Profile

Mark C. Chappell, Ph.D.Wake Forest School of Medicine

Mark C. Chappell, Ph.D.

Professor,



Contact Information

Academic: 336-716-9236 | Department: 336-716-9236

Email: mchappel@wakehealth.edu

Education & Training

  • B.A., American University , 1983
  • Ph.D., Cleveland State University , 1993
  • Fellowship, Cardiovascular Disease, WFU School of Medicine, 1996

Memberships

  • Western Nc Chpt Soc For Neuros
  • Am Soc Biochem Molecular Bio
  • Am Heart Association
  • Am Physiological Society
  • Council For High Blood Pressur
  • Endocrine Society
Mark C. Chappell, Ph.D.

Mark C. Chappell, Ph.D.

Professor, Surgical Sciences-Hypertension
Hypertension and Vascular Research Center
Center for Diabetes Research
Physiology & Pharmacology

Research Interests

diabetes, women's health issues

Contact Information

Academic: 336-716-9236 | Department: 336-716-9236

Email: mchappel@wakehealth.edu

Recent Publications

Chappell MC, Marshall AC, Alzayadneh EM, Shaltout HA, Diz DI. Update on the angiotensin converting enzyme 2-angiotensin (1-7)-Mas receptor axis: fetal programing, sex differences, and intracellular pathways. Front Endocrinol (Lausanne). 2014;4():201.

Zhao Z, Wang H, Jessup JA, Lindsey SH, Chappell MC, Groban L. Role of estrogen in diastolic dysfunction. Am J Physiol Heart Circ Physiol. 2014;306(5):H628-H640.

Marshall AC, Shaltout HA, Pirro NT, Rose JC, Diz DI, Chappell MC. Enhanced activity of an angiotensin-(1-7) neuropeptidase in glucocorticoid-induced fetal programming. Peptides. 2014;52():74-81.


Washburn LK, Brosnihan KB, Chappell MC, Diz DI, Gwathmey TM, Nixon PA, Russell GB, Snively BM, O'Shea TM. The renin-angiotensin-aldosterone system in adolescent offspring born prematurely to mothers with preeclampsia. J Renin Angiotensin Aldosterone Syst. 2014;():.

Marshall AC, Pirro NT, Rose JC, Diz DI, Chappell MC. Evidence for an angiotensin-(1-7) neuropeptidase expressed in the brain medulla and CSF of sheep. J Neurochem. 2014;():.

Gwathmey TM, Chappell MC, Nixon PA, Washburn LK. Prenatal steroid exposure promotes expression of renal injury indices in African American females [abstract]. FASEB J. 2014;28(1 Suppl):1134.11.

Marshall A, Pirro N, Rose J, Diz D, Chappell M. Evidence for an angiotensin-(1-7) neuropeptidase in the brain medulla of sheep [abstract]. FASEB J. 2014;28(1 Suppl):1140.6.

Wilson B, Marshall A, Pirro N, Su Y, Rose J, Chappell M. Expression of an angiotensin-(1-7) endopeptidase in proximal tubules of the sheep and human kidney [abstract]. FASEB J. 2014;28(1 Suppl):1088.10.

Wilson B, Rose J, Chappell M. Functional neprilysin-angiotensin-(1-7) system within mitochondria of the sheep kidney [abstract]. FASEB J. 2014;28(1 Suppl):1088.9.


Nautiyal M, Shaltout HA, de Lima DC, do Nascimento K, Chappell MC, Diz DI. Response to angiotensin-(1-7) and bradykinin in baroreceptor reflex sensitivity in hypertension [letter]. Hypertension. 2013;61(2):e20.

Marshall AC, Shaltout HA, Nautiyal M, Rose JC, Chappell MC, Diz DI. Fetal betamethasone exposure attenuates angiotensin-(1-7)-Mas receptor expression in the dorsal medulla of adult sheep. Peptides. 2013;44(C):25-31.

Marshall AC, Shaltout HA, Pirro NT, Rose JC, Diz DI, Chappell MC. Differential expression of renin-angiotensin system components in the choroid plexus of betamethasone exposed and control sheep [abstract]. FASEB J. 2013;27(Meeting Abstracts):1107.12.

Nautiyal M, Shaltout HA, Chappell MC, Diz DI. Reduction in central mitochondrial ROS improves cardiovagal baroreflex function independent of blood pressure in (mRen2)27 rats [abstract]. FASEB J. 2013;27(Meeting Abstracts):890.4.

Chen K, Bi J, Su Y, Figueroa J, Chappell M, Rose J. Gender affects responses of renal ACE and ACE2 activity to unilateral nephrectomy [abstract]. Reprod Sci. 2013;20(3 Suppl 1A):335A.

Chen K, Bi J, Figueroa J, Chappell M, Rose J. Gender differences in effects of prenatal betamethasone exposure on sheep renal ACE and ACE2 activity: a possible mechanism in fetal programmed hypertension in males [abstract]. Reprod Sci. 2013;20(3 Suppl 1A):275A.

Gwathmey TM, Zerihun L, Simington SW, Chappell MC, Washburn LK. Antenatal betamethasone exposure increases oxidative stress in African-American adolescents born prematurely [abstract]. Circulation. 2013;127():AP241.

Lindsey SH, da Silva AS, Silva MS, Chappell MC. Reduced vasorelaxation to estradiol and G-1 in aged female and adult male rats is associated with GPR30 downregulation. Am J Physiol Endocrinol Metab. 2013;305(1):E113-E118.

Alzayadneh EM, Pirro NT, Chappell MC. Thimet oligopeptidase forms angiontensin-(1-7) in the nucleus of NRK-52E cells [abstract]. FASEB J. 2013;27():lb857.

Americao A, Pirro N, Brosnihan KB, Chappell M. Processing of angiotensinogen to angiotensin-(1-12) by a non-renin enzyme in the salt-sensitive mRen2.Lewis rat [abstract]. FASEB J. 2013;27():909.1.

Bi JL, Contag S, Su YX, Chen K, Figueroa J, Chappell M, Rose JC. Sex differences in oxidative stress following uniphrectomy in antenatal glucocorticoid exposed sheep [abstract]. FASEB J. 2013;27():733.2.

Guan MJ, Nautiyal M, Hakuda D, de Lima R, Rose J, Pirro NT, Chappell MC. Renal mitochondria predominantly express [des-Ang I]- angiotensinogen and renin [abstract]. FASEB J. 2013;27():909.5.

Schaich C, Nautiyal M, Howlett A, Chappell M, Diz D. Enhanced CB1 cannabinoid receptor tone contributes to impaired baroreflex sensitivity in hypertensive (mRen2)27 transgenic rats [abstract]. FASEB J. 2013;27():926.13.

Wang H, Jessup JA, Zhao Z, Da Silva J, Lin M, Macnamara LM, Ahmad S, Chappell MC, Ferrario CM, Groban L. Characterization of the cardiac renin angiotensin system in oophorectomized and estrogen-replete mRen2.Lewis rats. PLoS One. 2013;8(10):e76992.

Chappell MC. Of diabetic mice and ACE2: a new biomarker of renal disease? [editorial]. Am J Physiol Renal Physiol. 2013;305(7):F970-F972.

Bi J, Contag SA, Carey LC, Tang L, Valego NK, Chappell MC, Rose JC. Antenatal betamethasone exposure alters renal responses to angiotensin-(1-7) in uninephrectomized adult male sheep. J Renin Angiotensin Aldosterone Syst. 2013;14(4):290-298.

Marshall AC, Shaltout HA, Pirro NT, Rose JC, Diz DI, Chappell MC. Antenatal betamethasone exposure is associated with lower ANG-(1-7) and increased ACE in the CSF of adult sheep. Am J Physiol Regul Integr Comp Physiol. 2013;305(7):R679-R688.

Chappell MC. Differential expression of the estrogen receptors GPR30 and ERa in the kidney of the diabetic hypertensive mRen2.Lewis strain [abstract]. Hypertension. 2013;62(3 Suppl):612.

Hukuda D, de Lima H, Pirro NT, Yamaleyeva LM, Grabenauer, MA, Thomas BT, Chappell MC. Enhanced expression of the endocannabinoid 2-AG and CB-1 receptor in the kidney of the diabetic hypertensive female rat [abstract]. Hypertension. 2013;62(3 Suppl):501.

Marshall AC, Shaltout HA, Pirro NT, Rose JC, Diz DI, Chappell MC. Antenatal betamethasone exposure reduces Ang-(1-7) but enhances angiotensin-converting enzyme and a thiol peptidase to metabolize Ang-(1-7) in the cerebrospinal fluid [abstract]. Hypertension. 2013;62(3 Suppl):177.

Nautiyal M, Shaltout HA, Chappell MC, Diz DI. Combined intracerebroventricular angiotensin-(1-7) and candesartan normalizes blood pressure and improves baroreflex function in transgenic (mRen2)27 hypertensive rats [abstract]. Hypertension. 2013;62(3 Suppl):607.

Pulgar VM, Jeffers AB, Chappell MC, Aileru AA. The endothelin B receptor attenuates endothelin contraction via an endothelium independent mechanism In mesenteric arteries of (mRen2)27 rats [abstract]. Hypertension. 2013;62(3 Suppl):644.

Nautiyal M, Tommasi E, Chappell MC, Diz DI. MAP kinase phosphatase-1 inhibitor injection into the solitary tract nucleus impairs cardiovagal baroreflex function in transgenic ASrAOGEN rats [abstract]. Hypertension. 2013;62(3 Suppl):A157.

Diz DI, Schaich CL, Thomas BF, Grabenauer MA, Chappell MC, Howlett AC. Elevated endocannabinoids via CB1receptors in the solitary tract nucleus contibute to age-related impairments in baroreflex sensitivity in Sprague-Dawley rats [abstract]. In: Conference Program of the 2013 Carolina Cannabinoid Collaborative Conference; 2013 Oct 25-27; Richmond (VA). 2013;():.

Hakuda D, Thomas BF, Yamaleyeva LM, Grabenauer MA, Diz, DI, Chappell MC. Enhanced expression of 2-arachidonoylglycerol in the kidney of diabetic hypertensive rats [abstract]. In: Conference Program of the 2013 Carolina Cannabinoid Collaborative Conference; 2013 Oct 25-27; Richmond (VA). 2013;():.

Schaich CL, Howlett A, Thomas B, Grabenauer M, Chappell M, Diz D. Chronic systemic CB1 cannabinoid receptor blockade reduces weight gain and lowers blood pressure in hypertensive (mRen2)27 rats [abstract]. In: Conference Program of the 2013 Carolina Cannabinoid Collaborative Conference; 2013 Oct 25-27; Richmond (VA). 2013;():.

Schaich CL, Howlett A, Thomas B, Grabenauer M, Chappell M, Diz D. Chronic systemic CB1 cannabinoid receptor blockade reduces weight gain and lowers blood pressure in hypertensive (mRen2)27 rats [abstract]. In: Conference Program of the 2013 Carolina Cannabinoid Collaborative Conference; 2013 June 21-26; Vancouver (CA). 2013;():.


Gwathmey TM, Alzayadneh EM, Pendergrass KD, Chappell MC. Novel roles of nuclear angiotensin receptors and signaling mechanisms. Am J Physiol Regul Integr Comp Physiol. 2012;302(5):R518-R530.

Yamaleyeva LM, Lindsey SH, Varagic J, Zhang LL, Gallagher PE, Chen AF, Chappell MC. Amelioration of renal injury and oxidative stress by the nNOS inhibitor L-VNIO in the salt-sensitive mRen2.Lewis congenic rat. J Cardiovasc Pharmacol. 2012;59(6):529-538.


Marshall AC, Shaltout HA, Nautiyal M, Chappell MC, Diz DI. Fetal betamethasone exposure and age influence the expression of AT7/mas receptors in the solitary tract nucleus [abstract]. FASEB J. 2012;26(Meeting Abstracts):1101.12.

Bi J, Su Y, Figueroa J, Chappell MC, Rose JC. Impact of antenatal betamethasone (B) on p47 phox in kidney and 8-isoprostane responses to angiotensin II in proximal tubule cells in male sheep after uninephrectomy [abstract]. FASEB J. 2012;26(Meeting Abstracts):1101.10.

Yamaleyeva LM, Gilliam-Davis S, Almeida I, Brosnihan KB, Lindsey SH, Chappell MC. Differential regulation of circulating and renal ACE2 and ACE in hypertensive mRen2.Lewis rats with early-onset diabetes. Am J Physiol Renal Physiol. 2012;302(11):F1374-84.

Garcia-Espinosa MA, Shaltout HA, Gallagher PE, Chappell MC, Diz DI. In vivo expression of angiotensin-(1-7) lowers blood pressure and improves baroreflex function in transgenic (mRen2)27 rats. J Cardiovasc Pharmacol. 2012;60(2):150-157.

Harrison-Bernard LM, Chappell MC. Unraveling the glomerular RAS: one peptidase at a time [editorial]. Am J Physiol Renal Physiol. 2012;303(3):F373-374.

Nautiyal M, Shaltout HA, de Lima DC, do Nascimento K, Chappell MC, Diz DI. Central angiotensin-(1-7) improves vagal function independent of blood pressure in hypertensive (mRen2)27 rats. Hypertension. 2012;60(5):1257-1265.

Nautiyal M, Katakam PV, Busija DW, Gallagher PE, Tallant EA, Chappell MC, Diz DI. Differences in oxidative stress status and expression of MKP-1 in dorsal medulla of transgenic rats with altered brain renin-angiotensin system. Am J Physiol Regul Integr Comp Physiol. 2012;303(8):R799-806.

Gwathmey TM, Nixon P, Chappell M, Washburn L. 25-Hydroxyvitamin D and body mass index in female adolescents [abstract]. FASEB J. 2012;26(Meeting Abstracts Suppl):1093.15.

Santiago N, Melo MB, Chappell M, Varagic J, Santos RAS, Campagnole-Santos MJ. Diabetes abolishes the cardioprotective effect of estrogen on systolic cardiac function [abstract]. FASEB J. 2012;26(Meeting Abstracts Suppl):1057.23.

Chappell MC. Nonclassical renin-angiotensin system and renal function. Compr Physiol. 2012;2(4):2733-2752.

Nautiyal M, Katakam PV, Busija DW, Chappell MC, Diz DI. Increased mitochondrial oxidative stress and activate AMP-kinase in the brain dorsal medulla of hypertensive (MRenw)27 transgenic rats [abstract]. Hypertension. 2012;60(Suppl 3):622.

Marshall AC, Shaltout HA, Nautiyal M, Chappell MC, Diz DI. Fetal betamethasone exposure enhances the peptide ration of angiotensin II to angiotensin-(1-7) in the dorsal medulla of adult sheep [abstract]. Hypertension. 2012;60(Suppl 3):118.

Ahmad S, Varagic J, Westwood BM, Chappell MC, Ferrario CM. Uptake and metabolism of the novel peptide angiotensin-(1-12) by neonatal cardiac myocytes. PLoS ONE. 2011;6(1):e15759.

Gwathmey TM, Shaltout HA, Rose JC, Diz DI, Chappell MC. Glucocorticoid-induced fetal programming alters the functional complement of angiotensin receptor subtypes within the kidney. Hypertension. 2011;57(3):620-626.

Lindsey SH, Carver KA, Prossnitz ER, Chappell MC. Vasodilation in response to the GPR30 agonist G-1 is not different from estradiol in the mRen2.Lewis female rat. J Cardiovasc Pharmacol. 2011;57(5):598-603.


Jessup JA, Zhang L, Chen AF, Presley TD, Kim-Shapiro DB, Chappell MC, Wang H, Groban L. Neuronal nitric oxide synthase inhibition improves diastolic function and reduces oxidative stress in ovariectomized mRen2.Lewis rats. Menopause. 2011;18(6):698-708.

Tang L, Bi J, Chappell M, Figueroa J, Rose JC. The effect of antenatal steroid exposure on sodium uptake in ovine renal proximal tubule cells (RPTC) [abstract]. FASEB J. 2011;25(Meeting Abstracts):1029.12.

Bi J, Tang L, Figueroa J, Chappell MC, Rose JC. Antenatal betamethasone (B) and gender affect 8-isoprostane responses to unilateral nephrectomy [abstract]. FASEB J. 2011;25(Meeting Abstracts):1029.11.

Lindsey SH, Bhat M, Aileru A, Chappell M. GPR30 attenuates functional AT1 receptor expression in rat mesenteric smooth muscle cells [abstract]. FASEB J. 2011;25(Meeting Abstracts):1088.8.

Shaltout HA, Chappell MC, Rose JC, Diz DI. Exaggerated sympathetic mediated responses to behavioral or pharmacological challenges following antenatal betamethasone exposure. Am J Physiol Endocrinol Metab. 2011;300(6):E979-985.

Gilliam-Davis S, Gallagher PE, Payne VS, Kasper SO, Tommasi EN, Westwood BM, Robbins ME, Chappell MC, Diz DI. Long-term systemic angiotensin II type 1 receptor blockade regulates mRNA expression of dorsomedial medulla renin-angiotensin system components. Physiol Genomics. 2011;43(13):829-835.

Bi J, Figueroa JP, Chappell MC, Rose JC. Effect of prenatal betamethasone exposure on renal functional reserve in the young adult female sheep [abstract]. Reprod Sci. 2011;18(4 Suppl):90A.

Su Y, Shaltout HA, Figueroa JP, Chappell M, Rose JC. Effect of early glucocorticoid treatment on GR and MR expression in adult sheep kidney [abstract]. Reprod Sci. 2011;18(4 Suppl):220A.

Zhang J, Massmann AG, Chappell MC, Figueroa JP. Antenatal glucocorticoids and diet-induced obesity alter adipose tissue function [abstract]. Reprod Sci. 2011;18(4 Suppl):223A.

Lindsey SH, Yamaleyeva LM, Brosnihan KB, Gallagher PE, Chappell MC. Estrogen receptor GPR30 reduces oxidative stress and proteinuria in the salt-sensitive female mRen2.Lewis rat. Hypertension. 2011;58(4):665-671.

Bharadwaj MS, Strawn WB, Groban L, Yamaleyeva LM, Chappell MC, Horta C, Atkins K, Firmes L, Gurley SB, Brosnihan KB. Angiotensin-converting enzyme 2 deficiency is associated with impaired gestational weight gain and fetal growth restriction. Hypertension. 2011;58(5):852-858.

Ahmad S, Simmons T, Varagic J, Moniwa N, Chappell MC, Lively M, Ferrario CM. Localization and metabolism of angiotensin-(1-12) in human atrial tissue [abstract]. Hypertension. 2011;58(5):e50.

Alzayadneh EM, Bassosy H, Chappell M. Enhanced intracellular expression of nox4 and angiotensin II within the kidney of the diabetic female mRen2.Lewis rat [abstract]. Hypertension. 2011;58(5):e154.

El-Bassossy H, Lindsey SH, Yamaleyeva LM, Chappell MC. Renal GPR30 is upregulated in diabetes: association with renal protection in intact but not estrogen-depleted diabetic rats [abstract]. Hypertension. 2011;58(5):e152.

Gwathmey TM, Nixon PA, O'Shea TM, Brosnihan KB, Chappell MC, Washburn LK. Premature birth is associated with higher diastolic blood pressure and reduced vitamin D in African American adolescents [abstract]. Hypertension. 2011;58(5):e165.

Lindsey SH, da Silva A, Schaan BD, Chappell MC. GPR30-dependent relaxation of mesenteric arteries involves both nitric oxide and cyclic AMP activation of protein kinase G [abstract]. Hypertension. 2011;58(5):e180.

Lindsey SH, Yamaleyeva LM, Gallagher P, Chappell MC. GPR30 restores megalin expression in the renal cortex of salt-sensitive mRen2.Lewis females [abstract]. Hypertension. 2011;58(5):e182-e183.

Marshall A, Shaltout HA, Nautiyal M, Arter A, Chappell MC, Diz DI. Localization and regulation of angiotensin receptor subtypes in sheep solitary tract nucleus: effects of in utero exposure to glucocorticoid [abstract]. Hypertension. 2011;58(5):e75.

Muller C, Shewale S, Pirro N, Gurley SB, Brosnihan KB, Fiorino P, Chappell MC. Sex and species differences in ACE, ACE2 and neprilysin of the renal brush border [abstract]. Hypertension. 2011;58(5):e153.

Nautiyal M, Shaltout HA, Chappell MC, Diz DI. Chronic intracerebroventricular angiotensin-(1-7) infusion, but not AT1 receptor blockade, improves vagal components of the baroreflex function in hypertensive (mRen2)27 transgenic rats [abstract]. Hypertension. 2011;58(5):e96.

Santiago NM, Yamaleyeva LM, Campagnole-Santos MJ, Chappell M, Varagic J. Early diabetes is associated with lower cardiac ACE2 activity but not altered blood pressure in female hypertensive mRen2.Lewis rats [abstract]. Hypertension. 2011;58(5):e126-e127.

Shaltout HA, Rose JC, Chappell MC, Diz DI. Ang-(1-7) deficiency and impairment of baroreflex for control of heart rate precede the antenatal betamethasone exposure-induced elevation in blood pressure [abstract]. Hypertension. 2011;58(5):e76.

Yamaleyeva LM, Gilliam-Davis SM, Chappell MC. Diabetes induces circulating ACE2 in hypertensive male and female rats but does not prevent increased plasma Ang II [abstract]. Hypertension. 2011;58(5):e38-e39.

Ahmad S, Simmons T, Varagic J, Moniwa N, Chappell MC, Ferrario CM. Chymase-dependent generation of angiotensin II from angiotensin-(1-12) in human atrial tissue. PLoS ONE. 2011;6(12):e28501.



Yamaleyeva L, Bharadwaj M, Strawn W, Chappell M, Groban L, Atkins K, Horta C, Firmes L, Farah L, Gurly S, Brosnihan KB. ACE2 deficiency is associated with impaired gestational weight gain and fetal growth restriction [abstract]. Physiologist. 2011;54(6):22.

Gwathmey TM, Pendergrass KD, Reid SD, Rose JC, Diz DI, Chappell MC. Angiotensin-(1-7)-angiotensin-converting enzyme 2 attenuates reactive oxygen species formation to angiotensin II within the cell nucleus. Hypertension. 2010;55(1):166-171.

Brosnihan KB, Hering L, Dechend R, Chappell MC, Herse F. Increased angiotensin II in the mesometrial triangle of a transgenic rat model of preeclampsia. Hypertension. 2010;55(2 Pt 2):562-566.

Park S, Bivona BJ, Kobori H, Seth DM, Chappell MC, Lazartigues E, Harrison-Bernard LM. Major role for ACE-independent intrarenal ANG II formation in type II diabetes. Am J Physiol Renal Physiol. 2010;298(1):F37-F48.

Chappell MC. Does ACE2 contribute to the development of hypertension? [commentary]. Hypertens Res. 2010;33(2):107-109.

Varagic J, Ahmad S, Brosnihan KB, Groban L, Chappell MC, Tallant EA, Gallagher PE, Ferrario CM. Decreased cardiac Ang-(1-7) is associated with salt-induced cardiac remodeling and dysfunction. Ther Adv Cardiovasc Dis. 2010;4(1):17-25.

Trask AJ, Groban L, Westwood BM, Varagic J, Ganten D, Gallagher PE, Chappell MC, Ferrario CM. Inhibition of angiotensin-converting enzyme 2 exacerbates cardiac hypertrophy and fibrosis in Ren-2 hypertensive rats. Am J Hypertens. 2010;23(6):687-693.

Contag SA, Bi J, Chappell MC, Rose JC. Developmental effect of antenatal exposure to betamethasone on renal angiotensin II activity in the young adult sheep. Am J Physiol Renal Physiol. 2010;298(4):F847-F856.

Gwathmey TM, Shaltout HA, Nixon PA, Rose JC, Washburn LK, Chappell MC. Antenatal steroid exposure is associated with reduced urinary ACE2 activity in adolescents [abstract]. FASEB J. 2010;24(1 Meeting Abstracts):605.1.

Ahmad S, Varagic J, Westwood B, Chappell MC, Strawn WB, Simmons T, Ferrario CM. Chymase-dependent generation of angiotensin II from angiotensin-(1-12) in human atrial tissue [abstract]. FASEB J. 2010;24(1 Meeting Abstracts):605.4.

Gilliam S, Yamaleyeva L, Westwood B, Chappell M. Type I induced diabetes increases circulating ACE2 in male and female mRen2.Lewis hypertensive rats [abstract]. FASEB J. 2010;24(1 Meeting Abstracts):1041.2.

Westwood B, Gwathmey T, Shaltout H, Diz D, Rose J, Chappell M. Immunocytochemical distribution of the Ang-(1-7)/mas receptor in the sheep kidney [abstract]. FASEB J. 2010;24(1 Meeting Abstracts):605.6.

Tang L, Valego N, Sun X, Bi J, Carey L, Chappell M, Rose JC. Prenatal steroid exposure attenuates the nitric oxide (NO) - cyclic guanosine monophosphate (cGMP) to Ang-(1-7) in mature male sheep [abstract]. FASEB J. 2010;24(1 Meeting Abstracts):1040.4.

Lindsey SH, Yamaleyeva LM, Cohen JA, Chappell MC. GPER-1 activation reduces oxidative stress and alters renin-angiotensin system components in the kidneys of salt-sensitive mRen2.Lewis females [abstract]. FASEB J. 2010;24(1 Meeting Abstracts):1040.9.

Arter A, Nautiyal M, Shaltout H, Chappell M, Diz D. Mas and AT1 receptor expression in adult sheep dorsomedial medulla [abstract]. FASEB J. 2010;24(1 Meeting Abstracts):625.5.

Shaltout HA, Rose JC, Chappell MC, Diz DI. Modulation of baroreflex sensitivity by endogenous angiotensins in lamb solitary tract nucleus [abstract]. FASEB J. 2010;24(1 Meeting Abstracts):624.7.

Gwathmey TM, Shaltout HA, Nixon PA, Rose JC, Washburn LK, Chappell MC. Sex and racial background influence angiotensin peptide metabolism in young adults [abstract]. FASEB J. 2010;24(1 Meeting Abstracts):1024.31.

Gilliam S, Pirro N, Cohen J, Chappell M, Yamaleyeva L. Type 1 induced diabetes abolishes sex differences in proteinuria and angiotensinogen excretion in mRen2.Lewis hypertensive Rats [abstract]. FASEB J. 2010;24(1 Meeting Abstracts):812.13.

Wilson BA, Gwathmey T, Pirro N, Chappell MC. Evidence for protein kinase C dependent stimulation of reactive oxygen species in isolated nuclei of renal epithelial cells [abstract]. FASEB J. 2010;24(1 Meeting Abstracts):1059.3.

Nautiyal M, Tallant EA, Chappell MC, Diz DI. Mitogen-activated protein kinase phosphatase-1 (MKP-1) is low in dorsal medulla of hypertensive (mRen2)27 transgenic rats [abstract]. FASEB J. 2010;24(1 Meeting Abstracts):955.11.

Bi JL, Contag S, Su YX, Valego N, Massman A, Chappell MC, Rose JC. Renal angiotensinogen (AGT) gene and protein expression are icreased in adult male sheep after prenatal betamethasone (B) exposure [abstract]. Reprod Sci. 2010;17(3 Suppl):215A.

Cohen JA, Lindsey SH, Pirro NT, Brosnihan KB, Gallagher PE, Chappell MC. Influence of estrogen depletion and salt loading on renal angiotensinogen expression in the mRen(2).Lewis strain. Am J Physiol Renal Physiol. 2010;299(1):F35-F42.

Dhaunsi GS, Yousif MHM, Akhtar S, Chappell MC, Diz DI, Benter IF. Angiotensin-(1-7) prevents diabetes-induced attenuation in PPAR-gamma and catalase activities. Eur J Pharmacol. 2010;638(1-3):108-114.


Shaltout HA, Rose JC, Figueroa JP, Chappell MC, Diz DI, Averill DB. Acute AT1-receptor blockade reverses the hemodynamic and baroreflex impairment in adult sheep exposed to antenatal betamethasone. Am J Physiol Heart Circ Physiol. 2010;299(2):H541-H547.

Jessup JA, Lindsey SH, Wang H, Chappell MC, Groban L. Attenuation of salt-induced cardiac remodeling and diastolic dysfunction by the GPER agonist G-1 in female mRen2.Lewis rats. PLoS ONE. 2010;5(11):e15433.

Arnold AC, Isa K, Shaltout HA, Nautiyal M, Ferrario CM, Chappell MC, Diz DI. Angiotensin-(1-12) requires angiotensin converting enzyme and AT1 receptors for cardiovascular actions within the solitary tract nucleus. Am J Physiol Heart Circ Physiol. 2010;299(3):H763-H771.

Tang L, Bi J, Valego N, Carey L, Figueroa J, Chappell M, Rose JC. Prenatal betamethasone exposure alters renal function in immature sheep: sex differences in effects. Am J Physiol Regul Integr Comp Physiol. 2010;299(3):R793-R803.

Alzayadneh EM, Gilliam S, Chappell MC. Streptozotocin-induced diabetes is associated with upregulation of intracellular angiotensin II AT1 receptors in the rat kidney [abstract]. Hypertension. 2010;56(5):e133.

Cohen JA, Gilliam-Davis S, Chappell MC. Urinary angiotensinogen as an early marker of renal injury in the diabetic female mRen(2) Lewis rat [abstract]. Hypertension. 2010;56(5):e161.

Gilliam-Davis S, Cohen JA, Lindsey SH, Yamaleyeva L, Chappell M. The estrogen receptor GPR30 is renoprotective in diabetic hypertensive female rats [abstract]. Hypertension. 2010;56(5):e56.

Gwathmey TM, Westwood BM, Pirro NT, Tang L, Rose JC, Diz DI, Chappell MC. Nuclear angiotensin-(1-7) receptor is functionally coupled to the formation of nitric oxide. Am J Physiol Renal Physiol. 2010;299(5):F983-F990.

Nautiyal M, Katakam PV, Busija DW, Gallagher PE, Tallant EA, Chappell MC, Diz DI. Oxidative stress and low expression of mitogen-activated protein kinase phosphatase-1 (MKP-1) in dorsal medulla of hypertensive (mRen2)27 transgenic rats [abstract]. Hypertension. 2010;56(5):e156.

Santiago NM, Yamaleyeva LM, Campagnole-Santos MJ, Chappell M, Varagic J. Cardiac remodeling is associated with altered cardiac AT(1) receptor/eNOS pathway in ovariectomized mRen2 Lewis diabetic rats [abstract]. Hypertension. 2010;56(5):e81.

Shaltout HA, Rose JC, Chappell MC, Diz DI. Antenatal betamethasone exposure attenuates the functional role of angiotensin-(1-7) in the NTS [abstract]. Hypertension. 2010;56(5):e103.

Bi J, Contag S, Chappel M [sic] [Chappell M], Rose JC. Evidence that prenatal steroid exposure produces oxidative stress in the kidney in male sheep [abstract]. FASEB J. 2010;24(Meeting Abstracts):793.1.

Shaltout HA, Figueroa JP, Rose JC, Diz DI, Chappell MC. Alterations in circulatory and renal angiotensin-converting enzyme and angiotensin-converting enzyme 2 in fetal programmed hypertension. Hypertension. 2009;53(2):404-408.

Tang L, Carey LC, Bi J, Valego N, Sun X, Deibel P, Perrott J, Figueroa JP, Chappell MC, Rose JC. Gender differences in the effects of antenatal betamethasone exposure on renal function in adult sheep. Am J Physiol Regul Integr Comp Physiol. 2009;296(2):R309-317.

Ferrario CM, Varagic J, Habibi J, Nagata S, Kato J, Chappell MC, Trask AJ, Kitamura K, Whaley-Connell A, Sowers JR. Differential regulation of angiotensin-(1-12) in plasma and cardiac tissue in response to bilateral nephrectomy. Am J Physiol Heart Circ Physiol. 2009;296(4):H1184-1192.

Pendergrass KD, Gwathmey TM, Michalek RD, Grayson JM, Chappell MC. The angiotensin II-AT1 receptor stimulates reactive oxygen species within the cell nucleus. Biochem Biophys Res Commun. 2009;384(2):149-154.

Gwathmey TM, Shaltout HA, Pendergrass KD, Pirro NT, Figueroa JP, Rose JC, Diz DI, Chappell MC. Nuclear angiotensin II type 2 (AT2) receptors are functionally linked to nitric oxide production. Am J Physiol Renal Physiol. 2009;296(6):F1484-1493.

Isa K, Garcia-Espinosa MA, Arnold AC, Pirro NT, Tommasi EN, Ganten D, Chappell MC, Ferrario CM, Diz DI. Chronic immunoneutralization of brain angiotensin-(1-12) lowers blood pressure in transgenic (mRen2)27 hypertensive rats. Am J Physiol Regul Integr Comp Physiol. 2009;297(1):R111-115.

Lindsey SH, Cohen JA, Brosnihan KB, Gallagher PE, Chappell MC. Chronic treatment with the G protein-coupled receptor 30 agonist G-1 decreases blood pressure in ovariectomized mRen2.Lewis rats. Endocrinology. 2009;150(8):3753-3758.


Jia HP, Look DC, Tan P, Shi L, Hickey M, Gakhar L, Chappell MC, Wohlford-Lenane C, McCray PB Jr. Ectodomain shedding of angiotensin converting enzyme 2 in human airway epithelia. Am J Physiol Lung Cell Mol Physiol. 2009;297(1):L84-L96.

Groban L, Lin MR, Jessup JA, Chappell MC, Brunso-Bechtold JK. GH repletion increases intracardiac Ang-1-7/ACE2 and restores diastolic function in aged male BNF344 rats [abstract]. J Card Fail. 2009;15(6 Suppl 1):S33-S34.

Jessup JA, Lindsey SH, Chappell MC, Groban L. GPR30 receptor activation improves cardiac function in intact female mRen2.Lewis rats [abstract]. J Card Fail. 2009;15(6 Suppl 1):S75.

Ahmad S, Varagic J, Westwood B, Chappell MC, Ferrario CM. Uptake of novel peptide angiotensin-(1-12) by cardiac myocytes [abstract]. Hypertension. 2009;54(4):e111.

Cohen JA, Lindsey SH, Pirro NT, Chappell MC. Urinary angiotensinogen associates with estrogen and salt sensitivity [abstract]. Hypertension. 2009;54(4):e80.

Gilliam-Davis S, Tommasi EN, Garcia-Espinosa MA, Chappell MC, Brosnihan KB, Diz DI. Bilateral renal denervation prevents age-related proteinuria without altering excretion of intrarenal angiotensin peptides in Sprague-Dawley rats [abstract]. Hypertension. 2009;54(4):e76.

Gwathmey TM, Pendergrass KD, Shaltout HA, Reid SD, Rose JC, Diz DI, Chappell MC. Steroid-induced fetal programming differentially alters nuclear angiotensin II receptor expression and function [abstract]. Hypertension. 2009;54(4):e42.

Gwathmey TM, Pendergrass KD, Rose JC, Diz DI, Chappell MC. Nuclear angiotensin-(1-7) receptors mediate the production of nitric oxide [abstract]. Hypertension. 2009;54(4):e74.

Isa K, Arnold AC, Chappell MC, Diz DI. Angiotensin-converting enzyme inhibition, but not AT1 receptor blockade, in the solitary tract nucleus improves baroreflex sensitivity in anesthetized transgenic hypertensive (mRen2)27 rats [abstract]. Hypertension. 2009;54(4):e98.

Lindsey SH, Chappell MC. The GPR30 agonist G-1 induces nitric oxide-independent relaxation in resistance arteries [abstract]. Hypertension. 2009;54(4):e43.

Shaltout HA, Diz DI, Figueroa JP, Chappell MC, Rose JC. Sympathetic nervous system mediated responses to behavioral or pharmacologic challenges are exaggerated as a result of antenatal betamethasone exposure [abstract]. Hypertension. 2009;54(4):e101`.

Silberman Y, Bajo M, Chappell AM, Christian DT, Cruz M, Diaz MR, Kash T, Lack AK, McCool BA, Weiner JL, et al. Neurobiological mechanisms contributing to alcohol-stress-anxiety interactions. Alcohol. 2009;43(7):509-519.

Shaltout HA, Figueroa JP, Rose JC, Chappell MC, Averill DB, Diz DI. Antenatal betamethasone causes alterations in angiotensin receptors in sheep brain in a gender specific manner [abstract]. FASEB J. 2009;23(1 Meeting Abstracts):941.11.

Pendergrass KD, Gwathmey TYM, Grayson JM, Chappell MC. Protein kinase C and PI3 kinase mediate Ang II-dependent generation of reactive oxygen species in renal nuclei [abstract]. FASEB J. 2009;23(1 Meeting Abstracts):803.7.

Diz H, Pendergrass K, Westwood B, Chappell M. Chronic angiotensin II infusion in Lewis rats does not reveal sex differences in blood pressure or renal injury apparent in the mRen2.Lewis strain [abstract]. FASEB J. 2009;23(1 Meeting Abstracts):1013.3.

Yamaleyeva LM, Lindsey SH, Cahppell MC. Disparate effects of chronic AT1 receptor blockade on blood pressure and renal injury in the aging female mRen2.Lewis strain [abstract]. FASEB J. 2009;23(1 Meeting Abstracts):606.5.

Lindsey SH, Chappell MC. GPR30 activation in salt-sensitive mRen2.Lewis females induces beneficial effects independent of alterations in blood pressure [abstract]. FASEB J. 2009;23(1 Meeting Abstracts):1017.18.

Gilliam-Davis S, Tommasi EN, Garcia-Espinosa MA, Chappell MC, Diz DI. Bilateral renal denervation transiently lowers blood pressure and delays the development of proteinuria in aging Sprague-Dawley rats [abstract]. FASEB J. 2009;23(Meeting Abstracts):1015.2.

Benter IF, Yousif MHM, Dhaunsi GS, Kaur J, Chappell MC, Diz DI. Angiotensin-(1-7) prevents activation of NADPH oxidase and renal vascular dysfunction in diabetic hypertensive rats. Am J Nephrol. 2008;28(1):25-33.

Ferrario CM, Chappell MC. Angiotensin formation and degradation In: Izzo JL, Sica DA, Black HR, eds. Hypertension primer: the essentials of high blood pressure: basic science, population science, and clinical management. 4th ed. Philadelphia: Lippincott Williams & Wilkins;2008: 52-54.

Groban L, Yamaleyeva LM, Westwood BM, Houle TT, Lin M, Kitzman DW, Chappell MC. Progressive diastolic dysfunction in the female mRen(2).Lewis rat: influence of salt and ovarian hormones. J Gerontol A Biol Sci Med Sci. 2008;63(1):3-11.

Bi JL, Contag S, Figueroa JP, Tang LJ, Chappell MC, Rose JC. Effect of intrarenal infusion of angiotensin-(1-7) (Ang 1-7) in male sheep with or without prenatal exposure to betamethasone (B) [abstract]. Reprod Sci. 2008;15(2 Suppl):272A.

Contag SA, Bi J, Figueroa JP, Tang L, Chappell M, Rose JC. Effect of intrarenal infusion of angiotensin II (Ang II) in male sheep with or without prenatal exposure to antenatal betamethasone (B) [abstract]. Reprod Sci. 2008;15(2 Suppl):275A.

Kantorowicz L, Valego NK, Figueroa JP, Chappell MC, Tang L, Rose JC. Plasma renin concentration in female sheep following antenatal betamethasone exposure [abstract]. Reprod Sci. 2008;15(2 Suppl):275A.

Smith JG, Nakahara S, Westwood B, Figueora [sic] J [Figueroa J], Chappell MC, Rose JC. Prenatal betamethasone exposure alters renin angiotensin system enzyme expression in adult male sheep [abstract]. Reprod Sci. 2008;15(2 Suppl):274A.

Smith JG, Westwood B, Nakara S, Fiqueroa [sic] J, [Figueroa J], Chappell MC, Rose JC. Gender differences in key enzymes of the renin angiotensin system in adult sheep [abstract]. Reprod Sci. 2008;15(2 Suppl):276A.

Tang LJ, Carrey L, Valego N, Deibel P, Perrott J, Figueroa J, Chappell M, Rose JC. The effect of betamethasone exposure in mid-gestation on renal sodium excretion in male sheep [abstract]. Reprod Sci. 2008;15(2 Suppl):233A.

Jessup JA, Brosnihan KB, Gallagher PE, Chappell MC, Ferrario CM. Differential effect of low-dose thiazides on the renin angiotensin system in genetically hypertensive and normotensive rats. J Am Soc Hypertens. 2008;2(2):106-115.


Diz DI, Garcia-Espinosa MA, Gegick S, Tommasi EN, Ferrario CM, Tallant EA, Chappell MC, Gallagher PE. Injections of angiotensin-converting enzyme 2 inhibitor MLN4760 into nucleus tractus solitarii reduce baroreceptor reflex sensitivity for heart rate control in rats. Exp Physiol. 2008;93(5):694-700.

Garabelli PJ, Modrall JG, Penninger JM, Ferrario CM, Chappell MC. Distinct roles for angiotensin-converting enzyme 2 and carboxypeptidase A in the processing of angiotensins within the murine heart. Exp Physiol. 2008;93(5):613-621.

Trask AJ, Jessup JA, Chappell MC, Ferrario CM. Angiotensin-(1-12) is an alternate substrate for angiotensin peptide production in the heart. Am J Physiol Heart Circ Physiol. 2008;294(5):H2242-2247.

Varagic J, Trask AJ, Jessup JA, Chappell MC, Ferrario CM. New angiotensins. J Mol Med. 2008;86(6):663-671.

Jessup JA, Trask AJ, Chappell MC, Nagata S, Kato J, Kitamura K, Ferrario CM. Localization of the novel angiotensin peptide, angiotensin-(1-12), in heart and kidney of hypertensive and normotensive rats. Am J Physiol Heart Circ Physiol. 2008;294(6):H2614-2618.

Pendergrass KD, Pirro NT, Westwood BM, Ferrario CM, Brosnihan KB, Chappell MC. Sex differences in circulating and renal angiotensins of hypertensive mRen(2).Lewis but not normotensive Lewis rats. Am J Physiol Heart Circ Physiol. 2008;295(1):H10-H20.

Ferrario CM, Varagic J, Chappell MC, Trask AJ, Nagata S, Kato J. Bilateral nephrectomy augments the cardiac content of angiotensin-(1-12) and angiotensin I in Wistar Kyoto rats [abstract]. Hypertension. 2008;52(4):e126.

Garcia-Espinosa MA, Shaltout HA, Chappell MC, Gallagher PE, Ferrario CM, Ganten D, Reudelhuber TL, Diz DI. Angiotensin-(1-7) replacement gene transfer in the cisterna magna lowers blood pressure and improves baroreflex function in transgenic (mRen2)27 rats [abstract]. Hypertension. 2008;52(4):e36.

Gwathmey TM, Pendergrass KD, Reid SD, Rose JC, Chappell MC. Evidence that the ACE2-angiotensin-(1-7) pathway counterbalances angiotensin II-induced formation of reactive oxygen species in renal nuclei [abstract]. Hypertension. 2008;52(4):e124-e125.

Isa K, Garcia-Espinosa MA, Arnold AC, Pirro NT, Tommasi EN, Ferrario CM, Chappell MC, Diz DI. Angiotensin-(1-12) contributes to renin-independent angiotensin II activity in brain [abstract]. Hypertension. 2008;52(4):e81.

Lindsey SH, Chappell MC. GPR30 receptor activation reduces blood pressure in ovariectomized female but not intact male mRen2.Lewis rats [abstract]. Hypertension. 2008;52(4):e48.

Pendergrass KD, Gwathmey TM, Michalek RD, Grayson JM, Chappell MC. Nuclear angiotensin II AT1 receptors mediate the formation of reactive oxygen species [abstract]. Hypertension. 2008;52(4):e48.

Shaltout HA, Figueroa JP, Rose JC, Diz DI, Chappell MC. Reduced renal ACE2 in fetal programmed hypertension [abstract]. Hypertension. 2008;52(4):e52.

Shaltout HA, Figueroa JP, Rose JC, Chappell MC, Averill DB, Diz DI. Evidence of Ang-(1-7) deficiency in antenatal betamethasone-treated young adult sheep [abstract]. Hypertension. 2008;52(4):e107.

Trask AJ, Jessup JA, Tallant EA, Chappell MC, Ferrario CM. Renin-independent processing of angiotensin-(1-12) in the rat heart and isolated myocytes [abstract]. Hypertension. 2008;52(4):e45-e46.

Yamaleyeva LM, Lindsey SH, Gallagher PE, Chappell MC. Distribution and regulation of the novel estrogen receptor GPR30 in the female mRen2.Lewis rat kidney [abstract]. Hypertension. 2008;52(4):e93.

Yamaleyeva LM, Chappell MC. Antifibrotic effects of the nNOS inhibitor L-VNIO are associated with reduced oxidative stress in the kidney [abstract]. Hypertension. 2008;52(4):e116.

Kantorowicz L, Valego NK, Tang L, Figueroa JP, Chappell MC, Carey LC, Rose JC. Plasma and renal renin concentrations in adult sheep after prenatal betamethasone exposure. Reprod Sci. 2008;15(8):831-838.

Jessup JA, Westwood BM, Chappell MC, Groban L. Combination renin angiotensin system improves ventricular lusitropy without affecting cardiac fibrosis or cardiac RAS in the hypertensive mRen2.Lewis rat [abstract]. Circ Res. 2008;103(5):e48-e49.

Jessup JA, Brosnihan KB, Gallagher PE, Chappell MC, Ferrario CM. Differential effect of low dose thiazides on the renin angiotensin system in genetically hypertensive and normotensive rats. J Am Soc Hypertens. 2008;2(2):106-115.

Lindsey SH, Chappell MC. GPR30-mediated vasorelaxation is enhanced in female mRen2.Lewis rats and attenuated by high salt [abstract]. FASEB J. 2008;22(Meeting Abstracts):A968.10.

Shaltout HA, Westwood BM, Averill DB, Ferrario CM, Figueroa JP, Diz DI, Rose JC, Chappell MC. Angiotensin metabolism in renal proximal tubules, urine and serum of sheep: evidence for ACE2-dependent processing of angiotensin II. Am J Physiol Renal Physiol. 2007;292(1):F82-F91.

Yamaleyeva LM, Gallagher PE, Vinsant S, Chappell MC. Discoordinate regulation of renal nitric oxide synthase isoforms in ovariectomized mRen2.Lewis rats. Am J Physiol Regul Integr Comp Physiol. 2007;292(2):R819-R826.

Yamaleyeva LM, Gallagher PE, Groban L, Chappell MC. Increased intra-renal IGF-1 is associated with renal injury in older estrogen-depleted mRen2.Lewis rats [abstract]. FASEB J. 2007;21(6 Pt II):A1421.

Yamaleyeva LM, Westwood BM, Chappell MC. AT1 receptor blockade abolishes renal injury in salt-sensitive female mRen2.Lewis rats with chronic COX-2 inhibition [abstract]. FASEB J. 2007;21(5 Pt I):A591.

Shaltout HA, Figueroa JP, Rose JC, Chappell MC, Averill DB, Diz DI. Gender differences in the development of insulin resistance in adult sheep as result of antenatal betamethasone [abstract]. FASEB J. 2007;21(5 Pt I):A434.

Pendergrass KD, Brosnihan KB, Chappell MC. An enhanced intrarenal remin angiotensin system contributes to the gender disparity in blood pressure of the hypertensive mRen2.Lewis rat [abstract]. FASEB J. 2007;21(6):A1415.

Trask AJ, Averill DB, Ganten D, Chappell MC, Ferrario CM. Primary role of angiotensin-converting enzyme-2 in cardiac production of angiotensin-(1-7) in transgenic Ren-2 hypertensive rats. Am J Physiol Heart Circ Physiol. 2007;292(6):H3019-3024.

Joyner J, Neves LAA, Granger JP, Alexander BT, Merrill DC, Chappell MC, Ferrario CM, Davis WP, Brosnihan KB. Temporal-spatial expression of ANG-(1-7) and angiotensin-converting enzyme 2 in the kidney of normal and hypertensive pregnant rats. Am J Physiol Regul Integr Comp Physiol. 2007;293(1):R169-R177.

Yamaleyeva LM, Pendergrass KD, Pirro NT, Gallagher PE, Groban L, Chappell MC. Ovariectomy is protective against renal injury in the high-salt fed older mRen2.Lewis rat. Am J Physiol Heart Circ Physiol. 2007;293(4):H2064-2071.


Oudit GY, Kassiri Z, Patel MP, Chappell M, Butany J, Backx PH, Tsushima RG, Scholey JW, Khokha R, Penninger JM. Angiotensin II-mediated oxidative stress and inflammation mediate the age-dependent cardiomyopathy in ACE2 null mice. Cardiovasc Res. 2007;75(1):29-39.

Chappell MC, Westwood BM, Pendergrass KD, Jessup J, Ferrario CM. Distinct processing pathways for the novel peptide angiotensin-(1-12) in the serum and kidney of the hypertensive mRen2.Lewis rat [abstract]. Hypertension. 2007;50(4):e139.

Gilliam-Davis S, Chappell MC, Diz DI. Elevated angiotensin I and creatinine excretion precede the increase in proteinuria during aging in Sprague-Dawley rats [abstract]. Hypertension. 2007;50(4):e121.

Gwathmey TM, Diz DI, Pirro NT, Figueroa J, Rose JC, Chappell MC. Nuclear angiotensin II-type 2 receptors are differentially expressed in the sheep kidney [abstract]. Hypertension. 2007;50(4):e97.

Jessup JA, Ferrario CM, Chappell MC, Nagata S, Kato J, Kitamura K. Localization of the novel angiotensin peptide, proangiotensin-12, in the heart and kidney of hypertensive and normotensive rats [abstract]. Hypertension. 2007;50(4):e101.

Pendergrass K, Westwood B, Chappell MC. Differential expression of neprilysin and angiotensin-converting enzyme 2 may contribute to the gender disparity in the hypertensive mRen2. Lewis strain [abstract]. Hypertension. 2007;50(4):e78-e79.

Trask AJ, Chappell MC, Ferrario CM. Major role for angiotensin-converting enzyme 2 in cardiac angiotensin-(1-7) production in the congenic hypertensive mRen2.Lewis rat [abstract]. Hypertension. 2007;50(4):e140.

Yamaleyeva LM, Wilson BA, Westwood BM, Pirro NT, Chappell MC. Estrogen-depleted mRen2.Lewis rats exhibit COX-2 dependent responses distinct from either the intact female or male strain [abstract]. Hypertension. 2007;50(4):e149.

Yousif MH, Benter IF, Diz DI, Chappell MC. Evidence that multiple receptor subtypes mediate angiotensin-(1-7) dependent vasodilation of the rat renal artery [abstract]. Hypertension. 2007;50(4):e154-e155.

Pendergrass K, Westwood B, Chappell M. Differential expression of neprilysin and angiotensin converting enzyme 2 (ACE2) may contribute to decreased organ damage in the female hypertensive mRen2.Lewis rat [abstract]. Physiologist. 2007;50(6):19.

Ferrario CM, Averill DB, Brosnihan KB, Chappell MC, Diz DI, Gallagher PE, Neves L, Tallant EA. Regulation of cardiovascular control mechanisms by angiotensin (1-7) and angiotensin-converting enzyme 2 In: Carey RM, ed. Hypertension and hormone mechanisms. Totowa (NJ): Humana Press;2007: 43-59.

Chappell MC. Role of ACE, ACE2 and neprilysin in the kidney In: Leung PS, ed. Frontiers in research of the renin-angiotensin system on human disease. Dordrecht (Netherlands): Springer;2007: 1-20.

Chappell MC, Yamaleyeva LM, Westwood BM. Estrogen and salt senstivity in the female mRen(2).Lewis rat. Am J Physiol Regul Integr Comp Physiol. 2006;291(5):R1557-1563.

Neves LAA, Chappell MC, Ferrario CM, Gallagher PE, Ganten D, Brosnihan KB. Effect of estrogen on neprilysin expression in uterus and kidney of Sprague-Dawley normotensive and heterozygous (mRen2)27-transgenic hypertensive rats. Peptides. 2006;27(11):2912-2918.

Chappel [sic] MC [Chappell MC], Ferrario CM. ACE and ACE2: their role to balance the expression of angiotensin II and angiotensin-(1-7) [commentary]. Kidney Int. 2006;70(1):8-10.

Joyner J, Neves LAA, Gallagher PE, Chappell MC, Ferrario CM, Brosnihan KB. Kidney ACE2 mRNA and activity in virgin and normal pregnant Sprague Dawley rats [abstract]. J N C Acad Sci. 2006;122(2):80.

Jessup JA, Gallagher PE, Averill DB, Brosnihan KB, Tallant EA, Chappell MC, Ferrario CM. Effect of angiotensin II blockade on a new congenic model of hypertension derived from transgenic Ren-2 rats. Am J Physiol Heart Circ Physiol. 2006;291(5):H2166-2172.

Chappell MC, Westwood BM, Groban L, Yamaleyeva LI. Protective effects of ovariectomy in the aged female mRen2.Lewis rat [abstract]. J Hypertens. 2006;24(Suppl 6):67-68.

Chappell MC, Figueroa J, Rose JC, Westwood BM. Gender difference in serum ACE2-dependent metabolism of angiotensin II [abstract]. J Hypertens. 2006;24(Suppl 6):125.

Jessup JA, Gallagher PE, Chappell MC, Ferrario CM. Impaired counter-regulatory response of angiotensin converting enzyme 2 (ACE2) and angiotensin-(1-7) [Ang-(1-7)] in the heart of a new congenic model of hypertension derived from [mRen2]27 transgenic rats [abstract]. Hypertension. 2006;48(4):e74.

Shaltout HA, Figueroa JP, Rose JC, Chappell M, Diz DI, Averill DB. Antenatal betamethasone causes angiotensin II-mediated impairment of cardiovascular function [abstract]. Hypertension. 2006;48(4):e32.

Shaltout HA, Figueroa JP, Rose JC, Chappell MC, Diz DI, Averill DB. Antenatal betamethasone causes angiotensin II-mediated impairment of baroreflex control of heart rate [abstract]. J Hypertens. 2006;24(Suppl 6):159.

Shaltout HA, Figueroa JP, Rose JC, Averill DB, Diz DI, Chappell MC. Increased blood pressure is associated with lower serum ACE2 activity and higher ACE activity following antenatal steroid exposure [abstract]. J Hypertens. 2006;24(Suppl 6):127.

Trask AJ, Averill DB, Chappell MC, Ferrario CM. Predominance of angiotensin converting enzyme 2 to cardiac angiotensin-(1-7) production in [mRen2]27 transgenic hypertensive rats [abstract]. Hypertension. 2006;48(4):e72.

Westwood BM, Figueroa J, Rose JC, Chappell MC. Gender differences in ACE2-dependent metabolism of angiotensin II in the serum of sheep [abstract]. Hypertension. 2006;48(4):e46.

Westwood BM, Chappell MC. Application of correlate summation to data clustering in the estrogen- and salt-sensitive female mRen2.Lewis rat [abstract]. J Hypertens. 2006;24(Suppl 6):402.

Yamaleyeva LM, Westwood BM, Groban L, Chappell MC. Ovariectomy is protective against salt-induced renal injury in the older female mRen2.Lewis strain [abstract]. Hypertension. 2006;48(4):e28-e29.

Garcia-Espinosa MA, Vinsant S, Gallagher PE, Ferrario CM, Ganten D, Chappell MC, Diz DI. Regulation of brain neprilysin and ACE2 in transgenic rats during aging [abstract]. Am J Med Sci. 2006;331(2):61.

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