Steven R. Childers, Ph.D.Wake Forest School of Medicine

Steven R. Childers, Ph.D.


Contact Information

Academic: 336-716-3791 | Department: 336-716-3791


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Education & Training

  • B.S., University of Texas-Austin, 1972
  • Ph.D., University of Wisconsin-Madison, 1976
  • Fellowship, Johns Hopkins University Schoo, 1979


  • Coll on Probs of Drug Dependen
  • Federation Of Am.Soc.Experimen
  • Int'l Cannabinoid Society
  • Society for Neuroscience
Steven R. Childers, Ph.D.

Steven R. Childers, Ph.D.

Professor, Physiology & Pharmacology

Research Interests

drugs/therapeutic agents pharm, mental disorders/psychiatry/ps, neurosciences/behavior, substance abuse

Contact Information

Academic: 336-716-3791 | Department: 336-716-3791


Related Links

Recent Publications

Keegan BM, Beveridge TJ, Pezor JJ, Xiao R, Sexton T, Childers SR, Howlett AC. Chronic baclofen desensitizes GABAB-mediated G-protein activation and stimulates phosphorylation of kinases in mesocorticolimbic rat brain. Neuropharmacology. 2015;95():492-502.

McIntosh S, Sexton T, Pattison LP, Childers SR, Hemby SE. Increased sensitivity to cocaine self-administration in HIV-1 transgenic rats is associated with changes in striatal dopamine transporter binding. J Neuroimmune Pharmacol. 2015;10(3):493-505.

Pattison LP, Mcintosh S, Sexton T, Childers SR, Hemby SE. Changes in dopamine transporter binding in nucleus accumbens following chronic self-administration cocaine: heroin combinations. Synapse. 2014;68(10):437-444.

Blume LC, Bass CE, Childers SR, Dalton GD, Roberts DC, Richardson JM, Xiao R, Selley DE, Howlett AC. Striatal CB1 and D2 receptors regulate expression of each other, CRIP1A and delta opioid systems. J Neurochem. 2013;124(6):808-820.

Antonio T, Childers SR, Rothman RB, Dersch CM, King C, Kuehne M, Bornmann WG, Eshleman AJ, Janowsky A, Simon ER, Reith ME, Alper K. Effect of Iboga alkaloids on mu-opioid receptor-coupled G protein activation. PLoS One. 2013;8(10):e77262.

Nieves-Martinez E, Haynes K, Childers SR, Sonntag WE, Nicolle MM. Muscarinic receptor/G-protein coupling is reduced in the dorsomedial striatum of cognitively impaired aged rats. Behav Brain Res. 2012;227(1):258-264.

Martin TJ, Buechler NL, Kim SA, Ewan EE, Xiao R, Childers SR. Involvement of the lateral amygdala in the antiallodynic and reinforcing effects of heroin in rats after peripheral nerve injury. Anesthesiology. 2011;114(3):633-642.

Howlett AC, Reggio PH, Childers SR, Hampson RE, Ulloa NM, Deutsch DG. Endocannabinoid tone versus constitutive activity of cannabinoid receptors. Br J Pharmacol. 2011;163(7):1329-1343.

Manning JR, Sexton T, Childers SR, Davies HML. 1-Naphthyl and 4-indolyl arylalkylamines as selective monoamine reuptake inhibitors. Bioorg Med Chem Lett. 2009;19(1):58-61.

Oleson EB, Talluri S, Childers SR, Smith JE, Roberts DCS, Bonin KD, Budygin EA. Dopamine uptake changes associated with cocaine self-administration. Neuropsychopharmacology. 2009;34(5):1174-1184.

Murthy V, Martin TJ, Kim S, Davies HML, Childers SR. In vivo characterization of a novel phenylisothiocyanate tropane analog at monoamine transporters in rat brain. J Pharmacol Exp Ther. 2008;326(2):587-595.

Martin TJ, Kahn WR, Xiao R, Childers SR. Differential regional effects of methadone maintenance compared to heroin dependence on mu-opioid receptor desensitization in rat brain. Synapse. 2007;61(3):176-184.

Clayton BA, Hayashida K-i, Childers SR, Xiao R, Eisenach JC. Oral donepezil reduces hypersensitivity after nerve injury by a spinal muscarinic receptor mechanism. Anesthesiology. 2007;106(5):1019-1025.

Murthy V, Davies HML, Hedley SJ, Childers SR. Irreversible binding of a novel phenylisothiocyanate tropane analog to monoamine transporters in rat brain. Biochem Pharmacol. 2007;74(2):336-344.

Martin TJ, Eisenach JC, Misler J, Childers SR. Chronic activation of spinal adenosine A1 receptors results in hypersensitivity. Neuroreport. 2006;17(15):1619-1622.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Steven R. Childers, Ph.D.

Steven R. Childers, Ph.D.

Professor, Physiology & Pharmacology

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