William R. Brown, Ph.D., Associate Professor Radiologic Sciences-Radiology

William R. Brown, Ph.D.

Professor, Radiology
Comprehensive Cancer Center
Brain Tumor Center of Excellence

Contact Information

Academic: 336-716-2225 | Department: 336-716-2225

Email: wibrown@wakehealth.edu

Education & Training

Ph.D., University Of Guelph-Canada , 1983
B.I.S., Waterloo University-Canada , 1975
M.Sc., University Of Windsor-Canada , 1978
Fellowship, University Of Guelph-Canada, 1983
Fellowship, University Toronto Med-Canada, 1987

Memberships

Int'L Society Of Neuropatholog
N Am Vascular Biology Organiza
Am Assn Of Advancement Of Scie
Am Assn Of Neuropathologists
Society for Neuroscience

William R. Brown, Ph.D.

Professor, Radiology Comprehensive Cancer Center
Brain Tumor Center of Excellence

Research Interests

degenerative disorders, immunology/allergy/inflammatio, vascular diseases

Contact Information

Academic: 336-716-2225 | Department: 336-716-2225

Email: wibrown@wakehealth.edu

Recent Publications

Brown WR. Vascular pathology in neurodegeneration and ageing [abstract]. Clin Neuropathol. 2012;31(4):233.

Brown WR, Thore CR. Review: cerebral microvascular pathology in ageing and neurodegeneration. Neuropathol Appl Neurobiol. 2011;37(1):56-74.

Brown WR, Thore CR. Perivascular fibrosis in multiple sclerosis lesions [letter]. Brain Pathol. 2011;21(3):355.

Brown WR. A review of string vessels or collapsed, empty basement membrane tubes. J Alzheimers Dis. 2010;21(3):725-739.

Robbins ME, Payne V, Tommasi E, Diz DI, Hsu F-C, Brown WR, Wheeler KT, Olson J, Zhao W. The AT1 receptor antagonist, L-158,809, prevents or ameliorates fractionated whole-brain irradiation-induced cognitive impairment. Int J Radiat Oncol Biol Phys. 2009;73(2):499-505.

Brown WR. Association of preterm birth with brain malformations. Pediatr Res. 2009;65(6):642-646.

Brown WR, Moody DM, Thore CR, Anstrom JA, Challa VR. Microvascular changes in the white mater [sic] in dementia. J Neurol Sci. 2009;283(1-2):28-31.

Brown WR, Thore CR, Moody DM, Anstrom JA. String vessels (capillary remnants) in the brain and eye in development, senescence, Alzheimer's disease, leukoaraiosis, and after irradiation [abstract]. J Neurol Sci. 2009;283(1-2 Special Issue):288.

Mott RT, Thore CR, Moody DM, Glazier SS, Ellis TL, Brown WR. Reduced ratio of afferent to total vascular density in mesial temporal sclerosis. J Neuropathol Exp Neurol. 2009;68(10):1147-1154.

Anstrom JA, Thore CR, Moody DM, Brown WR. Immunolocalization of tight junction proteins in blood vessels in human germinal matrix and cortex. Histochem Cell Biol. 2007;127(2):205-213.

Thore CR, Anstrom JA, Moody DM, Challa VR, Marion MC, Brown WR. Morphometric analysis of arteriolar tortuosity in human cerebral white matter of preterm, young, and aged subjects. J Neuropathol Exp Neurol. 2007;66(5):337-345.

Anstrom JA, Thore CR, Moody DM, Mott RT, Brown WR. Differentiation of human germinal matrix vessels in the third trimester [abstract]. FASEB J. 2007;21(5):A230.

Brown WR. Leptomeningeal brain protrusions: a new type of leptomeningeal heterotopia [abstract]. FASEB J. 2007;21(5):A402.

Brown WR, Blair RM, Moody DM, Thore CR, Ahmed S, Robbins ME, Wheeler KT. Capillary loss precedes the cognitive impairment induced by fractionated whole-brain irradiation: a potential rat model of vascular dementia. J Neurol Sci. 2007;257(1-2):67-71.

Brown WR, Moody DM, Thore CR, Challa VR, Anstrom JA. Vascular dementia in leukoaraiosis may be a consequence of capillary loss not only in the lesions, but in normal-appearing white matter and cortex as well. J Neurol Sci. 2007;257(1-2):62-66.

Brown WR. Leptomeningeal brain protrusions: a new type of leptomeningeal heterotopia [abstract]. J Neuropathol Exp Neurol. 2007;66(5):453.

Brown WR, Thore CR, Moody DM, Mott RT, Anstrom JA. String vessels (capillary remnants) in the brain and eye in development, senescence, neurodegeneration, and after irradiation [abstract]. J Neuropathol Exp Neurol. 2007;66(5):446.

Atwood T, Payne VS, Zhao W, Brown WR, Wheeler KT, Zhu J-M, Robbins ME. Quantitative magnetic resonance spectroscopy reveals a potential relationship between radiation-induced changes in rat brain metabolites and cognitive impairment. Radiat Res. 2007;168(5):574-581.