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Heng-Jie Cheng, M.D., Ph.D.Wake Forest School of Medicine

Heng-Jie Cheng, M.D., Ph.D.

Assistant Professor,

Contact Information

Academic: 336-713-1473 | Department: 336-713-1473

Education & Training

  • Ph.D., Wayne State University School of Medicine, 1991
  • Fellowship, Cardiology, WFU School of Medicine, 2001
Heng-Jie Cheng, M.D., Ph.D.

Heng-Jie Cheng, M.D., Ph.D.

Assistant Professor, Cardiology

Research Interests

Receptors, Adrenergic, beta-3; Heart Failure; Ventricular Dysfunction, Left; Cardiomyopathy, Alcoholic; Myocytes, Cardiac
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Contact Information

Academic: 336-713-1473 | Department: 336-713-1473

Recent Publications

Overexpression myocardial inducible nitric oxide synthase exacerbates cardiac dysfunction and beta-adrenergic desensitization in experimental hypothyroidism. Shao Q, Cheng HJ, Callahan MF, Kitzman DW, Li WM, Cheng CP.. Int J Cardiol. 2016;204():229-241.

C-type natriuretic peptide improves left ventricular functional performance at rest and restores normal exercise responses after heart failure. Li T, Cheng HJ, Ohte N, Hasegawa H, Morimoto A, Herrington D, Little W [deceased], Li W, Cheng CP.. J Pharmacol Exp Ther. 2016;357(3):545-553.

Modulation of cardiac L-type Ca2+ current by angiotensin-(1-7): normal versus heart failure. Zhou P, Cheng CP, Li T, Ferrario CM, Cheng HJ.. Ther Adv Cardiovasc Dis. 2015;9(6):342-353.

In vitro evaluations of 3-D bioprinted cardiac tissue constructs [abstract]. Wang Z, Cheng H, Seol Y, Yoo JJ, Lee S, Atala A.. Tissue Eng Part A. 2015;21(Suppl 1):S233.

Altered cardiomyocyte functional response to vasopressin in heart failure [abstract]. Li T, Zhang X, Cheng H-J, Li W-M, Cheng C-P.. Circulation. 2015;132(Suppl 3):A11921.

Oxidative stress from altered cardiac beta3-adrenergic receptor-activated inducible nitric oxide synthase/NO pathways promotes cardiac aging [abstract]. Cheng C-P, Cheng H-J, Zhou P, Li T, Zhang X, Kitzman D, Callahan M.. Circulation. 2015;132(Suppl 3):A15427.

Cariporide, a selective Na+-H+ exchange inhibitor, improves cardiac basal and beta-adrenergic stimulated functional performance in experimental hypothyroidism [abstract]. Li T, Zhang X, Cheng H-J, Shao Q, Li W-M, Cheng C-P.. Circulation. 2015;132(Suppl 3):A12686.

Upregulation of cardiac beta3-adrenergic signaling promotes heart failure progression [abstract]. Zhang X, Li T, Cheng H-J, Zhou P, Callahan M, Cheng C-P.. Circulation. 2015;132(Suppl 3):A16113.

Molecular basis of the protective effect of beta3-adrenergic receptor deficiency on myocardial aging: reversal of aging-induced contrast changes of cardiac SERCA 2a and inducible nitric oxide synthase [abstract]. Cheng H-J, Zhou P, Li T, Zhang X, Masutani S, Kitzman D, Little W, Cheng C-P.. Circulation. 2015;132(Suppl 3):A14261.

Restoration of normal cardiomyocyte basal and beta-adrenergic receptor (AR) subtype modulation in heart failure by chronic phosphodiesterase type 5 inhibition with sildenafil [abstract]. Li T, Cheng H-J, Qasem SA, Callahan M, Li W-M, Cheng C-P.. Circulation. 2014;130(Suppl 2):A15848.

Acute inhibition of phosphodiesterase type 5A (PDE5) with sildenafil augments contractility of LV and myocyte in heart failure [abstract]. Li T, Cheng H-J, Zhang X, Li W-M, Cheng C-P.. Circulation. 2014;130(Suppl 2):A13200.

Molecular mechanism of chronic sildenafil-caused regression of heart failure: effects on the express of cardiac SR Ca2+-ATPase, subtype of beta-adrenergic receptors and nitric oxide synthase isoforms [abstract]. Cheng H-J, Li T, Cheng C-P.. Circulation. 2014;130(Suppl 2):A15295.

Cellular basis of angiotensin-(1-7) produced augmentation on left ventricular contractile function in heart failure [abstract]. Zhang X, Cheng H-J, Zhou P, Li T, Li W-M, Cheng C-P.. Circulation. 2014;130(Suppl 2):A13171.

C-type natriuretic peptide improves left ventricular systolic and diastolic functional performance at rest and during exercise after heart failure [abstract]. Cheng C-P, Hasegawa H, Morimoto A, Cheng H-J, Little WC.. Circulation. 2014;130(Suppl 2):A12583.

Upregulation of cardiac beta3-adrenergic signaling promotes heart failure progression: evidence from chronic beta3-adrenoceptor (AR) deficiency or beta3-AR blockade mice [abstract]. Cheng H-J, Zhou P, Li T, Kitzman D, Callahan MF, Masutani S.. Circulation. 2014;130(Suppl 2):A14636.

Mechanism of chronic CaMKII inhibition-caused regression of heart failure: beneficial effects on neurohormonal activation, left ventricular and cardiomyocyte contractile function, [Ca2+]i regulation and beta-adrenergic modulation [abstract]. Cheng CP, Shao Q, Cheng H-J, Callahan MF.. Circ Res. 2013;113(4 Suppl):A035.

Reversal of aging-induced contrast changes of cardiac SERCA 2a and inducible nitric oxide synthase in mice deficient in beta3-adrenoreceptor: insights into the molecular mechanism of cardiac aging [abstract]. Cheng CP, Cheng H-J, Zhou P, Li T-K, Kitzman DW, Kritchevsky SB, Little WC.. Circ Res. 2013;113(4 Suppl):A087.

Beta 3-adrenergic receptor antagonist improves exercise performance in pacing-induced heart failure. Masutani S, Cheng HJ, Morimoto A, Hasegawa H, Han QH, Little WC, Cheng CP.. Am J Physiol Heart Circ Physiol. 2013;305(6):H923-30.

Vasopeptidase inhibitor, omapatrilat, enhances cardiac positive inotropic and lusitropic responses to dobutamine and exercise in heart failures: assessment by pressure-volume analysis [abstract]. Hasegawa H, Cheng H-J, Morimoto A, Little WC, Cheng CP.. Circulation. 2013;128(22 Suppl):A11563.

Direct cardiac positive inotropic and lusitropic effect of colforsin daropate is enhanced while isoproterenol is attenuated in hypothyroidism [abstract]. Shao Q, Li T, Cheng H-J, Li W-M, Cheng CP.. Circulation. 2013;128(22 Suppl):A14090.

Intrinsic cardiomyocyte defects and dystrophic cardiomyocyte in a canine model of Duchenne muscular dystrophy [abstract]. Cheng CP, Cheng H-J, Zhou P, Shao Q.. Circulation. 2013;128(22 Suppl):A14718.

Oxidative stress from upregulation of cardiac beta3-AR-activated iNOS uncoupling promotes diabetic cardiomyopathy in cynomolgous monkeys with naturally-occurring type 2 diabetes [abstract]. Cheng H-J, Shao Q, Zhang L, Wagner JD, Cheng CP.. Circulation. 2013;128(22 Suppl):A13243.

Cardiomyopathy in a rat model of high-fat diet-induced obesity: effects of left ventricle and myocyte functional performance, [Ca2+]i transient response and beta-adrenergic modulation [abstract]. Wajih N, Li T, Shao Q, Cheng H-J, Qasem SA, Cheng CP.. Circulation. 2013;128(22 Suppl):A16005.

Molecular basis of hypothyroid cardiomyopathy: contrasting changes between cardiac beta1-adrenergic receptors, SERCA2a and inducible nitric oxide synthase [abstract]. Cheng H-J, Shao Q, Li T, Wajih N, Li W-M, Cheng CP.. Circulation. 2013;128(22 Suppl):A13136.

Mechanism of chronic phosphodiesterase type 5 inhibition-caused regression of heart failure: beneficial effects of left ventricular and myocyte function, [Ca2+]i regulation and beta-adrenergic modulation [abstract]. Li T, Shao Q, Cheng H-J, Callahan MF, Li W-M, Cheng CP.. Circulation. 2013;128(22 Suppl):A11545.

Restoration of normal cardiomyocyte basal and beta-adrenergic receptor (AR) subtype modulation of L-type calcium current in heart failure by chronic beta3-AR deficiency: insights into the underlying electrophysiological mechanism [abstract]. Zhou P, Cheng H-J, Cheng CP.. Circulation. 2012;126(21 Suppl):A9675.

Late initiation of chronic CaMKII inhibition causes regression in rat model of progressive heart failure: insights into the underlying cellular mechanim [abstract]. Shao Q, Cheng H-J, Callahan MF, Li W-M, Cheng CP.. Circulation. 2012;126(21 Suppl):A11401.

Overexpression myocardial inducible nitric oxide synthase (iNOS) exacerbates cardiac dysfunction and beta-adrenergic desensitization in rats with experimental hypothyroidism [abstract]. Shao Q, Cheng H-J, Callahan MF, Li W-M, Cheng CP.. Circulation. 2012;126(21 Suppl):A11340.

Upregulation of cardiac beta3-adrenergic receptor-activated inducible nitric oxide synthase promotes cardiac aging: role of oxidant stress [abstract]. Cheng H-J, Zhou P, Shao Q, Kitzman DW, Kritchevsky SB, Sane DC, Little WC, Cheng CP.. Circulation. 2012;126(21 Suppl):A11645.

Chronic urotensin II receptor blockade causes regression of heart failure: beneficial effects on neurohormonal activation, cardiomyocyte contractile function [Ca2+]i regulation and beta-adrenergic modulation [abstract]. Cheng CP, Zhou P, Cheng H-J, Shao Q, Sane DC, Little WC.. Circulation. 2012;126(21 Suppl):A9932.

Levosimendan restores the positive force-frequency relation in heart failure. Masutani S, Cheng H-J, Tachibana H, Little WC, Cheng C-P.. Am J Physiol Heart Circ Physiol. 2011;301(2):H488-496.

Cellular basis for angiotensin-(1-7)-induced positive modulation on cardiac contractile performance in heart failure [abstract]. Cheng CP, Zhou P, Cheng H-J.. J Card Fail. 2011;17(8 Suppl):S62.

Downregulation of SR Ca2+-ATPase as a contributing cause of impaired cardiomyocyte basal and beta-adrenergic regulation of [Ca2+]i with myocyte dysfunction in monkeys with chronic heavy alcohol consumption [abstract]. Wajih N, Cheng H-J, Zhou P, Daunais JB, Friedman DP, Little WC, Grant KA, Cheng CP.. Circulation. 2011;124(21 Suppl):A9254.

Mechanism of thyroid-hormone-deficiency-caused cardiac injury in a rat model: effects of left ventricle and myocyte functional performance, [Ca2+]i transient response and beta-adrenergic modulation [abstract]. Shao Q, Cheng H-J, Callahan MF, Wong SH, Wesley DJ, Li W-M, Cheng CP.. Circulation. 2011;124(21 Suppl):A9149.

Upregulation and adverse effects of cardiac beta3-adrenoreceptor-mediated inducible nitric oxide synthase (iNOS)-coupled pathway in monkeys with naturally occurring type 2 diabetes [abstract]. Cheng H-J, Shao Q, Zhang L, Callahan MF, Wagner JD, Cheng CP.. Circulation. 2011;124(21 Suppl):A10649.

Upregulation of cardiac urotensin II (UII) exacerbates UII stimulation-induced negative modulation on myocyte contractile function and Ca2+ current in streptozotocin-induced diabetic rats [abstract]. Cheng H-J, Zhou P, Zhao W, Wajih N, Han Q-H, Little WC, Cheng CP.. Circulation. 2011;124(21 Suppl):A9259.

Is beta3-adrenoceptor (AR) a target for heart failure therapy? Evidence from beta3-AR knockout mice [abstract]. Cheng CP, Cheng H-J, Zhou P, Masutani S, Callahan MF, Cline JM, Little WC.. Circulation. 2011;124(21 Suppl):A12986.

Up-regulation and functional effect of cardiac beta(3)-adrenoreceptors in alcoholic monkeys. Cheng H-J, Grant KA, Han Q-H, Daunais JB, Friedman DP, Masutani S, Little WC, Cheng C-P.. Alcohol Clin Exp Res. 2010;34(7):1171-1181.

Is up-regulation of beta3-adrenergic receptor (AR) in the failing myocardium detrimental or beneficial?--Effect on chronic beta3-AR blockade in pacing-induced heart failure [abstract]. Cheng C-P, Han Q-H, Cheng H-J, Onishi K, Ukai T, Ohte N, Little WC.. Circulation. 2010;122(21 Suppl):A17062.

Reversal of aging-induced upregulation of cardiac inducible nitric oxide synthase and beta-adrenergic desensitization in mice lacking the beta3-adrenoreceptor [abstract]. Cheng H-J, Zhou P, Kitzman DW, Kritchevsky SB, Sane DC, Little WC, Cheng C-P.. Circulation. 2010;122(21 Suppl):A13008.

Inducible nitric oxide synthase stimulation depresses cardiomyocyte basal and beta-adrenergic response of L-type calcium current in heart failure: insights into the underlying electrophysiological mechanism [abstract]. Zhou P, Cheng H-J, Zhang Z-S, Little WC, Cheng C-P.. Circulation. 2010;122(21 Suppl):A15884.

Functional significance of cardiac beta3 adrenergic receptors in alcoholic cardiomyopathy [abstract]. Cheng C-P, Cheng H-J, Masutani S, Hundley WG, Daunais JB, Friedman DP, Grant KA.. J Card Fail. 2009;15(Suppl 6):S42.

Pathophysiology of anthrax. Frankel AE, Kuo SR, Dostal D, Watson L, Duesbery NS, Cheng CP, Cheng HJ, Tang WJ, Leppla SH.. Front Biosci. 2009;14():4516-4524.

Na+-H+ exchange inhibition by cariporide enhances cardiac positive inotropic and lusitropic responses to dobutamine in heart failure: assessment by pressure-volume analysis [abstract]. Cheng C-P, Cheng H-J, Hasegawa H, Morimoto A, Zhou P, Cross M, Little WC.. Circulation. 2009;120(18 Suppl):S733-S734.

Modulation of cardiac L-type Ca2+ current by angiotensin-(1-7): normal vs heart failure [abstract]. Zhou P, Cheng H-J, Cross M, Little WC, Cheng C-P.. Circulation. 2009;120(18 Suppl):S694.

Cardiomyopathy in a canine model of Duchenne muscular dystrophy: effects of left ventricle and myocyte systolic and diastolic functional performance, L-type calcium current response and beta-adrenergic modulation [abstract]. Cheng C-P, Cheng H-J, Zhou P, Markert CD, Cross M, Kornegay JN, Stedman H, Childers MK.. Circulation. 2009;120(18 Suppl):S667.

Upregulation of cardiac SERCA 2a by chronic beta3-adrenergic receptor (AR) deficiency: a key molecular mechanism of the protective effect of beta3-AR deficiency on myocardial aging [abstract]. Cheng H-J, Zhou P, Cross M, Kitzman D, Kritchevsky S, Sane DC, Little WC, Cheng C-P.. Circulation. 2009;120(18 Suppl):S584-S585.

Enhanced C-type natriuretic peptide positive modulation on cardiac performance in heart failure: effects on left ventricle and myocyte contraction, [Ca2+]i transient and Ca2+ current [abstract]. Zhou P, Cheng H-J, Hasegawa H, Morimoto A, Cross M, Cheng C-P.. Circulation. 2009;120(18 Suppl):S820.

Orally available levosimendan dose-related positive inotropic and lusitropic effect in conscious chronically instrumented normal and heart failure dogs. Masutani S, Cheng H-J, Hyttila-Hopponen M, Levijoki J, Heikkila A, Vuorela A, Little WC, Cheng C-P.. J Pharmacol Exp Ther. 2008;325(1):236-247.

Restrictive left ventricular filling pattern does not result from increased left atrial pressure alone. Masutani S, Little WC, Hasegawa H, Cheng H-J, Cheng C-P.. Circulation. 2008;117(12):1550-1554.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Assistant Professor, Cardiology

Heng-Jie Cheng, M.D., Ph.D.

Heng-Jie Cheng, M.D., Ph.D.

Assistant Professor, Cardiology

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