Gregory L. Burke, M.D.Wake Forest School of Medicine

Education & Training

  • B.A., University of Northern Iowa, 1977
  • M.D., University of Iowa College of Medicine, 1981
  • M.S., University of Iowa, 1983
  • Fellowship, University of Iowa College of, 1983


  • Am Heart Association
  • Am Soc of Preventiv Cardiology
  • American Epidemiologic Society
Gregory L. Burke, M.D.

Gregory L. Burke, M.D.

Shared Resource Director, Translational Science Institute
Director, Public Health Sciences
Professor, Translational Science Institute
Public Health Sciences
Center for Comparative Medicine Research
Center for Integrative Medicine
Hypertension and Vascular Research Center
Maya Angelou Center for Health Equity
Sticht Center on Aging

Research Interests

aging, atherosclerosis/thrombosis, cardiac function, diabetes, drugs/therapeutic agents pharm, engineering/bioengineering, epidemiology, genetics/genome, health services, research/outc, immunology/allergy/inflammatio, minority health issues, nutrition, prevention, primary care, radiology imaging/nuclear medi, vascular diseases, cognition/learning

Contact Information

Academic: 336-716-2930 | Department: 336-716-2930


Media Medical Expert »

Recent Publications

Yu B, Pulit SL, Hwang SJ, Brody JA, Amin N, Auer PL, Bis JC, Boerwinkle E, Burke GL, Chakravarti A, Correa A, Dreisbach AW, Franco OH, Ehret GB, Franceschini N, Hofman A, Lin DY, Metcalf GA, Musani SK, Muzny D, Palmas W, Raffel L, Reiner A,. Rare exome sequence variants in CLCN6 reduce blood pressure levels and hypertension risk. Circ Cardiovasc Genet. 2016;9(1):64-70.

Mahler SA, Riley RF, Russell GB, Hiestand BC, Hoekstra JW, Lefebvre CW, Nicks BA, Cline DM, Askew KL, Bringolf J, Elliott SB, Herrington DM, Burke GL, Miller CD. Adherence to an accelerated diagnostic protocol for chest pain: secondary analysis of the HEART Pathway randomized trial. Acad Emerg Med. 2016;23(1):70-77.

Yeboah J, Young R, McClelland RL, Delaney JC, Polonsky TS, Dawood FZ, Blaha MJ, Miedema MD, Sibley CT, Carr JJ, Burke GL, Goff DC Jr, Psaty BM, Greenland P, Herrington DM. Utility of nontraditional risk markers in atherosclerotic cardiovascular disease risk assessment. J Am Coll Cardiol. 2016;67(2):139-147.

Mahler SA, Burke GL, Duncan PW, Case LD, Herrington DM, Riley RF, Wells BJ, Hiestand BC, Miller CD. HEART pathway accelerated diagnostic protocol implementation: prospective pre-post interrupted time series design and methods. JMIR Res Protoc. 2016;5(1):e10.

Blaha MJ, Cainzos-Achirica M, Greenland P, McEvoy JW, Blankstein R, Budoff MJ, Dardari Z, Sibley CT, Burke GL, Kronmal RA, Szklo M, Blumenthal RS, Nasir K. Role of coronary artery calcium score of zero and other negative risk markers for cardiovascular disease: the Multi-Ethnic Study of Atherosclerosis (MESA). Circulation. 2016;133(9):849-858.

Adhikari R, D'Souza J, Soliman EZ, Burke GL, Daviglus M, Jacobs DR Jr, Park SK, Sheppard L, Thorne PS, Kaufman JD, Larson TV, Adar SD. Long-term coarse particulate matter exposure and heart rate variability in the Multi-Ethnic Study of Atherosclerosis. Epidemiology. 2016;27(3):405-413.

Fisher DE, Klein BE, Wong TY, Rotter JI, Li X, Shrager S, Burke GL, Klein R, Cotch MF. Incidence of age-related macular degeneration in a multi-ethnic United States population: the Multi-Ethnic Study of Atherosclerosis. Ophthalmology. 2016;123(6):1297-1308.

Chahal H, Bluemke DA, Wu CO, McClelland R, Liu K, Shea SJ, Burke G, Balfour P, Herrington D, Shi P, Post W, Olson J, Watson KE, Folsom AR, Lima JA. Heart failure risk prediction in the Multi-Ethnic Study of Atherosclerosis. Heart. 2015;101(1):58-64.

Benjamin I, Brown N, Burke G, Correa A, Houser SR, Jones DW, Loscalzo J, Vasan RS, Whitman GR. American Heart Association Cardiovascular Genome-Phenome Study: foundational basis and program. Circulation. 2015;131(1):100-112.

Bacharova L, Chen H, Estes EH, Mateasik A, Bluemke DA, Lima JA, Burke GL, Soliman EZ. Determinants of discrepancies in detection and comparison of the prognostic significance of left ventricular hypertrophy by electrocardiogram and cardiac magnetic resonance imaging. Am J Cardiol. 2015;115(4):515-522.

Gepner AD, Young R, Delaney JA, Tattersall MC, Blaha MJ, Post WS, Gottesman RF, Kronmal R, Budoff MJ, Burke GL, Folsom AR, Liu K, Kaufman J, Stein JH. Comparison of coronary artery calcium presence, carotid plaque presence, and carotid intima-media thickness for cardiovascular disease prediction in the Multi-Ethnic Study of Atherosclerosis. Circ Cardiovasc Imaging. 2015;8(1):e002262.

Arnan MK, Hsieh TC, Yeboah J, Bertoni AG, Burke GL, Bahrainwala Z, Grega MA, Baumgartner WA, Gottesman RF. Postoperative blood urea nitrogen is associated with stroke in cardiac surgical patients. Ann Thorac Surg. 2015;99(4):1314-1320.

Mahler SA, Riley RF, Hiestand BC, Russell GB, Hoekstra JW, Lefebvre CW, Nicks BA, Cline DM, Askew KL, Elliott SB, Herrington DM, Burke GL, Miller CD. The HEART pathway randomized trial: identifying emergency department patients with acute chest pain for early discharge. Circ Cardiovasc Qual Outcomes. 2015;8(2):195-203.

Yeboah J, Sillau S, Delaney JC, Blaha MJ, Michos ED, Young R, Qureshi WT, McClelland R, Burke GL, Psaty BM, Herrington DM. Implications of the new American College of Cardiology/American Heart Association cholesterol guidelines for primary atherosclerotic cardiovascular disease event prevention in a multi ethnic cohort: Multi-Ethnic Study of Atherosclerosis (MESA). Am Heart J. 2015;169(3):387-395.e3.

Reynolds LM, Ding J, Taylor JR, Lohman K, Soranzo N, de la Fuente A, Liu TF, Johnson C, Barr RG, Register TC, Donohue KM, Talor MV, Cihakova D, Gu C, Divers J, Siscovick D, Burke G, Post W, Shea S, Jacobs DR Jr, Hoeschele I, McCall CE,. Transcriptomic profiles of aging in purified human immune cells. BMC Genomics. 2015;16(1):333.

van Ballegooijen AJ, Robinson-Cohen C, Katz R, Criqui M, Budoff M, Li D, Siscovick D, Hoofnagle A, Shea SJ, Burke G, de Boer IH, Kestenbaum B. Vitamin D metabolites and bone mineral density: the Multi-Ethnic Study of Atherosclerosis. Bone. 2015;78():186-193.

Colangelo LA, Vu TH, Szklo M, Burke GL, Sibley C, Liu K. Is the association of hypertension with cardiovascular events stronger among the lean and normal weight than among the overweight and obese? The Multi-Ethnic Study of Atherosclerosis. Hypertension. 2015;66(2):286-293.

Corriere MA, Avise JA, Peterson LA, Stafford JM, Easterling D, Boone DS Sr, Ip E, Hyde AS, Burke GL. Exploring patient involvement in decision making for vascular procedures. J Vasc Surg. 2015;62(4):.

Murad K, Goff DC Jr, Morgan TM, Burke GL, Bartz TM, Kizer JR, Chaudhry SI, Gottdiener JS, Kitzman DW. Burden of comorbidities and functional and cognitive impairments in elderly patients at the initial diagnosis of heart failure and their impact on total mortality: the Cardiovascular Health Study. JACC Heart Fail. 2015;3(7):542-550.

Adar SD, D'Souza J, Mendelsohn-Victor K, Jacobs DR, Cushman M, Sheppard L, Thorne PS, Burke GL, Daviglus ML, Szpiro AA, Diez Roux AV, Kaufman JD, Larson TV. Markers of inflammation and coagulation after long-term exposure to coarse particulate matter: a cross-sectional analysis from the Multi-Ethnic Study of Atherosclerosis. Environ Health Perspect. 2015;123(6):541-548.

Yeboah J, Polonsky TS, Young R, McClelland RL, Delaney JC, Dawood F, Blaha MJ, Miedema MD, Sibley CT, Carr JJ, Burke GL, Goff DC Jr, Psaty BM, Greenland P, Herrington DM. Utility of nontraditional risk markers in individuals ineligible for statin therapy according to the 2013 American College of Cardiology/American Heart Association cholesterol guidelines. Circulation. 2015;132(10):916-922.

Reynolds LM, Wan M, Ding J, Taylor JR, Lohman K, Su D, Bennett BD, Porter DK, Gimple R, Pittman GS, Wang X, Howard TD, Siscovick D, Psaty BM, Shea S, Burke GL, Jacobs DR Jr, Rich SS, Hixson JE, Stein JH, Stunnenberg H, Barr RG,. DNA methylation of the aryl hydrocarbon receptor repressor associations with cigarette smoking and subclinical atherosclerosis. Circ Cardiovasc Genet. 2015;8(5):707-716.

Corriere MA, Avise JA, Stafford JM, Peterson LA, Easterling D, Ip EH, Boone DS, Hyde AS, Guzman RJ, Burke GL. Impact of race and education on patients' preferred decision-making roles for vascular procedures and perceptions of treatment success [abstract]. J Am Coll Surg. 2015;221(4 Suppl 1):S179-S180.

Fisher DE, Shrager S, Shea SJ, Burke GL, Klein R, Wong TY, Klein BE, Cotch MF. Visual impairment in white, Chinese, black, and Hispanic participants from the Multi-Ethnic Study of Atherosclerosis cohort. Ophthalmic Epidemiol. 2015;22(5):321-332.

Liu K, Colangelo LA, Daviglus ML, Goff DC, Pletcher M, Schreiner PJ, Sibley CT, Burke GL, Post WS, Michos ED, Lloyd-Jones DM. Can antihypertensive treatment restore the risk of cardiovascular disease to ideal levels?: the Coronary Artery Risk Development in Young Adults (CARDIA) study and the Multi-Ethnic Study of Atherosclerosis (MESA). J Am Heart Assoc. 2015;4(9):e002275.

McClelland RL, Jorgensen NW, Budoff M, Blaha MJ, Post WS, Kronmal RA, Bild DE, Shea S, Liu K, Watson KE, Folsom AR, Khera A, Ayers C, Mahabadi AA, Lehmann N, Jockel KH, Moebus S, Carr JJ, Erbel R, Burke GL. 10-year coronary heart disease risk prediction using coronary artery calcium and traditional risk factors: derivation in the MESA (Multi-Ethnic Study of Atherosclerosis) with validation in the HNR (Heinz Nixdorf Recall) Study. J Am Coll Cardiol. 2015;66(15):1643-1653.

Turkbey EB, Nacif MS, Guo M, McClelland RL, Teixeira PB, Bild DE, Barr RG, Shea S, Post W, Burke G, Budoff MJ, Folsom AR, Liu CY, Lima JA, Bluemke DA. Prevalence and correlates of myocardial scar in a US cohort. JAMA. 2015;314(18):1945-1954.

Whitlock MC, Yeboah J, Burke GL, Chen H, Klepin HD, Hundley WG. Cancer and its association with the development of coronary artery calcification: an assessment from the Multi-Ethnic Study of Atherosclerosis. J Am Heart Assoc. 2015;4(11):e002533.

Arguelles W, Llabre MM, Penedo FJ, Daviglus ML, Sacco RL, Liu K, Szklo M, Polak JF, Eng J, Burke GL, Schneiderman N. Relationship of change in traditional cardiometabolic risk factors to change in coronary artery calcification among individuals with detectable subclinical atherosclerosis: the Multi-Ethnic Study of Atherosclerosis. Int J Cardiol. 2014;174(1):51-56.

Bild DE, McClelland R, Kaufman JD, Blumenthal R, Burke GL, Carr JJ, Post WS, Register TC, Shea S, Szklo M. Ten-year trends in coronary calcification in individuals without clinical cardiovascular disease in the Multi-Ethnic Study of Atherosclerosis. PLoS One. 2014;9(4):e94916.

Yeboah J, Delaney JA, Nance R, McClelland RL, Polak JF, Sibley CT, Bertoni A, Burke GL, Carr JJ, Herrington DM. Mediation of cardiovascular risk factor effects through subclinical vascular disease: the Multi-Ethnic Study of Atherosclerosis. Arterioscler Thromb Vasc Biol. 2014;34(8):1778-1783.

Burkart KM, Manichaikul A, Wilk JB, Ahmed FS, Burke GL, Enright P, Hansel NN, Haynes D, Heckbert SR, Hoffman EA, Kaufman JD, Kurai J, Loehr L, London SJ, Meng Y, O'Connor GT, Oelsner E, Petrini M, Pottinger TD, Powell CA, Redline S,. APOM and high-density lipoprotein cholesterol are associated with lung function and per cent emphysema. Eur Respir J. 2014;43(4):1003-1017.

Zhang K, Larson TV, Gassett A, Szpiro AA, Daviglus M, Burke GL, Kaufman JD, Adar SD. Characterizing spatial patterns of airborne coarse particulate (PM10-2.5) mass and chemical components in three cities: the Multi-Ethnic Study of Atherosclerosis. Environ Health Perspect. 2014;122(8):823-830.

Venkatesh BA, Volpe GJ, Donekal S, Mewton N, Liu CY, Shea S, Liu K, Burke G, Wu C, Bluemke DA, Lima JA. Association of longitudinal changes in left ventricular structure and function with myocardial fibrosis: the Multi-Ethnic Study of Atherosclerosis Study. Hypertension. 2014;64(3):508-515.

Sinner MF, Stepas KA, Moser CB, Krijthe BP, Aspelund T, Sotoodehnia N, Fontes JD, Janssens AC, Kronmal RA, Magnani JW, Witteman JC, Chamberlain AM, Lubitz SA, Schnabel RB, Vasan RS, Wang TJ, Agarwal SK, McManus DD, Franco OH, Yin X, Larson MG,. B-type natriuretic peptide and C-reactive protein in the prediction of atrial fibrillation risk: the CHARGE-AF consortium of community-based cohort studies. Europace. 2014;16(10):1426-1433.

Cohen R, Budoff M, McClelland RL, Sillau S, Burke G, Blaha M, Szklo M, Uretsky S, Rozanski A, Shea S. Significance of a positive family history for coronary heart disease in patients with a zero coronary artery calcium score (from the Multi-Ethnic Study of Atherosclerosis). Am J Cardiol. 2014;114(8):1210-1214.

Desai CS, Ning H, Soliman EZ, Burke GL, Shea S, Nazarian S, Lloyd-Jones DM, Greenland P. Electrocardiographic abnormalities and coronary artery calcium for coronary heart disease prediction and reclassification: the Multi-Ethnic Study of Atherosclerosis (MESA). Am Heart J. 2014;168(3):391-397.

McAuley PA, Chen H, Lee DC, Artero EG, Bluemke DA, Burke GL. Physical activity, measures of obesity, and cardiometabolic risk: the Multi-Ethnic Study of Atherosclerosis (MESA). J Phys Act Health. 2014;11(4):831-837.

Yeboah J, Erbel R, Delaney JC, Nance R, Guo M, Bertoni AG, Budoff M, Moebus S, Jockel KH, Burke GL, Wong ND, Lehmann N, Herrington DM, Mohlenkamp S, Greenland P. Development of a new diabetes risk prediction tool for incident coronary heart disease events: the Multi-Ethnic Study of Atherosclerosis and the Heinz Nixdorf Recall Study. Atherosclerosis. 2014;236(2):411-417.

Arnan MK, Burke GL, Bushnell C. Secondary prevention of stroke in the elderly: focus on drug therapy. Drugs Aging. 2014;31(10):721-730.

Shea MK, Cushman M, Booth SL, Burke GL, Chen H, Kritchevsky SB. Associations between vitamin K status and haemostatic and inflammatory biomarkers in community-dwelling adults. The Multi-Ethnic Study of Atherosclerosis. Thromb Haemost. 2014;112(3):438-444.

Reynolds LM, Taylor JR, Ding J, Lohman K, Johnson C, Siscovick D, Burke G, Post W, Shea S, Jacobs DR Jr, Stunnenberg H, Kritchevsky SB, Hoeschele I, McCall CE, Herrington DM, Tracy RP, Liu Y. Age-related variations in the methylome associated with gene expression in human monocytes and T cells. Nat Commun. 2014;5():5366.

Avise JA, Peterson LA, Stafford JM, Boone DS Sr, Easterling D, Burke GL, Corriere MA. Exploring patient involvement in decision making for vascular procedures [abstract]. J Vasc Surg. 2014;60(6):1726-1727.

Idu HI, Carty C, Burke GL, Naik RP, Adams RJ, Gee BE, Longstreth W, Egede L, Lackland DT, Greenberg CS, Hunt J, Kindy MM, Taylor H, Manson JE, Allison M, James WG, Reiner A. Is sickle cell trait associated with incident cardiovascular outcomes in African Americans? [abstract]. Blood. 2014;124(21):4920.

Azeem A, Yeboah J, Bertoni A, Burke G, Turkbey E, Szklo M, Herrington D. Association of hemoglobin A1C with cardiovascular disease and all-cause mortality in individuals without diabetes--the Multi-Ethnic Study of Atherosclerosis [abstract]. Circulation. 2013;127(12 Suppl):AP278.

Mahler SA, Hiestand BC, Nwanaji-Enwerem J, Goff DC, Burke GL, Douglas Case L, Nicks B, Miller CD. Reduction in observation unit length of stay with coronary computed tomography angiography depends on time of emergency department presentation. Acad Emerg Med. 2013;20(3):231-239.

Shah SA, Herrington DM, Howard TD, Divers J, Arnett DK, Burke GL, Kao WH, Guo X, Siscovick DS, Chakravarti A, Lima JA, Psaty BM, Tomaselli GF, Rich SS, Bowden DW, Post W. Associations between NOS1AP single nucleotide polymorphisms (SNPs) and QT interval duration in four racial/ethnic groups in the Multi-Ethnic Study of Atherosclerosis (MESA). Ann Noninvasive Electrocardiol. 2013;18(1):29-40.

Mewton N, Opdahl A, Choi EY, Almeida AL, Kawel N, Wu CO, Burke GL, Liu S, Liu K, Bluemke DA, Lima JA. Left ventricular global function index by magnetic resonance imaging--a novel marker for assessment of cardiac performance for the prediction of cardiovascular events: the Multi-Ethnic Study of Atherosclerosis. Hypertension. 2013;61(4):770-778.

Mahler SA, Burke GL, Goff DC Jr, Hiestand BC, Nicks BA, Hoekstra JW, Case LD, Miller CD. Avoidable utilization of the chest pain observation unit: evaluation of very-low-risk patients. Crit Pathw Cardiol. 2013;12(2):59-64.

McClain J, Hsu F, Brown E, Burke G, Carr J, Harris T, Kritchevsky S, Szklo M, Tracy R, Ding J. Pericardial adipose tissue and coronary artery calcification in the Multi-ethnic Study of Atherosclerosis (MESA. Obesity (Silver Spring). 2013;21(5):1056-1063.

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