Michael D. Chan, M.D.Wake Forest Baptist Health

Doctor Rating

4.8 out of 5

175 Ratings

Michael D. Chan, M.D.

Associate Professor,

Clinical Interests

Brain Tumors

Contact Information

Returning Patient Appointments: 336-713-3600
Department: 336-713-3600


Insurance Accepted »

Education & Training

  • B.A., Johns Hopkins University, 1998
  • M.D., New York University School of Medicine, 2004

Board Certifications

  • American Board of Radiology, Radiation Oncology

NPI Number

  • 1225151152
Michael D. Chan, M.D.

Doctor Rating

4.8 out of 5

175 Ratings

Michael D. Chan, M.D.

Associate Professor, Radiation Oncology

Research Interests

Radiosurgery; Brain Neoplasms; Trigeminal Neuralgia; Radiotherapy; Multiple Sclerosis
More »

Contact Information

Academic: 336-713-3600 | Department: 336-713-3600


Recent Publications

Biology and treatment of metastasis of sarcoma to the brain. Ahmad O, Chan M, Savage P, Watabe K, Lo HW, Qasem S.. Front Biosci (Elite Ed). 2016;8():233-244.

Recent advances in radiosurgical management of brain metastases. Devoid HM, McTyre ER, Page BR, Metheny-Barlow L, Ruiz J, Chan MD.. Front Biosci (Schol Ed). 2016;8():203-214.

Treatment of brain metastases of lung cancer in the era of precision medicine. Haughton ME, Chan MD, Watabe K, Bonomi M, Debinski W, Lesser GJ, Ruiz J.. Front Biosci (Elite Ed). 2016;8():219-232.

Targeting the sonic hedgehog signaling pathway: review of smoothened and GLI inhibitors. Rimkus TK, Carpenter RL, Qasem S, Chan M, Lo HW.. Cancers (Basel). 2016;8(2):E22.

Emerging indications for fractionated gamma knife radiosurgery. McTyre E, Helis CA, Farris M, Wilkins L, Sloan D, Hinson WH, Bourland JD, Dezarn WA, Munley MT, Watabe K, Xing F, Laxton AW, Tatter SB, Chan MD.. Neurosurgery. 2016;():.

Pseudo progression identification of glioblastoma with dictionary learning. Zhang J, Yu H, Qian X, Liu K, Tan H, Yang T, Wang M, Li KC, Chan MD, Debinski W, Paulsson A, Wang G, Zhou X.. Comput Biol Med. 2016;73():94-101.

Identification of biomarkers for pseudo and true progression of GBM based on radiogenomics study. Qian X, Tan H, Zhang J, Liu K, Yang T, Wang M, Debinskie W, Zhao W, Chan MD, Zhou X.. Oncotarget. 2016;7(34):55377-94.

Activation of the c-Met pathway mobilizes an inflammatory network in the brain microenvironment to promote brain metastasis of breast cancer. Xing F, Liu Y, Sharma S, Wu K, Chan MD, Lo HW, Carpenter RL, Metheny-Barlow LJ, Zhou X, Qasem SA, Pasche B, Watabe K.. Cancer Res. 2016;76(17):4970-4980.

Repeat stereotactic radiosurgery as salvage therapy for locally recurrent brain metastases previously treated with radiosurgery. McKay WH, McTyre ER, Okoukoni C, Alphonse-Sullivan NK, Ruiz J, Munley MT, Qasem S, Lo HW, Xing F, Laxton AW, Tatter SB, Watabe K, Chan MD.. J Neurosurg. 2016;():.

Predictors of neurologic and nonneurologic death in patients with brain metastasis initially treated with upfront stereotactic radiosurgery without whole-brain radiation therapy. McTyre ER, Johnson AG, Ruiz J, Isom S, Lucas JT Jr, Hinson WH, Watabe K, Laxton AW, Tatter SB, Chan MD.. Neuro Oncol. 2016;():.

Brain metastasis velocity: a novel prognostic metric predictive of overall survival and freedom from whole-brain radiation therapy after upfront radiosurgery alone for brain metastases [abstract]. Farris M, McTyre E, Hughes RT, Ayala-Peacock DN, Randolph DM II, Bourland JD, Tatter SB, Laxton AW, Watabe K, Ruiz J, Li W, Zhou X, Chan MD.. Int J Radiat Oncol Biol Phys. 2016;96(2 Suppl):S180.

Outcomes for metastatic melanoma treated with stereotactic radiosurgery in the era of targeted systemic therapies [abstract]. Henson A, McTyre E, Ayala-Peacock DN, Triozzi P, Savage P, Laxton AW, Chan MD.. Int J Radiat Oncol Biol Phys. 2016;96(2 Suppl):E135-E136.

Multi-institutional competing risks analysis predicting distant brain failure and salvage patterns after upfront radiosurgery without whole-brain radiation therapy for brain metastasis [abstract]. McTyre E, Ayala-Peacock DN, Contessa JN, Chung C, Fiveash JB, Ahluwalia M, Kotecha R, Chao ST, Attia A, Hepel JT, Braunstein SE, Chan MD.. Int J Radiat Oncol Biol Phys. 2016;96(2 Suppl):S180-S181.

Hippocampal dosimetry predicts for cancer-related cognitive impairment in patients treated with cranial radiation therapy: dosimetric results of a prospective clinical trial [abstract]. Okoukoni C, McTyre E, Peiffer AM, Hinson W, Strowd RE, Rapp S, Chan MD.. Int J Radiat Oncol Biol Phys. 2016;96(2 Suppl):S90-S91.

Toxicity results of a phase 1 safety study of pioglitazone as a cytoprotective agent against radiation-induced cognitive decline [abstract]. Sullivan NA, Page BR, Peiffer AM, Isom S, Metheny-Barlow L, Brown DR, Blackstock AW, Chan MD.. Int J Radiat Oncol Biol Phys. 2016;96(2 Suppl):E595.

Genomic predictors of imaging response and survival in glioblastoma [abstract]. Soike M, McTyre E, Holmes JA, Paulsson AK, Miller L, Lesser GJ, Strowd RE, Johnson A, Lo HW, Laxton AW, Tatter SB, Debinski W, Chan MD.. Int J Radiat Oncol Biol Phys. 2016;96(2 Suppl):E121-E122.

A phase II clinical trial of CPI-613 in patients with relapsed or refractory small cell lung carcinoma. Lycan TW, Pardee TS, Petty WJ, Bonomi M, Alistar A, Lamar ZS, Isom S, Chan MD, Miller AA, Ruiz J.. PLoS One. 2016;11(10):e0164244.

Local control of brain metastases after stereotactic radiosurgery: the impact of whole brain radiotherapy and treatment paradigm. Hughes RT, Black PJ, Page BR, Lucas JT, Qasem SA, Watabe K, Ruiz J, Laxton AW, Tatter SB, Debinski W, Chan MD.. J Radiosurg SBRT. 2016;4(2):89-96.

Predictors of trigeminal nerve dysfunction following stereotactic radiosurgery for trigeminal neuralgia. Lucas JT, Huang AJ, Bourland JD, Laxton AW, Tatter SB, Chan MD.. J Radiosurg SBRT. 2016;4(2):117-123.

Impact of timing of radiotherapy in patients with newly diagnosed glioblastoma. Randolph DM II, McTyre ER, Paulsson AK, Holmes JA, Hinson WH, Lesser GJ, Strowd R, Lo HW, Laxton AW, Tatter SB, Debinski W, Chan MD.. Clin Neurol Neurosurg. 2016;151():73-78.

Induction of robust type-I CD8+ T-cell responses in WHO grade 2 low-grade glioma patients receiving peptide-based vaccines in combination with poly-ICLC. Okada H, Butterfield LH, Hamilton RL, Hoji A, Sakaki M, Ahn BJ, Kohanbash G, Drappatz J, Engh J, Amankulor N, Lively MO, Chan MD, Salazar AM, Shaw EG, Potter DM, Lieberman FS.. Clin Cancer Res. 2015;21(2):286-294.

Tumor resection with carmustine wafer placement as salvage therapy after local failure of radiosurgery for brain metastasis. Mu F, Lucas JT Jr, Watts JM, Johnson AJ, Daniel Bourland J, Laxton AW, Chan MD, Tatter SB.. J Clin Neurosci. 2015;22(3):561-565.

Roles of the cyclooxygenase 2-matrix metalloproteinase 1 pathway in brain metastasis of breast cancer. Wu K, Fukuda K, Xing F, Zhang Y, Sharma S, Liu Y, Chan M, Zhou X, Qasem S, Pochampally R, Mo YY, Watabe K.. J Biol Chem. 2015;290(15):9842-9854.

Gamma Knife radiosurgery for meningiomas in patients with neurofibromatosis Type 2. Liu A, Kuhn EN, Lucas JT Jr, Laxton AW, Tatter SB, Chan MD.. J Neurosurg. 2015;122(3):536-542.

Anaplastic ganglioglioma: a report of three cases and review of the literature. Lucas JT Jr, Huang AJ, Mott RT, Lesser GJ, Tatter SB, Chan MD.. J Neurooncol. 2015;123(1):171-177.

Donepezil for irradiated brain tumor survivors: a phase III randomized placebo-controlled clinical trial. Rapp SR, Case LD, Peiffer A, Naughton MM [sic] [Naughton MJ], Chan MD, Stieber VW, Moore DF Jr, Falchuk SC, Piephoff JV, Edenfield WJ, Giguere JK, Loghin ME, Shaw EG.. J Clin Oncol. 2015;33(15):1653-1659.

Phase II double-blind placebo-controlled randomized study of armodafinil for brain radiation-induced fatigue. Page BR, Shaw EG, Lu L, Bryant D, Grisell D, Lesser GJ, Monitto DC, Naughton MJ, Rapp SR, Savona SR, Shah S, Case D, Chan MD.. Neuro Oncol. 2015;17(10):1393-1401.

Recent technical advances and indications for radiation therapy in low-grade glioma. Chan MD.. Semin Radiat Oncol. 2015;25(3):189-196.

Competing risk analysis of neurologic versus nonneurologic death in patients undergoing radiosurgical salvage after whole-brain radiation therapy failure: who actually dies of their brain metastases?. Lucas JT Jr, Colmer HG IV, White L, Fitzgerald N, Isom S, Bourland JD, Laxton AW, Tatter SB, Chan MD.. Int J Radiat Oncol Biol Phys. 2015;92(5):1008-1015.

Impact of systemic targeted agents on the clinical outcomes of patients with brain metastases. Johnson AG, Ruiz J, Hughes R, Page BR, Isom S, Lucas JT, McTyre ER, Houseknecht KW, Ayala-Peacock DN, Bourland DJ, Hinson WH, Laxton AW, Tatter SB, Debinski W, Watabe K, Chan MD.. Oncotarget. 2015;6(22):18945-55.

Repeat radiosurgery for trigeminal neuralgia. Helis CA, Lucas JT Jr, Bourland JD, Chan MD, Tatter SB, Laxton AW.. Neurosurgery. 2015;77(5):755-761.

Immunologic response to high-dose influenza vaccination in patients with primary central nervous system malignancy (PCNSM) [abstract]. Strowd RE, Russell G, Harmon M, Carter AF, Chan MD, Tatter SB, Laxton AW, High K, Lesser G.. J Clin Oncol. 2015;33(15 Suppl):e20669.

Factors that determine local control with gamma knife radiosurgery: the role of primary histology. Black PJ, Page BR, Lucas JT Jr, Hughes RT, Laxton AW, Tatter SB, Munley MT, Chan MD.. J Radiosurg SBRT. 2015;3(4):281-286.

Genomic predictors of patterns of progression in glioblastoma and possible influences on radiation field design. Holmes JA, Paulsson AK, Page BR, Miller LD, Liu W, Xu J, Hinson WH, Lesser GJ, Laxton AW, Tatter SB, Debinski W, Chan MD.. J Neurooncol. 2015;124(3):447-453.

A multi-institutional analysis of patients treated with stereotactic radiosurgery for brain metastases from radioresistant histologies [abstract]. Smith CA, McTyre E, Isom S, Kennedy VE, Luo G, Morales-Paliza M, Hinson W, Cmelak AJ, Tatter SB, Chan MD, Attia A.. Int J Radiat Oncol Biol Phys. 2015;93(3):E87-E88.

A competing risks analysis assessing predictors of neurologic and non-neurologic death in patients with brain metastasis initially treated with upfront stereotactic radiosurgery without whole-brain radiation therapy [abstract]. McTyre E, Johnson A, Ruiz J, Isom S, Lucas JT Jr, Hinson W, Watabe K, Laxton AW, Tatter SB, Chan MD.. Int J Radiat Oncol Biol Phys. 2015;93(3 Suppl):S176.

Outcomes for anaplastic glioma treated with radiation therapy with or without concurrent temozolomide [abstract]. McTyre E, Lucas JT Jr, Helis C, Farris M, Houseknecht K, Mott R, Laxton AW, Tatter SB, Lesser GJ, Chan MD.. Int J Radiat Oncol Biol Phys. 2015;93(3 Suppl):E108.

Multi-institutional nomogram predicting survival free from salvage whole-brain radiation after radiosurgery for brain metastases [abstract]. Gorovets D, Ayala-Peacock DN, Tybor DJ, Rava PS, Ebner DK, Chan MD, Hepel JT.. Int J Radiat Oncol Biol Phys. 2015;93(3 Suppl):E77.

A comprehensive assessment of radiographic, clinical, and treatment related risk factors for metastasis related intracranial hemorrhage in metastatic melanoma following radiation therapy [abstract]. Lucas JT Jr, Lack C, Wagner B, Kuremsky JG, Mu F, Chan MD, Sweeney A, Maldjian J, Whitlow C.. Int J Radiat Oncol Biol Phys. 2015;93(3 Suppl):E111.

Impact of socioeconomic status on brain metastasis outcomes at a large academic radiosurgery center [abstract]. Houseknecht K, Taksler GB, Johnson A, Page BR, Hinson W, Laxton AW, Tatter SB, Weaver KE, Chan MD, Ruiz J.. Int J Radiat Oncol Biol Phys. 2015;93(3 Suppl):E366.

The peroxisomal proliferator-activated receptor (PPAR) alpha agonist, fenofibrate, prevents fractionated whole-brain irradiation-induced cognitive impairment. Greene-Schloesser D, Payne V, Peiffer AM, Hsu FC, Riddle DR, Zhao W, Chan MD, Metheny-Barlow L, Robbins ME [deceased].. Radiat Res. 2014;181(1):33-44.

Clinical and economic outcomes of patients with brain metastases based on symptoms: an argument for routine brain screening of those treated with upfront radiosurgery. Lester SC, Taksler GB, Kuremsky JG, Lucas JT Jr, Ayala-Peacock DN, Randolph DM II, Bourland JD, Laxton AW, Tatter SB, Chan MD.. Cancer. 2014;120(3):433-441.

Local control and toxicity outcomes in brainstem metastases treated with single fraction radiosurgery: is there a volume threshold for toxicity?. Kilburn JM, Ellis TL [deceased], Lovato JF, Urbanic JJ, Bourland JD, Munley MT, Deguzman AF, McMullen KP, Shaw EG, Tatter SB, Chan MD.. J Neurooncol. 2014;117(1):167-174.

Single-institution retrospective series of gamma knife radiosurgery in the treatment of multiple sclerosis-related trigeminal neuralgia: factors that predict efficacy. Weller M, Marshall K, Lovato JF, Bourland JD, deGuzman AF, Munley MT, Shaw EG, Tatter SB, Chan MD.. Stereotact Funct Neurosurg. 2014;92(1):53-58.

Predictive nomogram for the durability of pain relief from gamma knife radiation surgery in the treatment of trigeminal neuralgia. Lucas JT Jr, Nida AM, Isom S, Marshall K, Bourland JD, Laxton AW, Tatter SB, Chan MD.. Int J Radiat Oncol Biol Phys. 2014;89(1):120-126.

Limited margins using modern radiotherapy techniques does not increase marginal failure rate of glioblastoma. Paulsson AK, McMullen KP, Peiffer AM, Hinson WH, Kearns WT, Johnson AJ, Lesser GJ, Ellis TL, Tatter SB, Debinski W, Shaw EG, Chan MD.. Am J Clin Oncol. 2014;37(2):177-181.

Influenza vaccine immunogenicity in patients with primary central nervous system malignancy. Strowd RE, Swett K, Harmon M, Carter AF, Pop-Vicas A, Chan M, Tatter SB, Ellis T [deceased], Blevins M, High K, Lesser GJ.. Neuro Oncol. 2014;16(12):1639-1644.

A nomogram for predicting distant brain failure in patients treated with gamma knife stereotactic radiosurgery without whole brain radiotherapy. Ayala-Peacock DN, Peiffer AM, Lucas JT, Isom S, Kuremsky JG, Urbanic JJ, Bourland JD, Laxton AW, Tatter SB, Shaw EG, Chan MD.. Neuro Oncol. 2014;16(9):1283-1288.

Predictors of survival, neurologic death, local failure, and distant failure after gamma knife radiosurgery for melanoma brain metastases. Neal MT, Chan MD, Lucas JT Jr, Loganathan A, Dillingham C, Pan E, Stewart JH IV, Bourland JD, Shaw EG, Tatter SB, Ellis TL.. World Neurosurg. 2014;82(6):1250-1255.

Local control and results of Leksell Gamma Knife therapy for the treatment of uveal melanoma. Joye RP, Williams LB, Chan MD, Witkin AJ, Schirmer CM, Mignano JE, Wazer DE, Yao KC, Wu JK, Duker JS.. Ophthalmic Surg Lasers Imaging Retina. 2014;45(2):125-131.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Associate Professor, Radiation Oncology

Clinical Interests

Brain Tumors
Michael D. Chan, M.D.

Michael D. Chan, M.D.

Associate Professor, Radiation Oncology

Doctor Rating

4.8 out of 5

Michael D. Chan, M.D.175 Ratings


Doctor Ratings

The overall Patient Rating score is the average of responses to the nine questions listed below. The questions are from the Press Ganey Patient Satisfaction Survey. Responses are measured on a 1 to 5 scale, where 1 represents "very poor" and 5 represents "very good."
Press Ganey Patient Satisfaction Survey

CP concern for questions/worries
CP efforts to include in decisions
CP explanations of prob/condition
CP spoke using clear language
Friendliness/courtesy of CP
Likelihood of recommending CP
Patients' confidence in CP
Time CP spent with patient
Wait time at clinic

Patient Comments

Comments are taken from the Care Provider section of the Press Ganey Patient Satisfaction Survey. Comments are posted exactly as they are written. Comments are added weekly. To protect patient privacy and confidentiality, patient names are not included.


All went well.


My experience with *Dr. Chas has been excellent!


Dr. Chan is very respected by me and my family I would recommend to everyone


I have recommended Dr. Chan and all my doctors at the Comprehensive Cancer Center without fail. I want EVERYONE who suffers from cancer to have the opportunity to be cared for by this most amazing team of medical professionals. God used them in mighty ways to save my life. I love them all like family.


Dr. Chan saw that I was very sick and helped get me a hospital bed even though I was being admitted to another Dr's service.


good experience


Even though you have bad news, they are so nice and make you feel it will be OK - *Dr. Chan is EXCELLENT!


*Dr. Chan was very nice and willing to answer questions that I had. He couldn't been any nicer. Thank you.


very good and uplifting


Dr. Chan was very reassuring and knowledgeable...awesome Dr




*Dr. Chan very professional & easy going. Makes patient to be relaxed & comfortable to communicate with. (PBC)


Very compassionate and answered all of our questions


Very good.


Everything went very well.





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