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Che-Ping Cheng, M.D., Ph.D.Wake Forest School of Medicine

Che-Ping Cheng, M.D., Ph.D.

Professor,


Contact Information

Academic: 336-716-2887 | Department: 336-716-6674

Education & Training

  • M.D., Nanjing Railway Medical University-China, 1977
  • Ph.D., Wayne State University School of Medicine, 1986
  • Fellowship, WFU School of Medicine, 1988

Memberships

  • Int'l Soc of Heart Research
  • Am Assn for the Adv of Science
  • Am Soc Biochem Molecular Bio
  • Am Federation Of Clinical Rese
  • Am Heart Association
  • Am Physiological Society
  • Cardiovascular Systems Dynamic
  • Heart Failure Society of Am
  • Int'L Soc Biomedical Rsrch Alc
Che-Ping Cheng, M.D., Ph.D.

Che-Ping Cheng, M.D., Ph.D.

Professor, Cardiology
Office of Women in Medicine and Science
Physiology & Pharmacology

Research Interests

cardiac function, drugs/therapeutic agents pharm, molecular biology/molecular me

Contact Information

Academic: 336-716-2887 | Department: 336-716-6674

Recent Publications

Zhou P, Cheng CP, Li T, Ferrario CM, Cheng HJ. Modulation of cardiac L-type Ca2+ current by angiotensin-(1-7): normal versus heart failure. Ther Adv Cardiovasc Dis. 2015;():.

Dong J, Zhao J, Zhang M, Liu G, Wang X, Liu Y, Yang N, Liu Y, Zhao G, Sun J, Tian J, Cheng C, Wei L, Li Y, Li W. beta3-adrenoceptor impairs mitochondrial biogenesis and energy metabolism during rapid atrial pacing-induced atrial fibrillation. J Cardiovasc Pharmacol Ther. 2015;():.

Li T, Cheng H-J, Qasem SA, Callahan M, Li W-M, Cheng C-P. Restoration of normal cardiomyocyte basal and beta-adrenergic receptor (AR) subtype modulation in heart failure by chronic phosphodiesterase type 5 inhibition with sildenafil [abstract]. Circulation. 2014;130(Suppl 2):A15848.

Li T, Cheng H-J, Zhang X, Li W-M, Cheng C-P. Acute inhibition of phosphodiesterase type 5A (PDE5) with sildenafil augments contractility of LV and myocyte in heart failure [abstract]. Circulation. 2014;130(Suppl 2):A13200.

Cheng H-J, Li T, Cheng C-P. Molecular mechanism of chronic sildenafil-caused regression of heart failure: effects on the express of cardiac SR Ca2+-ATPase, subtype of beta-adrenergic receptors and nitric oxide synthase isoforms [abstract]. Circulation. 2014;130(Suppl 2):A15295.

Zhang X, Cheng H-J, Zhou P, Li T, Li W-M, Cheng C-P. Cellular basis of angiotensin-(1-7) produced augmentation on left ventricular contractile function in heart failure [abstract]. Circulation. 2014;130(Suppl 2):A13171.

Cheng C-P, Hasegawa H, Morimoto A, Cheng H-J, Little WC. C-type natriuretic peptide improves left ventricular systolic and diastolic functional performance at rest and during exercise after heart failure [abstract]. Circulation. 2014;130(Suppl 2):A12583.

Cheng CP, Shao Q, Cheng H-J, Callahan MF. Mechanism of chronic CaMKII inhibition-caused regression of heart failure: beneficial effects on neurohormonal activation, left ventricular and cardiomyocyte contractile function, [Ca2+]i regulation and beta-adrenergic modulation [abstract]. Circ Res. 2013;113(4 Suppl):A035.

Cheng CP, Cheng H-J, Zhou P, Li T-K, Kitzman DW, Kritchevsky SB, Little WC. Reversal of aging-induced contrast changes of cardiac SERCA 2a and inducible nitric oxide synthase in mice deficient in beta3-adrenoreceptor: insights into the molecular mechanism of cardiac aging [abstract]. Circ Res. 2013;113(4 Suppl):A087.

Masutani S, Cheng HJ, Morimoto A, Hasegawa H, Han QH, Little WC, Cheng CP. Beta 3-adrenergic receptor antagonist improves exercise performance in pacing-induced heart failure. Am J Physiol Heart Circ Physiol. 2013;305(6):H923-30.

Hasegawa H, Cheng H-J, Morimoto A, Little WC, Cheng CP. Vasopeptidase inhibitor, omapatrilat, enhances cardiac positive inotropic and lusitropic responses to dobutamine and exercise in heart failures: assessment by pressure-volume analysis [abstract]. Circulation. 2013;128(22 Suppl):A11563.

Shao Q, Li T, Cheng H-J, Li W-M, Cheng CP. Direct cardiac positive inotropic and lusitropic effect of colforsin daropate is enhanced while isoproterenol is attenuated in hypothyroidism [abstract]. Circulation. 2013;128(22 Suppl):A14090.

Cheng CP, Cheng H-J, Zhou P, Shao Q. Intrinsic cardiomyocyte defects and dystrophic cardiomyocyte in a canine model of Duchenne muscular dystrophy [abstract]. Circulation. 2013;128(22 Suppl):A14718.

Cheng H-J, Shao Q, Zhang L, Wagner JD, Cheng CP. Oxidative stress from upregulation of cardiac beta3-AR-activated iNOS uncoupling promotes diabetic cardiomyopathy in cynomolgous monkeys with naturally-occurring type 2 diabetes [abstract]. Circulation. 2013;128(22 Suppl):A13243.

Wajih N, Li T, Shao Q, Cheng H-J, Qasem SA, Cheng CP. Cardiomyopathy in a rat model of high-fat diet-induced obesity: effects of left ventricle and myocyte functional performance, [Ca2+]i transient response and beta-adrenergic modulation [abstract]. Circulation. 2013;128(22 Suppl):A16005.

Cheng H-J, Shao Q, Li T, Wajih N, Li W-M, Cheng CP. Molecular basis of hypothyroid cardiomyopathy: contrasting changes between cardiac beta1-adrenergic receptors, SERCA2a and inducible nitric oxide synthase [abstract]. Circulation. 2013;128(22 Suppl):A13136.

Li T, Shao Q, Cheng H-J, Callahan MF, Li W-M, Cheng CP. Mechanism of chronic phosphodiesterase type 5 inhibition-caused regression of heart failure: beneficial effects of left ventricular and myocyte function, [Ca2+]i regulation and beta-adrenergic modulation [abstract]. Circulation. 2013;128(22 Suppl):A11545.

Liu Y, Geng J, Liu Y, Li Y, Shen J, Xiao X, Sheng L, Yang B, Cheng C, Li W. Beta 3-adrenoceptor mediates metabolic protein remodeling in a rabbit model of tachypacing-induced atrial fibrillation. Cell Physiol Biochem. 2013;32(6):1631-1642.

Zhou P, Cheng H-J, Cheng CP. Restoration of normal cardiomyocyte basal and beta-adrenergic receptor (AR) subtype modulation of L-type calcium current in heart failure by chronic beta3-AR deficiency: insights into the underlying electrophysiological mechanism [abstract]. Circulation. 2012;126(21 Suppl):A9675.

Shao Q, Cheng H-J, Callahan MF, Li W-M, Cheng CP. Late initiation of chronic CaMKII inhibition causes regression in rat model of progressive heart failure: insights into the underlying cellular mechanim [abstract]. Circulation. 2012;126(21 Suppl):A11401.

Shao Q, Cheng H-J, Callahan MF, Li W-M, Cheng CP. Overexpression myocardial inducible nitric oxide synthase (iNOS) exacerbates cardiac dysfunction and beta-adrenergic desensitization in rats with experimental hypothyroidism [abstract]. Circulation. 2012;126(21 Suppl):A11340.

Cheng H-J, Zhou P, Shao Q, Kitzman DW, Kritchevsky SB, Sane DC, Little WC, Cheng CP. Upregulation of cardiac beta3-adrenergic receptor-activated inducible nitric oxide synthase promotes cardiac aging: role of oxidant stress [abstract]. Circulation. 2012;126(21 Suppl):A11645.

Cheng CP, Zhou P, Cheng H-J, Shao Q, Sane DC, Little WC. Chronic urotensin II receptor blockade causes regression of heart failure: beneficial effects on neurohormonal activation, cardiomyocyte contractile function [Ca2+]i regulation and beta-adrenergic modulation [abstract]. Circulation. 2012;126(21 Suppl):A9932.

Masutani S, Cheng H-J, Tachibana H, Little WC, Cheng C-P. Levosimendan restores the positive force-frequency relation in heart failure. Am J Physiol Heart Circ Physiol. 2011;301(2):H488-496.

Cheng CP, Zhou P, Cheng H-J. Cellular basis for angiotensin-(1-7)-induced positive modulation on cardiac contractile performance in heart failure [abstract]. J Card Fail. 2011;17(8 Suppl):S62.

Wajih N, Cheng H-J, Zhou P, Daunais JB, Friedman DP, Little WC, Grant KA, Cheng CP. Downregulation of SR Ca2+-ATPase as a contributing cause of impaired cardiomyocyte basal and beta-adrenergic regulation of [Ca2+]i with myocyte dysfunction in monkeys with chronic heavy alcohol consumption [abstract]. Circulation. 2011;124(21 Suppl):A9254.

Shao Q, Cheng H-J, Callahan MF, Wong SH, Wesley DJ, Li W-M, Cheng CP. Mechanism of thyroid-hormone-deficiency-caused cardiac injury in a rat model: effects of left ventricle and myocyte functional performance, [Ca2+]i transient response and beta-adrenergic modulation [abstract]. Circulation. 2011;124(21 Suppl):A9149.

Cheng H-J, Shao Q, Zhang L, Callahan MF, Wagner JD, Cheng CP. Upregulation and adverse effects of cardiac beta3-adrenoreceptor-mediated inducible nitric oxide synthase (iNOS)-coupled pathway in monkeys with naturally occurring type 2 diabetes [abstract]. Circulation. 2011;124(21 Suppl):A10649.

Cheng H-J, Zhou P, Zhao W, Wajih N, Han Q-H, Little WC, Cheng CP. Upregulation of cardiac urotensin II (UII) exacerbates UII stimulation-induced negative modulation on myocyte contractile function and Ca2+ current in streptozotocin-induced diabetic rats [abstract]. Circulation. 2011;124(21 Suppl):A9259.

Cheng CP, Cheng H-J, Zhou P, Masutani S, Callahan MF, Cline JM, Little WC. Is beta3-adrenoceptor (AR) a target for heart failure therapy? Evidence from beta3-AR knockout mice [abstract]. Circulation. 2011;124(21 Suppl):A12986.

Cheng H-J, Grant KA, Han Q-H, Daunais JB, Friedman DP, Masutani S, Little WC, Cheng C-P. Up-regulation and functional effect of cardiac beta(3)-adrenoreceptors in alcoholic monkeys. Alcohol Clin Exp Res. 2010;34(7):1171-1181.

Cheng C-P, Han Q-H, Cheng H-J, Onishi K, Ukai T, Ohte N, Little WC. Is up-regulation of beta3-adrenergic receptor (AR) in the failing myocardium detrimental or beneficial?--Effect on chronic beta3-AR blockade in pacing-induced heart failure [abstract]. Circulation. 2010;122(21 Suppl):A17062.

Cheng H-J, Zhou P, Kitzman DW, Kritchevsky SB, Sane DC, Little WC, Cheng C-P. Reversal of aging-induced upregulation of cardiac inducible nitric oxide synthase and beta-adrenergic desensitization in mice lacking the beta3-adrenoreceptor [abstract]. Circulation. 2010;122(21 Suppl):A13008.

Zhou P, Cheng H-J, Zhang Z-S, Little WC, Cheng C-P. Inducible nitric oxide synthase stimulation depresses cardiomyocyte basal and beta-adrenergic response of L-type calcium current in heart failure: insights into the underlying electrophysiological mechanism [abstract]. Circulation. 2010;122(21 Suppl):A15884.

Cheng C-P, Cheng H-J, Masutani S, Hundley WG, Daunais JB, Friedman DP, Grant KA. Functional significance of cardiac beta3 adrenergic receptors in alcoholic cardiomyopathy [abstract]. J Card Fail. 2009;15(Suppl 6):S42.

Frankel AE, Kuo SR, Dostal D, Watson L, Duesbery NS, Cheng CP, Cheng HJ, Tang WJ, Leppla SH. Pathophysiology of anthrax. Front Biosci. 2009;14():4516-4524.

Cheng C-P, Cheng H-J, Hasegawa H, Morimoto A, Zhou P, Cross M, Little WC. Na+-H+ exchange inhibition by cariporide enhances cardiac positive inotropic and lusitropic responses to dobutamine in heart failure: assessment by pressure-volume analysis [abstract]. Circulation. 2009;120(18 Suppl):S733-S734.

Zhou P, Cheng H-J, Cross M, Little WC, Cheng C-P. Modulation of cardiac L-type Ca2+ current by angiotensin-(1-7): normal vs heart failure [abstract]. Circulation. 2009;120(18 Suppl):S694.

Cheng C-P, Cheng H-J, Zhou P, Markert CD, Cross M, Kornegay JN, Stedman H, Childers MK. Cardiomyopathy in a canine model of Duchenne muscular dystrophy: effects of left ventricle and myocyte systolic and diastolic functional performance, L-type calcium current response and beta-adrenergic modulation [abstract]. Circulation. 2009;120(18 Suppl):S667.

Cheng H-J, Zhou P, Cross M, Kitzman D, Kritchevsky S, Sane DC, Little WC, Cheng C-P. Upregulation of cardiac SERCA 2a by chronic beta3-adrenergic receptor (AR) deficiency: a key molecular mechanism of the protective effect of beta3-AR deficiency on myocardial aging [abstract]. Circulation. 2009;120(18 Suppl):S584-S585.

Zhou P, Cheng H-J, Hasegawa H, Morimoto A, Cross M, Cheng C-P. Enhanced C-type natriuretic peptide positive modulation on cardiac performance in heart failure: effects on left ventricle and myocyte contraction, [Ca2+]i transient and Ca2+ current [abstract]. Circulation. 2009;120(18 Suppl):S820.

Masutani S, Cheng H-J, Hyttila-Hopponen M, Levijoki J, Heikkila A, Vuorela A, Little WC, Cheng C-P. Orally available levosimendan dose-related positive inotropic and lusitropic effect in conscious chronically instrumented normal and heart failure dogs. J Pharmacol Exp Ther. 2008;325(1):236-247.

Masutani S, Little WC, Hasegawa H, Cheng H-J, Cheng C-P. Restrictive left ventricular filling pattern does not result from increased left atrial pressure alone. Circulation. 2008;117(12):1550-1554.

Cheng C-P, Masutani S, Cheng H-J, Morimoto A, Hasegawa H, Little WC. Cardiac beta3-adrenergic receptor: a new target for the treatment of exercise intolerance in heart failure [abstract]. J Card Fail. 2008;14(6 Suppl 1):S12.

Cheng C-P, Masutani S, Cheng H-J, Little WC, Hyttila-Hopponen M, Levijoki J, Heikkila A, Vuorela A. Use of oral levosimendan to treat congestive heart failure: a pharmacodynamic versus pharmacokinetic relationship study [abstract]. J Card Fail. 2008;14(6 Suppl 1):S79.

Masutani S, Little WC, Hasegawa H, Cheng H-J, Cheng C-P. Response to letter regarding article, 'Restrictive left ventricular filling pattern does not result from increased left atrial pressure alone' [reply to letter]. Circulation. 2008;118(13):e506.

Zhou P, Cheng H-J, Cross M, Callahan MF, Brosnihan B, Little WC, Cheng C-P. Functional effect of chronic urotensin II receptor antagonist on L-type Ca2+ current in mouse model of progressive heart failure [abstract]. Circulation. 2008;118(18 Suppl 2):S398.

Cheng H-J, Masutani S, Zhang C-X, Cross M, Little WC, Cheng C-P. Upregulation of beta3-adrenoceptors (AR) as a contributing cause of reduced positive modulation of adrenergic signaling in aged hearts: evidence from beta3-AR knockout mice [abstract]. Circulation. 2008;118(18 Suppl 2):S425.

Cheng C-P, Zhou P, Cheng H-J, Cross M, Little WC. Direct cardiac effect and cellular mechanism of angiotensin-(1-7) in heart failure [abstract]. Circulation. 2008;118(18 Suppl 2):S513.

Cheng H-J, Zhou P, Cross M, Callahan MF, Little WC, Cheng C-P. Normalization of beta adrenergic receptor signaling improves left ventricular myocyte function with urotensin II receptor blockade in murine heart failure [abstract]. Circulation. 2008;118(18 Suppl 2):S797.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Cardiology

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