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Mark C. Chappell, Ph.D.Wake Forest School of Medicine

Mark C. Chappell, Ph.D.

Professor,



Contact Information

Academic: 336-716-9236 | Department: 336-716-9236

Email: mchappel@wakehealth.edu

Education & Training

  • B.A., American University, 1983
  • Ph.D., Cleveland State University, 1993
  • Fellowship, Cardiovascular Disease, WFU School of Medicine, 1996

Memberships

  • Western Nc Chpt Soc For Neuros
  • Am Soc Biochem Molecular Bio
  • Am Heart Association
  • Am Physiological Society
  • Council For High Blood Pressur
  • Endocrine Society
Mark C. Chappell, Ph.D.

Mark C. Chappell, Ph.D.

Professor, Hypertension
Hypertension and Vascular Research Center
Center for Diabetes Research
Physiology & Pharmacology

Research Interests

diabetes, hypertension, women's health issues

Contact Information

Academic: 336-716-9236 | Department: 336-716-9236

Email: mchappel@wakehealth.edu

Recent Publications

Wilson BA, Cruz-Diaz N, Marshall AC, Pirro NT, Su Y, Gwathmey TM, Rose JC, Chappell MC. An angiotensin-(1-7) peptidase in the kidney cortex, proximal tubules, and human HK-2 epithelial cells that is distinct from insulin degrading enzyme. Am J Physiol Renal Physiol. 2015;308(6):F594-F601.

Yamaleyeva LM, Chappell MC, Bridget Brosnihan K, Anton L, Pirro N, McGee C, Merrill DC, Mertz HL. Apelin as a novel therapeutic target in preeclampsia [abstract]. Pregnancy Hypertens. 2015;5(1):140-141.

Su Y, Bi J, Pulgar VM, Figueroa JP, Chappell MC, Rose JC. Antenatal glucocorticoid treatment alters sodium uptake in renal proximal tubule cells from adult offspring in a sex specific manner. Am J Physiol Renal Physiol. 2015;308(11):F1268-1275.

Lawson MJ, Figueroa JP, Rose JC, Chappell MC, Diz DI, Shaltout HA. Intracerebroventricular infusion of angiotensin-(1-7) improves baroreflex sensitivity in antenatal betamethasone exposed sheep [abstract]. FASEB J. 2015;29(1 Suppl):811.30.

Lawson MJ, Shaltout HA, Chappell MC, Diz DI, Figueroa JP. Obesity induces further autonomic impairment in sheep exposed antenatally to betamethasone [abstract]. FASEB J. 2015;29(1 Suppl):LB724.

Chappell MC, Marshall AC, Alzayadneh EM, Shaltout HA, Diz DI. Update on the angiotensin converting enzyme 2-angiotensin (1-7)-Mas receptor axis: fetal programing, sex differences, and intracellular pathways. Front Endocrinol (Lausanne). 2014;4():201.

Zhao Z, Wang H, Jessup JA, Lindsey SH, Chappell MC, Groban L. Role of estrogen in diastolic dysfunction. Am J Physiol Heart Circ Physiol. 2014;306(5):H628-H640.

Marshall AC, Shaltout HA, Pirro NT, Rose JC, Diz DI, Chappell MC. Enhanced activity of an angiotensin-(1-7) neuropeptidase in glucocorticoid-induced fetal programming. Peptides. 2014;52():74-81.

Lindsey SH, Liu L, Chappell MC. Vasodilation by GPER in mesenteric arteries involves both endothelial nitric oxide and smooth muscle cAMP signaling. Steroids. 2014;81():99-102.

Washburn LK, Brosnihan KB, Chappell MC, Diz DI, Gwathmey TM, Nixon PA, Russell GB, Snively BM, O'Shea TM. The renin-angiotensin-aldosterone system in adolescent offspring born prematurely to mothers with preeclampsia. J Renin Angiotensin Aldosterone Syst. 2014;():.

Marshall AC, Pirro NT, Rose JC, Diz DI, Chappell MC. Evidence for an angiotensin-(1-7) neuropeptidase expressed in the brain medulla and CSF of sheep. J Neurochem. 2014;130(2):313-323.

Gwathmey TM, Chappell MC, Nixon PA, Washburn LK. Prenatal steroid exposure promotes expression of renal injury indices in African American females [abstract]. FASEB J. 2014;28(1 Suppl):1134.11.

Marshall A, Pirro N, Rose J, Diz D, Chappell M. Evidence for an angiotensin-(1-7) neuropeptidase in the brain medulla of sheep [abstract]. FASEB J. 2014;28(1 Suppl):1140.6.

Wilson B, Marshall A, Pirro N, Su Y, Rose J, Chappell M. Expression of an angiotensin-(1-7) endopeptidase in proximal tubules of the sheep and human kidney [abstract]. FASEB J. 2014;28(1 Suppl):1088.10.

Wilson B, Rose J, Chappell M. Functional neprilysin-angiotensin-(1-7) system within mitochondria of the sheep kidney [abstract]. FASEB J. 2014;28(1 Suppl):1088.9.

Alzayadneh EM, Chappell MC. Angiotensin-(1-7) abolishes AGE-induced cellular hypertrophy and myofibroblast transformation via inhibition of ERK1/2. Cell Signal. 2014;26(12):3027-3035.

Bi J, Contag SA, Chen K, Su Y, Figueroa JP, Chappell MC, Rose JC. Sex-specific effect of antenatal betamethasone exposure on renal oxidative stress induced by angiotensins in adult sheep. Am J Physiol Renal Physiol. 2014;307(9):F1013-1022.

Wilson BA, Marshall AC, Alzayadneh EM, Chappell MC. The ins and outs of angiotensin processing within the kidney. Am J Physiol Regul Integr Comp Physiol. 2014;307(5):R487-R489.

Bil JL, Chen K, Su YX, Chappell M, Rose J. Sex specific effect of antenatal glucocorticoids on nitric oxide production stimulated by angiotensin peptides in renal proximal tubule cells [abstract]. FASEB J. 2014;28(1 Suppl):1085.6.

Alzayadneh EM, Chappell MC. Nuclear expression of renin-angiotensin system components in NRK-52E renal epithelial cells. J Renin Angiotensin Aldosterone Syst. 2014;():.

Alzayadneh EM, Chappell MC. Angiotensin-(1-7) abolishes AGE-induced chronic ERK activation and myofibroblast transition [abstract]. Hypertension. 2014;64(Suppl 1):A233.

Alzayadneh EM, Wilson BA, Marshal AC, Chappell MC. AGEs enhance the metabolism of angiotensin-(1-7) and lower intracellular peptide expression [abstract]. Hypertension. 2014;64(Suppl 1):A234.

Yamaleyeva LM, Chappell MC, Brosnihan KB, Anton L, Pirro N, McGee C, Merrill DC, Mertz HL. Apelin as a novel therapeutic target in preeclampsia [abstract]. Hypertension. 2014;64(Suppl 1):A634.

Nautiyal M, Arnold AC, Chappell MC, Diz DI. The brain renin-angiotensin system and mitochondrial function: influence on blood pressure and baroreflex in transgenic rat strains. Int J Hypertens. 2013;2013():136028.

Nautiyal M, Shaltout HA, de Lima DC, do Nascimento K, Chappell MC, Diz DI. Response to angiotensin-(1-7) and bradykinin in baroreceptor reflex sensitivity in hypertension [letter]. Hypertension. 2013;61(2):e20.

Marshall AC, Shaltout HA, Nautiyal M, Rose JC, Chappell MC, Diz DI. Fetal betamethasone exposure attenuates angiotensin-(1-7)-Mas receptor expression in the dorsal medulla of adult sheep. Peptides. 2013;44(C):25-31.

Marshall AC, Shaltout HA, Pirro NT, Rose JC, Diz DI, Chappell MC. Differential expression of renin-angiotensin system components in the choroid plexus of betamethasone exposed and control sheep [abstract]. FASEB J. 2013;27(Meeting Abstracts):1107.12.

Nautiyal M, Shaltout HA, Chappell MC, Diz DI. Reduction in central mitochondrial ROS improves cardiovagal baroreflex function independent of blood pressure in (mRen2)27 rats [abstract]. FASEB J. 2013;27(Meeting Abstracts):890.4.

Chen K, Bi J, Su Y, Figueroa J, Chappell M, Rose J. Gender affects responses of renal ACE and ACE2 activity to unilateral nephrectomy [abstract]. Reprod Sci. 2013;20(3 Suppl 1A):335A.

Chen K, Bi J, Figueroa J, Chappell M, Rose J. Gender differences in effects of prenatal betamethasone exposure on sheep renal ACE and ACE2 activity: a possible mechanism in fetal programmed hypertension in males [abstract]. Reprod Sci. 2013;20(3 Suppl 1A):275A.

Gwathmey TM, Zerihun L, Simington SW, Chappell MC, Washburn LK. Antenatal betamethasone exposure increases oxidative stress in African-American adolescents born prematurely [abstract]. Circulation. 2013;127():AP241.

Lindsey SH, da Silva AS, Silva MS, Chappell MC. Reduced vasorelaxation to estradiol and G-1 in aged female and adult male rats is associated with GPR30 downregulation. Am J Physiol Endocrinol Metab. 2013;305(1):E113-E118.

Alzayadneh EM, Pirro NT, Chappell MC. Thimet oligopeptidase forms angiontensin-(1-7) in the nucleus of NRK-52E cells [abstract]. FASEB J. 2013;27():lb857.

Americao A, Pirro N, Brosnihan KB, Chappell M. Processing of angiotensinogen to angiotensin-(1-12) by a non-renin enzyme in the salt-sensitive mRen2.Lewis rat [abstract]. FASEB J. 2013;27():909.1.

Bi JL, Contag S, Su YX, Chen K, Figueroa J, Chappell M, Rose JC. Sex differences in oxidative stress following uniphrectomy in antenatal glucocorticoid exposed sheep [abstract]. FASEB J. 2013;27():733.2.

Guan MJ, Nautiyal M, Hakuda D, de Lima R, Rose J, Pirro NT, Chappell MC. Renal mitochondria predominantly express [des-Ang I]- angiotensinogen and renin [abstract]. FASEB J. 2013;27():909.5.

Schaich C, Nautiyal M, Howlett A, Chappell M, Diz D. Enhanced CB1 cannabinoid receptor tone contributes to impaired baroreflex sensitivity in hypertensive (mRen2)27 transgenic rats [abstract]. FASEB J. 2013;27():926.13.

Wang H, Jessup JA, Zhao Z, Da Silva J, Lin M, Macnamara LM, Ahmad S, Chappell MC, Ferrario CM, Groban L. Characterization of the cardiac renin angiotensin system in oophorectomized and estrogen-replete mRen2.Lewis rats. PLoS One. 2013;8(10):e76992.

Chappell MC. Of diabetic mice and ACE2: a new biomarker of renal disease? [editorial]. Am J Physiol Renal Physiol. 2013;305(7):F970-F972.

Bi J, Contag SA, Carey LC, Tang L, Valego NK, Chappell MC, Rose JC. Antenatal betamethasone exposure alters renal responses to angiotensin-(1-7) in uninephrectomized adult male sheep. J Renin Angiotensin Aldosterone Syst. 2013;14(4):290-298.

Marshall AC, Shaltout HA, Pirro NT, Rose JC, Diz DI, Chappell MC. Antenatal betamethasone exposure is associated with lower ANG-(1-7) and increased ACE in the CSF of adult sheep. Am J Physiol Regul Integr Comp Physiol. 2013;305(7):R679-R688.

Chappell MC. Differential expression of the estrogen receptors GPR30 and ERa in the kidney of the diabetic hypertensive mRen2.Lewis strain [abstract]. Hypertension. 2013;62(3 Suppl):612.

Hukuda D, de Lima H, Pirro NT, Yamaleyeva LM, Grabenauer, MA, Thomas BT, Chappell MC. Enhanced expression of the endocannabinoid 2-AG and CB-1 receptor in the kidney of the diabetic hypertensive female rat [abstract]. Hypertension. 2013;62(3 Suppl):501.

Marshall AC, Shaltout HA, Pirro NT, Rose JC, Diz DI, Chappell MC. Antenatal betamethasone exposure reduces Ang-(1-7) but enhances angiotensin-converting enzyme and a thiol peptidase to metabolize Ang-(1-7) in the cerebrospinal fluid [abstract]. Hypertension. 2013;62(3 Suppl):177.

Nautiyal M, Shaltout HA, Chappell MC, Diz DI. Combined intracerebroventricular angiotensin-(1-7) and candesartan normalizes blood pressure and improves baroreflex function in transgenic (mRen2)27 hypertensive rats [abstract]. Hypertension. 2013;62(3 Suppl):607.

Pulgar VM, Jeffers AB, Chappell MC, Aileru AA. The endothelin B receptor attenuates endothelin contraction via an endothelium independent mechanism In mesenteric arteries of (mRen2)27 rats [abstract]. Hypertension. 2013;62(3 Suppl):644.

Nautiyal M, Tommasi E, Chappell MC, Diz DI. MAP kinase phosphatase-1 inhibitor injection into the solitary tract nucleus impairs cardiovagal baroreflex function in transgenic ASrAOGEN rats [abstract]. Hypertension. 2013;62(3 Suppl):A157.

Diz DI, Schaich CL, Thomas BF, Grabenauer MA, Chappell MC, Howlett AC. Elevated endocannabinoids via CB1receptors in the solitary tract nucleus contibute to age-related impairments in baroreflex sensitivity in Sprague-Dawley rats [abstract]. In: Conference Program of the 2013 Carolina Cannabinoid Collaborative Conference; 2013 Oct 25-27; Richmond (VA). 2013;():.

Hakuda D, Thomas BF, Yamaleyeva LM, Grabenauer MA, Diz, DI, Chappell MC. Enhanced expression of 2-arachidonoylglycerol in the kidney of diabetic hypertensive rats [abstract]. In: Conference Program of the 2013 Carolina Cannabinoid Collaborative Conference; 2013 Oct 25-27; Richmond (VA). 2013;():.

Schaich CL, Howlett A, Thomas B, Grabenauer M, Chappell M, Diz D. Chronic systemic CB1 cannabinoid receptor blockade reduces weight gain and lowers blood pressure in hypertensive (mRen2)27 rats [abstract]. In: Conference Program of the 2013 Carolina Cannabinoid Collaborative Conference; 2013 Oct 25-27; Richmond (VA). 2013;():.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Hypertension

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