Profile

Heng-Jie Cheng, M.D., Ph.D.Wake Forest School of Medicine

Heng-Jie Cheng, M.D., Ph.D.

Assistant Professor,

Contact Information

Academic: 336-713-7076 | Department: 336-713-7076

Education & Training

  • Ph.D., Wayne State University School of Medicine , 1991
  • Fellowship, Cardiology, WFU School of Medicine, 2001
Heng-Jie Cheng, M.D., Ph.D.

Heng-Jie Cheng, M.D., Ph.D.

Assistant Professor, Institute for Regenerative Medicine
Cardiology

Research Interests

aging, cardiac function, drugs/therapeutic agents pharm, molecular biology/molecular me

Contact Information

Academic: 336-713-7076 | Department: 336-713-7076

Recent Publications

Cheng CP, Shao Q, Cheng H-J, Callahan MF. Mechanism of chronic CaMKII inhibition-caused regression of heart failure: beneficial effects on neurohormonal activation, left ventricular and cardiomyocyte contractile function, [Ca2+]i regulation and beta-adrenergic modulation [abstract]. Circ Res. 2013;113(4 Suppl):A035.

Cheng CP, Cheng H-J, Zhou P, Li T-K, Kitzman DW, Kritchevsky SB, Little WC. Reversal of aging-induced contrast changes of cardiac SERCA 2a and inducible nitric oxide synthase in mice deficient in beta3-adrenoreceptor: insights into the molecular mechanism of cardiac aging [abstract]. Circ Res. 2013;113(4 Suppl):A087.

Masutani S, Cheng HJ, Morimoto A, Hasegawa H, Han QH, Little WC, Cheng CP. Beta 3-adrenergic receptor antagonist improves exercise performance in pacing-induced heart failure. Am J Physiol Heart Circ Physiol. 2013;305(6):H923-30.

Hasegawa H, Cheng H-J, Morimoto A, Little WC, Cheng CP. Vasopeptidase inhibitor, omapatrilat, enhances cardiac positive inotropic and lusitropic responses to dobutamine and exercise in heart failures: assessment by pressure-volume analysis [abstract]. Circulation. 2013;128(22 Suppl):A11563.

Shao Q, Li T, Cheng H-J, Li W-M, Cheng CP. Direct cardiac positive inotropic and lusitropic effect of colforsin daropate is enhanced while isoproterenol is attenuated in hypothyroidism [abstract]. Circulation. 2013;128(22 Suppl):A14090.

Cheng CP, Cheng H-J, Zhou P, Shao Q. Intrinsic cardiomyocyte defects and dystrophic cardiomyocyte in a canine model of Duchenne muscular dystrophy [abstract]. Circulation. 2013;128(22 Suppl):A14718.

Cheng H-J, Shao Q, Zhang L, Wagner JD, Cheng CP. Oxidative stress from upregulation of cardiac beta3-AR-activated iNOS uncoupling promotes diabetic cardiomyopathy in cynomolgous monkeys with naturally-occurring type 2 diabetes [abstract]. Circulation. 2013;128(22 Suppl):A13243.

Wajih N, Li T, Shao Q, Cheng H-J, Qasem SA, Cheng CP. Cardiomyopathy in a rat model of high-fat diet-induced obesity: effects of left ventricle and myocyte functional performance, [Ca2+]i transient response and beta-adrenergic modulation [abstract]. Circulation. 2013;128(22 Suppl):A16005.

Cheng H-J, Shao Q, Li T, Wajih N, Li W-M, Cheng CP. Molecular basis of hypothyroid cardiomyopathy: contrasting changes between cardiac beta1-adrenergic receptors, SERCA2a and inducible nitric oxide synthase [abstract]. Circulation. 2013;128(22 Suppl):A13136.

Li T, Shao Q, Cheng H-J, Callahan MF, Li W-M, Cheng CP. Mechanism of chronic phosphodiesterase type 5 inhibition-caused regression of heart failure: beneficial effects of left ventricular and myocyte function, [Ca2+]i regulation and beta-adrenergic modulation [abstract]. Circulation. 2013;128(22 Suppl):A11545.

Zhou P, Cheng H-J, Cheng CP. Restoration of normal cardiomyocyte basal and beta-adrenergic receptor (AR) subtype modulation of L-type calcium current in heart failure by chronic beta3-AR deficiency: insights into the underlying electrophysiological mechanism [abstract]. Circulation. 2012;126(21 Suppl):A9675.

Shao Q, Cheng H-J, Callahan MF, Li W-M, Cheng CP. Late initiation of chronic CaMKII inhibition causes regression in rat model of progressive heart failure: insights into the underlying cellular mechanim [abstract]. Circulation. 2012;126(21 Suppl):A11401.

Shao Q, Cheng H-J, Callahan MF, Li W-M, Cheng CP. Overexpression myocardial inducible nitric oxide synthase (iNOS) exacerbates cardiac dysfunction and beta-adrenergic desensitization in rats with experimental hypothyroidism [abstract]. Circulation. 2012;126(21 Suppl):A11340.

Cheng H-J, Zhou P, Shao Q, Kitzman DW, Kritchevsky SB, Sane DC, Little WC, Cheng CP. Upregulation of cardiac beta3-adrenergic receptor-activated inducible nitric oxide synthase promotes cardiac aging: role of oxidant stress [abstract]. Circulation. 2012;126(21 Suppl):A11645.

Cheng CP, Zhou P, Cheng H-J, Shao Q, Sane DC, Little WC. Chronic urotensin II receptor blockade causes regression of heart failure: beneficial effects on neurohormonal activation, cardiomyocyte contractile function [Ca2+]i regulation and beta-adrenergic modulation [abstract]. Circulation. 2012;126(21 Suppl):A9932.

Masutani S, Cheng H-J, Tachibana H, Little WC, Cheng C-P. Levosimendan restores the positive force-frequency relation in heart failure. Am J Physiol Heart Circ Physiol. 2011;301(2):H488-496.

Cheng CP, Zhou P, Cheng H-J. Cellular basis for angiotensin-(1-7)-induced positive modulation on cardiac contractile performance in heart failure [abstract]. J Card Fail. 2011;17(8 Suppl):S62.

Wajih N, Cheng H-J, Zhou P, Daunais JB, Friedman DP, Little WC, Grant KA, Cheng CP. Downregulation of SR Ca2+-ATPase as a contributing cause of impaired cardiomyocyte basal and beta-adrenergic regulation of [Ca2+]i with myocyte dysfunction in monkeys with chronic heavy alcohol consumption [abstract]. Circulation. 2011;124(21 Suppl):A9254.

Shao Q, Cheng H-J, Callahan MF, Wong SH, Wesley DJ, Li W-M, Cheng CP. Mechanism of thyroid-hormone-deficiency-caused cardiac injury in a rat model: effects of left ventricle and myocyte functional performance, [Ca2+]i transient response and beta-adrenergic modulation [abstract]. Circulation. 2011;124(21 Suppl):A9149.

Cheng H-J, Shao Q, Zhang L, Callahan MF, Wagner JD, Cheng CP. Upregulation and adverse effects of cardiac beta3-adrenoreceptor-mediated inducible nitric oxide synthase (iNOS)-coupled pathway in monkeys with naturally occurring type 2 diabetes [abstract]. Circulation. 2011;124(21 Suppl):A10649.

Cheng H-J, Zhou P, Zhao W, Wajih N, Han Q-H, Little WC, Cheng CP. Upregulation of cardiac urotensin II (UII) exacerbates UII stimulation-induced negative modulation on myocyte contractile function and Ca2+ current in streptozotocin-induced diabetic rats [abstract]. Circulation. 2011;124(21 Suppl):A9259.

Cheng CP, Cheng H-J, Zhou P, Masutani S, Callahan MF, Cline JM, Little WC. Is beta3-adrenoceptor (AR) a target for heart failure therapy? Evidence from beta3-AR knockout mice [abstract]. Circulation. 2011;124(21 Suppl):A12986.

Cheng H-J, Grant KA, Han Q-H, Daunais JB, Friedman DP, Masutani S, Little WC, Cheng C-P. Up-regulation and functional effect of cardiac beta(3)-adrenoreceptors in alcoholic monkeys. Alcohol Clin Exp Res. 2010;34(7):1171-1181.

Cheng C-P, Han Q-H, Cheng H-J, Onishi K, Ukai T, Ohte N, Little WC. Is up-regulation of beta3-adrenergic receptor (AR) in the failing myocardium detrimental or beneficial?--Effect on chronic beta3-AR blockade in pacing-induced heart failure [abstract]. Circulation. 2010;122(21 Suppl):A17062.

Cheng H-J, Zhou P, Kitzman DW, Kritchevsky SB, Sane DC, Little WC, Cheng C-P. Reversal of aging-induced upregulation of cardiac inducible nitric oxide synthase and beta-adrenergic desensitization in mice lacking the beta3-adrenoreceptor [abstract]. Circulation. 2010;122(21 Suppl):A13008.

Zhou P, Cheng H-J, Zhang Z-S, Little WC, Cheng C-P. Inducible nitric oxide synthase stimulation depresses cardiomyocyte basal and beta-adrenergic response of L-type calcium current in heart failure: insights into the underlying electrophysiological mechanism [abstract]. Circulation. 2010;122(21 Suppl):A15884.

Cheng C-P, Cheng H-J, Masutani S, Hundley WG, Daunais JB, Friedman DP, Grant KA. Functional significance of cardiac beta3 adrenergic receptors in alcoholic cardiomyopathy [abstract]. J Card Fail. 2009;15(Suppl 6):S42.

Frankel AE, Kuo SR, Dostal D, Watson L, Duesbery NS, Cheng CP, Cheng HJ, Tang WJ, Leppla SH. Pathophysiology of anthrax. Front Biosci. 2009;14():4516-4524.

Cheng C-P, Cheng H-J, Hasegawa H, Morimoto A, Zhou P, Cross M, Little WC. Na+-H+ exchange inhibition by cariporide enhances cardiac positive inotropic and lusitropic responses to dobutamine in heart failure: assessment by pressure-volume analysis [abstract]. Circulation. 2009;120(18 Suppl):S733-S734.

Zhou P, Cheng H-J, Cross M, Little WC, Cheng C-P. Modulation of cardiac L-type Ca2+ current by angiotensin-(1-7): normal vs heart failure [abstract]. Circulation. 2009;120(18 Suppl):S694.

Cheng C-P, Cheng H-J, Zhou P, Markert CD, Cross M, Kornegay JN, Stedman H, Childers MK. Cardiomyopathy in a canine model of Duchenne muscular dystrophy: effects of left ventricle and myocyte systolic and diastolic functional performance, L-type calcium current response and beta-adrenergic modulation [abstract]. Circulation. 2009;120(18 Suppl):S667.

Cheng H-J, Zhou P, Cross M, Kitzman D, Kritchevsky S, Sane DC, Little WC, Cheng C-P. Upregulation of cardiac SERCA 2a by chronic beta3-adrenergic receptor (AR) deficiency: a key molecular mechanism of the protective effect of beta3-AR deficiency on myocardial aging [abstract]. Circulation. 2009;120(18 Suppl):S584-S585.

Zhou P, Cheng H-J, Hasegawa H, Morimoto A, Cross M, Cheng C-P. Enhanced C-type natriuretic peptide positive modulation on cardiac performance in heart failure: effects on left ventricle and myocyte contraction, [Ca2+]i transient and Ca2+ current [abstract]. Circulation. 2009;120(18 Suppl):S820.

Masutani S, Cheng H-J, Hyttila-Hopponen M, Levijoki J, Heikkila A, Vuorela A, Little WC, Cheng C-P. Orally available levosimendan dose-related positive inotropic and lusitropic effect in conscious chronically instrumented normal and heart failure dogs. J Pharmacol Exp Ther. 2008;325(1):236-247.

Masutani S, Little WC, Hasegawa H, Cheng H-J, Cheng C-P. Restrictive left ventricular filling pattern does not result from increased left atrial pressure alone. Circulation. 2008;117(12):1550-1554.

Cheng C-P, Masutani S, Cheng H-J, Morimoto A, Hasegawa H, Little WC. Cardiac beta3-adrenergic receptor: a new target for the treatment of exercise intolerance in heart failure [abstract]. J Card Fail. 2008;14(6 Suppl 1):S12.

Cheng C-P, Masutani S, Cheng H-J, Little WC, Hyttila-Hopponen M, Levijoki J, Heikkila A, Vuorela A. Use of oral levosimendan to treat congestive heart failure: a pharmacodynamic versus pharmacokinetic relationship study [abstract]. J Card Fail. 2008;14(6 Suppl 1):S79.


Zhou P, Cheng H-J, Cross M, Callahan MF, Brosnihan B, Little WC, Cheng C-P. Functional effect of chronic urotensin II receptor antagonist on L-type Ca2+ current in mouse model of progressive heart failure [abstract]. Circulation. 2008;118(18 Suppl 2):S398.

Cheng H-J, Masutani S, Zhang C-X, Cross M, Little WC, Cheng C-P. Upregulation of beta3-adrenoceptors (AR) as a contributing cause of reduced positive modulation of adrenergic signaling in aged hearts: evidence from beta3-AR knockout mice [abstract]. Circulation. 2008;118(18 Suppl 2):S425.

Cheng C-P, Zhou P, Cheng H-J, Cross M, Little WC. Direct cardiac effect and cellular mechanism of angiotensin-(1-7) in heart failure [abstract]. Circulation. 2008;118(18 Suppl 2):S513.

Cheng H-J, Zhou P, Cross M, Callahan MF, Little WC, Cheng C-P. Normalization of beta adrenergic receptor signaling improves left ventricular myocyte function with urotensin II receptor blockade in murine heart failure [abstract]. Circulation. 2008;118(18 Suppl 2):S797.

Masutani S, Cheng H-J, Han Q-H, Ohte N, Suzuki M, Little WC, Cheng C-P. Vasopressin V1 receptor improves left ventricular systolic and diastolic performance at rest and during exercise after heart failure [abstract]. Circulation. 2008;118(18 Suppl 2):S954.

Cheng CP, Masutani S, Cheng HJ, Cross M, Hyttila-Hopponen M, Levijoki J, Heikkila A, Vuorela A, Little WC. Oral levosimendan enhances left ventricular systolic and diastolic performance prior to and after pacing-induced heart failure in dogs [abstract]. J Vet Intern Med. 2007;21(3):632-633.

Cheng C-P, Masutani S, Cheng H-J, Cross M, Zhang C-X, Zhou P, Cann J, Cline JM, Little WC, Kuo S-R, et al. Progressive left ventricle, myocyte dysfunction, and heart failure in the lethality of anthrax toxin in conscious dogs [abstract]. Circulation. 2007;116(16 Suppl II):II-758.

Cheng H-J, Han Q-H, Zhou P, Morimoto A, Masutani S, Little WC, Cheng C-P. Coordinated upregulation of cardiomyocyte urotensin II (U-II) and its receptor (UT) exhibits enhanced inhibition of L-type calcium current in heart failure [abstract]. Circulation. 2007;116(16 Supp II):II-148.

Cheng H-J, Cunningham CC, Zhang ZS, Shihabi ZK, Sane DC, Wannenburg T, Masutani S, Little WC, Cheng C-P. Upregulation of cardiac AT1 receptor signaling inhibits myocyte contractile performance, [Ca2+]i transient, and Ca2+ current in alcoholic dogs: insights into the underlying molecular mechanism [abstract]. Circulation. 2007;116(16 Suppl II):II-311.

Zhou P, Zhang Z-S, Cheng H-J, Masutani S, Cross M, Little WC, Cheng C-P. Electrophysiological effects of endothelin-1: altered inotropic response of left ventricle in heart failure [abstract]. Circulation. 2007;116(16 Suppl II):II-12.

Cheng C-P, Cheng H-J, Cunningham C, Shihabi ZK, Sane DC, Wannenburg T, Little WC. Angiotensin II type 1 receptor blockade prevents alcoholic cardiomyopathy. Circulation. 2006;114(3):226-236.

Cheng C-P, Shihabi ZK, Masutani S, Cheng H-J, Zhao Y, Cross M. Protective effects of L-carnitine on left ventricular and myocyte dysfunction after short-term oral alcohol administration in rat [abstract]. Circulation. 2006;114(18 Suppl):II-3.

Masutani S, Little WC, Hasegawa H Cheng H-J, Cheng C-P. Restrictive left ventricular filling pattern does not result from increased left atrial pressure alone [abstract]. Circulation. 2006;114(18 Suppl):II-134.

Cheng H-J, Masutani S, Zhao Y, Cross M, Shihabi ZK, Cheng C-P. L-carnitine prevents alcohol-induced altered cardiac TNF-alpha and beta-adrenergic receptor (AR) expression and restores normal positive inotropic response to beta-AR stimulation after short-term alcohol consumption [abstract]. Circulation. 2006;114(18 Suppl):II-486.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Heng-Jie Cheng, M.D., Ph.D.

Heng-Jie Cheng, M.D., Ph.D.

Assistant Professor, Institute for Regenerative Medicine
Cardiology

Quick Reference

Request an Appointment
New Patients

336-716-WAKE
888-716-WAKE

Existing patients may contact the clinic directly.
Find a Doctor Ways to Give
USNWR 2013-2014Magnet Hospital RecognitionConsumer Choice2014 Best DoctorsJoint Commission Report

Disclaimer: The information on this website is for general informational purposes only and SHOULD NOT be relied upon as a substitute for sound professional medical advice, evaluation or care from your physician or other qualified health care provider.