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Mark C. Chappell, Ph.D.Wake Forest School of Medicine

Mark C. Chappell, Ph.D.

Professor,

Contact Information

Academic: 336-716-9236 | Department: 336-716-9236

Email: mchappel@wakehealth.edu

Education & Training

  • B.A., American University, 1983
  • Ph.D., Cleveland State University, 1993
  • Fellowship, Cardiovascular Disease, WFU School of Medicine, 1996

Memberships

  • Western Nc Chpt Soc For Neuros
  • Am Soc Biochem Molecular Bio
  • Am Heart Association
  • Am Physiological Society
  • Council For High Blood Pressur
  • Endocrine Society
Mark C. Chappell, Ph.D.

Mark C. Chappell, Ph.D.

Professor, Hypertension
Physiology & Pharmacology

Research Interests

Peptidyl-Dipeptidase A; Renin-Angiotensin System; Angiotensin I; Peptide Fragments; Kidney
More »

Contact Information

Academic: 336-716-9236 | Department: 336-716-9236

Email: mchappel@wakehealth.edu

Recent Publications

Antenatal corticosteroids and the renin-angiotensin-aldosterone system in adolescents born preterm. South AM, Nixon PA, Chappell MC, Diz DI, Russell GB, Snively BM, Shaltout HA, Rose JC, O'Shea TM, Washburn LK.. Pediatr Res. 2017;81(1):88-93.

Angiotensinogen import in isolated proximal tubules: evidence for mitochondrial trafficking and uptake. Wilson BA, Cruz-Diaz N, Su Y, Rose JC, Gwathmey TM, Chappell MC.. Am J Physiol Renal Physiol. 2017;312(5):F879-F886.

Measurement of angiotensin peptides: HPLC-RIA. Brosnihan KB, Chappell MC.. Methods Mol Biol. 2017;1527():81-99.

Antenatal betamethasone attenuates the angiotensin-(1-7)-Mas receptor-nitric oxide axis in isolated proximal tubule cells. Su Y, Bi J, Pulgar VM, Chappell MC, Rose JC.. Am J Physiol Renal Physiol. 2017;312(6):F1056-1062.

Angiotensin-(1-7)-dependent vasorelaxation of the renal artery exhibits unique angiotensin and bradykinin receptor selectivity. Yousif MH, Benter IF, Diz DI, Chappell MC.. Peptides. 2017;90():10-16.

No brain renin-angiotensin system: deja vu all over again? [editorial]. Sigmund CD, Diz DI, Chappell MC.. Hypertension. 2017;69(6):1007-1010.

Assessment of the renin-angiotensin system in cellular organelle: new arenas for study in the mitochondria. Wilson BA, Chappell MC.. Methods Mol Biol. 2017;1614():99-121.

Fetal betamethasone exposure markedly attenuates the protein expression of angiotensin converting enzyme 2 but not dipeptidyl peptidase 3 within the brain dorsomedial medulla of adult female sheep [abstract]. Hendricks AS, Shaltout HA, Chappell MC, Diz DI.. FASEB J. 2017;31(1 Suppl):997.6.

Adult males of very low birth weight with antenatal corticosteroid exposure exhibit an enhanced blood pressure response to acute stress [abstract]. Washburn L, Chappell M, Beavers D, Diz D, Jensen E, Nixon P, Shaltout H, South A, Taylor R, Rose J.. FASEB J. 2017;31(1 Suppl):852.8.

Sex-specific changes in renal angiotensin-converting enzyme and angiotensin-converting enzyme 2 gene expression and enzyme activity at birth and over the first year of life. Chen K, Bi J, Su Y, Chappell MC, Rose JC.. Reprod Sci. 2016;23(2):200-210.

Biochemical evaluation of the renin-angiotensin system - the good, bad, and absolute?. Chappell MC.. Am J Physiol Heart Circ Physiol. 2016;310(2):H137-H152.

Evidence for a mitochondrial angiotensin-(1-7) system in the kidney. Wilson BA, Nautiyal M, Gwathmey TM, Rose JC, Chappell MC.. Am J Physiol Renal Physiol. 2016;310(7):F637-F645.

GPER activation ameliorates aortic remodeling induced by salt-sensitive hypertension. Liu L, Kashyap S, Murphy B, Hutson DD, Budish RA, Trimmer EH, Zimmerman MA, Trask AJ, Miller KS, Chappell MC, Lindsey SH.. Am J Physiol Heart Circ Physiol. 2016;310(8):H953-H961.

'Letter to the editor: angiotensin quantification by mass spectrometry' [reply to letter]. Chappell MC.. Am J Physiol Heart Circ Physiol. 2016;310(3):H454.

Sex specific effects of prenatal betamethesone (beta) exposure and unilateral nephrectomy on angiotensin - (1-7) (ang-(1-7))-mas receptor expression and inhibition of sodium uptake by ang(1-7) in ovine proximal tubule cells [abstract]. Su YX, Bi JL, Chappell MC, Rose JC.. Reprod Sci. 2016;23(Suppl 1):307A.

Amiloride and the diabetic kidney [editorial comment]. Chappell MC.. J Hypertens. 2016;34(8):1500-1501.

Sex specific differences in key signaling pathways involved in sympathetic nervous system control within the dorsal medulla of adult sheep with fetal betamethasone exposure [abstract]. Hendricks AS, Diz DI, Shaltout HA, Chappell MC.. FASEB J. 2016;30(1 Suppl):716.5.

Identification of dipeptidyl peptidase 3 as the Angiotensin-(1-7) degrading peptidase in human HK-2 renal epithelial cells. Cruz-Diaz N, Wilson BA, Pirro NT, Brosnihan KB, Marshall AC, Chappell MC.. Peptides. 2016;83():29-37.

Influence of race and obesity on the renin-angiotensin-aldosterone system in adolescents born preterm [abstract]. South AM, Nixon PA, Chappell MC, Diz DI, Russell GB, Snively BM, Shaltout HA, Rose JC, O'Shea TM, Washburn LK.. Hypertension. 2016;68(Suppl 1):A136.

Antenatal corticosteroids and alterations in renal function in adolescents born preterm [abstract]. South AM, Nixon PA, Chappell MC, Diz DI, Russell GB, Snively BM, Shaltout HA, Rose JC, O'Shea TM, Washburn LK.. Hypertension. 2016;68(Suppl 1):AP121.

The renin-angiotensin-aldosterone system in adolescent offspring born prematurely to mothers with preeclampsia. Washburn LK, Brosnihan KB, Chappell MC, Diz DI, Gwathmey TM, Nixon PA, Russell GB, Snively BM, O'Shea TM.. J Renin Angiotensin Aldosterone Syst. 2015;16(3):529-538.

An angiotensin-(1-7) peptidase in the kidney cortex, proximal tubules, and human HK-2 epithelial cells that is distinct from insulin degrading enzyme. Wilson BA, Cruz-Diaz N, Marshall AC, Pirro NT, Su Y, Gwathmey TM, Rose JC, Chappell MC.. Am J Physiol Renal Physiol. 2015;308(6):F594-F601.

Apelin as a novel therapeutic target in preeclampsia [abstract]. Yamaleyeva LM, Chappell MC, Bridget Brosnihan K, Anton L, Pirro N, McGee C, Merrill DC, Mertz HL.. Pregnancy Hypertens. 2015;5(1):140-141.

Antenatal glucocorticoid treatment alters sodium uptake in renal proximal tubule cells from adult offspring in a sex specific manner. Su Y, Bi J, Pulgar VM, Figueroa JP, Chappell MC, Rose JC.. Am J Physiol Renal Physiol. 2015;308(11):F1268-1275.

Intracerebroventricular infusion of angiotensin-(1-7) improves baroreflex sensitivity in antenatal betamethasone exposed sheep [abstract]. Lawson MJ, Figueroa JP, Rose JC, Chappell MC, Diz DI, Shaltout HA.. FASEB J. 2015;29(1 Suppl):811.30.

Obesity induces further autonomic impairment in sheep exposed antenatally to betamethasone [abstract]. Lawson MJ, Shaltout HA, Chappell MC, Diz DI, Figueroa JP.. FASEB J. 2015;29(1 Suppl):LB724.

Nuclear expression of renin-angiotensin system components in NRK-52E renal epithelial cells. Alzayadneh EM, Chappell MC.. J Renin Angiotensin Aldosterone Syst. 2015;16(4):1135-1148.

Downregulation of apelin in the human placental chorionic villi from preeclamptic pregnancies. Yamaleyeva LM, Chappell MC, Brosnihan KB, Anton L, Caudell DL, Shi S, McGee C, Pirro N, Gallagher PE, Taylor RN, Merrill DC, Mertz HL.. Am J Physiol Endocrinol Metab. 2015;309(10):E852-E860.

Effect of antenatal betamethasone on ovine renal function in obese offspring [abstract]. Bi JL, Figueroa J, Chappell M, Rose J.. FASEB J. 2015;29(Suppl 1):LB762.

Intracerebroventricular (ICV) infusion of angiotensin-(1-7) lowers blood pressure and improves autonomic function in antenatal betamethasone exposed sheep [abstract]. Lawson MJ, Figueroa JP, Chappell MC, Diz DI, Shaltout HA.. Hypertension. 2015;66(Suppl 1):A081.

Update on the angiotensin converting enzyme 2-angiotensin (1-7)-Mas receptor axis: fetal programing, sex differences, and intracellular pathways. Chappell MC, Marshall AC, Alzayadneh EM, Shaltout HA, Diz DI.. Front Endocrinol (Lausanne). 2014;4():201.

Role of estrogen in diastolic dysfunction. Zhao Z, Wang H, Jessup JA, Lindsey SH, Chappell MC, Groban L.. Am J Physiol Heart Circ Physiol. 2014;306(5):H628-H640.

Enhanced activity of an angiotensin-(1-7) neuropeptidase in glucocorticoid-induced fetal programming. Marshall AC, Shaltout HA, Pirro NT, Rose JC, Diz DI, Chappell MC.. Peptides. 2014;52():74-81.

Vasodilation by GPER in mesenteric arteries involves both endothelial nitric oxide and smooth muscle cAMP signaling. Lindsey SH, Liu L, Chappell MC.. Steroids. 2014;81():99-102.

Evidence for an angiotensin-(1-7) neuropeptidase expressed in the brain medulla and CSF of sheep. Marshall AC, Pirro NT, Rose JC, Diz DI, Chappell MC.. J Neurochem. 2014;130(2):313-323.

Prenatal steroid exposure promotes expression of renal injury indices in African American females [abstract]. Gwathmey TM, Chappell MC, Nixon PA, Washburn LK.. FASEB J. 2014;28(1 Suppl):1134.11.

Evidence for an angiotensin-(1-7) neuropeptidase in the brain medulla of sheep [abstract]. Marshall A, Pirro N, Rose J, Diz D, Chappell M.. FASEB J. 2014;28(1 Suppl):1140.6.

Expression of an angiotensin-(1-7) endopeptidase in proximal tubules of the sheep and human kidney [abstract]. Wilson B, Marshall A, Pirro N, Su Y, Rose J, Chappell M.. FASEB J. 2014;28(1 Suppl):1088.10.

Functional neprilysin-angiotensin-(1-7) system within mitochondria of the sheep kidney [abstract]. Wilson B, Rose J, Chappell M.. FASEB J. 2014;28(1 Suppl):1088.9.

Angiotensin-(1-7) abolishes AGE-induced cellular hypertrophy and myofibroblast transformation via inhibition of ERK1/2. Alzayadneh EM, Chappell MC.. Cell Signal. 2014;26(12):3027-3035.

Sex-specific effect of antenatal betamethasone exposure on renal oxidative stress induced by angiotensins in adult sheep. Bi J, Contag SA, Chen K, Su Y, Figueroa JP, Chappell MC, Rose JC.. Am J Physiol Renal Physiol. 2014;307(9):F1013-1022.

The ins and outs of angiotensin processing within the kidney. Wilson BA, Marshall AC, Alzayadneh EM, Chappell MC.. Am J Physiol Regul Integr Comp Physiol. 2014;307(5):R487-R489.

Sex specific effect of antenatal glucocorticoids on nitric oxide production stimulated by angiotensin peptides in renal proximal tubule cells [abstract]. Bil JL, Chen K, Su YX, Chappell M, Rose J.. FASEB J. 2014;28(1 Suppl):1085.6.

Angiotensin-(1-7) abolishes AGE-induced chronic ERK activation and myofibroblast transition [abstract]. Alzayadneh EM, Chappell MC.. Hypertension. 2014;64(Suppl 1):A233.

AGEs enhance the metabolism of angiotensin-(1-7) and lower intracellular peptide expression [abstract]. Alzayadneh EM, Wilson BA, Marshal AC, Chappell MC.. Hypertension. 2014;64(Suppl 1):A234.

Apelin as a novel therapeutic target in preeclampsia [abstract]. Yamaleyeva LM, Chappell MC, Brosnihan KB, Anton L, Pirro N, McGee C, Merrill DC, Mertz HL.. Hypertension. 2014;64(Suppl 1):A634.

The brain renin-angiotensin system and mitochondrial function: influence on blood pressure and baroreflex in transgenic rat strains. Nautiyal M, Arnold AC, Chappell MC, Diz DI.. Int J Hypertens. 2013;2013():136028.

Response to angiotensin-(1-7) and bradykinin in baroreceptor reflex sensitivity in hypertension [letter]. Nautiyal M, Shaltout HA, de Lima DC, do Nascimento K, Chappell MC, Diz DI.. Hypertension. 2013;61(2):e20.

Fetal betamethasone exposure attenuates angiotensin-(1-7)-Mas receptor expression in the dorsal medulla of adult sheep. Marshall AC, Shaltout HA, Nautiyal M, Rose JC, Chappell MC, Diz DI.. Peptides. 2013;44(C):25-31.

Differential expression of renin-angiotensin system components in the choroid plexus of betamethasone exposed and control sheep [abstract]. Marshall AC, Shaltout HA, Pirro NT, Rose JC, Diz DI, Chappell MC.. FASEB J. 2013;27(Meeting Abstracts):1107.12.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Hypertension

Mark C. Chappell, Ph.D.

Mark C. Chappell, Ph.D.

Professor, Hypertension
Physiology & Pharmacology

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