Profile

Yong Q. Chen, Ph.D.Wake Forest School of Medicine

Yong Q. Chen, Ph.D.

Professor,

Contact Information

Academic: 336-713-7655 | Department: 336-713-7655

Email: yqchen@wakehealth.edu

Education & Training

  • B.S., Fudan University, Shanghai, China, 1982
  • Ph.D., Free University of Brussels, Belgium, 1989

Memberships

  • New York Academy Of Sciences
  • Am Assn Of Advancement Of Scie
  • Am Assn Of Cancer Research
Yong Q. Chen, Ph.D.

Yong Q. Chen, Ph.D.

Professor, Cancer Biology

Research Interests

cancer/oncogenesis, genetics/genome, hormones/cytokines/signalling

Contact Information

Academic: 336-713-7655 | Department: 336-713-7655

Email: yqchen@wakehealth.edu

Recent Publications

Wang H, Zhang C, Chen H, Yang Q, Zhou X, Gu Z, Zhang H, Chen W, Chen YQ. Characterization of an fungal l-fucokinase involved in Mortierella alpina GDP-l-fucose salvage pathway. Glycobiology. 2016;():.

Hao G, Chen H, Gu Z, Zhang H, Chen W, Chen YQ. Metabolic engineering of Mortierella alpina for enhanced arachidonic acid production through the NADPH supplying strategy. Appl Environ Microbiol. 2016;82(11):3280-3288.

Yang Q, Sun J, Chen YQ. Multi-dimensional, comprehensive sample extraction combined with LC-GC/MS analysis for complex biological samples: application in the metabolomics study of acute pancreatitis. RSC Adv. 2016;6(31):.

Zhang Y, Navarro E, Canovas-Marquez JT, Almagro L, Chen H, Chen YQ, Zhang H, Torres-Martinez S, Chen W, Garre V. A new regulatory mechanism controlling carotenogenesis in the fungus Mucor circinelloides as a target to generate beta-carotene over-producing strains by genetic engineering. Microb Cell Fact. 2016;15(1):99.

Xing J, Wang F, Xu Q, Yin B, Fang D, Zhao J, Zhang H, Chen YQ, Wang G, Chen W. Screening of potential probiotic lactic acid bacteria based on gastrointestinal properties and perfluorooctanoate toxicity. Appl Microbiol Biotechnol. 2016;():.

Tang X, Zan X, Zhao L, Chen H, Chen YQ, Chen W, Song Y, Ratledge C. Proteomics analysis of high lipid-producing strain Mucor circinelloides WJ11: an explanation for the mechanism of lipid accumulation at the proteomic level. Microb Cell Fact. 2016;15():35.

Cui SM, Zhao JX, Liu XM, Chen YQ, Zhang H, Chen W. Maximum-biomass concentration prediction for Bifidobacteria in the pH-controlled fed-batch culture. Lett Appl Microbiol. 2016;62(3):256-263.

Zhao L, Canovas-Marquez JT, Tang X, Chen H, Chen YQ, Chen W, Garre V, Song Y, Ratledge C. Role of malate transporter in lipid accumulation of oleaginous fungus Mucor circinelloides. Appl Microbiol Biotechnol. 2016;100(3):1297-1305.

Cui S, Zhao J, Liu X, Chen YQ, Zhang H, Chen W. Maximum-biomass prediction of homofermentative Lactobacillus. J Biosci Bioeng. 2016;122(1):52-57.

Shang H, Sun J, Chen YQ. Clostridium butyricum CGMCC0313.1 modulates lipid profile, insulin resistance and colon homeostasis in obese mice. PLoS One. 2016;11(4):e0154373.

Xing J, Wang G, Zhao J, Wang E, Yin B, Fang D, Zhao J, Zhang H, Chen YQ, Chen W. Toxicity assessment of perfluorooctane sulfonate using acute and subchronic male C57BL/6J mouse models. Environ Pollut. 2016;210():388-396.

Shamoon M, Deng Y, Chen YQ, Bhatia M, Sun J. Therapeutic implications of innate immune system in acute pancreatitis. Expert Opin Ther Targets. 2016;20(1):73-87.

Sun J, Xu M, Ortsater H, Lundeberg E, Juntti-Berggren L, Chen YQ, Haeggstrom JZ, Gudmundsson GH, Diana J, Agerberth B. Cathelicidins positively regulate pancreatic beta-cell functions. FASEB J. 2016;30(2):884-894.

Hao GF, Chen HQ, Yang B, Du K, Wang HC, Gu ZN, Zhang H, Chen W, Chen YQ. Substrate specificity of Mortierella alpina Delta 9-III fatty acid desaturase and its value for the production of omega-9 MUFA. Eur J Lipid Sci Technol. 2016;118(5):753-760.

Chen H, Hao G, Wang L, Wang H, Gu Z, Liu L, Zhang H, Chen W, Chen YQ. Identification of a critical determinant that enables efficient fatty acid synthesis in oleaginous fungi. Sci Rep. 2015;5():11247.

Bernardo MM, Kaplun A, Dzinic SH, Li X, Irish J, Mujagic A, Jakupovic B, Back JB, Van Buren E, Han X, Dean I, Chen YQ, Heath E, Sakr W, Sheng S. Maspin expression in prostate tumor cells averts stemness and stratifies drug sensitivity. Cancer Res. 2015;75(18):3970-3979.

Weylandt KH, Chen YQ, Lim K, Su HM, Cittadini A, Calviello G. Omega -3 PUFAs in the prevention and cure of inflammatory, degenerative, and neoplastic diseases 2014 [editorial]. Biomed Res Int. 2015;2015():695875.

Weylandt KH, Serini S, Chen YQ, Su HM, Lim K, Cittadini A, Calviello G. Omega-3 polyunsaturated fatty acids: the way forward in times of mixed evidence. Biomed Res Int. 2015;2015():143109.

Hao DH, Chen HQ, Hao GF, Yang B, Zhang BX, Zhang H, Chen W, Chen YQ. Production of conjugated linoleic acid by heterologous expression of linoleic acid isomerase in oleaginous fungus Mortierella alpina. Biotechnol Lett. 2015;37(10):1983-1992.

Yang B, Chen H, Tian F, Zhao J, Gu Z, Zhang H, Chen YQ, Chen W. Complete genome sequence of Lactobacillus plantarum ZS2058, a probiotic strain with high conjugated linoleic acid production ability. J Biotechnol. 2015;214():212-213.

Gu Z, Shan K, Chen H, Chen YQ. n-3 polyunsaturated fatty acids and their role in cancer chemoprevention. Curr Pharmacol Rep. 2015;1(5):283-294.

Hao G, Chen H, Gu Z, Zhang H, Chen W, Chen YQ. Metabolic engineering of Mortierella alpina for arachidonic acid production with glycerol as carbon source. Microb Cell Fact. 2015;14(1):205.

Shi H, Chen H, Gu Z, Song Y, Zhang H, Chen W, Chen YQ. Molecular mechanism of substrate specificity for delta 6 desaturase from Mortierella alpina and Micromonas pusilla. J Lipid Res. 2015;56(12):2309-2321.

Zhao L, Zhang H, Wang L, Chen H, Chen YQ, Chen W, Song Y. (13)C-metabolic flux analysis of lipid accumulation in the oleaginous fungus Mucor circinelloides. Bioresour Technol. 2015;197():23-29.

Zhang Q, Ai C, Wang G, Liu X, Tian F, Zhao J, Zhang H, Chen YQ1, Chen W. Oral application of lactic acid bacteria following treatment with antibiotics inhibits allergic airway inflammation. J Appl Microbiol. 2015;119(3):809-817.

Wang G, Xia Y, Gu Z, Zhang H, Chen YQ, Chen H, Ai L, Chen W. A new potential secretion pathway for recombinant proteins in Bacillus subtilis. Microb Cell Fact. 2015;14(1):179.

Suburu J, Lim K, Calviello G, Chen YQ. RE: serum phospholipid fatty acids and prostate cancer risk in the SELECT trial [letter]. J Natl Cancer Inst. 2014;106(4):dju023.

Hao GF, Chen HQ, Wang L, Gu ZN, Song YD, Zhang H, Chen W, Chen YQ. Role of malic enzyme during fatty acid synthesis in the oleaginous fungus mortierella alpina. Appl Environ Microbiol. 2014;80(9):2672-2678.

Liu Y, He Y, Jin A, Tikunov AP, Zhou L, Tollini LA, Leslie P, Kim TH, Li LO, Coleman RA, Gu Z, Chen YQ, Macdonald JM, Graves LM, Zhang Y. Ribosomal protein-Mdm2-p53 pathway coordinates nutrient stress with lipid metabolism by regulating MCD and promoting fatty acid oxidation. Proc Natl Acad Sci U S A. 2014;111(23):E2414-2422.

Hao G, Chen H, Du K, Huang X, Song Y, Gu Z, Wang L, Zhang H, Chen W, Chen YQ. Increased fatty acid unsaturation and production of arachidonic acid by homologous over-expression of the mitochondrial malic enzyme in Mortierella alpina. Biotechnol Lett. 2014;36(9):1827-1834.

Yang B, Chen H, Gu Z, Tian F, Ross RP, Stanton C, Chen YQ, Chen W, Zhang H. Synthesis of conjugated linoleic acid by the linoleate isomerase complex in food-derived lactobacilli. J Appl Microbiol. 2014;117(2):430-439.

Yang B, Chen H, Song Y, Chen YQ, Zhang H, Chen W. Myosin-cross-reactive antigens from four different lactic acid bacteria are fatty acid hydratases. Biotechnol Lett. 2013;35(1):75-81.

Chen H, Gu Z, Zhang H, Wang M, Chen W, Lowther WT, Chen YQ. Expression and purification of integral membrane fatty acid desaturases. PLoS One. 2013;8(3):e58139.

Chen YQ. Introduction. Cancer Metastasis Rev. 2013;32(1-2):3-4.

Gu Z, Suburu J, Chen H, Chen YQ. Mechanisms of omega-3 polyunsaturated fatty acids in prostate cancer prevention. Biomed Res Int. 2013;2013():824563.

Chen YQ. Introduction [special issue: animal models in cancer research] [editorial]. Cancer Metastasis Rev. 2013;32(1-2):3-4.

Conley-LaComb MK, Saliganan A, Kandagatla P, Chen YQ, Cher ML, Chinni SR. PTEN loss mediated Akt activation promotes prostate tumor growth and metastasis via CXCL12/CXCR4 signaling. Mol Cancer. 2013;12():85.

Gu Z, Wu J, Wang S, Suburu J, Chen H, Thomas MJ, Shi L, Edwards IJ, Berquin IM, Chen YQ. Polyunsaturated fatty acids affect the localization and signaling of PIP3/AKT in prostate cancer cells. Carcinogenesis. 2013;34(9):1968-1975.

Wang M, Chen H, Gu Z, Zhang H, Chen W, Chen YQ. Omega 3 fatty acid desaturases from microorganisms: structure, function, evolution, and biotechnological use. Appl Microbiol Biotechnol. 2013;97(24):10255-62.

Suburu J, Gu Z, Chen H, Chen W, Zhang H, Chen YQ. Fatty acid metabolism: implications for diet, genetic variation, and disease. Food Biosci. 2013;4():1-12.

Conley-Lacomb K, Saliganan A, Chen YQ, Kim HRC, Cher ML, Chinni S. PTEN loss mediated Akt activation promotes prostate tumor growth via CXCL12/CXCR4 signaling [abstract]. Cancer Res. 2013;73(8 Suppl 1):A4088.

Wang S, Wu J, Suburu J, Gu Z, Cai J, Axanova LS, Cramer SD, Thomas MJ, Perry DL, Edwards IJ, Mucci LA, Sinnott JA, Loda MF, Sui G, Berquin IM, Chen YQ. Effect of dietary polyunsaturated fatty acids on castration-resistant Pten-null prostate cancer. Carcinogenesis. 2012;33(2):404-412.

Conley-LaComb MK, Huang W, Wang S, Shi D, Jung YS, Najy A, Fridman R, Bonfil RD, Cher ML, Chen YQ, Kim H-R C. PTEN regulates PDGF ligand switch for beta-PDGFR signaling in prostate cancer. Am J Pathol. 2012;180(3):1017-1027.

Hou TY, Monk JM, Fan Y-Y, Barhoumi R, Chen YQ, Rivera GM, McMurray DN, Chapkin RS. n-3 polyunsaturated fatty acids suppress phosphatidylinositol 4,5-bisphosphate-dependent actin remodelling during CD4+ T-cell activation. Biochem J. 2012;443(Pt 1):27-37.

Suburu J, Chen YQ. Lipids and prostate cancer. Prostaglandins Other Lipid Mediat. 2012;98(1-2):1-10.

Zhao J-X, Yang L, Gu Z-N, Chen H-Q, Tian F-W, Chen Y-Q, Zhang H, Chen W. Stabilization of the single-chain fragment variable by an interdomain disulfide bond and its effect on antibody affinity. Int J Mol Sci. 2011;12(1):1-11.

Sun H, Hu Y, Gu Z, Wilson MD, Chen YQ, Rudel LL, Willingham MC, Edwards IJ. Endogenous synthesis of n-3 polyunsaturated fatty acids in fat-1 mice is associated with increased mammary gland and liver syndecan-1. PLoS ONE. 2011;6(5):e20502.

Sun H, Hu Y, Gu Z, Owens RT, Chen YQ, Edwards IJ. Omega-3 fatty acids induce apoptosis in human breast cancer cells and mouse mammary tissue through syndecan-1 inhibition of the MEK-Erk pathway. Carcinogenesis. 2011;32(10):1518-1524.

Berquin IM, Edwards IJ, Kridel SJ, Chen YQ. Polyunsaturated fatty acid metabolism in prostate cancer. Cancer Metastasis Rev. 2011;30(3-4):295-309.

Wang L, Chen W, Feng Y, Ren Y, Gu Z, Chen H, Wang H, Thomas MJ, Zhang B, Berquin IM, Li Y, Wu J, Zhang H, Song Y, Liu X, Norris JS, Wang S, Du P, Shen J, Wang N, Yang Y, Wang W, Feng L, Ratledge C, Zhang H, Chen YQ. Genome characterization of the oleaginous fungus Mortierella alpina. PLoS ONE. 2011;6(12):e28319.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Cancer Biology

Yong Q. Chen, Ph.D.

Yong Q. Chen, Ph.D.

Professor, Cancer Biology

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