Profile

Yong Q. Chen, Ph.D.

Yong Q. Chen, Ph.D.

Professor, Cancer Biology
Comprehensive Cancer Center
Center for Cancer Genomics
Translational Science Institute
Urology
Translational Science Institute
Contact Information
Office:
336-713-7655
Fax:
336-716-0255
Email: yqchen@wakehealth.edu
Education & Training
  BS Shanghai Medical University-China 1982
  PhD Free Standing Institute-Belgium 1989
Memberships
New York Academy of Sciences
American Association of Advancement of Science
American Association of Cancer Research
Yong Q. Chen, Ph.D.

Yong Q. Chen, Ph.D.

Professor, Cancer Biology
Comprehensive Cancer Center
Center for Cancer Genomics
Translational Science Institute
Urology
Translational Science Institute
Contact Information
Office:
336-713-7655
Fax:
336-716-0255
Email: yqchen@wakehealth.edu
Research Interests
cancer/oncogenesis , genetics/genome
Recent Publications
Wang S, Wu J, Suburu J, Gu Z, Cai J, Axanova LS, Cramer SD, Thomas MJ, Perry DL, Edwards IJ, Mucci LA, Sinnott JA, Loda MF, Sui G, Berquin IM, Chen YQ. Effect of dietary polyunsaturated fatty acids on castration-resistant Pten-null prostate cancer. Carcinogenesis. 2012; 33(2):404-412.

Conley-LaComb MK, Huang W, Wang S, Shi D, Jung YS, Najy A, Fridman R, Bonfil RD, Cher ML, Chen YQ, Kim H-R C. PTEN regulates PDGF ligand switch for beta-PDGFR signaling in prostate cancer. Am J Pathol. 2012; 180(3):1017-1027.

Zhao J-X, Yang L, Gu Z-N, Chen H-Q, Tian F-W, Chen Y-Q, Zhang H, Chen W. Stabilization of the single-chain fragment variable by an interdomain disulfide bond and its effect on antibody affinity. Int J Mol Sci. 2011; 12(1):1-11.

Sun H, Hu Y, Gu Z, Wilson MD, Chen YQ, Rudel LL, Willingham MC, Edwards IJ. Endogenous synthesis of n-3 polyunsaturated fatty acids in fat-1 mice is associated with increased mammary gland and liver syndecan-1. PLoS ONE. 2011; 6(5):e20502.

Sun H, Hu Y, Gu Z, Owens RT, Chen YQ, Edwards IJ. Omega-3 fatty acids induce apoptosis in human breast cancer cells and mouse mammary tissue through syndecan-1 inhibition of the MEK-Erk pathway. Carcinogenesis. 2011; 32(10):1518-1524.

Berquin IM, Edwards IJ, Kridel SJ, Chen YQ. Polyunsaturated fatty acid metabolism in prostate cancer. Cancer Metastasis Rev. 2011; 30(3-4):295-309.

Wang L, Chen W, Feng Y, Ren Y, Gu Z, Chen H, Wang H, Thomas MJ, Zhang B, Berquin IM, Li Y, Wu J, Zhang H, Song Y, Liu X, Norris JS, Wang S, Du P, Shen J, Wang N, Yang Y, Wang W, Feng L, Ratledge C, Zhang H, Chen YQ. Genome characterization of the oleaginous fungus Mortierella alpina. PLoS ONE. 2011; 6(12):e28319.

Berquin IM, Edwards IJ, O'Flaherty JT, Chen YQ. Omega-3 PUFAs: interventional trials for the prevention and treatment of breast and prostate cancer. In: Calviello G, Serini S, eds. Dietary omega-3 polyunsaturated fatty acids and cancer. New York: Springer; 2010: 149-166.

Edwards IJ, Berquin IM, Chen YQ, O'Flaherty JT. Omega-3 PUFAs, breast and prostate cancer: experimental studies. In: Calviello G, Serini S, eds. Dietary omega-3 polyunsaturated fatty acids and cancer. New York: Springer; 2010: 167-188.

Chial HJ, Lenart P, Chen YQ. APPL proteins FRET at the BAR: direct observation of APPL1 and APPL2 BAR domain-mediated interactions on cell membranes using FRET microscopy. PLoS ONE. 2010; 5(8):e12471.

Hu Y, Sun H, Owens RT, Gu Z, Wu J, Chen YQ, O'Flaherty JT, Edwards IJ. Syndecan-1-dependent suppression of PDK1/Akt/bad signaling by docosahexaenoic acid induces apoptosis in prostate cancer. Neoplasia. 2010; 12(10):826-836.

Kim S, Huang W, Mottillo EP, Sohail A, Ham Y-A, Conley-LaComb MK, Kim CJ, Tzivion G, Wang S, Chen YQ, et al. Posttranslational regulation of membrane type 1-matrix metalloproteinase (MT1-MMP) in mouse PTEN null prostate cancer cells: enhanced surface expression and differential O-glycosylation of MT1-MMP. Biochim Biophys Acta. 2010; 1803(11):1287-1297.

Axanova LS, Chen YQ, McCoy T, Sui G, Cramer SD. 1,25-dihydroxyvitamin D3 and PI3K/AKT inhibitors synergistically inhibit growth and induce senescence in prostate cancer cells. Prostate. 2010; 70(15):1658-1671.

Hu Y, Sun H, Owens RT, Wu J, Chen YQ, Berquin IM, Perry D, O'Flaherty JT, Edwards IJ. Decorin suppresses prostate tumor growth through inhibition of epidermal growth factor and androgen receptor pathways. Neoplasia. 2009; 11(10):1042-1053.

Yang L, Ding H, Gu Z, Zhao J, Chen H, Tian F, Chen YQ, Zhang H, Chen W. Selection of single chain fragment variables with direct coating of aflatoxin B1 to enzyme-linked immunosorbent assay plates. J Agric Food Chem. 2009; 57(19):8927-8932.

Chial HJ, Wu R, Ustach CV, McPhail LC, Mobley WC, Chen YQ. Membrane targeting by APPL1 and APPL2: dynamic scaffolds that oligomerize and bind phosphoinositides. Traffic. 2008; 9(2):215-229.

Edwards IJ, Sun H, Hu Y, Berquin IM, O'Flaherty JT, Cline JM, Rudel LL, Chen YQ. In vivo and in vitro regulation of syndecan 1 in prostate cells by n-3 polyunsaturated fatty acids. J Biol Chem. 2008; 283(26):18441-9.

Berquin IM, Edwards IJ, Chen YQ. Multi-targeted therapy of cancer by omega-3 fatty acids. Cancer Lett. 2008; 269(2):363-377.

Sastry KSR, Karpova Y, Prokopovich S, Smith AJ, Essau B, Gersappe A, Carson JP, Weber MJ, Register TC, Chen YQ, Penn RB, Kulik G, et al. Epinephrine protects cancer cells from apoptosis via activation of cAMP-dependent protein kinase and BAD phosphorylation. J Biol Chem. 2007; 282(19):14094-100.

Berquin IM, Min Y, Wu R, Wu J, Perry D, Cline JM, Thomas MJ, Thornburg T, Kulik G, Edwards IJ, D'Agostino R Jr, Chen YQ, et al. Modulation of prostate cancer genetic risk by omega-3 and omega-6 fatty acids. J Clin Invest. 2007; 117(7):1866-1875.

Chen YQ, Edwards IJ, Kridel SJ, Thornburg T, Berquin IM. Dietary fat-gene interactions in cancer. Cancer Metastasis Rev. 2007; 26(3-4):535-551.

Chen YQ, Berquin IM, Daniel LW, Edwards IJ, O'Flaherty JT, Thomas MJ, Tooze JA, Wykle B. Omega-3 fatty acids and cancer risk [letter]. JAMA. 2006; 296(3):282.
All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Back To Top
Last Updated 4/30/2012
Quick Reference
Request an Appointment
New Patients
336-716-WAKE
888-716-WAKE
Existing patients may contact the clinic directly.
Locate Faculty

e.g., "allergy," "diabetes"

US News Best Hospital AwardANCC Magnet Association AwardBest Doctors 2011-2012 AwardConsumer Choice #1 Award 2011-2102US News Best Medical Schools 2011 Award

Disclaimer: The information on this website is for general informational purposes only and SHOULD NOT be relied upon as a substitute for sound professional medical advice, evaluation or care from your physician or other qualified health care provider.