Profile

Larry D. Case, Ph.D.

Larry D. Case, Ph.D.

Professor, Department of Biostatistics
Comprehensive Cancer Center

Contact Information

Academic: 336-716-1048 | Department: 336-716-2011

Email: dcase@wakehealth.edu

Education & Training

  • Ph.D., University of North Carolina-Chapel Hill , 1987
  • B.S., University of North Carolina-Chapel Hill , 1978
  • M.S.P.H., University of North Carolina-Chapel Hill , 1981

Memberships

  • Soc Of Clinical Trial Research
  • Am Statistical Assn
  • Biometric Society
Larry D. Case, Ph.D.

Larry D. Case, Ph.D.

Professor, Department of Biostatistics Comprehensive Cancer Center

Research Interests

health services, research/outc, mental disorders/psychiatry/ps, statistics/mathematics

Contact Information

Academic: 336-716-1048 | Department: 336-716-2011

Email: dcase@wakehealth.edu

Recent Publications

Weaver KE, Geiger AM, Lu L, Case LD. Rural-urban disparities in health status among US cancer survivors. Cancer. 2013;119(5):1050-1057.

Mahler SA, Hiestand BC, Nwanaji-Enwerem J, Goff DC, Burke GL, Douglas Case L, Nicks B, Miller CD. Reduction in observation unit length of stay with coronary computed tomography angiography depends on time of emergency department presentation. Acad Emerg Med. 2013;20(3):231-239.


Sergeant S, Hugenschmidt CE, Rudock ME, Ziegler JT, Ivester P, Ainsworth HC, Vaidya D, Case LD, Langefeld CD, Freedman BI, Bowden DW, Mathias RA, Chilton FH. Differences in arachidonic acid levels and fatty acid desaturase (FADS) gene variants in African Americans and European Americans with diabetes or the metabolic syndrome. Br J Nutr. 2012;107(4):547-555.

Monjazeb AM, Ayala D, Jensen C, Case LD, Bourland JD, Ellis TL, McMullen KP, Chan MD, Tatter SB, Lesser GJ, Shaw EG. A phase I dose escalation study of hypofractionated IMRT field-in-field boost for newly diagnosed glioblastoma multiforme. Int J Radiat Oncol Biol Phys. 2012;82(2):743-748.

Yi-Frazier JP, Hood K, Case D, Waitzfelder B, Anderson A, Bloch CA, Naughton M, Seid M, Imperatore G, Loots B, Bell R, Lawrence JM. Caregiver reports of provider recommended frequency of blood glucose monitoring and actual testing frequency for youth with type 1 diabetes. Diabetes Res Clin Pract. 2012;95(1):68-75.

Ruiz J, Case D, Enevold G, Rosdhal R, Tatter SB, Ellis TL, McQuellon RP, McMullen KP, Stieber VW, Shaw EG, Lesser GJ. A phase II trial of thalidomide and procarbazine in adult patients with recurrent or progressive malignant gliomas. J Neurooncol. 2012;106(3):611-617.

Sohl SJ, Levine B, Case LD, Avis NE. Trajectories of illness intrusiveness domains following a diagnosis of breast cancer [abstract]. Ann Behav Med. 2012;43(Suppl 1):S76.

Akman SA, Adams M, Case D, Park G, Manderville RA. Mutagenicity of ochratoxin A and its hydroquinone metabolite in the SupF gene of the mutation reporter plasmid Ps189. Toxins. 2012;4(4):267-280.

Sams K, Case LD, Lesser GJ, Naughton MJ, Williford SK, Giguere JK, Garino A, Vitolins M, Shaw EG. Comparing three validated methods of patient self-reported fatigue in a prospective randomized clinical trial [abstract]. J Clin Oncol. 2012;30(15 Suppl):Abstr 9108.

Attia A, Rapp SR, Case LD, D'Agostino R, Lesser G, Naughton M, McMullen K, Rosdhal R, Shaw EG. Phase II study of Ginkgo biloba in irradiated brain tumor patients: effect on cognitive function, quality of life, and mood. J Neurooncol. 2012;109(2):357-363.

High KP, Case D, Hurd D, Powell B, Lesser G, Falsey AR, Siegel R, Metzner-Sadurski J, Krauss JC, Chinnasami B, Sanders G, Rousey S, Shaw EG. A randomized, controlled trial of Panax quinquefolius extract (CVT-E002) to reduce respiratory infection in patients with chronic lymphocytic leukemia. J Support Oncol. 2012;10(5):195-201.

Avis NE, Levine B, Naughton MJ, Case DL [sic] [Case LD], Naftalis E, Van Zee KJ. Explaining age-related differences in depression following breast cancer diagnosis and treatment. Breast Cancer Res Treat. 2012;136(2):581-591.

Vern-Gross TZ, Lawrence JA, Case LD, McMullen KP, Bourland JD, Metheny-Barlow LJ, Ellis TL [deceased], Tatter SB, Shaw EG, Urbanic JJ, Chan MD. Breast cancer subtype affects patterns of failure of brain metastases after treatment with stereotactic radiosurgery. J Neurooncol. 2012;110(3):381-388.

Imperatore G, Boyle JP, Thompson TJ, Case D, Dabelea D, Hamman RF, Lawrence JM, Liese AD, Liu LL, Mayer-Davis EJ, Rodriguez BL, Standiford D. Projections of type 1 and type 2 diabetes burden in the U.S. population aged greater than 20 years through 2050: dynamic modeling of incidence, mortality, and population growth. Diabetes Care. 2012;35(12):2515-2520.

Peiffer AM, Case D, Shaw EG, Rapp S. Magnetic resonance imaging associates with differences in neurocognitive performance for cancer survivors complaining of cognitive deficits following brain irradiation [abstract]. Neuro Oncol. 2012;14(Suppl 6):63.

Sergeant S, Lee TC, Ivester P, Ainsworth HC, Case LD, Chilton FH. Botanical oil supplementation alters insulin levels in diabetic/metabolic syndrome subjects in a genotypic-specific manner [abstract]. FASEB J. 2012;26(Meeting Abstracts Suppl):647.11.

Naughton M, Van Zee K, Naftalis E, Paskett E, Sukumvanich P, Corum C, Case LD. Mental health status after breast cancer treatment: a longitudinal assessment of survivors diagnosed prior to age 40 [abstract]. Breast. 2012;21(Suppl 1):S17.


Miller DP Jr, Spangler JG, Case LD, Goff DC Jr, Singh S, Pignone MP. Effectiveness of a web-based colorectal cancer screening patient decision aid: a randomized controlled trial in a mixed-literacy population. Am J Prev Med. 2011;40(6):608-615.

Butler SG, Stuart A, Case LD, Rees C, Vitolins M, Kritchevsky SB. Effects of liquid type, delivery method, and bolus volume on penetration-aspiration scores in healthy older adults during flexible endoscopic evaluation of swallowing. Ann Otol Rhinol Laryngol. 2011;120(5):288-295.

Miller C, Hwang W, Case D, Hoekstra JW, Lefebvre C, Blumstein H, Hamilton CA, Harper EN, Hundley WG. In emergency department patients with acute chest pain, stress cardiac MRI observation unit care reduces 1-year cardiac-related health care expenditures: a randomized trial [abstract]. J Am Coll Cardiol. 2011;57(14 Suppl 1):E1187.

Mathias RA, Sergeant S, Hugenschmidt CE, Ziegler JT, Ivester P, Case D, Freedman BI, Rudock ME, Langefeld CD, Bowden DW, Chilton FH, et al. The impact of FADS genetic variants on omega-6 polyunsaturated fatty acid metabolism in African Americans. BMC Genet. 2011;12():article 50.

Reynolds K, Liese AD, Anderson AM, Dabelea D, Standiford D, Daniels SR, Waitzfelder B, Case D, Loots B, Imperatore G, et al. Prevalence of tobacco use and association between cardiometabolic risk factors and cigarette smoking in youth with type 1 or type 2 diabetes mellitus. J Pediatr. 2011;158(4):594-601.

Soliman EZ, Prineas RJ, Case LD, Russell G, Rosamond W, Rea T, Sotoodehnia N, Post WS, Siscovick D, Burke GL, et al. Electrocardiographic and clinical predictors separating atherosclerotic sudden cardiac death from incident coronary heart disease. Heart. 2011;97(19):1597-1601.

Miller CD, Hwang W, Case D, Hoekstra JW, Lefebvre C, Blumstein H, Hamilton CA, Harper EN, Hundley WG. Stress CMR imaging observation unit in the emergency department reduces 1-year medical care costs in patients with acute chest pain: a randomized study for comparison with inpatient care. JACC Cardiovasc Imaging. 2011;4(8):862-870.

Waitzfelder B, Pihoker C, Klingensmith G, Case D, Anderson A, Bell RA, Lawrence JM, Mayer-Davis EJ, Imperatore G, Standiford D, et al. Adherence to guidelines for youths with diabetes mellitus. Pediatrics. 2011;128(3):531-538.

Vern-Gross TZ, McMullen KP, Case LD, Bourland JD, Ellis TL, Lawrence JA, Tatter SB, Shaw EG, Urbanic JJ, Chan MD. Patterns of failure in patients receiving gamma knife radiosurgery for breast carcinoma to the brain [abstract]. Int J Radiat Oncol Biol Phys. 2011;81(2 Suppl):S216-S217.

Vern-Gross TZ, McMullen KP, Case LD, Bourland JD, Ellis TL, Lawrence JA, Tatter SB, Shaw EG, Urbanic JJ, Chan MD. Patterns of failure in patients receiving gamma knife radiosurgery for breast carcinoma to the brain [abstract]. Neuro Oncol. 2011;13(Suppl 3):127.

Lesser GJ, Case LD, Mirlohi S, Harmon M, Chan M, Duncan S, Dietrich A. Taste and smell abnormalities (TSA) in patients with newly diagnosed malignant gliomas (MG) treated with combined modality therapy (CMT) [abstract]. J Clin Oncol. 2011;29(15 Suppl):e19646.

Heitz CR, Gaillard JP, Blumstein H, Case D, Messick C, Miller CD. Performance of the maximum modified early warning score to predict the need for higher care utilization among admitted emergency department patients. J Hosp Med. 2010;5(1):E46-E52.

Attia A, Case LD, D'Agostino R Jr, Lesser GJ, McMullen K, Naughton MJ, Rapp SR, Rosdhal R, Shaw EG. Phase II study of ginkgo biloba in irradiated brain tumor survivors: effects on quality of life (QOL), mood, and cognitive function [abstract]. J Clin Oncol. 2010;28(Suppl):e12523.

Rapp SR, Case LD, Loghin ME, Meyers CA, Saphner TJ, Sleckman BG, Stieber VW, Atkins JN, Giguere JK, Shaw EG. Correlation of cognitive symptoms with cognitive performance among brain cancer patients after radiation therapy [abstract]. J Clin Oncol. 2010;28(Suppl 7):abstr 2084.

Case LD, Naughton MJ, Lesser GJ, Rapp SR, Vitolins M, Sheidler VR, Enevold GL, Shaw EG. Recruitment and retention in the Wake Forest University CCOP Research Base [abstract]. J Clin Oncol. 2010;28(Suppl):e19543.

Naughton MJ, Case LD, Meyers CA, Loghin ME, Shaw EG, Saphner TJ, Sleckman BG, Giguere JK, Lesser GJ, Rapp SR. Quality of life (QOL) and cognitive performance among irradiated brain cancer patients [abstract]. J Clin Oncol. 2010;28(Suppl 7):abstr 9131.

Lesser GJ, Case LD, Stark N, Williford SK, Giguere JK, Garino A, Naughton MJ, Vitolins M, Lively M, Shaw EG. A randomized double-blind placebo-controlled study of oral coenzyme Q10 to relieve self-reported cancer-treatment-related fatigue in newly diagnosed breast cancer patients [abstract]. J Clin Oncol. 2010;28(15 Suppl):9006.

Vitolins M, Lesser GJ, Case LD, Williford SK, Giguere JK, Garino A, Naughton MJ, Lively M, Melin SA, Shaw EG. Self-reported compliance compared to biomarker levels of vitamin E in breast cancer patients participating in a CoQ10 clinical trial [abstract]. J Clin Oncol. 2010;28(15 Suppl):e19524.

High KP, Case LD, Siegel RD, Metzner-Sidurski J, Krauss JC, Chinnasami B, Sanders GH, Rousey S, Lesser GJ, Shaw EG. A phase III randomized, double-blind, placebo controlled trial of North American (NA) ginseng (Panax quinquefolium) extract (CVT-E002) in patients with chronic lymphocytic leukemia: effect on respiratory infection and antibiotic use [abstract]. J Clin Oncol. 2010;28(15 Suppl):6578.

Kaminski JP, Case D, Howard-McNatt M, Geisinger KR, Levine EA. Intraoperative imprint cytology of sentinel nodes in patients with breast cancer--costly or cost effective? [abstract]. Ann Surg Oncol. 2010;17(Suppl 1):S49.

Yi-Frazier JP, Waitzfelder B, Case D, Anderson A, Naughton M, Seid M, Bloch C, Bell R, Sadler M, Loots B, et al. Diabetes self-care recommendations and behaviors among youth with type 1 diabetes [abstract]. Ann Behav Med. 2010;39(Suppl 1):14.

Tegeler CJ, Grange RW, Bogan DJ, Markert CD, Case D, Kornegay JN, Childers MK. Eccentric contractions induce rapid isometric torque drop in dystrophin-deficient dogs. Muscle Nerve. 2010;42(1):130-132.

Sukumvanich P, Case LD, Van Zee K, Singletary SE, Paskett ED, Petrek JA, Naftalis E, Naughton MJ. Incidence and time course of bleeding after long-term amenorrhea after breast cancer treatment: a prospective study. Cancer. 2010;116(13):3102-3111.

Miller CD, Hwang W, Hoekstra JW, Case D, Lefebvre C, Blumstein H, Hiestand B, Hamilton CA, Harper EN, Hundley WG, et al. Stress cardiac magnetic resonance imaging with observation unit care reduces cost for patients with emergent chest pain: a randomized trial. Ann Emerg Med. 2010;56(3):209-219.

Kaminski JP, Case D, Howard-McNatt M, Geisinger KR, Levine EA. Sentinel lymph node intraoperative imprint cytology in patients with breast cancer--costly or cost effective?. Ann Surg Oncol. 2010;17(11):2920-2925.

Lawrence JM, Hood K, Anderson A, Yi-Frazier JP, Case LD, Dabelea D, Bell R, Williams DE, McKeown R. Longitudinal associations between depressive symptoms and glycaemic control among adolescents and young adults with type 1 or type 2 diabetes [abstract]. Diabetologia. 2010;53(Suppl 1):A933.

Vitolins MZ, Case LD, Morgan TM, Miller MA, Burke GL. Soy use and vasomotor symptoms: Soy Estrogen Alternative follow-up study. Int J Womens Health. 2010;2():381-386.

Ivester P, Sergeant S, Danhauer SC, Case LD, Lamb A, Chilton BG, Delar B, Hollingshead ML, Weaver KL, Chilton FH. Effect of a multifaceted, church-based wellness program on metabolic syndrome in 41 overweight or obese congregants. Prev Chronic Dis. 2010;7(4):A81.


Weaver KL, Ivester P, Seeds M, Case LD, Arm JP, Chilton FH. Effect of dietary fatty acids on inflammatory gene expression in healthy humans. J Biol Chem. 2009;284(23):15400-7.

Miller DP, Spangler JG, Case LD, Singh S, Pignone MP. The effectiveness of a literacy-sensitive web-based colorectal cancer screening patient decision aid [abstract]. J Gen Intern Med. 2009;24(Suppl 1):183.

Stroud N, Mazwi TML, Case LD, Brown RD Jr, Brott TG, Worrall BB, Meschia JF. Prestroke physical activity and early functional status after stroke. J Neurol Neurosurg Psychiatry. 2009;80(9):1019-1022.

Matarin M, Brown WM, Dena H, Britton A, De Vrieze FW, Brott TG, Brown RD Jr, Worrall BB, Case LD, Chanock SJ, et al. Candidate gene polymorphisms for ischemic stroke. Stroke. 2009;40(11):3436-3442.

Kahn HS, Morgan TM, Case LD, Dabelea D, Mayer-Davis EJ, Lawrence JM, Marcovina SM, Imperatore G. Association of type 1 diabetes with month of birth among U.S. youth: the SEARCH for Diabetes in Youth Study. Diabetes Care. 2009;32(11):2010-2015.

Gallahan WC, Case D, Bloomfeld RS. An analysis of the placebo effect in Crohn's disease over time. Aliment Pharmacol Ther. 2009;31(1):102-107.

Colonna S, Case D, Lawrence J. Correlation of the metabolic syndrome with estrogen receptor negative breast cancer in a retrospective review [abstract]. Cancer Res. 2009;69(24 Suppl 3):612S-613S.

Butler SG, Stuart A, Williamson J, Kritchevsky S, Case D, Rees C. Swallowing dysfunction is unrecognized in community-dwelling older adults [abstract]. Gerontologist. 2009;49(Suppl 2):173.

Miller CD, Hwang W, Case D, Lefebvre C, Hiestand B, Diercks DB, Hamilton CA, Harper EN, Hoekstra JW, Hundley WG. Stress cardiac MRI in an observation unit setting reduces index hospitalization cost in ED patients with chest pain at intermediate risk for acute coronary syndromes [abstract]. Circulation. 2009;120(18 Suppl 2):S337.

Miller CD, Hwang W, Hoekstra JW, Lefebvre C, Case D, Hundley WG. Randomized comparison of observation unit plus stress cardiac MRI and hospital admission [abstract]. J Cardiovasc Magn Reson. 2009;11(Suppl 1):0103.

Van Emburgh BO, Hu JJ, Levine EA, Mosley LJ, Case LD, Lin H-Y, Knight SN, Perrier ND, Willingham MC, Miller MS, et al. Polymorphisms in drug metabolism genes, smoking, and p53 mutations in breast cancer. Mol Carcinog. 2008;47(2):88-99.

Chen DT, Case LD, Brott TG, Brown RD Jr, Silliman SL, Meschia JF, Worrall BB. Impact of restricting enrollment in stroke genetics research to adults able to provide informed consent. Stroke. 2008;39(3):831-837.

Demark-Wahnefried W, Case LD, Blackwell K, Marcom PK, Kraus W, Aziz N, Snyder DC, Giguere JK, Shaw E. Results of a diet/exercise feasibility trial to prevent adverse body composition change in breast cancer patients on adjuvant chemotherapy. Clin Breast Cancer. 2008;8(1):70-79.

Hodges SJ, Zhou G, Deng F-M, Aboushwareb T, Turner C, Andersson K-E, Santago P, Case D, Sun T-T, Christ GJ. Voiding pattern analysis as a surrogate for cystometric evaluation in uroplakin II knockout mice. J Urol. 2008;179(5):2046-2051.

Matarin M, Simon-Sanchez J, Fung H-C, Scholz S, Gibbs JR, Hernandez DG, Crews C, Britton A, De Vrieze FW, Case LD, et al. Structural genomic variation in ischemic stroke. Neurogenetics. 2008;9(2):101-108.


Dall'Armellina E, Morgan TM, Ntim W, Carr JJ, Hamilton CA, Hoyle J, Clark H, Clark P, Link KM, Case D, Hundley WG, et al. Prediction of cardiac events in patients with reduced left ventricular ejection fraction with dobutamine cardiovascular magnetic resonance assessment of wall motion score index. J Am Coll Cardiol. 2008;52(4):279-286.


Monjazeb AM, Bourland JD, Case LD, Ellis TL, Lesser GJ, McMullen KP, Munley M, Tatter SB, Shaw EG. A phase I dose escalation study of IMRT field-in-field boost for newly diagnosed glioblastoma multiforme (GBM) [abstract]. Int J Radiat Oncol Biol Phys. 2008;72(1 Suppl 1):S227.

Gallahan W, Case D, Bloomfeld R. Placebo is becoming more effective in Crohn's disease [abstract]. Am J Gastroenterol. 2008;103(Suppl):S420-S421.


Lesser GJ, Case D, Ottery F, McQuellon R, Choksi JK, Sanders G, Rosdhal R, Shaw EG. A phase III randomized study comparing the effects of oxandrolone (Ox) and megestrol acetate (Meg) on lean body mass (LBM), weight (wt) and quality of life (QOL) in patients with solid tumors and weight loss receiving chemotherapy [abstract]. J Clin Oncol. 2008;26(15 Suppl Pt I):505s.

Miller AA, Case D, Harmon M, Savage P, Lesser G, Hurd D, Melin SA. Phase I study of lenalidomide in solid tumors. J Thorac Oncol. 2007;2(5):445-449.

Easler J, Fennimore B, Farmer M, Yacoub J, Geisinger K, Aklilu M, Blackstock W, Case D, Levine E, Mishra G. Molecular profiling with MIB-1 correlates with microscopic evidence of residual disease in patients undergoing neoadjuvant therapy for esophageal cancer (EC) [abstract]. Gastroenterology. 2007;132(4 Suppl 2):A854.

Paskett ED, Naughton MJ, McCoy TP, Case LD, Abbott JM. The epidemiology of arm and hand swelling in premenopausal breast cancer survivors. Cancer Epidemiol Biomarkers Prev. 2007;16(4):775-782.

Lesser GJ, Stieber V, Case D, Enevold G, Rosdhal R, Tatter S, Ellis T, McMullen K, Shaw E. A phase II trial of thalidomide (Thal) and procarbazine (Pro) in adults with recurrent or progressive malignant gliomas (MG) [abstract]. J Clin Oncol. 2007;25(18 Suppl Pt I):91s.

Matarin M, Brown WM, Scholz S, Simon-Sanchez J, Fung H-C, Hernandez D, Gibbs JR, Langefeld CD, Case LD, Rich SS, et al. A genome-wide genotyping study in patients with ischaemic stroke: initial analysis and data release. Lancet Neurol. 2007;6(5):414-420.


Case LD, Ambrosius WT. Power and sample size. Methods Mol Biol. 2007;404():377-408.

Gleason JF Jr, Case D, Rapp SR, Ip E, Naughton M, Butler JM Jr, McMullen K, Stieber V, Saconn P, Shaw EG. Symptom clusters in patients with newly-diagnosed brain tumors. J Support Oncol. 2007;5(9):427-33,436.

Kirk JK, Bertoni AG, Case D, Bell RA, Goff DC Jr, Narayan KMV. Predicted risk of coronary heart disease among persons with type 2 diabetes. Coron Artery Dis. 2007;18(8):595-600.

Butler JM Jr, Case LD, Frizzell B, Lesser G, McMullen K, McQuellon R, Naughton M, Rapp S, Stieber V, Shaw EG, et al. A phase III, double-blind, placebo-controlled prospective randomized clinical trial of d-threo-methylphenidate HCl in brain tumor patients receiving radiation therapy. Int J Radiat Oncol Biol Phys. 2007;69(5):1496-1501.

Blackstock AW, Mornex F, Partensky C, Descos L, Case LD, Melin SA, Levine EA, Mishra G, Limentani SA, Kachnic LA, et al. Adjuvant gemcitabine and concurrent radiation for patients with resected pancreatic cancer: a phase II study. Br J Cancer. 2006;95(3):260-265.

Meschia JF, Barrett KM, Chukwudelunzu F, Brown WM, Case LD, Kissela BM, Brown RD Jr, Brott TG, Olson TS, Rich SS, et al. Interobserver agreement in the Trial of Org 10172 in acute stroke treatment classification of stroke based on retrospective medical record review. J Stroke Cerebrovasc Dis. 2006;15(6):266-272.

Meschia JF, Case LD, Worrall BB, Brown RD Jr, Brott TG, Frankel M, Silliman S, Rich SS. Family history of stroke and severity of neurologic deficit after stroke. Neurology. 2006;67(8):1396-1402.


Miller AA, Case D, Atkins JN, Giguere JK, Bearden JD. Phase II study of carboplatin, irinotecan, and thalidomide in patients with advanced non-small cell lung cancer. J Thorac Oncol. 2006;1(8):832-836.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Department of Biostatistics

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