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Larry D. Case, Ph.D.Wake Forest School of Medicine

Larry D. Case, Ph.D.


Contact Information

Academic: 336-716-1048 | Department: 336-716-2011


Education & Training

  • B.S., University of North Carolina-Chapel Hill, 1978
  • M.S.P.H., University of North Carolina-Chapel Hill, 1981
  • Ph.D., University of North Carolina-Chapel Hill, 1987


  • Soc Of Clinical Trial Research
  • Am Statistical Assn
  • Biometric Society
Larry D. Case, Ph.D.

Larry D. Case, Ph.D.

Professor, Biostatistical Sciences

Research Interests

Breast Neoplasms; Survivors; Health Status Disparities; Brain Neoplasms; Rural Population
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Contact Information

Academic: 336-716-1048 | Department: 336-716-2011


Recent Publications

A randomized double-blind placebo-controlled trial of fruit and vegetable concentrates on intermediate biomarkers in head and neck cancer. Datta M, Shaw EG, Lesser GJ, Case LD, Vitolins MZ, Schneider C, Frizzell B, Sullivan C, Lively M, Franzmann E, Hu JJ.. Integr Cancer Ther. 2018;17(1):115-123.

The 24-month metabolic benefits of the healthy living partnerships to prevent diabetes: a community-based translational study. Pedley CF, Case LD, Blackwell CS, Katula JA, Vitolins MZ.. Diabetes Metab Syndr. 2018;12(3):215-220.

Effect of a digital health intervention on receipt of colorectal cancer screening in vulnerable patients: a randomized controlled trial. Miller DP Jr, Denizard-Thompson N, Weaver KE, Case LD, Troyer JL, Spangler JG, Lawler D, Pignone MP.. Ann Intern Med. 2018;168(8):550-557.

The healthy living partnerships to prevent diabetes and the diabetes prevention program: a comparison of year 1 and 2 intervention results. Vitolins MZ, Isom SP, Blackwell CS, Kernodle D, Sydell JM, Pedley CF, Katula JA, Case LD, Goff DC Jr.. Transl Behav Med. 2017;7(2):371-378.

Usability of a novel mobile health iPad app by vulnerable populations. Miller DP Jr, Weaver KE, Case LD, Babcock D, Lawler D, Denizard-Thompson N, Pignone MP, Spangler JG.. JMIR Mhealth Uhealth. 2017;5(4):e43.

Problems experienced by ovarian cancer survivors during treatment. Keim-Malpass J, Mihalko SL, Russell G, Case D, Miller B, Avis NE.. J Obstet Gynecol Neonatal Nurs. 2017;46(4):544-554.

A study of donepezil in female breast cancer survivors with self-reported cognitive dysfunction 1 to 5 years following adjuvant chemotherapy. Lawrence JA, Griffin L, Balcueva EP, Groteluschen DL, Samuel TA, Lesser GJ, Naughton MJ, Case LD, Shaw EG, Rapp SR.. J Cancer Surviv. 2016;10(1):176-184.

HEART pathway accelerated diagnostic protocol implementation: prospective pre-post interrupted time series design and methods. Mahler SA, Burke GL, Duncan PW, Case LD, Herrington DM, Riley RF, Wells BJ, Hiestand BC, Miller CD.. JMIR Res Protoc. 2016;5(1):e10.

Standardized rehabilitation and hospital length of stay among patients with acute respiratory failure: a randomized clinical trial. Morris PE, Berry MJ, Files DC, Thompson JC, Hauser J, Flores L, Dhar S, Chmelo E, Lovato J, Case LD, Bakhru RN, Sarwal A, Parry SM, Campbell P, Mote A, Winkelman C, Hite RD, Nicklas B, Chatterjee A, Young MP.. JAMA. 2016;315(24):2694-2702.

Effects of weight regain following intentional weight loss on glucoregulatory function in overweight and obese adults with pre-diabetes. Beavers KM, Case LD, Blackwell CS, Katula JA, Goff DC Jr, Vitolins MZ.. Obes Res Clin Pract. 2015;9(3):266-273.

Trajectories of posttraumatic growth and associated characteristics in women with breast cancer. Danhauer SC, Russell G, Case LD, Sohl SJ, Tedeschi RG, Addington EL, Triplett K, Van Zee KJ, Naftalis EZ, Levine B, Avis NE.. Ann Behav Med. 2015;49(5):650-659.

Donepezil for irradiated brain tumor survivors: a phase III randomized placebo-controlled clinical trial. Rapp SR, Case LD, Peiffer A, Naughton MM [sic] [Naughton MJ], Chan MD, Stieber VW, Moore DF Jr, Falchuk SC, Piephoff JV, Edenfield WJ, Giguere JK, Loghin ME, Shaw EG.. J Clin Oncol. 2015;33(15):1653-1659.

Tumor-induced loss of mural Connexin 43 gap junction activity promotes endothelial proliferation. Choudhary M, Naczki C, Chen W, Barlow KD, Case LD, Metheny-Barlow LJ.. BMC Cancer. 2015;15():427.

Effect of ArginMax on sexual functioning and quality of life among female cancer survivors: results of the WFU CCOP Research Base Protocol 97106. Greven KM, Case LD, Nycum LR, Zekan PJ, Hurd DD, Balcueva EP, Mills GM, Zon R, Flynn PJ, Biggs D, Shaw EG, Lesser G, Naughton MJ.. J Community Support Oncol. 2015;13(3):87-94.

Healthy Living Partnerships to Prevent Diabetes (HELP PD): a randomized controlled trial to prevent diabetes through diet and exercise: 2 year effects on the metabolic syndrome [abstract]. Pedley CF, Blackwell C, Case D, Katula JA, Vitolins MZ, Goff DC.. J Gen Intern Med. 2015;30(Suppl 2):S173.

Preliminary efficacy of an enhanced quitline smoking cessation intervention for cancer patients [abstract]. Weaver KE, Urbanic JJ, Case D, Kaplan SG, Lesser GJ, Zbikowski S, Bryant D, Dakhil SR, Wilson C, Shaw EG, Danhauer S.. J Clin Oncol. 2015;33(15 Suppl):e20671.

A prospective evaluation of radiotherapy (RT) related skin reactions in a multi-racial/ethnic population of women with newly diagnosed breast cancer (BC) [abstract]. Urbanic JJ, Case D, Baez-Diaz L, Brown DR, Strasser J, Enevold G, Naughton M, Weaver KE, Baglan K, Bryant D, Langefeld C, Lad TE, Lee L, Rine G, Curtis AE, Koprowski CD, Tomlinson WV, Lesser GJ, Shaw EG, Hu JJ,.. J Clin Oncol. 2015;33(15 Suppl):6593.

Trajectories of depressive symptoms following breast cancer diagnosis. Avis NE, Levine BJ, Case LD, Naftalis EZ, Van Zee KJ.. Cancer Epidemiol Biomarkers Prev. 2015;24(11):1789-1795.

Disparities in barriers to follow-up care between African American and White breast cancer survivor. Palmer NR, Weaver KE, Hauser SP, Lawrence JA, Talton J, Case LD, Geiger AM.. Support Care Cancer. 2015;23(11):3201-3209.

Metabolomic analysis of the target cohort identifies serum signatures that outperform lactate in sepsis prognosis [abstract]. Langley RJ, Flores L, Mohney R, Lovato J, Case L, Harrod KS, Morris PE.. Am J Respir Crit Care Med. 2015;191():A4007.

Feasibility of fall risk assessments within acute respiratory failure survivors with the falls efficacy scale-international [abstract]. Parry SM, Bakhru RN, Files DC, Dhar S, Young MT, Flores L, Lovato J, Hauser J, Chmelo FA, Mote P, Thompson C, Campbell P, Denehy L, Case L, Berry MJ, Morris PE.. Am J Respir Crit Care Med. 2015;191():A4495.

Trajectories of illness intrusiveness domains following a diagnosis of breast cancer. Sohl SJ, Levine B, Case LD, Danhauer SC, Avis NE.. Health Psychol. 2014;33(3):232-241.

Physicians' inability to estimate medical costs: a multisite survey [abstract]. Miller DP, Johnson D, Kohan L, Manogue M, Case LD, Atkinson H.. J Gen Intern Med. 2014;29(Suppl 1):S176.

The impact of polyunsaturated fatty acid-based dietary supplements on disease biomarkers in a metabolic syndrome/diabetes population. Lee TC, Ivester P, Hester AG, Sergeant S, Case LD, Morgan T, Kouba EO, Chilton FH.. Lipids Health Dis. 2014;13(1):196.

Racial disparities in barriers to follow-up care among breast cancer survivors [abstract]. Palmer N, Weaver K, Hauser S, Talton J, Case LD, Lawrence J, Dezern K, Geiger A.. Cancer Epidemiol Biomarkers Prev. 2014;23(11 Suppl):C35.

Rural-urban disparities in health status among US cancer survivors. Weaver KE, Geiger AM, Lu L, Case LD.. Cancer. 2013;119(5):1050-1057.

Reduction in observation unit length of stay with coronary computed tomography angiography depends on time of emergency department presentation. Mahler SA, Hiestand BC, Nwanaji-Enwerem J, Goff DC, Burke GL, Douglas Case L, Nicks B, Miller CD.. Acad Emerg Med. 2013;20(3):231-239.

Avoidable utilization of the chest pain observation unit: evaluation of very-low-risk patients. Mahler SA, Burke GL, Goff DC Jr, Hiestand BC, Nicks BA, Hoekstra JW, Case LD, Miller CD.. Crit Pathw Cardiol. 2013;12(2):59-64.

A randomized, double-blind, placebo-controlled study of oral coenzyme Q10 to relieve self-reported treatment-related fatigue in newly diagnosed patients with breast cancer. Lesser GJ, Case D, Stark N, Williford S, Giguere J, Garino LA, Naughton MJ, Vitolins MZ, Lively MO, Shaw EG.. J Support Oncol. 2013;11(1):31-42.

Potentially avoidable chest pain observation unit utilization: admission of very-low risk patients [abstract]. Mahler SA, Burke GL, Goff DC, Case LD, Miller CD.. Acad Emerg Med. 2013;20(5 Suppl 1):S33.

Fatty acid metabolites in rapidly proliferating breast cancer. O'Flaherty JT, Wooten RE, Samuel MP, Thomas MJ, Levine EA, Case LD, Akman SA, Edwards IJ.. PLoS One. 2013;8(5):e63076.

Age-related longitudinal changes in depressive symptoms following breast cancer diagnosis and treatment. Avis NE, Levine B, Naughton MJ, Case LD, Naftalis E, Van Zee KJ.. Breast Cancer Res Treat. 2013;139(1):199-206.

Nightmares and dysfunctional beliefs about sleep mediate the effect of insomnia symptoms on suicidal ideation. McCall WV, Batson N, Webster M, Case LD, Joshi I, Derreberry T, McDonough A, Farris SR.. J Clin Sleep Med. 2013;9(2):135-140.

Oral paricalcitol (19-nor-1,25-dihydroxyvitamin D2) in women receiving chemotherapy for metastatic breast cancer: a feasibility trial. Lawrence JA, Akman SA, Melin SA, Case LD, Schwartz GG.. Cancer Biol Ther. 2013;14(6):476-480.

Transition from pediatric to adult care for youth diagnosed with type 1 diabetes in adolescence. Lotstein DS, Seid M, Klingensmith G, Case D, Lawrence JM, Pihoker C, Dabelea D, Mayer-Davis EJ, Gilliam LK, Corathers S, Imperatore G, Dolan L, Anderson A, Bell RA, Waitzfelder B.. Pediatrics. 2013;131(4):E1062-70.

Stress CMR reduces revascularization, hospital readmission, and recurrent cardiac testing in intermediate-risk patients with acute chest pain. Miller CD, Case LD, Little WC, Mahler SA, Burke GL, Harper EN, Lefebvre C, Hiestand B, Hoekstra JW, Hamilton CA, Hundley WG.. JACC Cardiovasc Imaging. 2013;6(7):785-794.

Rural-urban differences in health behaviors and implications for health status among US cancer survivors. Weaver KE, Palmer N, Lu L, Case LD, Geiger AM.. Cancer Causes Control. 2013;24(8):1481-1490.

Impact of rural residence on forgoing healthcare after cancer because of cost. Palmer NRA, Geiger AM, Lu L, Case LD, Weaver KE.. Cancer Epidemiol Biomarkers Prev. 2013;22(10):1668-1676.

Incorporating prosocial behavior to promote physical activity in older adults: rationale and design of the Program for Active Aging and Community Engagement (PACE). Foy CG, Vitolins MZ, Case LD, Harris SJ, Massa-Fanale C, Hopley RJ, Gardner L, Rudiger N, Yamamoto K, Swain B, Goff DC Jr, Danhauer SC, Booth D, Gaspari J.. Contemp Clin Trials. 2013;36(1):284-297.

Predictors of posttraumatic growth in women with breast cancer. Danhauer SC, Case LD, Tedeschi R, Russell G, Vishnevsky T, Triplett K, Ip EH, Avis NE.. Psychooncology. 2013;22(12):2676-2683.

CNS tools and oncology: feasibility of cognition assessment prior to initial chemotherapy in an oncology clinic [abstract]. Attia M, Sink KM, Higgins A, Yacoub G, Case D, Klepin H, Lawrence JA.. Gerontologist. 2013;53(Suppl 1):321-322.

Ipad-based patient education and data collection for colorectal cancer screening [abstract]. Miller DP, Denizard-Thompson NM, Wofford JL, Babcock D, Weaver KE, Case LD, Spangler J, Pignone M.. J Gen Intern Med. 2013;28(Suppl 1):S245-S246.

The feasibility of computer assisted instruction for low literacy patients [abstract]. Miller DP, Duren-Winfield V, Wofford JL, Pignone M, Case LD.. J Gen Intern Med. 2013;28(Suppl 1):S202.

A retrospective review of the metabolic syndrome in women diagnosed with breast cancer and correlation with estrogen receptor. Colonna SV, Case LD, Lawrence JA.. Breast Cancer Res Treat. 2012;131(1):325-331.

Differences in arachidonic acid levels and fatty acid desaturase (FADS) gene variants in African Americans and European Americans with diabetes or the metabolic syndrome. Sergeant S, Hugenschmidt CE, Rudock ME, Ziegler JT, Ivester P, Ainsworth HC, Vaidya D, Case LD, Langefeld CD, Freedman BI, Bowden DW, Mathias RA, Chilton FH.. Br J Nutr. 2012;107(4):547-555.

A phase I dose escalation study of hypofractionated IMRT field-in-field boost for newly diagnosed glioblastoma multiforme. Monjazeb AM, Ayala D, Jensen C, Case LD, Bourland JD, Ellis TL, McMullen KP, Chan MD, Tatter SB, Lesser GJ, Shaw EG.. Int J Radiat Oncol Biol Phys. 2012;82(2):743-748.

Caregiver reports of provider recommended frequency of blood glucose monitoring and actual testing frequency for youth with type 1 diabetes. Yi-Frazier JP, Hood K, Case D, Waitzfelder B, Anderson A, Bloch CA, Naughton M, Seid M, Imperatore G, Loots B, Bell R, Lawrence JM.. Diabetes Res Clin Pract. 2012;95(1):68-75.

A phase II trial of thalidomide and procarbazine in adult patients with recurrent or progressive malignant gliomas. Ruiz J, Case D, Enevold G, Rosdhal R, Tatter SB, Ellis TL, McQuellon RP, McMullen KP, Stieber VW, Shaw EG, Lesser GJ.. J Neurooncol. 2012;106(3):611-617.

Trajectories of illness intrusiveness domains following a diagnosis of breast cancer [abstract]. Sohl SJ, Levine B, Case LD, Avis NE.. Ann Behav Med. 2012;43(Suppl 1):S76.

Mutagenicity of ochratoxin A and its hydroquinone metabolite in the SupF gene of the mutation reporter plasmid Ps189. Akman SA, Adams M, Case D, Park G, Manderville RA.. Toxins. 2012;4(4):267-280.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Larry D. Case, Ph.D.

Larry D. Case, Ph.D.

Professor, Biostatistical Sciences

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