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Heng-Jie Cheng, M.D., Ph.D.Wake Forest School of Medicine

Heng-Jie Cheng, M.D., Ph.D.

Associate Professor,
Cardiovascular Sciences Ctr

Contact Information

Academic: 336-713-7076 | Department: 336-713-7076

Education & Training

  • Ph.D., Wayne State University School of Medicine, 1991
  • Fellowship, Cardiology, WFU School of Medicine, 2001
Heng-Jie Cheng, M.D., Ph.D.

Heng-Jie Cheng, M.D., Ph.D.

Associate Professor, Cardiology
Cardiovascular Sciences Ctr

Research Interests

Myocytes, Cardiac; Heart Failure; Cardiotonic Agents; Calcium Signaling; Receptors, Adrenergic, beta-3
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Contact Information

Academic: 336-713-7076 | Department: 336-713-7076

Recent Publications

3D bioprinted functional and contractile cardiac tissue constructs. Wang Z, Lee SJ, Cheng HJ, Yoo JJ, Atala A.. Acta Biomater. 2018;70():48-56.

Cellular basis of angiotensin-(1-7)-induced augmentation of left ventricular functional performance in heart failure. Zhang X, Cheng HJ, Zhou P, Kitzman DW, Ferrario CM, Li WM, Cheng CP.. Int J Cardiol. 2017;236():405-412.

3D bioprinted functional and contractile cardiac tissue constructs [abstract]. Lee S, Wang Z, Cheng H, Yoo JJ, Atala A.. Tissue Eng Part A. 2017;23(Suppl 1):S96.

Aging-associated upregulation of cardiac beta3-adrenergic signaling is an important cause of cardiac aging [abstract]. Cheng HJ, Zhou P, Zhang Z, Masutani S, Kitzman D, Callahan M, Cheng CP.. Physiologist. 2017;60(6):17.

The role and mechanism of anti-tumor necrosis factor-alpha on left ventricular functional performance and exercise performance in dogs with pacing-induced heart failure [abstract]. Cheng CP, Cheng HJ, Zhang Z, Hasegawa H, Morimoto A, Igawa A.. Circulation. 2017;136(Suppl 1):A13839.

Reversal of angiotensin-(1-12)-caused positive modulation on left ventricular contractile performance in heart failure: assessment by left-ventricular pressure-volume analysis [abstract]. Li T, Zhang Z, Zhang X, Ahmad S, Chen Z, Varagic J, Ramirez SR, Cheng HJ, Ferrario C, Cheng CP.. Circulation. 2017;136(Suppl 1):A14677.

Sex-related differences in age-associated alterations in expression and function of beta-adrenergic receptor subtypes in murine left ventricular myocytes [abstract]. Cheng HJ, Zhang Z, Chen Z, Zhou P, Kitzman D, Groban L, Cheng CP.. Circulation. 2017;136(Suppl 1):A15763.

Upregulation of cardiac beta3-adrenergic receptor-activated inducible nitric oxide synthase promotes cardiac aging [abstract]. Cheng HJ, Zhou P, Zhang Z, Li T, Zhang X, Shao Q, Chen Z, Kitzman D, Cheng CP.. Circulation. 2017;136(Suppl1):A13820.

Adrenomedullin improves left ventricular systolic and diastolic performance at rest and during exercise after heart failure [abstract]. Zhang Z, Cheng HJ, Zhang X, Ohte N, Ukai T, Masutani S, Igawa A, Cheng CP.. Circulation. 2017;136(Suppl 1):A13837.

Chronic C-type natriuretic peptide causes regression in rat model of progressive heart failure: insights into the underlying cellular mechanism [abstract]. Zhang Z, Cheng HJ, Chen Z, Zhou P, Li T, Ohte N, Masutani S, Cheng CP.. Circulation. 2017;136(Suppl 1):A16021.

Direct effects of C-type natriuretic peptide on left ventricular contractile performance in heart failure: assessment by left ventricular pressure-volume analysis [abstract]. Zhang Z, Cheng HJ, Li T, Zhang X, Zhou G, Ohte N, Cheng CP.. Circulation. 2017;136(Suppl 1):A13697.

Aging on cardiovascular functional and structural responses: does the presence of beta3-adrenergic receptors have a role? [abstract]. Cheng CP, Callahan MF, Zhang Z, Li T, Zhang X, Masutani S, Kitzman D, Cheng HJ.. Circulation. 2017;136(Suppl 1):A16444.

Overexpression myocardial inducible nitric oxide synthase exacerbates cardiac dysfunction and beta-adrenergic desensitization in experimental hypothyroidism. Shao Q, Cheng HJ, Callahan MF, Kitzman DW, Li WM, Cheng CP.. Int J Cardiol. 2016;204():229-241.

C-type natriuretic peptide improves left ventricular functional performance at rest and restores normal exercise responses after heart failure. Li T, Cheng HJ, Ohte N, Hasegawa H, Morimoto A, Herrington D, Little W [deceased], Li W, Cheng CP.. J Pharmacol Exp Ther. 2016;357(3):545-553.

3D bioprinted in vitro cardiac tissue model [abstract]. Wang Z, Cheng H, Seol Y, Yoo JJ, Atala A, Lee S.. Tissue Eng Part A. 2016;22(Suppl 1):S62-S63.

Chronic GPER activation attenuates cardiac dysfunction in a male mouse model of progressive heart failure: insights into cellular mechanisms [abstract]. Zhang X, Li T, Wang H, Cheng H-J, Li W, Ferrario CM, Groban L, Cheng C-P.. Circulation. 2016;134(Suppl 1):A12559.

Altered cardiomyocyte inotropic response to chymase/Ang-(1-12) pathway activation in heart failure [abstract]. Li T, Zhang X, Ahmad S, Varagic J, Cheng H-J, Zhang Z, Groban L, Ferrario CM, Cheng C-P.. Circulation. 2016;134(Suppl 1):A12206.

Reversal of aging-induced upregulation of cardiac inducible nitric oxide synthase and beta-adrenergic desensitization in mice deficient in beta3-adrenoreceptor [abstract]. Cheng H-J, Zhou P, Li T, Zhang Z, Kitzman DW, Gorban L, Cheng C-P.. Circulation. 2016;134(Suppl 1):A14375.

Cellular basis of C-type natriuretic peptide produced augmentation on left ventricular systolic and diastolic functional performance in heart failure [abstract]. Zhang Z, Zhang X, Li T, Cheng H-J, Zhou P, Cheng C-P.. Circulation. 2016;134(Suppl 1):A12575.

Chronic inhibition of Ca2+/calmodulin-dependent protein kinase II by KN-93 causes regression of cardiac dysfunction in rats with isoproterenol-induced heart failure [abstract]. Cheng C-P, Shao Q, Cheng H-J, Callahan MF, Li T.. Circulation. 2016;134(Suppl 1):A14303.

Enhanced angiotensin-(1-7) positive modulation on left ventricular functional performance in conscious dog with pacing-induced heart failure: assessment by pressure-volume analysis [abstract]. Zhang X, Morimoto A, Cheng H-J, Li T, Ohte N, Herrington DM, Cheng C-P.. Circulation. 2016;134(Suppl 1):A14985.

Modulation of cardiac L-type Ca2+ current by angiotensin-(1-7): normal versus heart failure. Zhou P, Cheng CP, Li T, Ferrario CM, Cheng HJ.. Ther Adv Cardiovasc Dis. 2015;9(6):342-353.

In vitro evaluations of 3-D bioprinted cardiac tissue constructs [abstract]. Wang Z, Cheng H, Seol Y, Yoo JJ, Lee S, Atala A.. Tissue Eng Part A. 2015;21(Suppl 1):S233.

Altered cardiomyocyte functional response to vasopressin in heart failure [abstract]. Li T, Zhang X, Cheng H-J, Li W-M, Cheng C-P.. Circulation. 2015;132(Suppl 3):A11921.

Oxidative stress from altered cardiac beta3-adrenergic receptor-activated inducible nitric oxide synthase/NO pathways promotes cardiac aging [abstract]. Cheng C-P, Cheng H-J, Zhou P, Li T, Zhang X, Kitzman D, Callahan M.. Circulation. 2015;132(Suppl 3):A15427.

Cariporide, a selective Na+-H+ exchange inhibitor, improves cardiac basal and beta-adrenergic stimulated functional performance in experimental hypothyroidism [abstract]. Li T, Zhang X, Cheng H-J, Shao Q, Li W-M, Cheng C-P.. Circulation. 2015;132(Suppl 3):A12686.

Upregulation of cardiac beta3-adrenergic signaling promotes heart failure progression [abstract]. Zhang X, Li T, Cheng H-J, Zhou P, Callahan M, Cheng C-P.. Circulation. 2015;132(Suppl 3):A16113.

Molecular basis of the protective effect of beta3-adrenergic receptor deficiency on myocardial aging: reversal of aging-induced contrast changes of cardiac SERCA 2a and inducible nitric oxide synthase [abstract]. Cheng H-J, Zhou P, Li T, Zhang X, Masutani S, Kitzman D, Little W, Cheng C-P.. Circulation. 2015;132(Suppl 3):A14261.

Restoration of normal cardiomyocyte basal and beta-adrenergic receptor (AR) subtype modulation in heart failure by chronic phosphodiesterase type 5 inhibition with sildenafil [abstract]. Li T, Cheng H-J, Qasem SA, Callahan M, Li W-M, Cheng C-P.. Circulation. 2014;130(Suppl 2):A15848.

Acute inhibition of phosphodiesterase type 5A (PDE5) with sildenafil augments contractility of LV and myocyte in heart failure [abstract]. Li T, Cheng H-J, Zhang X, Li W-M, Cheng C-P.. Circulation. 2014;130(Suppl 2):A13200.

Molecular mechanism of chronic sildenafil-caused regression of heart failure: effects on the express of cardiac SR Ca2+-ATPase, subtype of beta-adrenergic receptors and nitric oxide synthase isoforms [abstract]. Cheng H-J, Li T, Cheng C-P.. Circulation. 2014;130(Suppl 2):A15295.

Cellular basis of angiotensin-(1-7) produced augmentation on left ventricular contractile function in heart failure [abstract]. Zhang X, Cheng H-J, Zhou P, Li T, Li W-M, Cheng C-P.. Circulation. 2014;130(Suppl 2):A13171.

C-type natriuretic peptide improves left ventricular systolic and diastolic functional performance at rest and during exercise after heart failure [abstract]. Cheng C-P, Hasegawa H, Morimoto A, Cheng H-J, Little WC.. Circulation. 2014;130(Suppl 2):A12583.

Upregulation of cardiac beta3-adrenergic signaling promotes heart failure progression: evidence from chronic beta3-adrenoceptor (AR) deficiency or beta3-AR blockade mice [abstract]. Cheng H-J, Zhou P, Li T, Kitzman D, Callahan MF, Masutani S.. Circulation. 2014;130(Suppl 2):A14636.

Mechanism of chronic CaMKII inhibition-caused regression of heart failure: beneficial effects on neurohormonal activation, left ventricular and cardiomyocyte contractile function, [Ca2+]i regulation and beta-adrenergic modulation [abstract]. Cheng CP, Shao Q, Cheng H-J, Callahan MF.. Circ Res. 2013;113(4 Suppl):A035.

Reversal of aging-induced contrast changes of cardiac SERCA 2a and inducible nitric oxide synthase in mice deficient in beta3-adrenoreceptor: insights into the molecular mechanism of cardiac aging [abstract]. Cheng CP, Cheng H-J, Zhou P, Li T-K, Kitzman DW, Kritchevsky SB, Little WC.. Circ Res. 2013;113(4 Suppl):A087.

Beta 3-adrenergic receptor antagonist improves exercise performance in pacing-induced heart failure. Masutani S, Cheng HJ, Morimoto A, Hasegawa H, Han QH, Little WC, Cheng CP.. Am J Physiol Heart Circ Physiol. 2013;305(6):H923-30.

Vasopeptidase inhibitor, omapatrilat, enhances cardiac positive inotropic and lusitropic responses to dobutamine and exercise in heart failures: assessment by pressure-volume analysis [abstract]. Hasegawa H, Cheng H-J, Morimoto A, Little WC, Cheng CP.. Circulation. 2013;128(22 Suppl):A11563.

Direct cardiac positive inotropic and lusitropic effect of colforsin daropate is enhanced while isoproterenol is attenuated in hypothyroidism [abstract]. Shao Q, Li T, Cheng H-J, Li W-M, Cheng CP.. Circulation. 2013;128(22 Suppl):A14090.

Intrinsic cardiomyocyte defects and dystrophic cardiomyocyte in a canine model of Duchenne muscular dystrophy [abstract]. Cheng CP, Cheng H-J, Zhou P, Shao Q.. Circulation. 2013;128(22 Suppl):A14718.

Oxidative stress from upregulation of cardiac beta3-AR-activated iNOS uncoupling promotes diabetic cardiomyopathy in cynomolgous monkeys with naturally-occurring type 2 diabetes [abstract]. Cheng H-J, Shao Q, Zhang L, Wagner JD, Cheng CP.. Circulation. 2013;128(22 Suppl):A13243.

Cardiomyopathy in a rat model of high-fat diet-induced obesity: effects of left ventricle and myocyte functional performance, [Ca2+]i transient response and beta-adrenergic modulation [abstract]. Wajih N, Li T, Shao Q, Cheng H-J, Qasem SA, Cheng CP.. Circulation. 2013;128(22 Suppl):A16005.

Molecular basis of hypothyroid cardiomyopathy: contrasting changes between cardiac beta1-adrenergic receptors, SERCA2a and inducible nitric oxide synthase [abstract]. Cheng H-J, Shao Q, Li T, Wajih N, Li W-M, Cheng CP.. Circulation. 2013;128(22 Suppl):A13136.

Mechanism of chronic phosphodiesterase type 5 inhibition-caused regression of heart failure: beneficial effects of left ventricular and myocyte function, [Ca2+]i regulation and beta-adrenergic modulation [abstract]. Li T, Shao Q, Cheng H-J, Callahan MF, Li W-M, Cheng CP.. Circulation. 2013;128(22 Suppl):A11545.

Restoration of normal cardiomyocyte basal and beta-adrenergic receptor (AR) subtype modulation of L-type calcium current in heart failure by chronic beta3-AR deficiency: insights into the underlying electrophysiological mechanism [abstract]. Zhou P, Cheng H-J, Cheng CP.. Circulation. 2012;126(21 Suppl):A9675.

Late initiation of chronic CaMKII inhibition causes regression in rat model of progressive heart failure: insights into the underlying cellular mechanim [abstract]. Shao Q, Cheng H-J, Callahan MF, Li W-M, Cheng CP.. Circulation. 2012;126(21 Suppl):A11401.

Overexpression myocardial inducible nitric oxide synthase (iNOS) exacerbates cardiac dysfunction and beta-adrenergic desensitization in rats with experimental hypothyroidism [abstract]. Shao Q, Cheng H-J, Callahan MF, Li W-M, Cheng CP.. Circulation. 2012;126(21 Suppl):A11340.

Upregulation of cardiac beta3-adrenergic receptor-activated inducible nitric oxide synthase promotes cardiac aging: role of oxidant stress [abstract]. Cheng H-J, Zhou P, Shao Q, Kitzman DW, Kritchevsky SB, Sane DC, Little WC, Cheng CP.. Circulation. 2012;126(21 Suppl):A11645.

Chronic urotensin II receptor blockade causes regression of heart failure: beneficial effects on neurohormonal activation, cardiomyocyte contractile function [Ca2+]i regulation and beta-adrenergic modulation [abstract]. Cheng CP, Zhou P, Cheng H-J, Shao Q, Sane DC, Little WC.. Circulation. 2012;126(21 Suppl):A9932.

Levosimendan restores the positive force-frequency relation in heart failure. Masutani S, Cheng H-J, Tachibana H, Little WC, Cheng C-P.. Am J Physiol Heart Circ Physiol. 2011;301(2):H488-496.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Associate Professor, Cardiology

Heng-Jie Cheng, M.D., Ph.D.

Heng-Jie Cheng, M.D., Ph.D.

Associate Professor, Cardiology
Cardiovascular Sciences Ctr

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