Profile

Gregory L. Burke, M.D.Wake Forest School of Medicine

Education & Training

  • B.A., University of Northern Iowa, 1977
  • M.D., University of Iowa College of Medicine, 1981
  • M.S., University of Iowa, 1983
  • Fellowship, University of Iowa College of, 1983

Memberships

  • Am Soc of Preventiv Cardiology
  • American Epidemiologic Society
  • Am Heart Association
Gregory L. Burke, M.D.

Gregory L. Burke, M.D.

Director, Public Health Sciences
Shared Resource Director, Translational Science Institute
Professor, Public Health Sciences
Translational Science Institute
Maya Angelou Center for Health Equity
Hypertension and Vascular Research Center
Sticht Center on Aging
Center for Comparative Medicine Research
Center for Integrative Medicine
Neurology

Research Interests

aging, atherosclerosis/thrombosis, cardiac function, diabetes, drugs/therapeutic agents pharm, engineering/bioengineering, epidemiology, genetics/genome, health services, research/outc, immunology/allergy/inflammatio, minority health issues, prevention, primary care, radiology imaging/nuclear medi, vascular diseases

Contact Information

Academic: 336-716-2930 | Department: 336-716-2930

Email: gburke@wakehealth.edu

Media Medical Expert »

Recent Publications

Chahal H, Bluemke DA, Wu CO, McClelland R, Liu K, Shea SJ, Burke G, Balfour P, Herrington D, Shi P, Post W, Olson J, Watson KE, Folsom AR, Lima JA. Heart failure risk prediction in the Multi-Ethnic Study of Atherosclerosis. Heart. 2015;101(1):58-64.

Benjamin I, Brown N, Burke G, Correa A, Houser SR, Jones DW, Loscalzo J, Vasan RS, Whitman GR. American Heart Association Cardiovascular Genome-Phenome Study: foundational basis and program. Circulation. 2015;131(1):100-112.

Bacharova L, Chen H, Estes EH, Mateasik A, Bluemke DA, Lima JA, Burke GL, Soliman EZ. Determinants of discrepancies in detection and comparison of the prognostic significance of left ventricular hypertrophy by electrocardiogram and cardiac magnetic resonance imaging. Am J Cardiol. 2015;115(4):515-522.

Gepner AD, Young R, Delaney JA, Tattersall MC, Blaha MJ, Post WS, Gottesman RF, Kronmal R, Budoff MJ, Burke GL, Folsom AR, Liu K, Kaufman J, Stein JH. Comparison of coronary artery calcium presence, carotid plaque presence, and carotid intima-media thickness for cardiovascular disease prediction in the Multi-Ethnic Study of Atherosclerosis. Circ Cardiovasc Imaging. 2015;8(1):e002262.

Arnan MK, Hsieh TC, Yeboah J, Bertoni AG, Burke GL, Bahrainwala Z, Grega MA, Baumgartner WA, Gottesman RF. Postoperative blood urea nitrogen is associated with stroke in cardiac surgical patients. Ann Thorac Surg. 2015;99(4):1314-1320.

Mahler SA, Riley RF, Hiestand BC, Russell GB, Hoekstra JW, Lefebvre CW, Nicks BA, Cline DM, Askew KL, Elliott SB, Herrington DM, Burke GL, Miller CD. The HEART pathway randomized trial: identifying emergency department patients with acute chest pain for early discharge. Circ Cardiovasc Qual Outcomes. 2015;8(2):195-203.

Yeboah J, Sillau S, Delaney JC, Blaha MJ, Michos ED, Young R, Qureshi WT, McClelland R, Burke GL, Psaty BM, Herrington DM. Implications of the new American College of Cardiology/American Heart Association cholesterol guidelines for primary atherosclerotic cardiovascular disease event prevention in a multi ethnic cohort: Multi-Ethnic Study of Atherosclerosis (MESA). Am Heart J. 2015;169(3):387-395.e3.

Reynolds LM, Ding J, Taylor JR, Lohman K, Soranzo N, de la Fuente A, Liu TF, Johnson C, Barr RG, Register TC, Donohue KM, Talor MV, Cihakova D, Gu C, Divers J, Siscovick D, Burke G, Post W, Shea S, Jacobs DR Jr, Hoeschele I, McCall CE,. Transcriptomic profiles of aging in purified human immune cells. BMC Genomics. 2015;16(1):333.

van Ballegooijen AJ, Robinson-Cohen C, Katz R, Criqui M, Budoff M, Li D, Siscovick D, Hoofnagle A, Shea SJ, Burke G, de Boer IH, Kestenbaum B. Vitamin D metabolites and bone mineral density: the Multi-Ethnic Study of Atherosclerosis. Bone. 2015;78():186-193.

Colangelo LA, Vu TH, Szklo M, Burke GL, Sibley C, Liu K. Is the association of hypertension with cardiovascular events stronger among the lean and normal weight than among the overweight and obese? The Multi-Ethnic Study of Atherosclerosis. Hypertension. 2015;66(2):286-293.

Corriere MA, Avise JA, Peterson LA, Stafford JM, Easterling D, Boone DS Sr, Ip E, Hyde AS, Burke GL. Exploring patient involvement in decision making for vascular procedures. J Vasc Surg. 2015;():.

Murad K, Goff DC Jr, Morgan TM, Burke GL, Bartz TM, Kizer JR, Chaudhry SI, Gottdiener JS, Kitzman DW. Burden of comorbidities and functional and cognitive impairments in elderly patients at the initial diagnosis of heart failure and their impact on total mortality: the Cardiovascular Health Study. JACC Heart Fail. 2015;3(7):542-550.

Arguelles W, Llabre MM, Penedo FJ, Daviglus ML, Sacco RL, Liu K, Szklo M, Polak JF, Eng J, Burke GL, Schneiderman N. Relationship of change in traditional cardiometabolic risk factors to change in coronary artery calcification among individuals with detectable subclinical atherosclerosis: the Multi-Ethnic Study of Atherosclerosis. Int J Cardiol. 2014;174(1):51-56.

Bild DE, McClelland R, Kaufman JD, Blumenthal R, Burke GL, Carr JJ, Post WS, Register TC, Shea S, Szklo M. Ten-year trends in coronary calcification in individuals without clinical cardiovascular disease in the Multi-Ethnic Study of Atherosclerosis. PLoS One. 2014;9(4):e94916.

Yeboah J, Delaney JA, Nance R, McClelland RL, Polak JF, Sibley CT, Bertoni A, Burke GL, Carr JJ, Herrington DM. Mediation of cardiovascular risk factor effects through subclinical vascular disease: the Multi-Ethnic Study of Atherosclerosis. Arterioscler Thromb Vasc Biol. 2014;34(8):1778-1783.

Burkart KM, Manichaikul A, Wilk JB, Ahmed FS, Burke GL, Enright P, Hansel NN, Haynes D, Heckbert SR, Hoffman EA, Kaufman JD, Kurai J, Loehr L, London SJ, Meng Y, O'Connor GT, Oelsner E, Petrini M, Pottinger TD, Powell CA, Redline S,. APOM and high-density lipoprotein cholesterol are associated with lung function and per cent emphysema. Eur Respir J. 2014;43(4):1003-1017.

Zhang K, Larson TV, Gassett A, Szpiro AA, Daviglus M, Burke GL, Kaufman JD, Adar SD. Characterizing spatial patterns of airborne coarse particulate (PM10-2.5) mass and chemical components in three cities: the Multi-Ethnic Study of Atherosclerosis. Environ Health Perspect. 2014;122(8):823-830.

Venkatesh BA, Volpe GJ, Donekal S, Mewton N, Liu CY, Shea S, Liu K, Burke G, Wu C, Bluemke DA, Lima JA. Association of longitudinal changes in left ventricular structure and function with myocardial fibrosis: the Multi-Ethnic Study of Atherosclerosis Study. Hypertension. 2014;64(3):508-515.

Sinner MF, Stepas KA, Moser CB, Krijthe BP, Aspelund T, Sotoodehnia N, Fontes JD, Janssens AC, Kronmal RA, Magnani JW, Witteman JC, Chamberlain AM, Lubitz SA, Schnabel RB, Vasan RS, Wang TJ, Agarwal SK, McManus DD, Franco OH, Yin X, Larson MG,. B-type natriuretic peptide and C-reactive protein in the prediction of atrial fibrillation risk: the CHARGE-AF consortium of community-based cohort studies. Europace. 2014;16(10):1426-1433.

Cohen R, Budoff M, McClelland RL, Sillau S, Burke G, Blaha M, Szklo M, Uretsky S, Rozanski A, Shea S. Significance of a positive family history for coronary heart disease in patients with a zero coronary artery calcium score (from the Multi-Ethnic Study of Atherosclerosis). Am J Cardiol. 2014;114(8):1210-1214.

Desai CS, Ning H, Soliman EZ, Burke GL, Shea S, Nazarian S, Lloyd-Jones DM, Greenland P. Electrocardiographic abnormalities and coronary artery calcium for coronary heart disease prediction and reclassification: the Multi-Ethnic Study of Atherosclerosis (MESA). Am Heart J. 2014;168(3):391-397.

McAuley PA, Chen H, Lee DC, Artero EG, Bluemke DA, Burke GL. Physical activity, measures of obesity, and cardiometabolic risk: the Multi-Ethnic Study of Atherosclerosis (MESA). J Phys Act Health. 2014;11(4):831-837.

Yeboah J, Erbel R, Delaney JC, Nance R, Guo M, Bertoni AG, Budoff M, Moebus S, Jockel KH, Burke GL, Wong ND, Lehmann N, Herrington DM, Mohlenkamp S, Greenland P. Development of a new diabetes risk prediction tool for incident coronary heart disease events: the Multi-Ethnic Study of Atherosclerosis and the Heinz Nixdorf Recall Study. Atherosclerosis. 2014;236(2):411-417.

Arnan MK, Burke GL, Bushnell C. Secondary prevention of stroke in the elderly: focus on drug therapy. Drugs Aging. 2014;31(10):721-730.

Shea MK, Cushman M, Booth SL, Burke GL, Chen H, Kritchevsky SB. Associations between vitamin K status and haemostatic and inflammatory biomarkers in community-dwelling adults. The Multi-Ethnic Study of Atherosclerosis. Thromb Haemost. 2014;112(3):438-444.

Reynolds LM, Taylor JR, Ding J, Lohman K, Johnson C, Siscovick D, Burke G, Post W, Shea S, Jacobs DR Jr, Stunnenberg H, Kritchevsky SB, Hoeschele I, McCall CE, Herrington DM, Tracy RP, Liu Y. Age-related variations in the methylome associated with gene expression in human monocytes and T cells. Nat Commun. 2014;5():5366.

Avise JA, Peterson LA, Stafford JM, Boone DS Sr, Easterling D, Burke GL, Corriere MA. Exploring patient involvement in decision making for vascular procedures [abstract]. J Vasc Surg. 2014;60(6):1726-1727.

Idu HI, Carty C, Burke GL, Naik RP, Adams RJ, Gee BE, Longstreth W, Egede L, Lackland DT, Greenberg CS, Hunt J, Kindy MM, Taylor H, Manson JE, Allison M, James WG, Reiner A. Is sickle cell trait associated with incident cardiovascular outcomes in African Americans? [abstract]. Blood. 2014;124(21):4920.

Azeem A, Yeboah J, Bertoni A, Burke G, Turkbey E, Szklo M, Herrington D. Association of hemoglobin A1C with cardiovascular disease and all-cause mortality in individuals without diabetes--the Multi-Ethnic Study of Atherosclerosis [abstract]. Circulation. 2013;127(12 Suppl):AP278.

Mahler SA, Hiestand BC, Nwanaji-Enwerem J, Goff DC, Burke GL, Douglas Case L, Nicks B, Miller CD. Reduction in observation unit length of stay with coronary computed tomography angiography depends on time of emergency department presentation. Acad Emerg Med. 2013;20(3):231-239.

Shah SA, Herrington DM, Howard TD, Divers J, Arnett DK, Burke GL, Kao WH, Guo X, Siscovick DS, Chakravarti A, Lima JA, Psaty BM, Tomaselli GF, Rich SS, Bowden DW, Post W. Associations between NOS1AP single nucleotide polymorphisms (SNPs) and QT interval duration in four racial/ethnic groups in the Multi-Ethnic Study of Atherosclerosis (MESA). Ann Noninvasive Electrocardiol. 2013;18(1):29-40.

Mewton N, Opdahl A, Choi EY, Almeida AL, Kawel N, Wu CO, Burke GL, Liu S, Liu K, Bluemke DA, Lima JA. Left ventricular global function index by magnetic resonance imaging--a novel marker for assessment of cardiac performance for the prediction of cardiovascular events: the Multi-Ethnic Study of Atherosclerosis. Hypertension. 2013;61(4):770-778.

Mahler SA, Burke GL, Goff DC Jr, Hiestand BC, Nicks BA, Hoekstra JW, Case LD, Miller CD. Avoidable utilization of the chest pain observation unit: evaluation of very-low-risk patients. Crit Pathw Cardiol. 2013;12(2):59-64.

McClain J, Hsu F, Brown E, Burke G, Carr J, Harris T, Kritchevsky S, Szklo M, Tracy R, Ding J. Pericardial adipose tissue and coronary artery calcification in the Multi-ethnic Study of Atherosclerosis (MESA. Obesity (Silver Spring). 2013;21(5):1056-1063.

Mahler SA, Burke GL, Goff DC, Case LD, Miller CD. Potentially avoidable chest pain observation unit utilization: admission of very-low risk patients [abstract]. Acad Emerg Med. 2013;20(5 Suppl 1):S33.

Polak JF, Szklo M, Kronmal RA, Burke GL, Shea S, Zavodni AE, O'Leary DH. The value of carotid artery plaque and intima-media thickness for incident cardiovascular disease: the Multi-Ethnic Study of Atherosclerosis. J Am Heart Assoc. 2013;2(2):e000087.

Pan CW, Klein BE, Cotch MF, Shrager S, Klein R, Folsom A, Kronmal R, Shea SJ, Burke GL, Saw SM, Wong TY. Racial variations in the prevalence of refractive errors in the United States: the Multi-Ethnic Study of Atherosclerosis. Am J Ophthalmol. 2013;155(6):1129-1138.

Monda KL, Chen GK, Taylor KC, Ng MCY, Liu Y, Freedman BI, Howard TD, Langefeld CD, Lohman K, Palmer ND, Shriner DA, Burke G, Ding J, et al. A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry. Nat Genet. 2013;45(6):690-696.

Alonso A, Krijthe BP, Aspelund T, Stepas KA, Pencina MJ, Moser CB, Sinner MF, Sotoodehnia N, Fontes JD, Janssens AC, Kronmal RA, Magnani JW, Witteman JC, Chamberlain AM, Lubitz SA, Schnabel RB, Agarwal SK, McManus DD,. Simple risk model predicts incidence of atrial fibrillation in a racially and geographically diverse population: the CHARGE-AF consortium. J Am Heart Assoc. 2013;2(2):e000102.

Winston GJ, Palmas W, Lima J, Polak JF, Bertoni AG, Burke G, Eng J, Gottesman R, Shea S. Pulse pressure and subclinical cardiovascular disease in the Multi-Ethnic Study of Atherosclerosis. Am J Hypertens. 2013;26(5):636-642.

Fu W, O'Connor TD, Jun G, Kang HM, Abecasis G, Leal SM, Gabriel S, Rieder MJ, Altshuler D, Shendure J, Nickerson DA, Bamshad MJ, Bowden DW, Burke G, Carr J, Goff D, Herrington DM, Liu Y, Bleecker E, Meyers D,. Analysis of 6,515 exomes reveals the recent origin of most human protein-coding variants. Nature. 2013;493(7431):216-220.

Shea MK, Booth SL, Miller ME, Burke GL, Chen H, Cushman M, Tracy RP, Kritchevsky SB. Association between circulating vitamin K1 and coronary calcium progression in community-dwelling adults: the Multi-Ethnic Study of Atherosclerosis. Am J Clin Nutr. 2013;98(1):197-208.

Miller CD, Case LD, Little WC, Mahler SA, Burke GL, Harper EN, Lefebvre C, Hiestand B, Hoekstra JW, Hamilton CA, Hundley WG. Stress CMR reduces revascularization, hospital readmission, and recurrent cardiac testing in intermediate-risk patients with acute chest pain. JACC Cardiovasc Imaging. 2013;6(7):785-794.

Liu CT, Monda KL, Taylor KC, Lange L, Demerath EW, Palmas W, Wojczynski MK, Ellis JC, Vitolins MZ, Liu S, Papanicolaou GJ, Irvin MR, Xue L, Griffin PJ, Nalls MA, Adeyemo A, Liu J, Li G, Ruiz-Narvaez EA, Chen WM, Chen F,. Genome-wide association of body fat distribution in african ancestry populations suggests new Loci. PLoS Genet. 2013;9(8):e1003681.

Ahmed HM, Blaha MJ, Nasir K, Jones SR, Rivera JJ, Agatston A, Blankstein R, Wong ND, Lakoski S, Budoff MJ, Burke GL, Sibley CT, Ouyang P, Blumenthal RS. Low-risk lifestyle, coronary calcium, cardiovascular events, and mortality: results from MESA. Am J Epidemiol. 2013;178(1):12-21.

Oza-Frank R, Chan C, Liu K, Burke G, Kanaya AM. Incidence of type 2 diabetes by place of birth in the Multi-Ethnic Study of Atherosclerosis (MESA). J Immigr Minor Health. 2013;15(5):918-924.

Mahler SA, Riley RF, Burke GL, Hiestand BC, Miller CD. Real-time use of a chest pain risk stratification clinical decision rule: a cautionary tale [abstract]. Ann Emerg Med. 2013;62(4 Suppl):S112.

Liu Y, Ding J, Reynolds LM, Lohman K, Register TC, De La Fuente A, Howard TD, Hawkins GA, Cui W, Morris J, Smith SG, Barr RG, Kaufman JD, Burke GL, Post W, Shea S, McCall CE, Siscovick D, Jacobs DR Jr, Tracy RP,. Methylomics of gene expression in human monocytes. Hum Mol Genet. 2013;22(24):5065-5074.

Patton KK, Heckbert SR, Alonso A, Bahrami H, Lima JA, Burke G, Kronmal RA. N-terminal pro-B-type natriuretic peptide as a predictor of incident atrial fibrillation in the Multi-Ethnic Study of Atherosclerosis: the effects of age, sex and ethnicity. Heart. 2013;99(24):1832-1836.

Soliman EZ, Alonso A, Misialek JR, Jain A, Watson KE, Lloyd-Jones DM, Lima J, Shea S, Burke GL, Heckbert SR. Reference ranges of PR duration and P-wave indices in individuals free of cardiovascular disease: the Multi-Ethnic Study of Atherosclerosis (MESA). J Electrocardiol. 2013;46(6):702-706.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

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