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Michael D. Chan, M.D.Wake Forest Baptist Health

Doctor Rating

4.8 out of 5

156 Ratings

Michael D. Chan, M.D.

Associate Professor,

Clinical Interests

Brain Tumors

Contact Information

Returning Patient Appointments: 336-713-3600
Department: 336-713-3600


Insurance Accepted »

Education & Training

  • B.A., Johns Hopkins University, 1998
  • M.D., New York University School of Medicine, 2004

Board Certifications

  • American Board of Radiology, Radiation Oncology

NPI Number

  • 1225151152
Michael D. Chan, M.D.

Doctor Rating

4.8 out of 5

156 Ratings

Michael D. Chan, M.D.

Associate Professor, Radiation Oncology

Research Interests

Radiosurgery; Brain Neoplasms; Glioblastoma; Meningioma; Trigeminal Neuralgia
More »

Contact Information

Academic: 336-713-3600 | Department: 336-713-3600


Recent Publications

Use of non-ionizing electromagnetic fields for the treatment of cancer. Jimenez H, Blackman C, Lesser G, Debinski W, Chan M, Sharma S, Watabe K, Lo HW, Thomas A, Godwin D, Blackstock W, Mudry A, Posey J, O'Connor R, Brezovich I, Bonin K, Kim-Shapiro D, Barbault A, Pasche B.. Front Biosci (Landmark Ed). 2018;23():284-297.

Emerging indications for fractionated gamma knife radiosurgery. McTyre E, Helis CA, Farris M, Wilkins L, Sloan D, Hinson WH, Bourland JD, Dezarn WA, Munley MT, Watabe K, Xing F, Laxton AW, Tatter SB, Chan MD.. Neurosurgery. 2017;80(2):210-216.

Repeat stereotactic radiosurgery as salvage therapy for locally recurrent brain metastases previously treated with radiosurgery. McKay WH, McTyre ER, Okoukoni C, Alphonse-Sullivan NK, Ruiz J, Munley MT, Qasem S, Lo HW, Xing F, Laxton AW, Tatter SB, Watabe K, Chan MD.. J Neurosurg. 2017;127(1):148-156.

Predictors of neurologic and nonneurologic death in patients with brain metastasis initially treated with upfront stereotactic radiosurgery without whole-brain radiation therapy. McTyre ER, Johnson AG, Ruiz J, Isom S, Lucas JT Jr, Hinson WH, Watabe K, Laxton AW, Tatter SB, Chan MD.. Neuro Oncol. 2017;19(4):558-566.

Multi-institutional nomogram predicting survival free from salvage whole brain radiation after radiosurgery in patients with brain metastases. Gorovets D, Ayala-Peacock D, Tybor DJ, Rava P, Ebner D, Cielo D, Noren G, Wazer DE, Chan M, Hepel JT.. Int J Radiat Oncol Biol Phys. 2017;97(2):246-253.

Stereotactic radiosurgical treatment of glomus jugulare tumors. Winford TW, Dorton LH, Browne JD, Chan MD, Tatter SB, Oliver ER.. Otol Neurotol. 2017;38(4):555-562.

Gamma Knife radiosurgery for brain metastases from gastrointestinal primary. Page BR, Wang EC, White L, McTyre E, Peiffer A, Alistar A, Mu F, Loganathan A, Bourland JD, Laxton AW, Tatter SB, Chan MD.. J Med Imaging Radiat Oncol. 2017;61(4):522-527.

Outcomes for anaplastic glioma treated with radiation therapy with or without concurrent temozolomide. McTyre E, Lucas JT, Helis C, Farris M, Soike M, Mott R, Laxton AW, Tatter SB, Lesser GJ, Strowd RE, Lo HW, Debinski W, Chan MD.. Am J Clin Oncol. 2017;():.

The evolving role for re-irradiation in the management of recurrent grade 4 glioma. Howard SP, Krauze A, Chan MD, Tsien C, Tome WA.. J Neurooncol. 2017;134(3):523-530.

The effects of smoking status and smoking history on patients with brain metastases from lung cancer. Shenker RF, McTyre ER, Ruiz J, Weaver KE, Cramer C, Alphonse-Sullivan NK, Farris M, Petty WJ, Bonomi MR, Watabe K, Laxton AW, Tatter SB, Warren GW, Chan MD.. Cancer Med. 2017;6(5):944-952.

Leptomeningeal failure in patients with breast cancer receiving stereotactic radiosurgery for brain metastases. Wang EC, Huang AJ, Huang KE, McTyre ER, Lo HW, Watabe K, Metheny-Barlow L, Laxton AW, Tatter SB, Strowd RE, Chan MD, Page BR.. J Clin Neurosci. 2017;43():6-10.

Combined inhibition of AKT and HSF1 suppresses breast cancer stem cells and tumor growth. Carpenter RL, Sirkisoon S, Zhu D, Rimkus T, Harrison A, Anderson A, Paw I, Qasem S, Xing F, Liu Y, Chan M, Metheny-Barlow L, Pasche BC, Debinski W, Watabe K, Lo HW.. Oncotarget. 2017;8(43):73947-63.

Prediction of new brain metastases after radiosurgery: validation and analysis of performance of a multi-institutional nomogram. Ayala-Peacock DN, Attia A, Braunstein SE, Ahluwalia MS, Hepel J, Chung C, Contessa J, McTyre E, Peiffer AM, Lucas JT Jr, Isom S, Pajewski NM, Kotecha R, Stavas MJ, Page BR, Kleinberg L, Shen C, Taylor RB, Onyeuku NE, Hyde AT, Gorovets D,.. J Neurooncol. 2017;135(2):403-411.

Stereotactic radiosurgery in the treatment of brain metastases from gynecologic primary cancer. Johnston H, McTyre ER, Cramer CK, Lesser GJ, Ruiz J, Bourland JD, Watabe K, Lo HW, Qasem S, Laxton AW, Tatter SB, Chan MD.. J Radiosurg SBRT. 2017;5(1):55-61.

Impact of radiosurgical management of geriatric patients with brain metastases: clinical and quality of life outcomes. Randolph DM, McTyre E, Klepin H, Peiffer AM, Ayala-Peacock D, Lester S, Laxton AW, Dohm A, Tatter SB, Shaw EG, Chan MD.. J Radiosurg SBRT. 2017;5(1):35-42.

Early or late radiotherapy following gross or subtotal resection for atypical meningiomas: clinical outcomes and local control. Dohm A, McTyre ER, Chan MD, Fan C, Isom S, Bourland JD, Mott RT, Cramer CK, Tatter SB, Laxton AW.. J Clin Neurosci. 2017;46():90-98.

Staged stereotactic radiosurgery for large brain metastases: local control and clinical outcomes of a one-two punch technique. Dohm A, McTyre ER, Okoukoni C, Henson A, Cramer CK, LeCompte MC, Ruiz J, Munley MT, Qasem S, Lo HW, Xing F, Watabe K, Laxton AW, Tatter SB, Chan MD.. Neurosurgery. 2017;():.

DBF 2.0: A web-based predictive model for distant brain failure, brain metastasis velocity, and early death after radiosurgery for brain metastases [abstract]. Henson A, Ayala-Peacock DN, Chung C, Hepel JT, Chao ST, Contessa JN, Fiveash JB, Attia A, McTyre E, Braunstein SE, Page BR, Shen C, Kleinberg LR, Watabe K, Pasche B, D'Agostino R Jr, Chan MD.. Int J Radiat Oncol Biol Phys. 2017;99(2 Suppl):E78-E79.

Clinical outcomes of upfront stereotactic radiosurgery alone for patients with greater than 4 brain metastases [abstract]. Hughes RT, McTyre E, LeCompte MC, Cramer CK, Munley MT, Laxton A, Tatter SB, Ruiz J, Pasche B, Watabe K, Chan MD.. Int J Radiat Oncol Biol Phys. 2017;99(2 Suppl):E80-E81.

Survival and failure outcomes predicted by brain metastasis kinetics following initial distant brain failure in melanoma patients treated upfront with stereotactic radiosurgery alone [abstract]. LeCompte MC, McTyre E, Henson A, Farris M, Okoukoni C, Cramer CK, Triozzi P, Munley MT, Qasem S, Xing F, Watabe K, Laxton A, Tatter SB, Chan MD.. Int J Radiat Oncol Biol Phys. 2017;99(2 Suppl):E86-E87.

Multi-institutional validation of brain metastasis velocity, a recently defined predictor of outcomes following stereotactic radiosurgery [abstract]. McTyre E, Farris M, Ayala-Peacock DN, Page BR, Shen C, Kleinberg LR, Contessa JN, Chung C, Ruiz J, Pasche B, Watabe K, Fiveash JB, Hepel JT, Chao ST, Braunstein SE, Attia A, Chan MD.. Int J Radiat Oncol Biol Phys. 2017;99(2 Suppl):E93.

Using a novel machine learning technique to predict brain metastasis velocity following stereotactic radiosurgery for brain metastases [abstract]. Muhlestein W, Farris M, McTyre E, Pajewski NM, Attia A, Chambless LB, Braunstein SE, Hepel JT, Chung C, Contessa JN, Chao ST, Fiveash JB, Chan MD, Ayala-Peacock DN.. Int J Radiat Oncol Biol Phys. 2017;99(2 Suppl):E96.

Drivers of the cost of management in patients treated with radiosurgery without whole brain radiation therapy for brain metastases [abstract]. Shenker RF, McTyre E, Cramer CK, Munley MT, Ruiz J, Watabe K, Pasche B, Laxton A, Tatter SB, Chan MD.. Int J Radiat Oncol Biol Phys. 2017;99(2 Suppl):E414-E415.

Using a novel machine learning technique to predict radiation oncology outcomes [abstract]. Muhlestein W, Chambless LB, Pajewski NM, Braunstein SE, Hepel JT, Chung C, Contessa JN, Chao ST, Fiveash JB, Attia A, Chan MD, Ayala-Peacock DN.. Int J Radiat Oncol Biol Phys. 2017;99(2 Suppl):E422-E423.

Determination of tumor gene expression in non-small cell lung cancer patients who develop brain metastasis diagnosis: analysis of a prospective trial [abstract]. Dohm AE, Su J, McTyre E, Soike M, Miller LD, Petty WJ, Xing F, Lo HW, Metheny-Barlow L, Watabe K, Chan MD, Ruiz J, Pasche B.. Int J Radiat Oncol Biol Phys. 2017;99(2 Suppl):E453.

Stereotactic radiosurgery for multiple sclerosis associated trigeminal neuralgia [abstract]. Helis CA, McTyre E, Munley MT, Bourland JD, Cramer CK, Laxton A, Tatter SB, Chan MD.. Int J Radiat Oncol Biol Phys. 2017;99(2 Suppl):E512-E513.

Initial brain metastasis velocity: does the rate at which cancers first seed the brain affect outcomes? [abstract]. Soike M, McTyre E, Farris M, Hughes RT, Cramer CK, LeCompte MC, Ruiz J, Bourland JD, Munley MT, Laxton A, Tatter SB, Chan MD.. Int J Radiat Oncol Biol Phys. 2017;99(2 Suppl):S170.

Expert consensus on re-irradiation for recurrent glioma. Krauze A, Attia A, Braunstein S, Chan M, Combs S, Fietkau R, Fiveash J, Flickinger J, Grosu A, Howard S, Nieder C, Niyazi M, Rowe L, Smart DD, Tsien C, Camphausen K.. Radiat Oncol. 2017;12(1):194.

Biology and treatment of metastasis of sarcoma to the brain. Ahmad O, Chan M, Savage P, Watabe K, Lo HW, Qasem S.. Front Biosci (Elite Ed). 2016;8():233-244.

Recent advances in radiosurgical management of brain metastases. Devoid HM, McTyre ER, Page BR, Metheny-Barlow L, Ruiz J, Chan MD.. Front Biosci (Schol Ed). 2016;8():203-214.

Treatment of brain metastases of lung cancer in the era of precision medicine. Haughton ME, Chan MD, Watabe K, Bonomi M, Debinski W, Lesser GJ, Ruiz J.. Front Biosci (Elite Ed). 2016;8():219-232.

Targeting the sonic hedgehog signaling pathway: review of smoothened and GLI inhibitors. Rimkus TK, Carpenter RL, Qasem S, Chan M, Lo HW.. Cancers (Basel). 2016;8(2):E22.

Pseudo progression identification of glioblastoma with dictionary learning. Zhang J, Yu H, Qian X, Liu K, Tan H, Yang T, Wang M, Li KC, Chan MD, Debinski W, Paulsson A, Wang G, Zhou X.. Comput Biol Med. 2016;73():94-101.

Identification of biomarkers for pseudo and true progression of GBM based on radiogenomics study. Qian X, Tan H, Zhang J, Liu K, Yang T, Wang M, Debinskie W, Zhao W, Chan MD, Zhou X.. Oncotarget. 2016;7(34):55377-94.

Activation of the c-Met pathway mobilizes an inflammatory network in the brain microenvironment to promote brain metastasis of breast cancer. Xing F, Liu Y, Sharma S, Wu K, Chan MD, Lo HW, Carpenter RL, Metheny-Barlow LJ, Zhou X, Qasem SA, Pasche B, Watabe K.. Cancer Res. 2016;76(17):4970-4980.

Brain metastasis velocity: a novel prognostic metric predictive of overall survival and freedom from whole-brain radiation therapy after upfront radiosurgery alone for brain metastases [abstract]. Farris M, McTyre E, Hughes RT, Ayala-Peacock DN, Randolph DM II, Bourland JD, Tatter SB, Laxton AW, Watabe K, Ruiz J, Li W, Zhou X, Chan MD.. Int J Radiat Oncol Biol Phys. 2016;96(2 Suppl):S180.

Outcomes for metastatic melanoma treated with stereotactic radiosurgery in the era of targeted systemic therapies [abstract]. Henson A, McTyre E, Ayala-Peacock DN, Triozzi P, Savage P, Laxton AW, Chan MD.. Int J Radiat Oncol Biol Phys. 2016;96(2 Suppl):E135-E136.

Multi-institutional competing risks analysis predicting distant brain failure and salvage patterns after upfront radiosurgery without whole-brain radiation therapy for brain metastasis [abstract]. McTyre E, Ayala-Peacock DN, Contessa JN, Chung C, Fiveash JB, Ahluwalia M, Kotecha R, Chao ST, Attia A, Hepel JT, Braunstein SE, Chan MD.. Int J Radiat Oncol Biol Phys. 2016;96(2 Suppl):S180-S181.

Hippocampal dosimetry predicts for cancer-related cognitive impairment in patients treated with cranial radiation therapy: dosimetric results of a prospective clinical trial [abstract]. Okoukoni C, McTyre E, Peiffer AM, Hinson W, Strowd RE, Rapp S, Chan MD.. Int J Radiat Oncol Biol Phys. 2016;96(2 Suppl):S90-S91.

Toxicity results of a phase 1 safety study of pioglitazone as a cytoprotective agent against radiation-induced cognitive decline [abstract]. Sullivan NA, Page BR, Peiffer AM, Isom S, Metheny-Barlow L, Brown DR, Blackstock AW, Chan MD.. Int J Radiat Oncol Biol Phys. 2016;96(2 Suppl):E595.

Genomic predictors of imaging response and survival in glioblastoma [abstract]. Soike M, McTyre E, Holmes JA, Paulsson AK, Miller L, Lesser GJ, Strowd RE, Johnson A, Lo HW, Laxton AW, Tatter SB, Debinski W, Chan MD.. Int J Radiat Oncol Biol Phys. 2016;96(2 Suppl):E121-E122.

A phase II clinical trial of CPI-613 in patients with relapsed or refractory small cell lung carcinoma. Lycan TW, Pardee TS, Petty WJ, Bonomi M, Alistar A, Lamar ZS, Isom S, Chan MD, Miller AA, Ruiz J.. PLoS One. 2016;11(10):e0164244.

Local control of brain metastases after stereotactic radiosurgery: the impact of whole brain radiotherapy and treatment paradigm. Hughes RT, Black PJ, Page BR, Lucas JT, Qasem SA, Watabe K, Ruiz J, Laxton AW, Tatter SB, Debinski W, Chan MD.. J Radiosurg SBRT. 2016;4(2):89-96.

Predictors of trigeminal nerve dysfunction following stereotactic radiosurgery for trigeminal neuralgia. Lucas JT, Huang AJ, Bourland JD, Laxton AW, Tatter SB, Chan MD.. J Radiosurg SBRT. 2016;4(2):117-123.

Impact of timing of radiotherapy in patients with newly diagnosed glioblastoma. Randolph DM II, McTyre ER, Paulsson AK, Holmes JA, Hinson WH, Lesser GJ, Strowd R, Lo HW, Laxton AW, Tatter SB, Debinski W, Chan MD.. Clin Neurol Neurosurg. 2016;151():73-78.

Stratification of pseudoprogression and true progression of glioblastoma multiform based on longitudinal diffusion tensor imaging without segmentation. Qian X, Tan H, Zhang J, Zhao W, Chan MD, Zhou X.. Med Phys. 2016;43(11):5889.

Upfront chemoradiotherapy in grade 2 low grade glioma, a single institution experience [abstract]. Wicks RT, Bandarage D, Mott RT, Strowd RE, Laxton AW, Tatter SB, Chan MD, Lesser GJ.. Neuro Oncol. 2016;18(Suppl 6):14.

Induction of robust type-I CD8+ T-cell responses in WHO grade 2 low-grade glioma patients receiving peptide-based vaccines in combination with poly-ICLC. Okada H, Butterfield LH, Hamilton RL, Hoji A, Sakaki M, Ahn BJ, Kohanbash G, Drappatz J, Engh J, Amankulor N, Lively MO, Chan MD, Salazar AM, Shaw EG, Potter DM, Lieberman FS.. Clin Cancer Res. 2015;21(2):286-294.

Tumor resection with carmustine wafer placement as salvage therapy after local failure of radiosurgery for brain metastasis. Mu F, Lucas JT Jr, Watts JM, Johnson AJ, Daniel Bourland J, Laxton AW, Chan MD, Tatter SB.. J Clin Neurosci. 2015;22(3):561-565.

Roles of the cyclooxygenase 2-matrix metalloproteinase 1 pathway in brain metastasis of breast cancer. Wu K, Fukuda K, Xing F, Zhang Y, Sharma S, Liu Y, Chan M, Zhou X, Qasem S, Pochampally R, Mo YY, Watabe K.. J Biol Chem. 2015;290(15):9842-9854.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Associate Professor, Radiation Oncology

Clinical Interests

Brain Tumors
Michael D. Chan, M.D.

Michael D. Chan, M.D.

Associate Professor, Radiation Oncology

Doctor Rating

4.8 out of 5

Michael D. Chan, M.D.156 Ratings


Doctor Ratings

The overall Patient Rating score is the average of responses to the nine questions listed below. The questions are from the Press Ganey Patient Satisfaction Survey. Responses are measured on a 1 to 5 scale, where 1 represents "very poor" and 5 represents "very good."
Press Ganey Patient Satisfaction Survey

CP concern for questions/worries
CP efforts to include in decisions
CP explanations of prob/condition
CP spoke using clear language
Friendliness/courtesy of CP
Likelihood of recommending CP
Patients' confidence in CP
Time CP spent with patient
Wait time at clinic

Patient Comments

Comments are taken from the Care Provider section of the Press Ganey Patient Satisfaction Survey. Comments are posted exactly as they are written. Comments are added weekly. To protect patient privacy and confidentiality, patient names are not included.


Excellent staff, everybody who saw me that day treated me well and with a lot of care and concern


Dr. Chan was very courteous and was very helpful in everything . He was the first Dr. to encourage me with things going on .


Dr. Chan was helpful in a problem I was having. He is very understanding and compassionate.


Dr. Chan is the best!


*Dr. Chan is very thorough doctor - He is very _____ and caring. He treats you as a person not a number!


*Dr. Chan is a wonderful doctor. He is always very kind also his staff. I am bless to have him as my doctor.


A very professional care provider.We would recommend him to anyone.


Dr Chan and his team are awesome. Dr Chan is probably the only person I do trust. he's been honest and up front with me about my condition from day 1. I adore him


very good


Dr. Chan was very professional and informative.


Dr Chan is definitely the A team at Winston Salem


Dr Chan was exceptional throughout.


Dr. Chan is caring and compassionate.


*Dr. Chan has been a wonderful partner in my health with cancer.


I find *Doctor Chan to be very professional and caring provider. He seems concerned about his patient care and strives to do the best for them.


We are very blessed to him at Baptist. *Dr. Michael Chan. 5. All of them. 9. He's the best. 10. We will.

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