Caroline Chiles, M.D.
Lung Neoplasms; Tomography, X-Ray Computed; Early Detection of Cancer; Mass Screening; Radiation Dosage
Academic: 336-716-4316 | Department: 336-716-4317
Lung cancer screening and smoking cessation clinical trials. SCALE (Smoking Cessation within the Context of Lung Cancer Screening) collaboration. Joseph AM, Rothman AJ, Almirall D, Begnaud A, Chiles C, Cinciripini PM, Fu SS, Graham AL, Lindgren BR, Melzer AC, Ostroff JS, Seaman EL, Taylor KL, Toll BA, Zeliadt SB, Vock DM.. Am J Respir Crit Care Med. 2018;197(2):172-182.
Reduced expiratory flow rate among heavy smokers increases lung cancer risk. Results from the National Lung Screening Trial-American College of Radiology Imaging Network cohort. Hopkins RJ, Duan F, Chiles C, Greco EM, Gamble GD, Aberle D, Young RP.. Ann Am Thorac Soc. 2017;14(3):392-402.
Lung cancer screening and the effects of competing causes of death in the ACRIN-NLST sub-study [abstract]. Hopkins RJ, Young RP, Duan F, Greco E, Chiles C, Aberle D, Gamble G.. Respir Med. 2017;132():279-280.
Chromosome 15Q25 locus and genetic susceptibility to lung cancer, COPD, and smoking: triple whammy effect in the ACRIN-NLST cohort sub-study (N=10,054) [abstract]. Hopkins RJ, Young RP, Duan F, Greco E, Chiles C, Aberle D, Gamble G.. Respir Med. 2017;132():279.
Stratification of NLST-ACRIN screening participants identifies the "sweet spot" of screening by identifying early stage lung cancers most amenable to curative surgery (N=10,054) [abstract]. Young RP, Hopkins RJ, Duan F, Greco E, Chiles C, Aberle D, Gamble G.. Respir Med. 2017;132():280.
Bone attenuation on computed tomography (CT) is inversely associated with all-cause mortality in elderly women in the National Lung Screening Trial [abstract]. Register T, Boutin R, Kritchevsky S, Chen HY, Chiles C, Wise B, Bateni C, Bayoumi A, Lenchik L.. J Bone Miner Res. 2017;32(Suppl 1):S365.
Computed tomographic screening for lung cancer trends at leading academic medical centers From 2013 to 2015 [research letter]. Boiselle PM, Chiles C, Ravenel JG, White CS.. JAMA Oncol. 2016;2(5):682-684.
Normative reference values of thoracic aortic diameter in American College of Radiology Imaging Network (ACRIN 6654) arm of National Lung Screening Trial. McComb BL, Munden RF, Duan F, Jain AA, Tuite C, Chiles C.. Clin Imaging. 2016;40(5):936-943.
Airflow limitation and lung cancer risk in a large prospective screening study (nlst-Acrin cohort analysis, N=18, 714) [abstract]. Hopkins RJ, Young RP, Duan F, Chiles C, Greco E, Gamble GD, Aberle D.. Am J Respir Crit Care Med. 2016;193():A6178.
Lung cancer screening: early results exceed Nlst-based expectations [abstract]. Stephens SE, Chiles C, Bellinger C.. Am J Respir Crit Care Med. 2016;193():A1282.
Lung cancer-specific mortality reduction with CT screening: outcomes according to airflow limitation in the Acrin Nlst Sub-Study (n=18,475) [abstract]. Young RP, Duan F, Greco E, Hopkins RJ, Chiles C, Gamble GD, Aberle D.. Am J Respir Crit Care Med. 2016;193():A6166.
Low-dose CT lung cancer screening practices and attitudes among primary care providers at an academic medical center. Lewis JA, Petty WJ, Tooze JA, Miller DP, Chiles C, Miller AA, Bellinger C, Weaver KE.. Cancer Epidemiol Biomarkers Prev. 2015;24(4):664-670.
Beyond metastatic disease: a pictorial review of multinodular lung disease with computed tomographic pathologic correlation. Shroff GS, Guirguis MS, Ocazionez D, Oldham SA, Restrepo CS, Chiles C.. Can Assoc Radiol J. 2015;66(1):16-23.
Abnormal stress-related measures of arterial stiffness in middle-aged and elderly men and women with impaired fasting glucose at risk for a first episode of symptomatic heart failure. Vasu S, Morgan TM, Kitzman DW, Bertoni A, Stacey RB, Hamilton C, Chiles C, Thohan V, Hundley WG.. J Am Heart Assoc. 2015;4(1):e000991.
Low dose CT screening for lung cancer: moving into the clinical arena [editorial]. Chiles C.. J Thorac Imaging. 2015;30(2):77-78.
Association of coronary artery calcification and mortality in the National Lung Screening Trial: a comparison of three scoring methods. Chiles C, Duan F, Gladish GW, Ravenel JG, Baginski SG, Snyder BS, DeMello S, Desjardins SS, Munden RF.. Radiology. 2015;276(1):82-90.
Estimation of pleural fluid volumes on chest radiography using computed tomography volumetric analysis: an update of the visual prediction rule. Mammarappallil JG, Anderson SA, Danelson KA, Stitzel JA, Chiles C.. J Thorac Imaging. 2015;30(5):336-339.
Mechanism of decreased sensitivity of dobutamine associated left ventricular wall motion analyses for appreciating inducible ischemia in older adults. Vasu S, Little WC, Morgan TM, Stacey RB, Ntim WO, Hamilton C, Thohan V, Chiles C, Hundley WG.. J Cardiovasc Magn Reson. 2015;17(1):26.
Low-dose computed tomographic screening for lung cancer. Christensen JD, Chiles C.. Clin Chest Med. 2015;36(2):147-160.
Airflow limitation and histology shift in the National Lung Screening Trial. The NLST-ACRIN Cohort Substudy. Young RP, Duan F, Chiles C, Hopkins RJ, Gamble GD, Greco EM, Gatsonis C, Aberle D.. Am J Respir Crit Care Med. 2015;192(9):1060-1067.
Implementing lung cancer screening in the real world: opportunity, challenges and solutions. Optican RJ, Chiles C.. Transl Lung Cancer Res. 2015;4(4):353-364.
COPD severity by GOLD status and lung cancer risk: results from a large prospective screening study (NLST-ACRIN cohort analysis, N=18, 714) [abstract]. Hopkins RJ, Young R, Duan FH, Chiles C, Gamble GD, Aberle DR.. J Thorac Oncol. 2015;10(9 Suppl 2):S345.
Favourable stage-shift limited to screening participants with COPD in a biomarker sub-study of the National Lung Screening Trial (NLST) [abstract]. Young R, Chiles C, Hopkins RJ, Duan FH, Gamble GD, Aberle DR.. J Thorac Oncol. 2015;10(9 Suppl 2):S733.
Histology-shift and overdiagnosis in the Nlst - the effect of COPD status in the acrin-biomarker cohort of 18,714 subjects [abstract]. Young RP, Chiles C, Duan F, Hopkins RJ, Gamble GD, Aberle DR.. Am J Respir Crit Care Med. 2015;191():A6115.
Lung cancer screening with low-dose computed tomography. Chiles C.. Radiol Clin North Am. 2014;52(1):27-46.
Overdiagnosis in low-dose computed tomography screening for lung cancer. Patz EF Jr, Pinsky P, Gatsonis C, Sicks JD, Kramer BS, Tammemagi MC, Chiles C, Black WC, Aberle DR.. JAMA Intern Med. 2014;174(2):269-274.
Projected outcomes using different nodule sizes to define a positive CT lung cancer screening examination. Gierada DS, Pinsky P, Nath H, Chiles C, Duan F, Aberle DR.. J Natl Cancer Inst. 2014;106(11):.
Low-dose CT lung cancer screening practices and attitudes among primary care providers at an academic medical center [abstract]. Lewis J, Petty WJ, Tooze JA, Miller DP, Chiles C, Miller AA, Weaver KE.. Int J Radiat Oncol Biol Phys. 2014;90(Suppl 5):S7-S8.
Semiautomatic method of quantifying pleural effusions using computed tomography scans--biomed 2013. Anderson SA, Danelson KA, Mammarappallil JG, Chiles C, Stitzel JD.. Biomed Sci Instrum. 2013;49():13-19.
Beyond lung cancer: a strategic approach to interpreting screening computed tomography scans on the basis of mortality data from the National Lung Screening Trial. Chiles C, Paul NS.. J Thorac Imaging. 2013;28(6):347-354.
Abnormal stress induced changes in arterial stiffness in middle aged men and women with impaired fasting glucose at risk of their first episode of symptomatic heart failure [abstract]. Vasu S, Morgan TM, Kitzman DW, Hamilton CA, Chiles C, Soots S, Thohan V, Hundley WG.. Circulation. 2013;128(22 Suppl):A18679.
Lung cancer risk mediated through susceptibility to COPD: preliminary results from a sub-analysis of the NLST [abstract]. Hopkins RJ, Young RP, Duan FH, Deng X, Chiles C, Gamble GD, Aberle D.. J Thorac Oncol. 2013;8(Suppl 2):S324.
COPD-based eligibility increases lung cancer detection rate and lowers over-diagnosis in CT screening studies [abstract]. Young RP, Duan FH, Hopkins RJ, Deng X, Chiles C, Gamble GD, Gatsonis C, Aberle D.. J Thorac Oncol. 2013;8(Suppl 2):S150-S151.
Perilymphatic nodules: definition, differential diagnosis, and demonstration of the 'pipe-cleaner' sign [abstract]. Shroff G, Konopka K, Chiles C.. AJR Am J Roentgenol. 2012;198(5 Suppl):E055.
Radiology of the chest. Chiles C, Gulla SM. In: Chen MYM, Pope TL, Ott DJ, eds. Basic radiology. 2nd ed. New York: McGraw Hill Medical;2011: 67-128.
Vascular pedicle width in acute lung injury: correlation with intravascular pressures and ability to discriminate fluid status. Rice TW, Ware LB, Haponik EF, Chiles C, Wheeler AP, Bernard GR, Steingrub JS, Hite RD, Matthay MA, Wright P, et al.. Crit Care. 2011;15(2):R86.
Impact and costs of targeted recruitment of minorities to the National Lung Screening Trial. Duda C, Mahon I, Chen MH, Snyder B, Barr R, Chiles C, Falk R, Fishman EK, Gemmel D, Goldin JG, et al.. Clin Trials. 2011;8(2):214-223.
Lung cancer screening: achieving a reduction in mortality. Chiles C.. Semin Roentgenol. 2011;46(3):230-240.
Correlating the extent of pulmonary contusion to vehicle crash parameters in near-side impacts. Danelson KA, Chiles C, Thompson AB, Donadino K, Weaver AA, Stitzel JD.. Ann Adv Automot Med. 2011;55():217-230.
Can tumor FDG-PET scan uptake (SUV) predict local control in stage III NSCLC? Preliminary results from ACRIN 6668/RTOG 0235 [abstract]. Machtay M, Duan F, Snyder B, Gorelick J, DeNittis AS, Chiles C, Mahon I, Alavi A, Siegel BA, Bradley JD.. Int J Radiat Oncol Biol Phys. 2011;81(2 Suppl):S134-S135.
Tracheobronchial foreign body aspiration in adults. Boyd M, Chatterjee A, Chiles C, Chin R Jr.. South Med J. 2009;102(2):171-174.
Nontraumatic acute aortic syndrome: imaging findings and complications. Olsen KM, Johnson DM, Chiles C.. Contemp Diagn Radiol. 2007;30(1):1-5.
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