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Ramon Casanova, Ph.D.Wake Forest School of Medicine

Ramon Casanova, Ph.D.

Associate Professor,

Contact Information

Academic: 336-716-8309 | Department: 336-716-2011


Additional Languages

French, Portuguese, Russian, Spanish

Education & Training

  • M.E.E., Non Medical School-Russia, 2002
  • Ph.D., Portugal-Aveiro University, 2004


  • Int'L Soc.Of Magnetic Resonanc
  • Org for Human Brain Map
  • Eastern North American Region(
  • Am Statistical Assoc
Ramon Casanova, Ph.D.

Ramon Casanova, Ph.D.

Associate Professor, Biostatistical Sciences
Office of Women in Medicine and Science
Center on Diabetes, Obesity, and Metabolism

Research Interests

Alzheimer Disease; Magnetic Resonance Imaging; Diabetes Mellitus, Type 2; Artificial Intelligence; Nerve Net
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Contact Information

Academic: 336-716-8309 | Department: 336-716-2011


Recent Publications

Long term effect of intensive lifestyle intervention on cerebral blood flow. Espeland MA, Luchsinger JA, Neiberg RH, Carmichael O, Laurienti PJ, Pi-Sunyer X, Wing RR, Cook D, Horton E, Casanova R, Erickson K, Nick Bryan R.. J Am Geriatr Soc. 2018;66(1):120-126.

The ACTIVE conceptual framework as a structural equation model. Gross AL, Payne BR, Casanova R, Davoudzadeh P, Dzierzewski JM, Farias S, Giovannetti T, Ip EH, Marsiske M, Rebok GW, Schaie KW, Thomas K, Willis S, Jones RN.. Exp Aging Res. 2018;44(1):1-17.

The Apathy in Dementia Methylphenidate Trial 2 (ADMET 2): study protocol for a randomized controlled trial. Scherer RW, Drye L, Mintzer J, Lanctot K, Rosenberg P, Herrmann N, Padala P, Brawman-Mintzer O, Burke W, Craft S, Lerner AJ, Levey A, Porsteinsson A, van Dyck CH, Baker LD, Williamson JD, Bell RA, Espeland M, Miller ME, Mott RT, Rapp S, Hayden K,.. Trials. 2018;19(1):46.

Brain and blood metabolite signatures of pathology and progression in Alzheimer disease: a targeted metabolomics study. Varma VR, Oommen AM, Varma S, Casanova R, An Y, Andrews RM, O'Brien R, Pletnikova O, Troncoso JC, Toledo J, Baillie R, Arnold M, Kastenmueller G, Nho K, Doraiswamy PM, Saykin AJ, Kaddurah-Daouk R, Legido-Quigley C, Thambisetty M.. PLoS Med. 2018;15(1):e1002482.

Neighborhoods, sleep quality, and cognitive decline: does where you live and how well you sleep matter?. Hunter JC, Handing EP, Casanova R, Kuchibhatla M, Lutz MW, Saldana S, Plassman BL, Hayden KM.. Alzheimers Dement. 2018;():.

Alpha-2 macroglobulin in Alzheimer's disease: a marker of neuronal injury through the RCAN1 pathway. Varma VR, Varma S, An Y, Hohman TJ, Seddighi S, Casanova R, Beri A, Dammer EB, Seyfried NT, Pletnikova O, Moghekar A, Wilson MR, Lah JJ, O'Brien RJ, Levey AI, Troncoso JC, Albert MS, Thambisetty M.. Mol Psychiatry. 2017;22(1):13-23.

Peril beyond the winner's curse-a small sample size is the bane of biomarker discovery [letter]. Thambisetty M, Casanova R, Varma S, Legido Quigley C.. Alzheimers Dement. 2017;13(5):606-607.

Sex differences in the association between insulin resistance and incident coronary heart disease and stroke among blacks without diabetes mellitus: the Jackson Heart Study. Effoe VS, Wagenknecht LE, Echouffo Tcheugui JB, Chen H, Joseph JJ, Kalyani RR, Bell RA, Wu WH, Casanova R, Bertoni AG.. J Am Heart Assoc. 2017;6(2):e004229.

The association between an inflammatory diet and global cognitive function and incident dementia in older women: the Women's Health Initiative Memory Study. Hayden KM, Beavers DP, Steck SE, Hebert JR, Tabung FK, Shivappa N, Casanova R, Manson JE, Padula CB, Salmoirago-Blotcher E, Snetselaar LG, Zaslavsky O, Rapp SR.. Alzheimers Dement. 2017;13(11):1187-1196.

Aldosterone, renin, cardiovascular events, and all-cause mortality among African Americans: the Jackson Heart Study. Joseph JJ, Echouffo-Tcheugui JB, Kalyani RR, Yeh HC, Bertoni AG, Effoe VS, Casanova R, Sims M, Wu WC, Wand GS, Correa A, Golden SH.. JACC Heart Fail. 2017;5(9):642-651.

Evidence for brain glucose dysregulation in Alzheimer's disease. An Y, Varma VR, Varma S, Casanova R, Dammer E, Pletnikova O, Chia CW, Egan JM, Ferrucci L, Troncoso J, Levey AI, Lah J, Seyfried NT, Legido-Quigley C, O'Brien R, Thambisetty M.. Alzheimers Dement. 2017;():.

A systematic approach to predicting the risk of unicompartmental knee arthroplasty revision. Zhang G, Smith BP, Plate JF, Casanova R, Hsu FC, Li J, Xia L, Li KC, Poehling GG, Zhou X.. Osteoarthritis Cartilage. 2016;24(6):991-999.

Blood metabolite markers of preclinical Alzheimer's disease in two longitudinally followed cohorts of older individuals. Casanova R, Varma S, Simpson B, Kim M, An Y, Saldana S, Riveros C, Moscato P, Griswold M, Sonntag D, Wahrheit J, Klavins K, Jonsson PV, Eiriksdottir G, Aspelund T, Launer LJ, Gudnason V, Quigley CL, Thambisetty M.. Alzheimers Dement. 2016;12(7):815-822.

Aldosterone, renin and diabetes mellitus in African Americans: the Jackson Heart Study. Joseph JJ, Echouffo-Tcheugui JB, Kalyani RR, Yeh HC, Bertoni AG, Effoe VS, Casanova R, Sims M, Correa A, Wu WC, Wand GS, Golden SH.. J Clin Endocrinol Metab. 2016;101(4):1770-1778.

Effects of hormone therapy on brain volumes changes of postmenopausal women revealed by optimally-discriminative voxel-based morphometry. Zhang T, Casanova R, Resnick SM, Manson JE, Baker LD, Padual CB, Kuller LH, Bryan RN, Espeland MA, Davatzikos C.. PLoS One. 2016;11(3):e0150834.

Obesity and structural brain integrity in older women: the Women's Health Initiative Magnetic Resonance Imaging Study. Driscoll I, Gaussoin SA, Wassertheil-Smoller S, Limacher M, Casanova R, Yaffe K, Resnick SM, Espeland MA.. J Gerontol A Biol Sci Med Sci. 2016;71(9):1216-1222.

Relative differences in resting-state brain connectivity associated with long term intensive lifestyle intervention. Casanova R, Hayasaka S, Saldana S, Bryan NR, Demos KE, Desiderio L, Erickson KI, Espeland MA, Nasrallah IM, Wadden T, Laurienti PJ.. Psychoneuroendocrinology. 2016;74():231-239.

Prediction of incident diabetes in the Jackson Heart Study using high-dimensional machine learning. Casanova R, Saldana S, Simpson SL, Lacy ME, Subauste AR, Blackshear C, Wagenknecht L, Bertoni AG.. PLoS One. 2016;11(10):e0163942.

A voxel-based morphometry study reveals local brain structural alterations associated with ambient fine particles in older women. Casanova R, Wang X, Reyes J, Akita Y, Serre ML, Vizuete W, Chui HC, Driscoll I, Resnick SM, Espeland MA, Chen JC.. Front Hum Neurosci. 2016;10():495.

Ambient air pollution and neurotoxicity on brain structure: evidence from Women's Health Initiative Memory Study. Chen JC, Wang X, Wellenius GA, Serre ML, Driscoll I, Casanova R, McArdle JJ, Manson JE, Chui HC, Espeland MA.. Ann Neurol. 2015;78(3):466-476.

Postmenopausal hormone therapy, type 2 diabetes mellitus, and brain volumes. Espeland MA, Brinton RD, Manson JE, Yaffe K, Hugenschmidt C, Vaughan L, Craft S, Edwards BJ, Casanova R, Masaki K, Resnick SM.. Neurology. 2015;85(13):1131-1138.

Application of random forests methods to diabetic retinopathy classification analyses. Casanova R, Saldana S, Chew EY, Danis RP, Greven CM, Ambrosius WT.. PLoS One. 2014;9(6):e98587.

Influence of type 2 diabetes on brain volumes and changes in brain volumes: results from the Women's Health Initiative magnetic resonance imaging studies. Espeland MA, Bryan RN, Goveas JS, Robinson JG, Siddiqui MS, Liu S, Hogan PE, Casanova R, Coker LH, Yaffe K, Masaki K, Rossom R, Resnick SM.. Diabetes Care. 2013;36(1):90-97.

Alzheimer's disease risk assessment using large-scale machine learning methods. Casanova R, Hsu FC, Sink KM, Rapp SR, Williamson JD, Resnick SM, Espeland MA.. PLoS One. 2013;8(11):e77949.

Combining graph and machine learning methods to analyze differences in functional connectivity across sex. Casanova R, Whitlow CT, Wagner B, Espeland MA, Maldjian JA.. Open Neuroimag J. 2012;6():1-9.

Cognitive function and retinal and ischemic brain changes: the Women's Health Initiative. Haan M, Espeland MA, Klein BE, Casanova R, Gaussoin SA, Jackson RD, Millen AE, Resnick SM, Rossouw JE, Shumaker SA, Wallace R, Yaffe K.. Neurology. 2012;78(13):942-949.

Classification of structural MRI images in Alzheimer's disease from the perspective of ill-posed problems. Casanova R, Hsu F-C, Espeland MA.. PLoS One. 2012;7(10):e44877.

Effect of resting-state functional MR imaging duration on stability of graph theory metrics of brain network connectivity. Whitlow CT, Casanova R, Maldjian JA.. Radiology. 2011;259(2):516-524.

Application of machine learning methods to describe the effects of conjugated equine estrogens therapy on region-specific brain volumes. Casanova R, Espeland MA, Goveas JS, Davatzikos C, Gaussoin SA, Maldjian JA, Brunner RL, Kuller LH, Johnson KC, Wagner B, et al.. Magn Reson Imaging. 2011;29(4):546-553.

High dimensional classification of structural MRI Alzheimer's disease data based on large scale regularization. Casanova R, Whitlow CT, Wagner B, Williamson J, Shumaker SA, Maldjian JA, Espeland MA.. Front Neuroinform. 2011;5():article 22.

Evaluating the impact of different factors on Voxel-based classification methods of ADNI structural MRI brain images. Casanova R, Maldjian JA, Espeland MA.. Int J Biomed Data Mining. 2011;1():B110102.

Application of machine learning methods to describe the effects of conjugated equine estrogens therapy on region-specific brain volumes [abstract]. Casanova R, Espeland MA, Goveas J, Davatzikos C, Gaussoin SA, Wagner B, Maldjian JA, Resnick SM.. Gerontologist. 2010;50(Suppl 1):308-309.

Aging and the interaction of sensory cortical function and structure. Peiffer AM, Hugenschmidt CE, Maldjian JA, Casavona R, Srikanth R, Hayasaka S, Burdette JH, Kraft RA, Laurienti PJ.. Hum Brain Mapp. 2009;30(1):228-240.

Evaluating the impact of spatio-temporal smoothness constraints on the BOLD hemodynamic response function estimation: an analysis based on Tikhonov regularization. Casanova R, Yang L, Hairston WD, Laurienti PJ, Maldjian JA.. Physiol Meas. 2009;30(5):N37-N51.

Closing the mind's eye: deactivation of visual cortex related to auditory task difficulty. Hairston WD, Hodges DA, Casanova R, Hayasaka S, Kraft R, Maldjian JA, Burdette JH.. Neuroreport. 2008;19(2):151-154.

Relating imaging indices of white matter integrity and volume in healthy older adults. Hugenschmidt CE, Peiffer AM, Kraft RA, Casanova R, Deibler AR, Burdette JH, Maldjian JA, Laurienti PJ.. Cereb Cortex. 2008;18(2):433-442.

The impact of temporal regularization on estimates of the BOLD hemodynamic response function: a comparative analysis. Casanova R, Ryali S, Serences J, Yang L, Kraft R, Laurienti PJ, Maldjian JA.. Neuroimage. 2008;40(4):1606-1618.

Biological parametric mapping: a statistical toolbox for multimodality brain image analysis. Casanova R, Srikanth R, Baer A, Laurienti PJ, Burdette JH, Hayasaka S, Flowers L, Wood F, Maldjian JA.. Neuroimage. 2007;34(1):137-143.

Estimation of false discovery rates for wavelet-denoised statistical parametric maps. Srikanth R, Casanova R, Laurienti PJ, Peiffer AM, Maldjian JA.. Neuroimage. 2006;33(1):72-84.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Associate Professor, Biostatistical Sciences

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