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Gregory L. Burke, M.D.Wake Forest School of Medicine

Education & Training

  • B.A., University of Northern Iowa, 1977
  • M.D., University of Iowa College of Medicine, 1981
  • M.S., University of Iowa, 1983
  • Fellowship, University of Iowa College of, 1983


  • Am Soc of Preventiv Cardiology
  • American Epidemiologic Society
  • Am Heart Association
Gregory L. Burke, M.D.

Gregory L. Burke, M.D.

Shared Resource Director, Translational Science Institute
Director, Public Health Sciences
Professor, Translational Science Institute
Public Health Sciences
Hypertension and Vascular Research Center

Research Interests

Atherosclerosis; Ethnic Groups; Cardiovascular Diseases; Coronary Artery Disease; Calcinosis
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Contact Information

Department: 336-716-2930


Media Medical Expert »

Recent Publications

Left ventricular shape predicts different types of cardiovascular events in the general population. Ambale-Venkatesh B, Yoneyama K, Sharma RK, Ohyama Y, Wu CO, Burke GL, Shea S, Gomes AS, Young AA, Bluemke DA, Lima JA.. Heart. 2017;103(7):499-507.

Associations of coffee, tea, and caffeine intake with coronary artery calcification and cardiovascular events. Miller PE, Zhao D, Frazier-Wood AC, Michos ED, Averill M, Sandfort V, Burke GL, Polak JF, Lima JA, Post WS, Blumenthal RS, Guallar E, Martin SS.. Am J Med. 2017;130(2):188-197.e5.

Smoking intensity (pack/day) is a better measure than pack-years or smoking status for modeling cardiovascular disease outcomes. Nance R, Delaney J, McEvoy JW, Blaha MJ, Burke G, Navas-Acien A, Kaufman JD, Oelsner EC, McClelland RL.. J Clin Epidemiol. 2017;81():111-119.

Guideline-based statin/lipid-lowering therapy eligibility for primary prevention and accuracy of coronary artery calcium and clinical cardiovascular events: the Multi-Ethnic Study of Atherosclerosis (MESA). Flueckiger P, Qureshi W, Michos ED, Blaha M, Burke G, Sandfort V, Herrington D, Yeboah J.. Clin Cardiol. 2017;40(3):163-169.

Progression of carotid arterial stiffness with treatment of hypertension over 10 years: the Multi-Ethnic Study of Atherosclerosis. Gepner AD, Tedla Y, Colangelo LA, Tattersall MC, Korcarz CE, Kaufman JD, Liu K, Burke GL, Shea S, Greenland P, Stein JH.. Hypertension. 2017;69(1):87-95.

Sickle cell trait is not associated with an increased risk of heart failure or abnormalities of cardiac structure and function. Bello NA, Hyacinth HI, Roetker NS, Seals SR, Naik RP, Derebail VK, Kshirsagar AV, Key NS, Wilson JG, Correa A, Adams RJ, Egede LD, Longstreth W, Choudhary G, Gee BE, Hughes AL, Shah AM, Manson JE, Allison M, Burke GL, Folsom AR, Carty CL,.. Blood. 2017;129(6):799-801.

Integrating data from multiple time-location measurement methods for use in exposure assessment: the Multi-Ethnic Study of Atherosclerosis and Air Pollution (MESA Air). Hazlehurst MF, Spalt EW, Curl CL, Davey ME, Vedal S, Burke GL, Kaufman JD.. J Expo Sci Environ Epidemiol. 2017;():.

Use of the HEART Pathway with high sensitivity cardiac troponins: a secondary analysis. Mahler SA, Stopyra JP, Apple FS, Riley RF, Russell GB, Hiestand BC, Hoekstra JW, Lefebvre CW, Nicks BA, Cline DM, Askew KL, Herrington DM, Burke GL, Miller CD.. Clin Biochem. 2017;():.

Association of cardiovascular health with subclinical disease and incident events: the Multi-Ethnic Study of Atherosclerosis. Polonsky TS, Ning H, Daviglus ML, Liu K, Burke GL, Cushman M, Eng J, Folsom AR, Lutsey PL, Nettleton JA, Post WS, Sacco RL, Szklo M, Lloyd-Jones DM.. J Am Heart Assoc. 2017;6(3):e004894.

Rare exome sequence variants in CLCN6 reduce blood pressure levels and hypertension risk. Yu B, Pulit SL, Hwang SJ, Brody JA, Amin N, Auer PL, Bis JC, Boerwinkle E, Burke GL, Chakravarti A, Correa A, Dreisbach AW, Franco OH, Ehret GB, Franceschini N, Hofman A, Lin DY, Metcalf GA, Musani SK, Muzny D, Palmas W, Raffel L, Reiner A,.. Circ Cardiovasc Genet. 2016;9(1):64-70.

Adherence to an accelerated diagnostic protocol for chest pain: secondary analysis of the HEART Pathway randomized trial. Mahler SA, Riley RF, Russell GB, Hiestand BC, Hoekstra JW, Lefebvre CW, Nicks BA, Cline DM, Askew KL, Bringolf J, Elliott SB, Herrington DM, Burke GL, Miller CD.. Acad Emerg Med. 2016;23(1):70-77.

Utility of nontraditional risk markers in atherosclerotic cardiovascular disease risk assessment. Yeboah J, Young R, McClelland RL, Delaney JC, Polonsky TS, Dawood FZ, Blaha MJ, Miedema MD, Sibley CT, Carr JJ, Burke GL, Goff DC Jr, Psaty BM, Greenland P, Herrington DM.. J Am Coll Cardiol. 2016;67(2):139-147.

HEART pathway accelerated diagnostic protocol implementation: prospective pre-post interrupted time series design and methods. Mahler SA, Burke GL, Duncan PW, Case LD, Herrington DM, Riley RF, Wells BJ, Hiestand BC, Miller CD.. JMIR Res Protoc. 2016;5(1):e10.

Role of coronary artery calcium score of zero and other negative risk markers for cardiovascular disease: the Multi-Ethnic Study of Atherosclerosis (MESA). Blaha MJ, Cainzos-Achirica M, Greenland P, McEvoy JW, Blankstein R, Budoff MJ, Dardari Z, Sibley CT, Burke GL, Kronmal RA, Szklo M, Blumenthal RS, Nasir K.. Circulation. 2016;133(9):849-858.

Long-term coarse particulate matter exposure and heart rate variability in the Multi-Ethnic Study of Atherosclerosis. Adhikari R, D'Souza J, Soliman EZ, Burke GL, Daviglus M, Jacobs DR Jr, Park SK, Sheppard L, Thorne PS, Kaufman JD, Larson TV, Adar SD.. Epidemiology. 2016;27(3):405-413.

Incidence of age-related macular degeneration in a multi-ethnic United States population: the Multi-Ethnic Study of Atherosclerosis. Fisher DE, Klein BE, Wong TY, Rotter JI, Li X, Shrager S, Burke GL, Klein R, Cotch MF.. Ophthalmology. 2016;123(6):1297-1308.

Chest pain risk stratification: a comparison of the 2-hour accelerated diagnostic protocol (ADAPT) and the HEART Pathway. Stopyra JP, Miller CD, Hiestand BC, Lefebvre CW, Nicks BA, Cline DM, Askew KL, Riley RF, Russell GB, Burke GL, Herrington D, Hoekstra JW, Mahler SA.. Crit Pathw Cardiol. 2016;15(2):46-49.

Association between air pollution and coronary artery calcification within six metropolitan areas in the USA (the Multi-Ethnic Study of Atherosclerosis and Air Pollution): a longitudinal cohort study. Kaufman JD, Adar SD, Barr RG, Budoff M, Burke GL, Curl CL, Daviglus ML, Roux AV, Gassett AJ, Jacobs DR Jr, Kronmal R, Larson TV, Navas-Acien A, Olives C, Sampson PD, Sheppard L, Siscovick DS, Stein JH, Szpiro AA, Watson KE.. Lancet. 2016;388(10045):696-704.

Physical activity, sedentary behaviors and the incidence of type 2 diabetes mellitus: the Multi-Ethnic Study of Atherosclerosis (MESA). Joseph JJ, Echouffo-Tcheugui JB, Golden SH, Chen H, Jenny NS, Carnethon MR, Jacobs D Jr, Burke GL, Vaidya D, Ouyang P, Bertoni AG.. BMJ Open Diabetes Res Care. 2016;4(1):e000185.

Impact of replacing the Pooled Cohort Equation with other cardiovascular disease risk scores on atherosclerotic cardiovascular disease risk assessment (from the Multi-Ethnic Study of Atherosclerosis [MESA]). Qureshi WT, Michos ED, Flueckiger P, Blaha M, Sandfort V, Herrington DM, Burke G, Yeboah J.. Am J Cardiol. 2016;118(5):691-696.

Anthracycline-associated T1 mapping characteristics are elevated independent of the presence of cardiovascular comorbidities in cancer survivors. Jordan JH, Vasu S, Morgan TM, D'Agostino RB Jr, Melendez GC, Hamilton CA, Arai AE, Liu S, Liu CY, Lima JA, Bluemke DA, Burke GL, Hundley WG.. Circ Cardiovasc Imaging. 2016;9(8):e004325.

Obesity severity and duration are associated with incident metabolic syndrome: evidence against metabolically healthy obesity from the Multi-Ethnic Study of Atherosclerosis. Mongraw-Chaffin M, Foster MC, Kalyani RR, Vaidya D, Burke GL, Woodward M, Anderson CA.. J Clin Endocrinol Metab. 2016;101(11):4117-4124.

The association of calcium supplementation and incident cardiovascular events in the Multi-Ethnic Study of Atherosclerosis (MESA). Raffield LM, Agarwal S, Hsu FC, de Boer IH, Ix JH, Siscovick D, Szklo M, Burke GL, Frazier-Wood AC, Herrington DM.. Nutr Metab Cardiovasc Dis. 2016;26(10):899-907.

Calcium intake from diet and supplements and the risk of coronary artery calcification and its progression among older adults: 10-year follow-up of the Multi-Ethnic Study of Atherosclerosis (MESA). Anderson JJ, Kruszka B, Delaney JA, He K, Burke GL, Alonso A, Bild DE, Budoff M, Michos ED.. J Am Heart Assoc. 2016;5(10):e003815.

The Multiethnic Study of Atherosclerosis [editorial]. Burke G, Lima J, Wong ND, Narula J.. Glob Heart. 2016;11(3):267-268.

Legacy of MESA. Olson JL, Bild DE, Kronmal RA, Burke GL.. Glob Heart. 2016;11(3):269-274.

Secondhand smoke exposure and subclinical cardiovascular disease: the Multi-Ethnic Study of Atherosclerosis. Jones MR, Magid HS, Al-Rifai M, McEvoy JW, Kaufman JD, Hinckley Stukovsky KD, Szklo M, Polak J, Burke GL, Post WS, Blaha MJ, Navas-Acien A.. J Am Heart Assoc. 2016;5(12):e002965.

Calcium intake and 10 year risk of incident coronary artery calcification in the Multi-Ethnic Study of Atherosclerosis [abstract]. Kruszka B, He K, Delaney JA, Burke GL, Alonso A, Bild D, Budoff MJ, Michos ED, Anderson JJB.. Pharmacoepidemiol Drug Saf. 2016;25(Suppl 3):256-257.

New statin use and left ventricular structure: estimating long-term associationsin the Multi-Ethnic Study of Atherosclerosis (MESA) [abstract]. Strand LN, Young RL, Delaney JA, Bertoni AG, Bluemke DA, Burke GL, Lima JA, Sotoodehnia N, Psaty BM, Heckbert SR, McClelland RL.. Pharmacoepidemiol Drug Saf. 2016;25(Suppl 3):568-569.

Heart failure risk prediction in the Multi-Ethnic Study of Atherosclerosis. Chahal H, Bluemke DA, Wu CO, McClelland R, Liu K, Shea SJ, Burke G, Balfour P, Herrington D, Shi P, Post W, Olson J, Watson KE, Folsom AR, Lima JA.. Heart. 2015;101(1):58-64.

American Heart Association Cardiovascular Genome-Phenome Study: foundational basis and program. Benjamin I, Brown N, Burke G, Correa A, Houser SR, Jones DW, Loscalzo J, Vasan RS, Whitman GR.. Circulation. 2015;131(1):100-112.

Determinants of discrepancies in detection and comparison of the prognostic significance of left ventricular hypertrophy by electrocardiogram and cardiac magnetic resonance imaging. Bacharova L, Chen H, Estes EH, Mateasik A, Bluemke DA, Lima JA, Burke GL, Soliman EZ.. Am J Cardiol. 2015;115(4):515-522.

Comparison of coronary artery calcium presence, carotid plaque presence, and carotid intima-media thickness for cardiovascular disease prediction in the Multi-Ethnic Study of Atherosclerosis. Gepner AD, Young R, Delaney JA, Tattersall MC, Blaha MJ, Post WS, Gottesman RF, Kronmal R, Budoff MJ, Burke GL, Folsom AR, Liu K, Kaufman J, Stein JH.. Circ Cardiovasc Imaging. 2015;8(1):e002262.

Postoperative blood urea nitrogen is associated with stroke in cardiac surgical patients. Arnan MK, Hsieh TC, Yeboah J, Bertoni AG, Burke GL, Bahrainwala Z, Grega MA, Baumgartner WA, Gottesman RF.. Ann Thorac Surg. 2015;99(4):1314-1320.

The HEART pathway randomized trial: identifying emergency department patients with acute chest pain for early discharge. Mahler SA, Riley RF, Hiestand BC, Russell GB, Hoekstra JW, Lefebvre CW, Nicks BA, Cline DM, Askew KL, Elliott SB, Herrington DM, Burke GL, Miller CD.. Circ Cardiovasc Qual Outcomes. 2015;8(2):195-203.

Implications of the new American College of Cardiology/American Heart Association cholesterol guidelines for primary atherosclerotic cardiovascular disease event prevention in a multi ethnic cohort: Multi-Ethnic Study of Atherosclerosis (MESA). Yeboah J, Sillau S, Delaney JC, Blaha MJ, Michos ED, Young R, Qureshi WT, McClelland R, Burke GL, Psaty BM, Herrington DM.. Am Heart J. 2015;169(3):387-395.e3.

Transcriptomic profiles of aging in purified human immune cells. Reynolds LM, Ding J, Taylor JR, Lohman K, Soranzo N, de la Fuente A, Liu TF, Johnson C, Barr RG, Register TC, Donohue KM, Talor MV, Cihakova D, Gu C, Divers J, Siscovick D, Burke G, Post W, Shea S, Jacobs DR Jr, Hoeschele I, McCall CE,.. BMC Genomics. 2015;16(1):333.

Vitamin D metabolites and bone mineral density: the Multi-Ethnic Study of Atherosclerosis. van Ballegooijen AJ, Robinson-Cohen C, Katz R, Criqui M, Budoff M, Li D, Siscovick D, Hoofnagle A, Shea SJ, Burke G, de Boer IH, Kestenbaum B.. Bone. 2015;78():186-193.

Is the association of hypertension with cardiovascular events stronger among the lean and normal weight than among the overweight and obese? The Multi-Ethnic Study of Atherosclerosis. Colangelo LA, Vu TH, Szklo M, Burke GL, Sibley C, Liu K.. Hypertension. 2015;66(2):286-293.

Exploring patient involvement in decision making for vascular procedures. Corriere MA, Avise JA, Peterson LA, Stafford JM, Easterling D, Boone DS Sr, Ip E, Hyde AS, Burke GL.. J Vasc Surg. 2015;62(4):.

Burden of comorbidities and functional and cognitive impairments in elderly patients at the initial diagnosis of heart failure and their impact on total mortality: the Cardiovascular Health Study. Murad K, Goff DC Jr, Morgan TM, Burke GL, Bartz TM, Kizer JR, Chaudhry SI, Gottdiener JS, Kitzman DW.. JACC Heart Fail. 2015;3(7):542-550.

Markers of inflammation and coagulation after long-term exposure to coarse particulate matter: a cross-sectional analysis from the Multi-Ethnic Study of Atherosclerosis. Adar SD, D'Souza J, Mendelsohn-Victor K, Jacobs DR, Cushman M, Sheppard L, Thorne PS, Burke GL, Daviglus ML, Szpiro AA, Diez Roux AV, Kaufman JD, Larson TV.. Environ Health Perspect. 2015;123(6):541-548.

Utility of nontraditional risk markers in individuals ineligible for statin therapy according to the 2013 American College of Cardiology/American Heart Association cholesterol guidelines. Yeboah J, Polonsky TS, Young R, McClelland RL, Delaney JC, Dawood F, Blaha MJ, Miedema MD, Sibley CT, Carr JJ, Burke GL, Goff DC Jr, Psaty BM, Greenland P, Herrington DM.. Circulation. 2015;132(10):916-922.

DNA methylation of the aryl hydrocarbon receptor repressor associations with cigarette smoking and subclinical atherosclerosis. Reynolds LM, Wan M, Ding J, Taylor JR, Lohman K, Su D, Bennett BD, Porter DK, Gimple R, Pittman GS, Wang X, Howard TD, Siscovick D, Psaty BM, Shea S, Burke GL, Jacobs DR Jr, Rich SS, Hixson JE, Stein JH, Stunnenberg H, Barr RG,.. Circ Cardiovasc Genet. 2015;8(5):707-716.

Impact of race and education on patients' preferred decision-making roles for vascular procedures and perceptions of treatment success [abstract]. Corriere MA, Avise JA, Stafford JM, Peterson LA, Easterling D, Ip EH, Boone DS, Hyde AS, Guzman RJ, Burke GL.. J Am Coll Surg. 2015;221(4 Suppl 1):S179-S180.

Visual impairment in white, Chinese, black, and Hispanic participants from the Multi-Ethnic Study of Atherosclerosis cohort. Fisher DE, Shrager S, Shea SJ, Burke GL, Klein R, Wong TY, Klein BE, Cotch MF.. Ophthalmic Epidemiol. 2015;22(5):321-332.

Can antihypertensive treatment restore the risk of cardiovascular disease to ideal levels?: the Coronary Artery Risk Development in Young Adults (CARDIA) study and the Multi-Ethnic Study of Atherosclerosis (MESA). Liu K, Colangelo LA, Daviglus ML, Goff DC, Pletcher M, Schreiner PJ, Sibley CT, Burke GL, Post WS, Michos ED, Lloyd-Jones DM.. J Am Heart Assoc. 2015;4(9):e002275.

10-year coronary heart disease risk prediction using coronary artery calcium and traditional risk factors: derivation in the MESA (Multi-Ethnic Study of Atherosclerosis) with validation in the HNR (Heinz Nixdorf Recall) Study. McClelland RL, Jorgensen NW, Budoff M, Blaha MJ, Post WS, Kronmal RA, Bild DE, Shea S, Liu K, Watson KE, Folsom AR, Khera A, Ayers C, Mahabadi AA, Lehmann N, Jockel KH, Moebus S, Carr JJ, Erbel R, Burke GL.. J Am Coll Cardiol. 2015;66(15):1643-1653.

Prevalence and correlates of myocardial scar in a US cohort. Turkbey EB, Nacif MS, Guo M, McClelland RL, Teixeira PB, Bild DE, Barr RG, Shea S, Post W, Burke G, Budoff MJ, Folsom AR, Liu CY, Lima JA, Bluemke DA.. JAMA. 2015;314(18):1945-1954.

Cancer and its association with the development of coronary artery calcification: an assessment from the Multi-Ethnic Study of Atherosclerosis. Whitlock MC, Yeboah J, Burke GL, Chen H, Klepin HD, Hundley WG.. J Am Heart Assoc. 2015;4(11):e002533.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

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