Yong Q. Chen, Ph.D.Wake Forest School of Medicine

Yong Q. Chen, Ph.D.


Contact Information

Academic: 336-713-7655 | Department: 336-713-7655


Education & Training

  • B.S., Fudan University, Shanghai, China, 1982
  • Ph.D., Free University of Brussels, Belgium, 1989


  • Am Assn Of Advancement Of Scie
  • Am Assn Of Cancer Research
  • New York Academy Of Sciences
Yong Q. Chen, Ph.D.

Yong Q. Chen, Ph.D.

Professor, Cancer Biology
Center for Cancer Genomics
Comprehensive Cancer Center

Research Interests

cancer/oncogenesis, genetics/genome, hormones/cytokines/signalling

Contact Information

Academic: 336-713-7655 | Department: 336-713-7655


Recent Publications

Wang H, Zhang C, Chen H, Yang Q, Zhou X, Gu Z, Zhang H, Chen W, Chen YQ. Characterization of an fungal l-fucokinase involved in Mortierella alpina GDP-l-fucose salvage pathway. Glycobiology. 2016;():.

Hao G, Chen H, Gu Z, Zhang H, Chen W, Chen YQ. Metabolic engineering of Mortierella alpina for enhanced arachidonic acid production through the NADPH supplying strategy. Appl Environ Microbiol. 2016;82(11):3280-3288.

Yang Q, Sun J, Chen YQ. Multi-dimensional, comprehensive sample extraction combined with LC-GC/MS analysis for complex biological samples: application in the metabolomics study of acute pancreatitis. RSC Adv. 2016;6(31):.

Chen H, Hao G, Wang L, Wang H, Gu Z, Liu L, Zhang H, Chen W, Chen YQ. Identification of a critical determinant that enables efficient fatty acid synthesis in oleaginous fungi. Sci Rep. 2015;5():11247.

Bernardo MM, Kaplun A, Dzinic SH, Li X, Irish J, Mujagic A, Jakupovic B, Back JB, Van Buren E, Han X, Dean I, Chen YQ, Heath E, Sakr W, Sheng S. Maspin expression in prostate tumor cells averts stemness and stratifies drug sensitivity. Cancer Res. 2015;75(18):3970-3979.

Weylandt KH, Chen YQ, Lim K, Su HM, Cittadini A, Calviello G. Omega -3 PUFAs in the prevention and cure of inflammatory, degenerative, and neoplastic diseases 2014 [editorial]. Biomed Res Int. 2015;2015():695875.

Weylandt KH, Serini S, Chen YQ, Su HM, Lim K, Cittadini A, Calviello G. Omega-3 polyunsaturated fatty acids: the way forward in times of mixed evidence. Biomed Res Int. 2015;2015():143109.

Hao DH, Chen HQ, Hao GF, Yang B, Zhang BX, Zhang H, Chen W, Chen YQ. Production of conjugated linoleic acid by heterologous expression of linoleic acid isomerase in oleaginous fungus Mortierella alpina. Biotechnol Lett. 2015;37(10):1983-1992.

Yang B, Chen H, Tian F, Zhao J, Gu Z, Zhang H, Chen YQ, Chen W. Complete genome sequence of Lactobacillus plantarum ZS2058, a probiotic strain with high conjugated linoleic acid production ability. J Biotechnol. 2015;214():212-213.

Gu Z, Shan K, Chen H, Chen YQ. n-3 polyunsaturated fatty acids and their role in cancer chemoprevention. Curr Pharmacol Rep. 2015;1(5):283-294.

Hao G, Chen H, Gu Z, Zhang H, Chen W, Chen YQ. Metabolic engineering of Mortierella alpina for arachidonic acid production with glycerol as carbon source. Microb Cell Fact. 2015;14(1):205.

Shi H, Chen H, Gu Z, Song Y, Zhang H, Chen W, Chen YQ. Molecular mechanism of substrate specificity for delta 6 desaturase from Mortierella alpina and Micromonas pusilla. J Lipid Res. 2015;56(12):2309-2321.

Suburu J, Lim K, Calviello G, Chen YQ. RE: serum phospholipid fatty acids and prostate cancer risk in the SELECT trial [letter]. J Natl Cancer Inst. 2014;106(4):dju023.

Hao GF, Chen HQ, Wang L, Gu ZN, Song YD, Zhang H, Chen W, Chen YQ. Role of malic enzyme during fatty acid synthesis in the oleaginous fungus mortierella alpina. Appl Environ Microbiol. 2014;80(9):2672-2678.

Liu Y, He Y, Jin A, Tikunov AP, Zhou L, Tollini LA, Leslie P, Kim TH, Li LO, Coleman RA, Gu Z, Chen YQ, Macdonald JM, Graves LM, Zhang Y. Ribosomal protein-Mdm2-p53 pathway coordinates nutrient stress with lipid metabolism by regulating MCD and promoting fatty acid oxidation. Proc Natl Acad Sci U S A. 2014;111(23):E2414-2422.

Hao G, Chen H, Du K, Huang X, Song Y, Gu Z, Wang L, Zhang H, Chen W, Chen YQ. Increased fatty acid unsaturation and production of arachidonic acid by homologous over-expression of the mitochondrial malic enzyme in Mortierella alpina. Biotechnol Lett. 2014;36(9):1827-1834.

Yang B, Chen H, Gu Z, Tian F, Ross RP, Stanton C, Chen YQ, Chen W, Zhang H. Synthesis of conjugated linoleic acid by the linoleate isomerase complex in food-derived lactobacilli. J Appl Microbiol. 2014;117(2):430-439.

Yang B, Chen H, Song Y, Chen YQ, Zhang H, Chen W. Myosin-cross-reactive antigens from four different lactic acid bacteria are fatty acid hydratases. Biotechnol Lett. 2013;35(1):75-81.

Chen H, Gu Z, Zhang H, Wang M, Chen W, Lowther WT, Chen YQ. Expression and purification of integral membrane fatty acid desaturases. PLoS One. 2013;8(3):e58139.

Chen YQ. Introduction. Cancer Metastasis Rev. 2013;32(1-2):3-4.

Gu Z, Suburu J, Chen H, Chen YQ. Mechanisms of omega-3 polyunsaturated fatty acids in prostate cancer prevention. Biomed Res Int. 2013;2013():824563.

Chen YQ. Introduction [special issue: animal models in cancer research] [editorial]. Cancer Metastasis Rev. 2013;32(1-2):3-4.

Conley-LaComb MK, Saliganan A, Kandagatla P, Chen YQ, Cher ML, Chinni SR. PTEN loss mediated Akt activation promotes prostate tumor growth and metastasis via CXCL12/CXCR4 signaling. Mol Cancer. 2013;12():85.

Gu Z, Wu J, Wang S, Suburu J, Chen H, Thomas MJ, Shi L, Edwards IJ, Berquin IM, Chen YQ. Polyunsaturated fatty acids affect the localization and signaling of PIP3/AKT in prostate cancer cells. Carcinogenesis. 2013;34(9):1968-1975.

Wang M, Chen H, Gu Z, Zhang H, Chen W, Chen YQ. Omega 3 fatty acid desaturases from microorganisms: structure, function, evolution, and biotechnological use. Appl Microbiol Biotechnol. 2013;97(24):10255-62.

Suburu J, Gu Z, Chen H, Chen W, Zhang H, Chen YQ. Fatty acid metabolism: implications for diet, genetic variation, and disease. Food Biosci. 2013;4():1-12.

Conley-Lacomb K, Saliganan A, Chen YQ, Kim HRC, Cher ML, Chinni S. PTEN loss mediated Akt activation promotes prostate tumor growth via CXCL12/CXCR4 signaling [abstract]. Cancer Res. 2013;73(8 Suppl 1):A4088.

Wang S, Wu J, Suburu J, Gu Z, Cai J, Axanova LS, Cramer SD, Thomas MJ, Perry DL, Edwards IJ, Mucci LA, Sinnott JA, Loda MF, Sui G, Berquin IM, Chen YQ. Effect of dietary polyunsaturated fatty acids on castration-resistant Pten-null prostate cancer. Carcinogenesis. 2012;33(2):404-412.

Conley-LaComb MK, Huang W, Wang S, Shi D, Jung YS, Najy A, Fridman R, Bonfil RD, Cher ML, Chen YQ, Kim H-R C. PTEN regulates PDGF ligand switch for beta-PDGFR signaling in prostate cancer. Am J Pathol. 2012;180(3):1017-1027.

Hou TY, Monk JM, Fan Y-Y, Barhoumi R, Chen YQ, Rivera GM, McMurray DN, Chapkin RS. n-3 polyunsaturated fatty acids suppress phosphatidylinositol 4,5-bisphosphate-dependent actin remodelling during CD4+ T-cell activation. Biochem J. 2012;443(Pt 1):27-37.

Suburu J, Chen YQ. Lipids and prostate cancer. Prostaglandins Other Lipid Mediat. 2012;98(1-2):1-10.

Zhao J-X, Yang L, Gu Z-N, Chen H-Q, Tian F-W, Chen Y-Q, Zhang H, Chen W. Stabilization of the single-chain fragment variable by an interdomain disulfide bond and its effect on antibody affinity. Int J Mol Sci. 2011;12(1):1-11.

Sun H, Hu Y, Gu Z, Wilson MD, Chen YQ, Rudel LL, Willingham MC, Edwards IJ. Endogenous synthesis of n-3 polyunsaturated fatty acids in fat-1 mice is associated with increased mammary gland and liver syndecan-1. PLoS ONE. 2011;6(5):e20502.

Sun H, Hu Y, Gu Z, Owens RT, Chen YQ, Edwards IJ. Omega-3 fatty acids induce apoptosis in human breast cancer cells and mouse mammary tissue through syndecan-1 inhibition of the MEK-Erk pathway. Carcinogenesis. 2011;32(10):1518-1524.

Berquin IM, Edwards IJ, Kridel SJ, Chen YQ. Polyunsaturated fatty acid metabolism in prostate cancer. Cancer Metastasis Rev. 2011;30(3-4):295-309.

Wang L, Chen W, Feng Y, Ren Y, Gu Z, Chen H, Wang H, Thomas MJ, Zhang B, Berquin IM, Li Y, Wu J, Zhang H, Song Y, Liu X, Norris JS, Wang S, Du P, Shen J, Wang N, Yang Y, Wang W, Feng L, Ratledge C, Zhang H, Chen YQ. Genome characterization of the oleaginous fungus Mortierella alpina. PLoS ONE. 2011;6(12):e28319.

Berquin IM, Edwards IJ, O'Flaherty JT, Chen YQ. Omega-3 PUFAs: interventional trials for the prevention and treatment of breast and prostate cancer In: Calviello G, Serini S, eds. Dietary omega-3 polyunsaturated fatty acids and cancer. New York: Springer;2010: 149-166.

Edwards IJ, Berquin IM, Chen YQ, O'Flaherty JT. Omega-3 PUFAs, breast and prostate cancer: experimental studies In: Calviello G, Serini S, eds. Dietary omega-3 polyunsaturated fatty acids and cancer. New York: Springer;2010: 167-188.

Chial HJ, Lenart P, Chen YQ. APPL proteins FRET at the BAR: direct observation of APPL1 and APPL2 BAR domain-mediated interactions on cell membranes using FRET microscopy. PLoS ONE. 2010;5(8):e12471.

Hu Y, Sun H, Owens RT, Gu Z, Wu J, Chen YQ, O'Flaherty JT, Edwards IJ. Syndecan-1-dependent suppression of PDK1/Akt/bad signaling by docosahexaenoic acid induces apoptosis in prostate cancer. Neoplasia. 2010;12(10):826-836.

Kim S, Huang W, Mottillo EP, Sohail A, Ham Y-A, Conley-LaComb MK, Kim CJ, Tzivion G, Wang S, Chen YQ, et al. Posttranslational regulation of membrane type 1-matrix metalloproteinase (MT1-MMP) in mouse PTEN null prostate cancer cells: enhanced surface expression and differential O-glycosylation of MT1-MMP. Biochim Biophys Acta. 2010;1803(11):1287-1297.

Axanova LS, Chen YQ, McCoy T, Sui G, Cramer SD. 1,25-dihydroxyvitamin D3 and PI3K/AKT inhibitors synergistically inhibit growth and induce senescence in prostate cancer cells. Prostate. 2010;70(15):1658-1671.

Hu Y, Sun H, Owens RT, Wu J, Chen YQ, Berquin IM, Perry D, O'Flaherty JT, Edwards IJ. Decorin suppresses prostate tumor growth through inhibition of epidermal growth factor and androgen receptor pathways. Neoplasia. 2009;11(10):1042-1053.

Yang L, Ding H, Gu Z, Zhao J, Chen H, Tian F, Chen YQ, Zhang H, Chen W. Selection of single chain fragment variables with direct coating of aflatoxin B1 to enzyme-linked immunosorbent assay plates. J Agric Food Chem. 2009;57(19):8927-8932.

Chial HJ, Wu R, Ustach CV, McPhail LC, Mobley WC, Chen YQ. Membrane targeting by APPL1 and APPL2: dynamic scaffolds that oligomerize and bind phosphoinositides. Traffic. 2008;9(2):215-229.

Edwards IJ, Sun H, Hu Y, Berquin IM, O'Flaherty JT, Cline JM, Rudel LL, Chen YQ. In vivo and in vitro regulation of syndecan 1 in prostate cells by n-3 polyunsaturated fatty acids. J Biol Chem. 2008;283(26):18441-9.

Berquin IM, Edwards IJ, Chen YQ. Multi-targeted therapy of cancer by omega-3 fatty acids. Cancer Lett. 2008;269(2):363-377.

Sastry KSR, Karpova Y, Prokopovich S, Smith AJ, Essau B, Gersappe A, Carson JP, Weber MJ, Register TC, Chen YQ, Penn RB, Kulik G, et al. Epinephrine protects cancer cells from apoptosis via activation of cAMP-dependent protein kinase and BAD phosphorylation. J Biol Chem. 2007;282(19):14094-100.

Berquin IM, Min Y, Wu R, Wu J, Perry D, Cline JM, Thomas MJ, Thornburg T, Kulik G, Edwards IJ, D'Agostino R Jr, Chen YQ, et al. Modulation of prostate cancer genetic risk by omega-3 and omega-6 fatty acids. J Clin Invest. 2007;117(7):1866-1875.

Chen YQ, Edwards IJ, Kridel SJ, Thornburg T, Berquin IM. Dietary fat-gene interactions in cancer. Cancer Metastasis Rev. 2007;26(3-4):535-551.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Cancer Biology

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