Profile

Kathleen B. Brosnihan Simmons, Ph.D.Wake Forest School of Medicine

Kathleen B. Brosnihan Simmons, Ph.D.

Professor,

Contact Information

Academic: 336-716-2795 | Department: 336-716-2795

Email: bbrosnih@wakehealth.edu

Education & Training

  • B.S., College of St Mary, 1965
  • M.S., Creighton University, 1970
  • Ph.D., Case Western Reserve, 1974
  • Fellowship, Cleveland Clinic Foundation, 1976

Memberships

  • Am Heart Association
  • Am Physiological Society
  • Cons for SE Hypertension Contr
  • Endocrine Society
  • Inter-Amer Soc of Hypertension
Kathleen B. Brosnihan Simmons, Ph.D.

Kathleen B. Brosnihan Simmons, Ph.D.

Professor, Hypertension
Office of Women in Medicine and Science

Contact Information

Academic: 336-716-2795 | Department: 336-716-2795

Email: bbrosnih@wakehealth.edu

Recent Publications

Hemodynamic and renoprotective actions of (Pyr1)-Apelin-13 in preeclampsia [abstract]. Yamaleyeva LM, Brosnihan KB, Mcgee C, Shi S, Varagic J, Bader M, Dechend R, Shaltout H.. Reprod Sci. 2016;23(Suppl 1):62A.

Identification of dipeptidyl peptidase 3 as the Angiotensin-(1-7) degrading peptidase in human HK-2 renal epithelial cells. Cruz-Diaz N, Wilson BA, Pirro NT, Brosnihan KB, Marshall AC, Chappell MC.. Peptides. 2016;83():29-37.

The renin-angiotensin-aldosterone system in adolescent offspring born prematurely to mothers with preeclampsia. Washburn LK, Brosnihan KB, Chappell MC, Diz DI, Gwathmey TM, Nixon PA, Russell GB, Snively BM, O'Shea TM.. J Renin Angiotensin Aldosterone Syst. 2015;16(3):529-538.

Local uterine Ang-(1-7) infusion augments the expression of cannabinoid receptors and differentially alters endocannabinoid metabolizing enzymes in the decidualized uterus of pseudopregnant rats. Brosnihan KB, Pulgar VM, Gallagher PE, Neves LA, Yamaleyeva LM.. Reprod Biol Endocrinol. 2015;13(1):5.

Vasoactive lipid mediators control uterine vascular reactivity at early pregnancy in the transgenic hAGNxhREN rat [abstract]. Pulgar VM, Yamaleyeva LM, Varagic J, McGee CM, Bader M, Dechend R, Howlett AC, Brosnihan KB.. Pregnancy Hypertens. 2015;5(1):8.

Apelin as a novel therapeutic target in preeclampsia [abstract]. Yamaleyeva LM, Chappell MC, Bridget Brosnihan K, Anton L, Pirro N, McGee C, Merrill DC, Mertz HL.. Pregnancy Hypertens. 2015;5(1):140-141.

Uterine artery dysfunction in pregnant ACE2 knockout mice is associated with placental hypoxia and reduced umbilical blood flow velocity. Yamaleyeva LM, Pulgar VM, Lindsey SH, Yamane L, Varagic J, McGee C, daSilva M, Bonfa PL, Gurley SB, Brosnihan KB.. Am J Physiol Endocrinol Metab. 2015;309(1):E84-E94.

Functional changes in the uterine artery precede the hypertensive phenotype in a transgenic model of hypertensive pregnancy. Pulgar VM, Yamaleyeva LM, Varagic J, McGee C, Bader M, Dechend R, Brosnihan KB.. Am J Physiol Endocrinol Metab. 2015;309(9):E811-E817.

Downregulation of apelin in the human placental chorionic villi from preeclamptic pregnancies. Yamaleyeva LM, Chappell MC, Brosnihan KB, Anton L, Caudell DL, Shi S, McGee C, Pirro N, Gallagher PE, Taylor RN, Merrill DC, Mertz HL.. Am J Physiol Endocrinol Metab. 2015;309(10):E852-E860.

Systemic administration of (Pyr1)-apelin-13 at late pregnancy reduces blood pressure, proteinuria, and improves autonomic function in preeclamptic rats [abstract]. Yamaleyeva LM, Brosnihan KB, McGee C, Shi S, Varagic J, Bader M, Dechend R, Shaltout HA.. Hypertension. 2015;66(Suppl 1):A126.

Impairment of autonomic function precedes blood pressure elevation in rat model of pre-eclampsia [abstract]. Shaltout HA, Yamaleyeva LM, Bader M, Dechend R, Brosnihan B.. Hypertension. 2015;66(Suppl 1):AP175.

Increased angiotensin II contraction of the uterine artery at early gestation in a transgenic model of hypertensive pregnancy is reduced by inhibition of endocannabinoid hydrolysis. Pulgar VM, Yamaleyeva LM, Varagic J, McGee CM, Bader M, Dechend R, Howlett AC, Brosnihan KB.. Hypertension. 2014;64(3):619-625.

Hemodynamic responses to angiotensin-(1-7) in women in their third trimester of pregnancy. Yamaleyeva LM, Merrill DC, Ebert TJ, Smith TL, Mertz HL, Brosnihan KB.. Hypertens Pregnancy. 2014;33(4):375-388.

Opposing interactions between angiotensin II and apelin in human placental chorionic villi [abstract]. Yamaleyeva LM, Brosnihan KB, Anton L, McGee C, Mertz HL, Gallagher PE, Merrill DC.. Reprod Sci. 2014;21(3 Suppl):393A.

Differential blood pressure response in normotensive rats and rats with angiotensin II-dependent hypertension following systemic cannabinoid CB1 receptor blockade [abstract]. Schaich C, Howlett A, Brosnihan K, Diz D.. FASEB J. 2014;28(1 Suppl):1140.11.

Acute and chronic systemic CB1 cannabinoid receptor blockade improves blood pressure regulation and metabolic profile in hypertensive (mRen2)27 rats. Schaich CL, Shaltout HA, Brosnihan KB, Howlett AC, Diz DI.. Physiol Rep. 2014;2(8):e12108.

Effects of a community-based weight loss intervention on adipose tissue circulating factors. Miller GD, Isom S, Morgan TM, Vitolins MZ, Blackwell C, Brosnihan KB, Diz DI, Katula J, Goff D.. Diabetes Metab Syndr. 2014;8(4):205-211.

Increased role of COX-derived prostanoids in regulating Ang II induced uterine artery contraction at early pregnancy in a transgenic model of preeclampsia [abstract]. Pulgar VM, Yamaleyeva LM, Varagic J, McGee CM, Bader M, Delbruck M, Dechend R, Brosnihan KB.. Hypertension. 2014;64(Suppl 1):A579.

Uterine artery dysfunction in ACE2 deficient mice is associated with placental hypoxia and reduced umbilical flow [abstract]. Yamaleyeva LM, Pulgar VM, Lindsey SH, Varagic J, McGee CM, Yamane L, Brosnihan KB.. Hypertension. 2014;64(Suppl 1):A092.

Increased uterine interimplantation levels of Ang II, AT1R, and CB1R are associated with reduced uterine permeability at early pregnancy in a transgenic model of preeclampsia [abstract]. Brosnihan KB, Pulgar VM, Varagic J, Oliva K, Bader M, Delbruck M, Dechend R, Gallagher P, Thomas BF, Grabenauer M, Yamaleyeva LM.. Hypertension. 2014;64(Suppl 1):A577.

Apelin as a novel therapeutic target in preeclampsia [abstract]. Yamaleyeva LM, Chappell MC, Brosnihan KB, Anton L, Pirro N, McGee C, Merrill DC, Mertz HL.. Hypertension. 2014;64(Suppl 1):A634.

Hemodynamic and hormonal changes to dual Renin-Angiotensin system inhibition in experimental hypertension. Moniwa N, Varagic J, Ahmad S, Voncannon JL, Simington SW, Wang H, Groban L, Brosnihan KB, Nagata S, Kato J, Kitamura K, Gomez RA, Lopez ML, Ferrario CM.. Hypertension. 2013;61(2):417-424.

Utero-placental expression of angiotensin-(1-7) and ACE2 in the pregnant guinea-pig. Valdes G, Corthorn J, Bharadwaj MS, Joyner J, Schneider D, Brosnihan KB.. Reprod Biol Endocrinol. 2013;11():5.

AT1, AT2, and AT1-7 receptor expression in the uteroplacental unit of normotensive and hypertensive rats during early and late pregnancy. Yamaleyeva LM, Neves LA, Coveleskie K, Diz DI, Gallagher PE, Brosnihan KB.. Placenta. 2013;34(6):497-502.

Predominance of AT(1) blockade over mas-mediated angiotensin-(1-7) mechanisms in the regulation of blood pressure and renin-angiotensin system in mRen2.Lewis rats. Varagic J, Ahmad S, VonCannon JL, Moniwa N, Brosnihan KB, Wysocki J, Batlle D, Ferrario CM.. Am J Hypertens. 2013;26(5):583-590.

Processing of angiotensinogen to angiotensin-(1-12) by a non-renin enzyme in the salt-sensitive mRen2.Lewis rat [abstract]. Americao A, Pirro N, Brosnihan KB, Chappell M.. FASEB J. 2013;27():909.1.

Local uterine Ang-(1-7) infusion augments expression of cannabinoid receptors and differentially alters endocannabinoid metabolizing enzymes in the decidualized uterus of pseudopregnant rats [abstract]. Brosnihan KB, Yamaleyeva LM, Gallagher PE, Pulgar VM, Neves LA.. Hypertension. 2013;62(3 Suppl):543.

Inhibition of metabolism of endogenous AEA and 2-AG reduces Ang II induced uterine artery contraction at early pregnancy in a transgenic model of preeclampsia [abstract]. Pulgar VM, Yamaleyeva LM, Varagic J, Bader M, Dechend R, Brosnihan KB.. Hypertension. 2013;62(3 Suppl):416.

Angiotensin II attenuates apelin-36 release from human placental chorionic villi [abstract]. Yamaleyeva LM, Brosnihan KB, Anton L, McGee CM, Mertz HL, Merrill DC.. Hypertension. 2013;62(3 Suppl):549.

A community-based weight loss intervention in obese adults improves adipose tissue circulating factors independently of baseline glucose tolerance [abstract]. Miller G, Blackwell CS, Vitolins M, Isom S, Morgan TM, Brosniham KB, Diz DI, Katula JA, Goff DC.. In: Obesityweek 2013 November 11-16; Atlanta (GA). 2013;():S86.

Local uterine Ang-(1-7) infusion augments the expression of CB1R, CB2 receptor and MAGL but not FAAH in the decidualized uterus of pseudopregnant rats [abstract]. Brosnihan KB, Yamaleyeva L, Gallagher PE, Pulgar V, Neves LAA.. In: Conference Program of the 2013 Carolina Cannabinoid Collaborative Conference; 2013 Oct 25-27; Richmond (VA). 2013;():.

Decidualized pseudopregnant rat uterus shows marked reduction in Ang II and Ang-(1-7) levels. Brosnihan KB, Bharadwaj MS, Yamaleyeva LM, Neves LAA.. Placenta. 2012;33(1):17-23.

Differential regulation of circulating and renal ACE2 and ACE in hypertensive mRen2.Lewis rats with early-onset diabetes. Yamaleyeva LM, Gilliam-Davis S, Almeida I, Brosnihan KB, Lindsey SH, Chappell MC.. Am J Physiol Renal Physiol. 2012;302(11):F1374-84.

Nebivolol reduces cardiac angiotensin II, associated oxidative stress and fibrosis but not arterial pressure in salt-loaded spontaneously hypertensive rats. Varagic J, Ahmad S, Voncannon JL, Moniwa N, Simington SW Jr, Brosnihan BK, Gallagher PE, Habibi J, Sowers JR, Ferrario CM.. J Hypertens. 2012;30(9):1766-1774.

ACE2 deficiency enhances angiotensin II-induced vasoconstriction of the uterine artery at mid-gestation in mice [abstract]. Yamaleyeva LM, Lindsey SH, Pulgar VM, Yamane L, daSilva M, Bonfa P, Brosnihan KB.. Hypertension. 2012;60(Suppl 3):317.

Nuclear renin-angiotensin system in renal proximal tubule cells [abstract]. Alzayadneh EM, Brosnihan KB, Diz DI.. Hypertension. 2012;60(3 Suppl):238.

Predominance of angiotensin II type 1 receptor blockade over antiotensin-(1-7) mechanisms in the regulation of blood pressure and renin angiotensin system in mRen.Lewis rats [abstract]. Varagic J, Ahmad S, Moniwa N, Brosnihan KB, Wysocki J, Batlle D, Ferrario CM.. Hypertension. 2012;60(Suppl 3):283.

Olmesartan reduces angiotensin II without affecting ACE activity in kidneys of mRen2.Lewis rats [abstract]. Varagic J, Ahmad S, Moniwa N, Brosnihan KB, Ferrario CM.. FASEB J. 2011;25(Meeting Abstracts):1b358.

Role of endogenous angiotensin-(1-7) in the regulation of prostaglandin synthetic enzymes in the uteroplacental unit in late gestation [abstract]. Bharadwaj MS, Brosnihan KB.. FASEB J. 2011;25(Meeting Abstracts):1b540.

Estrogen receptor GPR30 reduces oxidative stress and proteinuria in the salt-sensitive female mRen2.Lewis rat. Lindsey SH, Yamaleyeva LM, Brosnihan KB, Gallagher PE, Chappell MC.. Hypertension. 2011;58(4):665-671.

Angiotensin-converting enzyme 2 deficiency is associated with impaired gestational weight gain and fetal growth restriction. Bharadwaj MS, Strawn WB, Groban L, Yamaleyeva LM, Chappell MC, Horta C, Atkins K, Firmes L, Gurley SB, Brosnihan KB.. Hypertension. 2011;58(5):852-858.

Effects of circulating and local angiotensin II on maternal and fetal hearts during pregnancy [abstract]. Hering L, Herse F, Brosnihan KB, Muller DN, Dechend R.. Placenta. 2011;32(9):A40.

Angiotensin-(1-7) and ACE2 uteroplacental expression in guinea-pig pregnancy [abstract]. Bharadwaj MS, Joyner J, Corthorn J, Valdes G, Brosnihan KB.. Hypertension. 2011;58(5):e171.

Effect of ovariectomy on renin angiotensin system in aged rats [abstract]. Firmes L, Brosnihan B, dos Reis A.. Hypertension. 2011;58(5):e147.

Premature birth is associated with higher diastolic blood pressure and reduced vitamin D in African American adolescents [abstract]. Gwathmey TM, Nixon PA, O'Shea TM, Brosnihan KB, Chappell MC, Washburn LK.. Hypertension. 2011;58(5):e165.

Sex and species differences in ACE, ACE2 and neprilysin of the renal brush border [abstract]. Muller C, Shewale S, Pirro N, Gurley SB, Brosnihan KB, Fiorino P, Chappell MC.. Hypertension. 2011;58(5):e153.

Role of blood pressure reduction in prevention of cardiac and vascular hypertrophy. Yokoyama H, Averill DB, Brosnihan KB, Smith RD, Schiffrin EL, Ferrario CM.. Russ J Cardiol. 2011;4():102-108.

ACE2 deficiency is associated with impaired gestational weight gain and fetal growth restriction [abstract]. Yamaleyeva L, Bharadwaj M, Strawn W, Chappell M, Groban L, Atkins K, Horta C, Firmes L, Farah L, Gurly S, Brosnihan KB.. Physiologist. 2011;54(6):22.

Targeting the degradation of angiotensin II with recombinant angiotensin-convertng enzyme 2: prevention of angiotensin II-dependent hypertension. Wysocki J, Ye M, Rodriguez E, Gonzalez-Pacheco FR, Barrios C, Evora K, Schuster M, Brosnihan KB, Ferrario CM, et al.. Hypertension. 2010;55(1):90-98.

Increased angiotensin II in the mesometrial triangle of a transgenic rat model of preeclampsia. Brosnihan KB, Hering L, Dechend R, Chappell MC, Herse F.. Hypertension. 2010;55(2 Pt 2):562-566.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Hypertension

Kathleen B. Brosnihan Simmons, Ph.D.

Kathleen B. Brosnihan Simmons, Ph.D.

Professor, Hypertension
Office of Women in Medicine and Science

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