Research Interests
cardiac function
,
drugs/therapeutic agents pharm
,
molecular biology/molecular me
,
substance abuse
Recent Publications
Cheng CP, Zhou P, Cheng H-J.
Cellular basis for angiotensin-(1-7)-induced positive modulation on cardiac contractile performance in heart failure [abstract]. J Card Fail.
2011;
17(8 Suppl):S62.
Wajih N, Cheng H-J, Zhou P, Daunais JB, Friedman DP, Little WC, Grant KA, Cheng CP.
Downregulation of SR Ca2+-ATPase as a contributing cause of impaired cardiomyocyte basal and beta-adrenergic regulation of [Ca2+]i with myocyte dysfunction in monkeys with chronic heavy alcohol consumption [abstract]. Circulation.
2011;
124(21 Suppl):A9254.
Shao Q, Cheng H-J, Callahan MF, Wong SH, Wesley DJ, Li W-M, Cheng CP.
Mechanism of thyroid-hormone-deficiency-caused cardiac injury in a rat model: effects of left ventricle and myocyte functional performance, [Ca2+]i transient response and beta-adrenergic modulation [abstract]. Circulation.
2011;
124(21 Suppl):A9149.
Cheng H-J, Shao Q, Zhang L, Callahan MF, Wagner JD, Cheng CP.
Upregulation and adverse effects of cardiac beta3-adrenoreceptor-mediated inducible nitric oxide synthase (iNOS)-coupled pathway in monkeys with naturally occurring type 2 diabetes [abstract]. Circulation.
2011;
124(21 Suppl):A10649.
Cheng H-J, Zhou P, Zhao W, Wajih N, Han Q-H, Little WC, Cheng CP.
Upregulation of cardiac urotensin II (UII) exacerbates UII stimulation-induced negative modulation on myocyte contractile function and Ca2+ current in streptozotocin-induced diabetic rats [abstract]. Circulation.
2011;
124(21 Suppl):A9259.
Cheng CP, Cheng H-J, Zhou P, Masutani S, Callahan MF, Cline JM, Little WC.
Is beta3-adrenoceptor (AR) a target for heart failure therapy? Evidence from beta3-AR knockout mice [abstract]. Circulation.
2011;
124(21 Suppl):A12986.
Cheng C-P, Han Q-H, Cheng H-J, Onishi K, Ukai T, Ohte N, Little WC.
Is up-regulation of beta3-adrenergic receptor (AR) in the failing myocardium detrimental or beneficial?--Effect on chronic beta3-AR blockade in pacing-induced heart failure [abstract]. Circulation.
2010;
122(21 Suppl):A17062.
Cheng H-J, Zhou P, Kitzman DW, Kritchevsky SB, Sane DC, Little WC, Cheng C-P.
Reversal of aging-induced upregulation of cardiac inducible nitric oxide synthase and beta-adrenergic desensitization in mice lacking the beta3-adrenoreceptor [abstract]. Circulation.
2010;
122(21 Suppl):A13008.
Zhou P, Cheng H-J, Zhang Z-S, Little WC, Cheng C-P.
Inducible nitric oxide synthase stimulation depresses cardiomyocyte basal and beta-adrenergic response of L-type calcium current in heart failure: insights into the underlying electrophysiological mechanism [abstract]. Circulation.
2010;
122(21 Suppl):A15884.
Cheng C-P, Cheng H-J, Masutani S, Hundley WG, Daunais JB, Friedman DP, Grant KA.
Functional significance of cardiac beta3 adrenergic receptors in alcoholic cardiomyopathy [abstract]. J Card Fail.
2009;
15(Suppl 6):S42.
Frankel AE, Kuo SR, Dostal D, Watson L, Duesbery NS, Cheng CP, Cheng HJ, Tang WJ, Leppla SH.
Pathophysiology of anthrax. Front Biosci.
2009;
14():4516-4524.
Cheng C-P, Cheng H-J, Hasegawa H, Morimoto A, Zhou P, Cross M, Little WC.
Na+-H+ exchange inhibition by cariporide enhances cardiac positive inotropic and lusitropic responses to dobutamine in heart failure: assessment by pressure-volume analysis [abstract]. Circulation.
2009;
120(18 Suppl):S733-S734.
Zhou P, Cheng H-J, Cross M, Little WC, Cheng C-P.
Modulation of cardiac L-type Ca2+ current by angiotensin-(1-7): normal vs heart failure [abstract]. Circulation.
2009;
120(18 Suppl):S694.
Cheng C-P, Cheng H-J, Zhou P, Markert CD, Cross M, Kornegay JN, Stedman H, Childers MK.
Cardiomyopathy in a canine model of Duchenne muscular dystrophy: effects of left ventricle and myocyte systolic and diastolic functional performance, L-type calcium current response and beta-adrenergic modulation [abstract]. Circulation.
2009;
120(18 Suppl):S667.
Cheng H-J, Zhou P, Cross M, Kitzman D, Kritchevsky S, Sane DC, Little WC, Cheng C-P.
Upregulation of cardiac SERCA 2a by chronic beta3-adrenergic receptor (AR) deficiency: a key molecular mechanism of the protective effect of beta3-AR deficiency on myocardial aging [abstract]. Circulation.
2009;
120(18 Suppl):S584-S585.
Zhou P, Cheng H-J, Hasegawa H, Morimoto A, Cross M, Cheng C-P.
Enhanced C-type natriuretic peptide positive modulation on cardiac performance in heart failure: effects on left ventricle and myocyte contraction, [Ca2+]i transient and Ca2+ current [abstract]. Circulation.
2009;
120(18 Suppl):S820.
Cheng C-P, Masutani S, Cheng H-J, Morimoto A, Hasegawa H, Little WC.
Cardiac beta3-adrenergic receptor: a new target for the treatment of exercise intolerance in heart failure [abstract]. J Card Fail.
2008;
14(6 Suppl 1):S12.
Cheng C-P, Masutani S, Cheng H-J, Little WC, Hyttila-Hopponen M, Levijoki J, Heikkila A, Vuorela A.
Use of oral levosimendan to treat congestive heart failure: a pharmacodynamic versus pharmacokinetic relationship study [abstract]. J Card Fail.
2008;
14(6 Suppl 1):S79.
Zhou P, Cheng H-J, Cross M, Callahan MF, Brosnihan B, Little WC, Cheng C-P.
Functional effect of chronic urotensin II receptor antagonist on L-type Ca2+ current in mouse model of progressive heart failure [abstract]. Circulation.
2008;
118(18 Suppl 2):S398.
Cheng H-J, Masutani S, Zhang C-X, Cross M, Little WC, Cheng C-P.
Upregulation of beta3-adrenoceptors (AR) as a contributing cause of reduced positive modulation of adrenergic signaling in aged hearts: evidence from beta3-AR knockout mice [abstract]. Circulation.
2008;
118(18 Suppl 2):S425.
Cheng C-P, Zhou P, Cheng H-J, Cross M, Little WC.
Direct cardiac effect and cellular mechanism of angiotensin-(1-7) in heart failure [abstract]. Circulation.
2008;
118(18 Suppl 2):S513.
Cheng H-J, Zhou P, Cross M, Callahan MF, Little WC, Cheng C-P.
Normalization of beta adrenergic receptor signaling improves left ventricular myocyte function with urotensin II receptor blockade in murine heart failure [abstract]. Circulation.
2008;
118(18 Suppl 2):S797.
Masutani S, Cheng H-J, Han Q-H, Ohte N, Suzuki M, Little WC, Cheng C-P.
Vasopressin V1 receptor improves left ventricular systolic and diastolic performance at rest and during exercise after heart failure [abstract]. Circulation.
2008;
118(18 Suppl 2):S954.
Cheng CP, Masutani S, Cheng HJ, Cross M, Hyttila-Hopponen M, Levijoki J, Heikkila A, Vuorela A, Little WC.
Oral levosimendan enhances left ventricular systolic and diastolic performance prior to and after pacing-induced heart failure in dogs [abstract]. J Vet Intern Med.
2007;
21(3):632-633.
Cheng C-P, Masutani S, Cheng H-J, Cross M, Zhang C-X, Zhou P, Cann J, Cline JM, Little WC, Kuo S-R, et al.
Progressive left ventricle, myocyte dysfunction, and heart failure in the lethality of anthrax toxin in conscious dogs [abstract]. Circulation.
2007;
116(16 Suppl II):II-758.
Cheng H-J, Han Q-H, Zhou P, Morimoto A, Masutani S, Little WC, Cheng C-P.
Coordinated upregulation of cardiomyocyte urotensin II (U-II) and its receptor (UT) exhibits enhanced inhibition of L-type calcium current in heart failure [abstract]. Circulation.
2007;
116(16 Supp II):II-148.
Cheng H-J, Cunningham CC, Zhang ZS, Shihabi ZK, Sane DC, Wannenburg T, Masutani S, Little WC, Cheng C-P.
Upregulation of cardiac AT1 receptor signaling inhibits myocyte contractile performance, [Ca2+]i transient, and Ca2+ current in alcoholic dogs: insights into the underlying molecular mechanism [abstract]. Circulation.
2007;
116(16 Suppl II):II-311.
Zhou P, Zhang Z-S, Cheng H-J, Masutani S, Cross M, Little WC, Cheng C-P.
Electrophysiological effects of endothelin-1: altered inotropic response of left ventricle in heart failure [abstract]. Circulation.
2007;
116(16 Suppl II):II-12.
Cheng C-P, Shihabi ZK, Masutani S, Cheng H-J, Zhao Y, Cross M.
Protective effects of L-carnitine on left ventricular and myocyte dysfunction after short-term oral alcohol administration in rat [abstract]. Circulation.
2006;
114(18 Suppl):II-3.
Masutani S, Little WC, Hasegawa H Cheng H-J, Cheng C-P.
Restrictive left ventricular filling pattern does not result from increased left atrial pressure alone [abstract]. Circulation.
2006;
114(18 Suppl):II-134.
Cheng H-J, Masutani S, Zhao Y, Cross M, Shihabi ZK, Cheng C-P.
L-carnitine prevents alcohol-induced altered cardiac TNF-alpha and beta-adrenergic receptor (AR) expression and restores normal positive inotropic response to beta-AR stimulation after short-term alcohol consumption [abstract]. Circulation.
2006;
114(18 Suppl):II-486.
All Publications
For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.
For a list of earlier publications, visit the Carpenter Library Publication Search.