(1):68-77.

Bharadwaj MS, Brosnihan KB. Decidualization results in the polarization of Ang-(1-7), Ang II, and ACE2 to the antimesometrial pole [abstract]. FASEB J. 2010;24(Meeting Abstracts):1040.8.

Bushnell C, Archer D, Brosnihan B. Vascular cell adhesion molecule-1 (VCAM-1) levels in patients at risk for stroke: the impact of gender and risk factor load [abstract]. Stroke. 2010;41(4):E302.

Cohen JA, Lindsey SH, Pirro NT, Brosnihan KB, Gallagher PE, Chappell MC. Influence of estrogen depletion and salt loading on renal angiotensinogen expression in the mRen(2).Lewis strain. Am J Physiol Renal Physiol. 2010;299(1):F35-F42.

Hering L, Herse F, Geusens N, Verlohren S, Wenzel K, Staff AC, Brosnihan KB, Huppertz B, Luft FC, Muller DN, et al. Effects of circulating and local uteroplacental angiotensin II in rat pregnancy. Hypertension. 2010;56(2):311-318.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Hypertension

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