Evgeny Budygin, Ph.D.Wake Forest School of Medicine

Evgeny Budygin, Ph.D.

Associate Professor,

Contact Information

Academic: 336-716-4072 | Department: 336-716-4368


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Education & Training

  • Ph.D., Academy Medical Science of USSR-Russia, 1993
  • Pharm.D., I.P. Pavlov Leningrad-Russia, 1998
  • Fellowship, Academy Medical Science of USS, 1993
  • Fellowship, Academy Medical Science of USS, 1997
  • Fellowship, Univ of NC at Chapel Hill, 2000
  • Fellowship, WFU School of Medicine, 2002


  • Research Society On Alcoholism
  • Int Soc for Biomed Res on Alco
  • Society for Neuroscience
Evgeny Budygin, Ph.D.

Evgeny Budygin, Ph.D.

Associate Professor, Neurobiology & Anatomy

Research Interests

drugs/therapeutic agents pharm, hormones/cytokines/signalling, neurosciences/behavior, structural biology

Contact Information

Academic: 336-716-4072 | Department: 336-716-4368


Related Links

Recent Publications

Efimova EV, Gainetdinov RR, Budygin EA, Sotnikova TD. Dopamine transporter mutant animals: a translational perspective. J Neurogenet. 2016;30(1):5-15.

Fox ME, Mikhailova MA, Bass CE, Takmakov P, Gainetdinov RR, Budygin EA, Wightman RM. Cross-hemispheric dopamine projections have functional significance. Proc Natl Acad Sci U S A. 2016;113(25):6985-6990.

Park J, Bucher ES, Budygin EA, Wightman RM. Norepinephrine and dopamine transmission in 2 limbic regions differentially respond to acute noxious stimulation. Pain. 2015;156(2):318-327.

Gompf HS, Budygin EA, Fuller PM, Bass CE. Targeted genetic manipulations of neuronal subtypes using promoter-specific combinatorial AAVs in wild-type animals. Front Behav Neurosci. 2015;9():152.

Adamah-Biassi EB, Almonte AG, Blagovechtchenski E, Grinevich VP, Weiner JL, Bonin KD, Budygin EA. Real time adenosine fluctuations detected with fast-scan cyclic voltammetry in the rat striatum and motor cortex. J Neurosci Methods. 2015;256():56-62.

Adamah-Biassi EB, Almonte AG, Bonin KD, Weiner JL, Budygin EA. Effects of ethanol on real-time adenosine dynamics in the rat striatum [abstract]. Alcohol Clin Exp Res. 2015;39(Suppl 1):182A.

Budygin EA, Weiner JL. Exploring the neurochemical basis of alcohol addiction-related behaviors: translational research. Transl Biomed. 2015;6(Suppl Spec):.

Budygin EA, Grinevich VP, Carr A, Chappell AM, Bass CE, Bonin KD, Weiner JL. Modulation of ethanol and sucrose drinking behaviors by optogenetic stimulation of the mesolimbic dopamine system [abstract]. Alcohol Clin Exp Res. 2014;38(Suppl 1):169A.

Maex R, Grinevich VP, Grinevich V, Budygin E, Bencherif M, Gutkin B. Understanding the role alpha 7 nicotinic receptors play in dopamine efflux in nucleus accumbens. ACS Chem Neurosci. 2014;5(10):1032-1040.

Bass CE, Grinevich VP, Kulikova AD, Bonin KD, Budygin EA. Terminal effects of optogenetic stimulation on dopamine dynamics in rat striatum. J Neurosci Methods. 2013;214(2):149-155.

Grinevich VP, Bass CE, Gioia D, Chappell AM, Bonin KD, Weiner JL, Budygin EA. Preliminary evidence that optogenetic activation of VTA dopamine cells inhibits alcohol self-administration in male Long Evans rats [abstract]. Alcohol Clin Exp Res. 2013;37(Suppl 2):229A.

Bass CE, Grinevich VP, Gioia D, Day-Brown JD, Bonin KD, Stuber GD, Weiner JL, Budygin EA. Optogenetic stimulation of VTA dopamine neurons reveals that tonic but not phasic patterns of dopamine transmission reduce ethanol self-administration. Front Behav Neurosci. 2013;7():173.

Maex R, Grinevich V, Budygin E, Bencherif M, Gutkin B. Background cholinergic tone determines the effect of agonists of alpha7-type nicotinic acetylcholine receptors on the efflux of dopamine in a circuit model [abstract]. Soc Neurosci Abstr. 2013;2013(Neuroscience Meeting Planner):.

Budygin EA, Park J, Bass CE, Grinevich VP, Bonin KD, Wightman RM. Aversive stimulus differentially triggers subsecond dopamine release in reward regions. Neuroscience. 2012;201():331-337.

van Zessen R, Phillips JL, Budygin EA, Stuber GD. Activation of VTA GABA neurons disrupts reward consumption. Neuron. 2012;73(6):1184-1194.

Budygin EA. Manipulating brain dopamine transmission through optogenetics [abstract]. In: Proceedings of the 17th Multidisciplinary International Conference on Neuroscience and Biological Psychiatry: 'Stress and Behavior' ISBS Conference; 2012 May 16-19; St. Petersburg (Russia). 2012;():7-8.

Pattison LP, McIntosh S, Budygin EA, Hemby SE. Differential regulation of accumbal dopamine transmission in rats following cocaine, heroin and speedball self-administration. J Neurochem. 2012;122(1):138-146.

Budygin EA, Grinevich VP, Bonin KD, Bass CE. Optogenetic stimulation of striatal dopamine release detected in brain slices [abstract]. Soc Neurosci Abstr. 2012;2012(Neuroscience Meeting Planner):.

Maex R, Grinevich V, Budygin E, Bencherif M, Gutkin B. A computational model dissecting out the contribution of various receptor subtypes to nicotine-evoked dopamine efflux [abstract]. Soc Neurosci Abstr. 2012;2012(Neuroscience Meeting Planner):.

Grinevich V, Budygin E, Maex R, Gutkin B, Hauser TA, Bencherif M. Multiple nicotinic receptor subtypes modulate nicotine-evoked dopamine efflux in rat striatum [abstract]. Soc Neurosci Abstr. 2012;2012(Neuroscience Meeting Planner):.

Pattison LP, Bonin KD, Hemby SE, Budygin EA. Speedball induced changes in electrically stimulated dopamine overflow in rat nucleus accumbens. Neuropharmacology. 2011;60(2-3):312-317.

Adamantidis AR, Tsai H-C, Boutrel B, Zhang F, Stuber GD, Budygin EA, Tourino C, Bonci A, Deisseroth K, de Lecea L. Optogenetic interrogation of dopaminergic modulation of the multiple phases of reward-seeking behavior. J Neurosci. 2011;31(30):10829-35.

Zimin IA, Abaimov DA, Budygin EA, Zolotarev IuA, Kovalev GI. [Role of the brain dopaminergic and serotoninergic systems in psychopharmacological effects of ladasten and sydnocarb] [Russian]. Eksp Klin Farmakol. 2010;73(2):2-5.

Bass CE, Grinevich VP, Vance ZB, Sullivan RP, Bonin KD, Budygin EA. Optogenetic control of striatal dopamine release in rats. J Neurochem. 2010;114(5):1344-1352.

Oleson EB, Talluri S, Childers SR, Smith JE, Roberts DCS, Bonin KD, Budygin EA. Dopamine uptake changes associated with cocaine self-administration. Neuropsychopharmacology. 2009;34(5):1174-1184.

Anstrom KK, Miczek KA, Budygin EA. Increased phasic dopamine signaling in the mesolimbic pathway during social defeat in rats. Neuroscience. 2009;161(1):3-12.

Grinevich VP, O'Connor JA, Bencherif M, Budygin EA. Effects of nicotine on real-time dopamine dynamics in rat nucleus accumbens: in vivo voltammetric study [abstract]. Biochem Pharmacol. 2009;78(7 Special Issue):916.

O'Connor JA, Budygin EA, Grinevich VP, Bencherif M. Effect of partial nicotinic agonists on real-time dopamine responses in rat nucleus accumbens: in vivo voltammetric study [abstract]. Biochem Pharmacol. 2009;78(7):917.

Mathews TA, Brookshire BR, Budygin EA, Hamre K, Goldowitz D, Jones SR. Ethanol-induced hyperactivity is associated with hypodopaminergia in the 22-TNJ ENU-mutated mouse. Alcohol. 2009;43(6):421-431.

Oleson EB, Salek J, Bonin KD, Jones SR, Budygin EA. Real-time voltammetric detection of cocaine-induced dopamine changes in the striatum of freely moving mice. Neurosci Lett. 2009;467(2):144-146.

Mathews TA, Brookshire BR, Budygin EA, Daunais JB, Friedman DP, Jones SR. A neurochemical comparison of striatal dopamine function in drinking monkeys [abstract]. Alcohol Clin Exp Res. 2008;32(6 Suppl 1):35A.

Budygin EA, Oleson EB, Mathews TA, Lack AK, Diaz M, McCool BA, Jones SR. Terminal effects of chronic alcohol exposure on dopamine dynamics in rat striatum [abstract]. Alcohol Clin Exp Res. 2007;31(6 Suppl):83A.

Budygin EA, Oleson EB, Mathews TA, Lack AK, Diaz MR, McCool BA, Jones SR. Effects of chronic alcohol exposure on dopamine uptake in rat nucleus accumbens and caudate putamen. Psychopharmacology (Berl). 2007;193(4):495-501.

Chen KC, Budygin EA. Extracting the basal extracellular dopamine concentrations from the evoked responses: re-analysis of the dopamine kinetics. J Neurosci Methods. 2007;164(1):27-42.

Budygin EA. Dopamine uptake inhibition is positively correlated with cocaine-induced stereotyped behavior. Neurosci Lett. 2007;429(1):55-58.

Mathews TA, John CE, Lapa GB, Budygin EA, Jones SR. No role of the dopamine transporter in acute ethanol effects on striatal dopamine dynamics. Synapse. 2006;60(4):288-294.

Budygin EA, Jones SR. Accumbal dopamine release, but not uptake or synthesis, is altered by low and moderate doses of acute ethanol [abstract]. Alcohol Clin Exp Res. 2006;30(6 Suppl):182A.

John CE, Budygin EA, Weiner JL, Jones SR. NMDA receptor deficient mice display altered synaptic function and reward related behaviors [abstract]. Neuropsychopharmacology. 2006;31(Suppl):S76.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Associate Professor, Neurobiology & Anatomy

Evgeny Budygin, Ph.D.

Evgeny Budygin, Ph.D.

Associate Professor, Neurobiology & Anatomy

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