Profile

Yong Q. Chen, Ph.D.Wake Forest School of Medicine

Yong Q. Chen, Ph.D.

Professor,

Contact Information

Academic: 336-713-7655 | Department: 336-713-7655

Email: yqchen@wakehealth.edu

Education & Training

  • B.S., Fudan University, Shanghai, China, 1982
  • Ph.D., Free University of Brussels, Belgium, 1989

Memberships

  • New York Academy Of Sciences
  • Am Assn Of Advancement Of Scie
  • Am Assn Of Cancer Research
Yong Q. Chen, Ph.D.

Yong Q. Chen, Ph.D.

Professor, Cancer Biology

Research Interests

Fatty Acids, Omega-3; Prostatic Neoplasms; Fatty Acids, Omega-6; Fatty Acids, Unsaturated; Cell Membrane
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Contact Information

Academic: 336-713-7655 | Department: 336-713-7655

Email: yqchen@wakehealth.edu

Recent Publications

Characterization of an fungal l-fucokinase involved in Mortierella alpina GDP-l-fucose salvage pathway. Wang H, Zhang C, Chen H, Yang Q, Zhou X, Gu Z, Zhang H, Chen W, Chen YQ.. Glycobiology. 2016;():.

Metabolic engineering of Mortierella alpina for enhanced arachidonic acid production through the NADPH supplying strategy. Hao G, Chen H, Gu Z, Zhang H, Chen W, Chen YQ.. Appl Environ Microbiol. 2016;82(11):3280-3288.

Multi-dimensional, comprehensive sample extraction combined with LC-GC/MS analysis for complex biological samples: application in the metabolomics study of acute pancreatitis. Yang Q, Sun J, Chen YQ.. RSC Adv. 2016;6(31):.

A new regulatory mechanism controlling carotenogenesis in the fungus Mucor circinelloides as a target to generate beta-carotene over-producing strains by genetic engineering. Zhang Y, Navarro E, Canovas-Marquez JT, Almagro L, Chen H, Chen YQ, Zhang H, Torres-Martinez S, Chen W, Garre V.. Microb Cell Fact. 2016;15(1):99.

Screening of potential probiotic lactic acid bacteria based on gastrointestinal properties and perfluorooctanoate toxicity. Xing J, Wang F, Xu Q, Yin B, Fang D, Zhao J, Zhang H, Chen YQ, Wang G, Chen W.. Appl Microbiol Biotechnol. 2016;100(15):6755-6766.

Proteomics analysis of high lipid-producing strain Mucor circinelloides WJ11: an explanation for the mechanism of lipid accumulation at the proteomic level. Tang X, Zan X, Zhao L, Chen H, Chen YQ, Chen W, Song Y, Ratledge C.. Microb Cell Fact. 2016;15():35.

Maximum-biomass concentration prediction for Bifidobacteria in the pH-controlled fed-batch culture. Cui SM, Zhao JX, Liu XM, Chen YQ, Zhang H, Chen W.. Lett Appl Microbiol. 2016;62(3):256-263.

Role of malate transporter in lipid accumulation of oleaginous fungus Mucor circinelloides. Zhao L, Canovas-Marquez JT, Tang X, Chen H, Chen YQ, Chen W, Garre V, Song Y, Ratledge C.. Appl Microbiol Biotechnol. 2016;100(3):1297-1305.

Maximum-biomass prediction of homofermentative Lactobacillus. Cui S, Zhao J, Liu X, Chen YQ, Zhang H, Chen W.. J Biosci Bioeng. 2016;122(1):52-57.

Clostridium butyricum CGMCC0313.1 modulates lipid profile, insulin resistance and colon homeostasis in obese mice. Shang H, Sun J, Chen YQ.. PLoS One. 2016;11(4):e0154373.

Toxicity assessment of perfluorooctane sulfonate using acute and subchronic male C57BL/6J mouse models. Xing J, Wang G, Zhao J, Wang E, Yin B, Fang D, Zhao J, Zhang H, Chen YQ, Chen W.. Environ Pollut. 2016;210():388-396.

Therapeutic implications of innate immune system in acute pancreatitis. Shamoon M, Deng Y, Chen YQ, Bhatia M, Sun J.. Expert Opin Ther Targets. 2016;20(1):73-87.

Cathelicidins positively regulate pancreatic beta-cell functions. Sun J, Xu M, Ortsater H, Lundeberg E, Juntti-Berggren L, Chen YQ, Haeggstrom JZ, Gudmundsson GH, Diana J, Agerberth B.. FASEB J. 2016;30(2):884-894.

Substrate specificity of Mortierella alpina Delta 9-III fatty acid desaturase and its value for the production of omega-9 MUFA. Hao GF, Chen HQ, Yang B, Du K, Wang HC, Gu ZN, Zhang H, Chen W, Chen YQ.. Eur J Lipid Sci Technol. 2016;118(5):753-760.

Application of a delta-6 desaturase with alpha-linolenic acid preference on eicosapentaenoic acid production in Mortierella alpina. Shi H, Chen H, Gu Z, Zhang H, Chen W, Chen YQ.. Microb Cell Fact. 2016;15(1):117.

Biochemical characterization of an isoform of GDP-D-mannose-4,6-dehydratase from Mortierella alpina. Wang H, Zhang C, Chen H, Yang Q, Zhou X, Gu Z, Zhang H, Chen W, Chen YQ.. Biotechnol Lett. 2016;():.

Production of GDP-L-fucose from exogenous fucose through the salvage pathway in Mortierella alpina. Wang HC, Zhang C, Yang Q, Feng JH, Chen HQ, Gu ZN, Zhang H, Chen W, Chen YQ.. RSC Adv. 2016;6(52):.

Identification of a critical determinant that enables efficient fatty acid synthesis in oleaginous fungi. Chen H, Hao G, Wang L, Wang H, Gu Z, Liu L, Zhang H, Chen W, Chen YQ.. Sci Rep. 2015;5():11247.

Maspin expression in prostate tumor cells averts stemness and stratifies drug sensitivity. Bernardo MM, Kaplun A, Dzinic SH, Li X, Irish J, Mujagic A, Jakupovic B, Back JB, Van Buren E, Han X, Dean I, Chen YQ, Heath E, Sakr W, Sheng S.. Cancer Res. 2015;75(18):3970-3979.

Omega -3 PUFAs in the prevention and cure of inflammatory, degenerative, and neoplastic diseases 2014 [editorial]. Weylandt KH, Chen YQ, Lim K, Su HM, Cittadini A, Calviello G.. Biomed Res Int. 2015;2015():695875.

Omega-3 polyunsaturated fatty acids: the way forward in times of mixed evidence. Weylandt KH, Serini S, Chen YQ, Su HM, Lim K, Cittadini A, Calviello G.. Biomed Res Int. 2015;2015():143109.

Production of conjugated linoleic acid by heterologous expression of linoleic acid isomerase in oleaginous fungus Mortierella alpina. Hao DH, Chen HQ, Hao GF, Yang B, Zhang BX, Zhang H, Chen W, Chen YQ.. Biotechnol Lett. 2015;37(10):1983-1992.

Complete genome sequence of Lactobacillus plantarum ZS2058, a probiotic strain with high conjugated linoleic acid production ability. Yang B, Chen H, Tian F, Zhao J, Gu Z, Zhang H, Chen YQ, Chen W.. J Biotechnol. 2015;214():212-213.

n-3 polyunsaturated fatty acids and their role in cancer chemoprevention. Gu Z, Shan K, Chen H, Chen YQ.. Curr Pharmacol Rep. 2015;1(5):283-294.

Metabolic engineering of Mortierella alpina for arachidonic acid production with glycerol as carbon source. Hao G, Chen H, Gu Z, Zhang H, Chen W, Chen YQ.. Microb Cell Fact. 2015;14(1):205.

Molecular mechanism of substrate specificity for delta 6 desaturase from Mortierella alpina and Micromonas pusilla. Shi H, Chen H, Gu Z, Song Y, Zhang H, Chen W, Chen YQ.. J Lipid Res. 2015;56(12):2309-2321.

(13)C-metabolic flux analysis of lipid accumulation in the oleaginous fungus Mucor circinelloides. Zhao L, Zhang H, Wang L, Chen H, Chen YQ, Chen W, Song Y.. Bioresour Technol. 2015;197():23-29.

Oral application of lactic acid bacteria following treatment with antibiotics inhibits allergic airway inflammation. Zhang Q, Ai C, Wang G, Liu X, Tian F, Zhao J, Zhang H, Chen YQ1, Chen W.. J Appl Microbiol. 2015;119(3):809-817.

A new potential secretion pathway for recombinant proteins in Bacillus subtilis. Wang G, Xia Y, Gu Z, Zhang H, Chen YQ, Chen H, Ai L, Chen W.. Microb Cell Fact. 2015;14(1):179.

Suppression of dust mite allergy by mucosal delivery of a hypoallergenic derivative in a mouse model. Ai C, Zhang Q, Ding J, Ren C, Wang G, Liu X, Tian F, Zhao J, Zhang H, Chen YQ, Chen W.. Appl Microbiol Biotechnol. 2015;99(10):4309-4319.

Omega-3 free fatty acids inhibit tamoxifen-induced cell apoptosis. Wu S, Guo Y, Wu Y, Zhu S, He Z, Chen YQ.. Biochem Biophys Res Commun. 2015;459(2):294-299.

In vitro fermentation of fructooligosaccharides with human gut bacteria. Mao B, Li D, Zhao J, Liu X, Gu Z, Chen YQ, Zhang H, Chen W.. Food Funct. 2015;6(3):947-954.

RE: serum phospholipid fatty acids and prostate cancer risk in the SELECT trial [letter]. Suburu J, Lim K, Calviello G, Chen YQ.. J Natl Cancer Inst. 2014;106(4):dju023.

Role of malic enzyme during fatty acid synthesis in the oleaginous fungus mortierella alpina. Hao GF, Chen HQ, Wang L, Gu ZN, Song YD, Zhang H, Chen W, Chen YQ.. Appl Environ Microbiol. 2014;80(9):2672-2678.

Ribosomal protein-Mdm2-p53 pathway coordinates nutrient stress with lipid metabolism by regulating MCD and promoting fatty acid oxidation. Liu Y, He Y, Jin A, Tikunov AP, Zhou L, Tollini LA, Leslie P, Kim TH, Li LO, Coleman RA, Gu Z, Chen YQ, Macdonald JM, Graves LM, Zhang Y.. Proc Natl Acad Sci U S A. 2014;111(23):E2414-2422.

Increased fatty acid unsaturation and production of arachidonic acid by homologous over-expression of the mitochondrial malic enzyme in Mortierella alpina. Hao G, Chen H, Du K, Huang X, Song Y, Gu Z, Wang L, Zhang H, Chen W, Chen YQ.. Biotechnol Lett. 2014;36(9):1827-1834.

Synthesis of conjugated linoleic acid by the linoleate isomerase complex in food-derived lactobacilli. Yang B, Chen H, Gu Z, Tian F, Ross RP, Stanton C, Chen YQ, Chen W, Zhang H.. J Appl Microbiol. 2014;117(2):430-439.

Myosin-cross-reactive antigens from four different lactic acid bacteria are fatty acid hydratases. Yang B, Chen H, Song Y, Chen YQ, Zhang H, Chen W.. Biotechnol Lett. 2013;35(1):75-81.

Expression and purification of integral membrane fatty acid desaturases. Chen H, Gu Z, Zhang H, Wang M, Chen W, Lowther WT, Chen YQ.. PLoS One. 2013;8(3):e58139.

Introduction. Chen YQ.. Cancer Metastasis Rev. 2013;32(1-2):3-4.

Mechanisms of omega-3 polyunsaturated fatty acids in prostate cancer prevention. Gu Z, Suburu J, Chen H, Chen YQ.. Biomed Res Int. 2013;2013():824563.

Introduction [special issue: animal models in cancer research] [editorial]. Chen YQ.. Cancer Metastasis Rev. 2013;32(1-2):3-4.

PTEN loss mediated Akt activation promotes prostate tumor growth and metastasis via CXCL12/CXCR4 signaling. Conley-LaComb MK, Saliganan A, Kandagatla P, Chen YQ, Cher ML, Chinni SR.. Mol Cancer. 2013;12():85.

Polyunsaturated fatty acids affect the localization and signaling of PIP3/AKT in prostate cancer cells. Gu Z, Wu J, Wang S, Suburu J, Chen H, Thomas MJ, Shi L, Edwards IJ, Berquin IM, Chen YQ.. Carcinogenesis. 2013;34(9):1968-1975.

Omega 3 fatty acid desaturases from microorganisms: structure, function, evolution, and biotechnological use. Wang M, Chen H, Gu Z, Zhang H, Chen W, Chen YQ.. Appl Microbiol Biotechnol. 2013;97(24):10255-62.

Fatty acid metabolism: implications for diet, genetic variation, and disease. Suburu J, Gu Z, Chen H, Chen W, Zhang H, Chen YQ.. Food Biosci. 2013;4():1-12.

PTEN loss mediated Akt activation promotes prostate tumor growth via CXCL12/CXCR4 signaling [abstract]. Conley-Lacomb K, Saliganan A, Chen YQ, Kim HRC, Cher ML, Chinni S.. Cancer Res. 2013;73(8 Suppl 1):A4088.

Effect of dietary polyunsaturated fatty acids on castration-resistant Pten-null prostate cancer. Wang S, Wu J, Suburu J, Gu Z, Cai J, Axanova LS, Cramer SD, Thomas MJ, Perry DL, Edwards IJ, Mucci LA, Sinnott JA, Loda MF, Sui G, Berquin IM, Chen YQ.. Carcinogenesis. 2012;33(2):404-412.

PTEN regulates PDGF ligand switch for beta-PDGFR signaling in prostate cancer. Conley-LaComb MK, Huang W, Wang S, Shi D, Jung YS, Najy A, Fridman R, Bonfil RD, Cher ML, Chen YQ, Kim H-R C.. Am J Pathol. 2012;180(3):1017-1027.

n-3 polyunsaturated fatty acids suppress phosphatidylinositol 4,5-bisphosphate-dependent actin remodelling during CD4+ T-cell activation. Hou TY, Monk JM, Fan Y-Y, Barhoumi R, Chen YQ, Rivera GM, McMurray DN, Chapkin RS.. Biochem J. 2012;443(Pt 1):27-37.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Cancer Biology

Yong Q. Chen, Ph.D.

Yong Q. Chen, Ph.D.

Professor, Cancer Biology

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