Larry D. Case, Ph.D.Wake Forest School of Medicine

Larry D. Case, Ph.D.


Contact Information

Academic: 336-716-1048 | Department: 336-716-2011


Education & Training

  • B.S., University of North Carolina-Chapel Hill, 1978
  • M.S.P.H., University of North Carolina-Chapel Hill, 1981
  • Ph.D., University of North Carolina-Chapel Hill, 1987


  • Soc Of Clinical Trial Research
  • Am Statistical Assn
  • Biometric Society
Larry D. Case, Ph.D.

Larry D. Case, Ph.D.

Professor, Biostatistical Sciences

Research Interests

health services, research/outc, mental disorders/psychiatry/ps, statistics/mathematics

Contact Information

Academic: 336-716-1048 | Department: 336-716-2011


Recent Publications

Lawrence JA, Griffin L, Balcueva EP, Groteluschen DL, Samuel TA, Lesser GJ, Naughton MJ, Case LD, Shaw EG, Rapp SR. A study of donepezil in female breast cancer survivors with self-reported cognitive dysfunction 1 to 5 years following adjuvant chemotherapy. J Cancer Surviv. 2016;10(1):176-184.

Mahler SA, Burke GL, Duncan PW, Case LD, Herrington DM, Riley RF, Wells BJ, Hiestand BC, Miller CD. HEART pathway accelerated diagnostic protocol implementation: prospective pre-post interrupted time series design and methods. JMIR Res Protoc. 2016;5(1):e10.

Morris PE, Berry MJ, Files DC, Thompson JC, Hauser J, Flores L, Dhar S, Chmelo E, Lovato J, Case LD, Bakhru RN, Sarwal A, Parry SM, Campbell P, Mote A, Winkelman C, Hite RD, Nicklas B, Chatterjee A, Young MP. Standardized rehabilitation and hospital length of stay among patients with acute respiratory failure: a randomized clinical trial. JAMA. 2016;315(24):2694-2702.

Beavers KM, Case LD, Blackwell CS, Katula JA, Goff DC Jr, Vitolins MZ. Effects of weight regain following intentional weight loss on glucoregulatory function in overweight and obese adults with pre-diabetes. Obes Res Clin Pract. 2015;9(3):266-273.

Danhauer SC, Russell G, Case LD, Sohl SJ, Tedeschi RG, Addington EL, Triplett K, Van Zee KJ, Naftalis EZ, Levine B, Avis NE. Trajectories of posttraumatic growth and associated characteristics in women with breast cancer. Ann Behav Med. 2015;49(5):650-659.

Rapp SR, Case LD, Peiffer A, Naughton MM [sic] [Naughton MJ], Chan MD, Stieber VW, Moore DF Jr, Falchuk SC, Piephoff JV, Edenfield WJ, Giguere JK, Loghin ME, Shaw EG. Donepezil for irradiated brain tumor survivors: a phase III randomized placebo-controlled clinical trial. J Clin Oncol. 2015;33(15):1653-1659.

Choudhary M, Naczki C, Chen W, Barlow KD, Case LD, Metheny-Barlow LJ. Tumor-induced loss of mural Connexin 43 gap junction activity promotes endothelial proliferation. BMC Cancer. 2015;15():427.

Greven KM, Case LD, Nycum LR, Zekan PJ, Hurd DD, Balcueva EP, Mills GM, Zon R, Flynn PJ, Biggs D, Shaw EG, Lesser G, Naughton MJ. Effect of ArginMax on sexual functioning and quality of life among female cancer survivors: results of the WFU CCOP Research Base Protocol 97106. J Community Support Oncol. 2015;13(3):87-94.

Pedley CF, Blackwell C, Case D, Katula JA, Vitolins MZ, Goff DC. Healthy Living Partnerships to Prevent Diabetes (HELP PD): a randomized controlled trial to prevent diabetes through diet and exercise: 2 year effects on the metabolic syndrome [abstract]. J Gen Intern Med. 2015;30(Suppl 2):S173.

Weaver KE, Urbanic JJ, Case D, Kaplan SG, Lesser GJ, Zbikowski S, Bryant D, Dakhil SR, Wilson C, Shaw EG, Danhauer S. Preliminary efficacy of an enhanced quitline smoking cessation intervention for cancer patients [abstract]. J Clin Oncol. 2015;33(15 Suppl):e20671.

Urbanic JJ, Case D, Baez-Diaz L, Brown DR, Strasser J, Enevold G, Naughton M, Weaver KE, Baglan K, Bryant D, Langefeld C, Lad TE, Lee L, Rine G, Curtis AE, Koprowski CD, Tomlinson WV, Lesser GJ, Shaw EG, Hu JJ,. A prospective evaluation of radiotherapy (RT) related skin reactions in a multi-racial/ethnic population of women with newly diagnosed breast cancer (BC) [abstract]. J Clin Oncol. 2015;33(15 Suppl):6593.

Avis NE, Levine BJ, Case LD, Naftalis EZ, Van Zee KJ. Trajectories of depressive symptoms following breast cancer diagnosis. Cancer Epidemiol Biomarkers Prev. 2015;24(11):1789-1795.

Palmer NR, Weaver KE, Hauser SP, Lawrence JA, Talton J, Case LD, Geiger AM. Disparities in barriers to follow-up care between African American and White breast cancer survivor. Support Care Cancer. 2015;23(11):3201-3209.

Sohl SJ, Levine B, Case LD, Danhauer SC, Avis NE. Trajectories of illness intrusiveness domains following a diagnosis of breast cancer. Health Psychol. 2014;33(3):232-241.

Miller DP, Johnson D, Kohan L, Manogue M, Case LD, Atkinson H. Physicians' inability to estimate medical costs: a multisite survey [abstract]. J Gen Intern Med. 2014;29(Suppl 1):S176.

Lee TC, Ivester P, Hester AG, Sergeant S, Case LD, Morgan T, Kouba EO, Chilton FH. The impact of polyunsaturated fatty acid-based dietary supplements on disease biomarkers in a metabolic syndrome/diabetes population. Lipids Health Dis. 2014;13(1):196.

Palmer N, Weaver K, Hauser S, Talton J, Case LD, Lawrence J, Dezern K, Geiger A. Racial disparities in barriers to follow-up care among breast cancer survivors [abstract]. Cancer Epidemiol Biomarkers Prev. 2014;23(11 Suppl):C35.

Weaver KE, Geiger AM, Lu L, Case LD. Rural-urban disparities in health status among US cancer survivors. Cancer. 2013;119(5):1050-1057.

Mahler SA, Hiestand BC, Nwanaji-Enwerem J, Goff DC, Burke GL, Douglas Case L, Nicks B, Miller CD. Reduction in observation unit length of stay with coronary computed tomography angiography depends on time of emergency department presentation. Acad Emerg Med. 2013;20(3):231-239.

Mahler SA, Burke GL, Goff DC Jr, Hiestand BC, Nicks BA, Hoekstra JW, Case LD, Miller CD. Avoidable utilization of the chest pain observation unit: evaluation of very-low-risk patients. Crit Pathw Cardiol. 2013;12(2):59-64.

Lesser GJ, Case D, Stark N, Williford S, Giguere J, Garino LA, Naughton MJ, Vitolins MZ, Lively MO, Shaw EG. A randomized, double-blind, placebo-controlled study of oral coenzyme Q10 to relieve self-reported treatment-related fatigue in newly diagnosed patients with breast cancer. J Support Oncol. 2013;11(1):31-42.

Mahler SA, Burke GL, Goff DC, Case LD, Miller CD. Potentially avoidable chest pain observation unit utilization: admission of very-low risk patients [abstract]. Acad Emerg Med. 2013;20(5 Suppl 1):S33.

O'Flaherty JT, Wooten RE, Samuel MP, Thomas MJ, Levine EA, Case LD, Akman SA, Edwards IJ. Fatty acid metabolites in rapidly proliferating breast cancer. PLoS One. 2013;8(5):e63076.

Avis NE, Levine B, Naughton MJ, Case LD, Naftalis E, Van Zee KJ. Age-related longitudinal changes in depressive symptoms following breast cancer diagnosis and treatment. Breast Cancer Res Treat. 2013;139(1):199-206.

McCall WV, Batson N, Webster M, Case LD, Joshi I, Derreberry T, McDonough A, Farris SR. Nightmares and dysfunctional beliefs about sleep mediate the effect of insomnia symptoms on suicidal ideation. J Clin Sleep Med. 2013;9(2):135-140.

Lawrence JA, Akman SA, Melin SA, Case LD, Schwartz GG. Oral paricalcitol (19-nor-1,25-dihydroxyvitamin D2) in women receiving chemotherapy for metastatic breast cancer: a feasibility trial. Cancer Biol Ther. 2013;14(6):476-480.

Lotstein DS, Seid M, Klingensmith G, Case D, Lawrence JM, Pihoker C, Dabelea D, Mayer-Davis EJ, Gilliam LK, Corathers S, Imperatore G, Dolan L, Anderson A, Bell RA, Waitzfelder B. Transition from pediatric to adult care for youth diagnosed with type 1 diabetes in adolescence. Pediatrics. 2013;131(4):E1062-70.

Miller CD, Case LD, Little WC, Mahler SA, Burke GL, Harper EN, Lefebvre C, Hiestand B, Hoekstra JW, Hamilton CA, Hundley WG. Stress CMR reduces revascularization, hospital readmission, and recurrent cardiac testing in intermediate-risk patients with acute chest pain. JACC Cardiovasc Imaging. 2013;6(7):785-794.

Weaver KE, Palmer N, Lu L, Case LD, Geiger AM. Rural-urban differences in health behaviors and implications for health status among US cancer survivors. Cancer Causes Control. 2013;24(8):1481-1490.

Palmer NRA, Geiger AM, Lu L, Case LD, Weaver KE. Impact of rural residence on forgoing healthcare after cancer because of cost. Cancer Epidemiol Biomarkers Prev. 2013;22(10):1668-1676.

Foy CG, Vitolins MZ, Case LD, Harris SJ, Massa-Fanale C, Hopley RJ, Gardner L, Rudiger N, Yamamoto K, Swain B, Goff DC Jr, Danhauer SC, Booth D, Gaspari J. Incorporating prosocial behavior to promote physical activity in older adults: rationale and design of the Program for Active Aging and Community Engagement (PACE). Contemp Clin Trials. 2013;36(1):284-297.

Danhauer SC, Case LD, Tedeschi R, Russell G, Vishnevsky T, Triplett K, Ip EH, Avis NE. Predictors of posttraumatic growth in women with breast cancer. Psychooncology. 2013;22(12):2676-2683.

Attia M, Sink KM, Higgins A, Yacoub G, Case D, Klepin H, Lawrence JA. CNS tools and oncology: feasibility of cognition assessment prior to initial chemotherapy in an oncology clinic [abstract]. Gerontologist. 2013;53(Suppl 1):321-322.

Miller DP, Denizard-Thompson NM, Wofford JL, Babcock D, Weaver KE, Case LD, Spangler J, Pignone M. Ipad-based patient education and data collection for colorectal cancer screening [abstract]. J Gen Intern Med. 2013;28(Suppl 1):S245-S246.

Miller DP, Duren-Winfield V, Wofford JL, Pignone M, Case LD. The feasibility of computer assisted instruction for low literacy patients [abstract]. J Gen Intern Med. 2013;28(Suppl 1):S202.

Colonna SV, Case LD, Lawrence JA. A retrospective review of the metabolic syndrome in women diagnosed with breast cancer and correlation with estrogen receptor. Breast Cancer Res Treat. 2012;131(1):325-331.

Sergeant S, Hugenschmidt CE, Rudock ME, Ziegler JT, Ivester P, Ainsworth HC, Vaidya D, Case LD, Langefeld CD, Freedman BI, Bowden DW, Mathias RA, Chilton FH. Differences in arachidonic acid levels and fatty acid desaturase (FADS) gene variants in African Americans and European Americans with diabetes or the metabolic syndrome. Br J Nutr. 2012;107(4):547-555.

Monjazeb AM, Ayala D, Jensen C, Case LD, Bourland JD, Ellis TL, McMullen KP, Chan MD, Tatter SB, Lesser GJ, Shaw EG. A phase I dose escalation study of hypofractionated IMRT field-in-field boost for newly diagnosed glioblastoma multiforme. Int J Radiat Oncol Biol Phys. 2012;82(2):743-748.

Yi-Frazier JP, Hood K, Case D, Waitzfelder B, Anderson A, Bloch CA, Naughton M, Seid M, Imperatore G, Loots B, Bell R, Lawrence JM. Caregiver reports of provider recommended frequency of blood glucose monitoring and actual testing frequency for youth with type 1 diabetes. Diabetes Res Clin Pract. 2012;95(1):68-75.

Ruiz J, Case D, Enevold G, Rosdhal R, Tatter SB, Ellis TL, McQuellon RP, McMullen KP, Stieber VW, Shaw EG, Lesser GJ. A phase II trial of thalidomide and procarbazine in adult patients with recurrent or progressive malignant gliomas. J Neurooncol. 2012;106(3):611-617.

Sohl SJ, Levine B, Case LD, Avis NE. Trajectories of illness intrusiveness domains following a diagnosis of breast cancer [abstract]. Ann Behav Med. 2012;43(Suppl 1):S76.

Akman SA, Adams M, Case D, Park G, Manderville RA. Mutagenicity of ochratoxin A and its hydroquinone metabolite in the SupF gene of the mutation reporter plasmid Ps189. Toxins. 2012;4(4):267-280.

Sams K, Case LD, Lesser GJ, Naughton MJ, Williford SK, Giguere JK, Garino A, Vitolins M, Shaw EG. Comparing three validated methods of patient self-reported fatigue in a prospective randomized clinical trial [abstract]. J Clin Oncol. 2012;30(15 Suppl):Abstr 9108.

Attia A, Rapp SR, Case LD, D'Agostino R, Lesser G, Naughton M, McMullen K, Rosdhal R, Shaw EG. Phase II study of Ginkgo biloba in irradiated brain tumor patients: effect on cognitive function, quality of life, and mood. J Neurooncol. 2012;109(2):357-363.

High KP, Case D, Hurd D, Powell B, Lesser G, Falsey AR, Siegel R, Metzner-Sadurski J, Krauss JC, Chinnasami B, Sanders G, Rousey S, Shaw EG. A randomized, controlled trial of Panax quinquefolius extract (CVT-E002) to reduce respiratory infection in patients with chronic lymphocytic leukemia. J Support Oncol. 2012;10(5):195-201.

Avis NE, Levine B, Naughton MJ, Case DL [sic] [Case LD], Naftalis E, Van Zee KJ. Explaining age-related differences in depression following breast cancer diagnosis and treatment. Breast Cancer Res Treat. 2012;136(2):581-591.

Vern-Gross TZ, Lawrence JA, Case LD, McMullen KP, Bourland JD, Metheny-Barlow LJ, Ellis TL [deceased], Tatter SB, Shaw EG, Urbanic JJ, Chan MD. Breast cancer subtype affects patterns of failure of brain metastases after treatment with stereotactic radiosurgery. J Neurooncol. 2012;110(3):381-388.

Imperatore G, Boyle JP, Thompson TJ, Case D, Dabelea D, Hamman RF, Lawrence JM, Liese AD, Liu LL, Mayer-Davis EJ, Rodriguez BL, Standiford D. Projections of type 1 and type 2 diabetes burden in the U.S. population aged greater than 20 years through 2050: dynamic modeling of incidence, mortality, and population growth. Diabetes Care. 2012;35(12):2515-2520.

Peiffer AM, Case D, Shaw EG, Rapp S. Magnetic resonance imaging associates with differences in neurocognitive performance for cancer survivors complaining of cognitive deficits following brain irradiation [abstract]. Neuro Oncol. 2012;14(Suppl 6):63.

Sergeant S, Lee TC, Ivester P, Ainsworth HC, Case LD, Chilton FH. Botanical oil supplementation alters insulin levels in diabetic/metabolic syndrome subjects in a genotypic-specific manner [abstract]. FASEB J. 2012;26(Meeting Abstracts Suppl):647.11.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Larry D. Case, Ph.D.

Larry D. Case, Ph.D.

Professor, Biostatistical Sciences

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